Increased susceptibility of brain acetylcholinesterase activity to methylmalonate in young rats with renal failure.


:Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. Clinically, the disease is characterized by progressive neurological deterioration and renal failure, whose pathophysiology is still undefined. In the present study we investigated the effect of acute MMA administration on some important parameters of brain neurotransmission in cerebral cortex of rats, namely Na(+), K(+)-ATPase, ouabain-insensitive ATPases and acetylcholinesterase activities, in the presence or absence of kidney injury induced by gentamicin administration. Initially, thirty-day old Wistar rats received one intraperitoneal injection of saline or gentamicin (70 mg/kg). One hour after, the animals received three consecutive subcutaneous injections of MMA (1.67 μmol/g) or saline, with an 11 h interval between each injection. One hour after the last injection the animals were killed and the cerebral cortex isolated. MMA administration by itself was not able to modify Na(+), K(+)-ATPase, ATPases ouabain-insensitive or acetylcholinesterase activities in cerebral cortex of young rats. In rats receiving gentamicin simultaneously with MMA, it was observed an increase in the activity of acetylcholinesterase activity in cerebral cortex, without any alteration in the activity of the other studied enzymes. Therefore, it may be speculated that cholinergic imbalance may play a role in the pathogenesis of the brain damage. Furthermore, the pathophysiology of tissue damage cannot be exclusively attributed to MMA toxicity, and control of kidney function should be considered as a priority in the management of these patients, specifically during episodes of metabolic decompensation when MMA levels are higher.


Metab Brain Dis


Metabolic brain disease


Affonso AC,Machado DG,Malgarin F,Fraga DB,Ghedim F,Zugno A,Streck EL,Schuck PF,Ferreira GC




Has Abstract


2013-09-01 00:00:00












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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Thurston JH,Hauhart RE,Nelson JS

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  • Cortical benzodiazepine receptor binding in a rabbit model of hepatic encephalopathy: the effect of Triton X-100 on receptor solubilization.

    abstract::Increased benzodiazepine (BZ) receptor density has been reported in brains of rabbits with hepatic encephalopathy (HE) due to galactosamine (GalN)-induced fulminant hepatic failure (FHF). These data were generated using detergent-Triton X-100-treated neural membranes. While performing further studies it was noted that...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Rössle M,Mullen KD,Jones EA

    更新日期:1989-09-01 00:00:00

  • High mobility group box 1 enhances hyperthermia-induced seizures and secondary epilepsy associated with prolonged hyperthermia-induced seizures in developing rats.

    abstract::Levels of high mobility group box 1 (HMGB1), an important inflammatory mediator, are high in the serum of febrile seizure (FS) patients. However, its roles in FS and secondary epilepsy after prolonged FS are poorly understood. We demonstrate HMGB1's role in the pathogenesis of hyperthermia-induced seizures (HS) and se...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Ito M,Takahashi H,Yano H,Shimizu YI,Yano Y,Ishizaki Y,Tanaka J,Ishii E,Fukuda M

    更新日期:2017-12-01 00:00:00

  • Effect of propentofylline on the biochemical lesion of the rat brain in aluminium-induced neurotoxicity.

    abstract::Acute and chronic administration of Al-gluconate (12.7% Al) at the concentration of 1 mg/kg produces edema in the rat brain, as reflected by the increase in water and Na+ content. The permeability for Evans blue is also increased, which indicates the opening of the blood-brain barrier. Higher concentrations of the Al-...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Stefanovich V,Joó F

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  • Determinants of cognitive performance in children relying on cyanogenic cassava as staple food.

    abstract::While risk factors for konzo are known, determinants of cognitive impairment in konzo-affected children remain unknown. We anchored cognitive performance (KABC-II scores) to serum levels of free-thyroxine (free-T4), thyroid-stimulating hormone (TSH), albumin, and motor proficiency (BOT-2 scores) in 40 children includi...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Bumoko GM,Sombo MT,Okitundu LD,Mumba DN,Kazadi KT,Tamfum-Muyembe JJ,Lasarev MR,Boivin MJ,Banea JP,Tshala-Katumbay DD

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  • Prolactin, flupenthixol decanoate and first episode schizophrenia - clinical and laboratory correlates.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Retief M,Chiliza B,Phahladira L,Emsley R,Asmal L

    更新日期:2019-12-01 00:00:00

  • Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


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    更新日期:2015-12-01 00:00:00

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Mondal P,Trigun SK

    更新日期:2014-12-01 00:00:00

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Chastre A,Jiang W,Desjardins P,Butterworth RF

    更新日期:2010-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Cheng Y,Huang L,Zhang X,Zhong J,Ji Q,Xie S,Chen L,Zuo P,Zhang LJ,Shen W

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    pub_type: 杂志文章


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    journal_title:Metabolic brain disease

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    authors: Naicker M,Abbai N,Naidoo S

    更新日期:2019-10-01 00:00:00

  • EGb761 improves the cognitive function of elderly db/db-/- diabetic mice by regulating the beclin-1 and NF-κB signaling pathways.

