当前位置： SCI文献检索 > METABOLIC BRAIN DISEASE期刊下所有文献 > DRα1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury.

DRα1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury.

Abstract：

:Traumatic brain injury (TBI) results in severe neurological impairments without effective treatments. Inflammation appears to be an important contributor to key pathogenic events such as secondary brain injury following TBI and therefore serves as a promising target for novel therapies. We have recently demonstrated the ability of a molecular construct comprised of the human leukocyte antigen (HLA)-DRα1 domain linked covalently to mouse (m)MOG-35-55 peptide (DRα1-MOG-35-55 construct) to reduce CNS inflammation and tissue injury in animal models of multiple sclerosis and ischemic stroke. The aim of the current study was to determine if DRα1-MOG-35-55 treatment of a fluid percussion injury (FPI) mouse model of TBI could reduce the lesion size and improve disease outcome measures. Neurodeficits, lesion size, and immune responses were determined to evaluate the therapeutic potential and mechanisms of neuroprotection induced by DRα1-MOG-35-55 treatment. The results demonstrated that daily injections of DRα1-MOG-35-55 given after FPI significantly reduced numbers of infiltrating CD74+ and CD86+ macrophages and increased numbers of CD206+ microglia in the brain concomitant with smaller lesion sizes and improvement in neurodeficits. Conversely, DRα1-MOG-35-55 treatment of TBI increased numbers of circulating CD11b+ monocytes and their expression of CD74 but had no detectable effect on cell numbers or marker expression in the spleen. These results demonstrate that DRα1-MOG-35-55 therapy can reduce CNS inflammation and significantly improve histological and clinical outcomes after TBI. Future studies will further examine the potential of DRα1-MOG-35-55 for treatment of TBI.

journal_name

Metab Brain Dis

journal_title

Metabolic brain disease

authors

Yang L,Liu Z,Ren H,Zhang L,Gao S,Ren L,Chai Z,Meza-Romero R,Benedek G,Vandenbark AA,Offner H,Li M

doi

10.1007/s11011-017-9991-6

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

1395-1402

issue

5

eissn

0885-7490

issn

1573-7365

pii

10.1007/s11011-017-9991-6

journal_volume

32

pub_type

杂志文章

相关文献

METABOLIC BRAIN DISEASE文献大全
  • Brain metabolite clearance: impact on Alzheimer's disease.

    abstract：:Alzheimer's Disease (AD) is a complex neurodegenerative disorder often associated with aging and characterized by several critical molecular changes that take place in the brain. Among the molecular hallmarks of AD, increased levels of amyloid β-peptide (Aβ) and the subsequent Aβ-derived damage are the most well-studi...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,评审

    doi：10.1007/s11011-014-9527-2

    authors： Zolezzi JM,Inestrosa NC

    更新日期：2014-09-01 00:00:00

  • Erp72 expression activated by transient cerebral ischemia or disturbance of neuronal endoplasmic reticulum calcium stores.

    abstract：:Stress-induced activation of the expression of the endoplasmic reticulum (ER)-resident chaperon and member of the protein disulfide isomerase family erp72 was studied after transient cerebral ischemia in vivo using the four-vessel occlusion method and experimental depletion of ER calcium stores in primary neuronal cel...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1023/a:1020631029168

    authors： Paschen W,Gissel C,Linden T,Doutheil J

    更新日期：1998-03-01 00:00:00

  • Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles.

    abstract：:Cadmium (Cd) exposure leads to production of reactive oxygen species (ROS), which are associated with Cd-induced neurotoxicity and nephrotoxicity. Selenium nanoparticles (Se-NPs) have high bioavailability and antioxidant activities so it attracted wide spread attention. The present study examined the possible ameliora...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0053-x

    authors： Sadek KM,Lebda MA,Abouzed TK,Nasr SM,Shoukry M

    更新日期：2017-10-01 00:00:00

  • Propionic acid induces cytoskeletal alterations in cultured astrocytes from rat cerebral cortex.

    abstract：:Severe neurological symptoms, cerebral edema, and atrophy are common features of the inherited metabolic disorder propionic acidemia. However, the pathomechanisms involved in the neuropathology of this disease are not well established. In this study, we investigate the effects of propionic acid (PA), a metabolite accu...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-006-9002-9

    authors： de Almeida LM,Funchal C,Gottfried C,Wajner M,Pessoa-Pureur R

    更新日期：2006-03-01 00:00:00

  • Acute and long-term effects of intracerebroventricular administration of α-ketoisocaproic acid on oxidative stress parameters and cognitive and noncognitive behaviors.