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    pub_type: 杂志文章


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    更新日期:2018-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Borysiewicz E,Fil D,Dlaboga D,O'Donnell JM,Konat GW

    更新日期:2009-09-01 00:00:00

  • Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration.

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    pub_type: 杂志文章


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    更新日期:2017-04-01 00:00:00

  • Cerebral blood flow in hyperammonemia: heterogeneity and starling forces in capillaries.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审


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    更新日期:2002-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Divakaran P,Pavlina T,Johnson RC,Cotter R,Madsen D,Wiggins R

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    pub_type: 杂志文章


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    更新日期:2016-10-01 00:00:00

  • Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-therapeutic perspectives.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审


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    更新日期:2014-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Rackayova V,Braissant O,McLin VA,Berset C,Lanz B,Cudalbu C

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  • Regional metabolic status of the E-18 rat fetal brain following transient hypoxia/ischemia.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Pundik S,Robinson S,Lust WD,Zechel J,Buczek M,Selman WR

    更新日期:2006-12-01 00:00:00

  • Decrease of glutathione content in the prefrontal cortical mitochondria of rats with acute hepatic encephalopathy: prevention by histidine.

    abstract::Mitochondrial glutathione (mGSH) is a critical factor in the cell defense against oxidative and nitrosative stress (ONS), and ONS is a key pathogenic event in hepatic encephalopathy (HE). Acute HE in the thioacetamide (TAA) model caused a 54 % decrease of mGSH content in the rat prefrontal cortex (pfc), but not in the...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Ruszkiewicz J,Fręśko I,Hilgier W,Albrecht J

    更新日期:2013-03-01 00:00:00

  • Impaired tissue barriers as potential therapeutic targets for Parkinson's disease and amyotrophic lateral sclerosis.

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    pub_type: 杂志文章,评审


    authors: Fang X

    更新日期:2018-08-01 00:00:00

  • Heterogeneity of monoamine oxidase activities in synaptic and non-synaptic mitochondria derived from three brain regions: some functional implications.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Lai JC,Leung TK,Lim L

    更新日期:1994-03-01 00:00:00

  • Near infrared radiation rescues mitochondrial dysfunction in cortical neurons after oxygen-glucose deprivation.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Yu Z,Liu N,Zhao J,Li Y,McCarthy TJ,Tedford CE,Lo EH,Wang X

    更新日期:2015-04-01 00:00:00

  • Effect of exercise on dopamine neuron survival in prenatally stressed rats.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Mabandla MV,Kellaway LA,Daniels WM,Russell VA

    更新日期:2009-12-01 00:00:00

  • Creatine plus pyruvate supplementation prevents oxidative stress and phosphotransfer network disturbances in the brain of rats subjected to chemically-induced phenylketonuria.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Bortoluzzi VT,Brust L,Preissler T,de Franceschi ID,Wannmacher CMD

    更新日期:2019-12-01 00:00:00

  • Hydroxychloroquine effects on miR-155-3p and miR-219 expression changes in animal model of multiple sclerosis.

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Mazloumfard F,Mirian M,Eftekhari SM,Aliomrani M

    更新日期:2020-12-01 00:00:00

  • Acute administration of methionine and/or methionine sulfoxide impairs redox status and induces apoptosis in rat cerebral cortex.

    abstract::High plasma levels of methionine (Met) and its metabolites such as methionine sulfoxide (MetO) may occur in several genetic abnormalities. Patients with hypermethioninemia can present neurological dysfunction; however, the neurotoxicity mechanisms induced by these amino acids remain unknown. The aim of the present wor...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Soares MSP,Viau CM,Saffi J,Costa MZ,da Silva TM,Oliveira PS,Azambuja JH,Barschak AG,Braganhol E,S Wyse AT,Spanevello RM,Stefanello FM

    更新日期:2017-10-01 00:00:00

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    journal_title:Metabolic brain disease

    pub_type: 杂志文章


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    更新日期:2020-01-01 00:00:00