    abstract：:Maple Syrup Urine Disease (MSUD) is biochemically characterized by elevated levels of leucine, isoleucine and valine, as well as their corresponding transaminated branched-chain α-keto acids in tissue and biological fluids. Neurological symptoms and cerebral abnormalities, whose mechanisms are still unknown, are typic...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0035-z

    authors： Taschetto L,Scaini G,Zapelini HG,Ramos ÂC,Strapazzon G,Andrade VM,Réus GZ,Michels M,Dal-Pizzol F,Quevedo J,Schuck PF,Ferreira GC,Streck EL

    更新日期：2017-10-01 00:00:00

  • Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation.

    abstract：:Neuroinflammation has been recognized as a major contributor to brain injury caused by intracerebral hemorrhage (ICH). Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome acts as an important mediator of inflammatory response in various inflammation-related dis...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0003-7

    authors： Cheng Y,Wei Y,Yang W,Song Y,Shang H,Cai Y,Wu Z,Zhao W

    更新日期：2017-08-01 00:00:00

  • Brain edema: a valid endpoint for measuring hepatic encephalopathy?

    abstract：:Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairment, attention deficits and motor dysfunction which eventually c...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,评审

    doi：10.1007/s11011-016-9843-9

    authors： Bémeur C,Cudalbu C,Dam G,Thrane AS,Cooper AJ,Rose CF

    更新日期：2016-12-01 00:00:00

  • Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway.

    abstract：:The impaired insulin signaling has been recognized as a common pathogenetic mechanism between diabetes and Alzheimer's disease (AD). In the progression of AD, brain is characterized by defective insulin receptor substrate-1 (IRS-1) and increased oxidative stress. Thymol, a monoterpene phenol isolated from medicinal he...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-016-9921-z

    authors： FangFang,Li H,Qin T,Li M,Ma S

    更新日期：2017-04-01 00:00:00

  • The association of sleep-disordered breathing and white matter hyperintensities in heart failure patients.

    abstract：:Heart failure patients often manifest white matter hyperintensites on brain magnetic resonance imaging (MRI). White matter hyperintnsities have also been linked with cognitive problems in patients with heart failure. Sleep disordered breathing may contribute to structural brain changes in heart failure. The purpose of...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-018-0309-0

    authors： Moon C,Bendlin BB,Melah KE,Bratzke LC

    更新日期：2018-12-01 00:00:00

  • Changing metabolic and energy profiles in fetal, neonatal, and adult rat brain.

    abstract：:The regional energy status and the availability of metabolic substrates during brain development are important, since a variety of fetal metabolic insults have been increasingly implicated in the evolution of neonatal brain disorders. The response of the brain to a metabolic insult is determined, in large part, by the...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1023/a:1025503115837

    authors： Lust WD,Pundik S,Zechel J,Zhou Y,Buczek M,Selman WR

    更新日期：2003-09-01 00:00:00

  • Vegetarian diet and excessive tea consumption: a dangerous association?

    abstract：:Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-016-9893-z

    authors： Fiacco F,Barbato L,Pecoraro MG,Maggio P

    更新日期：2017-02-01 00:00:00

  • Mutation spectrum of PAH gene in phenylketonuria patients in Northwest China: identification of twenty novel variants.

    abstract：:This study was performed to analyze the mutational spectrum of the phenylalanine hydroxylase (PAH) gene in phenylketonuria (PKU) patients in Northwest China, to identify mutational hot spots, and to determine the correlation between variants and clinical phenotypes of PKU. A large cohort of 475 PKU families in Northwe...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-019-0387-7

    authors： Yan Y,Zhang C,Jin X,Zhang Q,Zheng L,Feng X,Hao S,Gao H,Ma X

    更新日期：2019-06-01 00:00:00

  • Novel mutations and clinical outcomes of copper-histidine therapy in Menkes disease patients.

    abstract：:Menkes disease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation. With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkes disease becomes of utmost importance for patients' prognosis. In the present study, the clinical characteristics of 12 Kore...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-014-9569-5

    authors： Kim JH,Lee BH,Kim YM,Choi JH,Kim GH,Cheon CK,Yoo HW

    更新日期：2015-02-01 00:00:00

  • Effect of blood ammonia elevation following oral glutamine load on the psychometric performance of cirrhotic patients.

    abstract：:Oral glutamine challenge is a method to increase blood ammonia and may be used to study the ammonia lowering effect of drugs potentially useful in hepatic encephalopathy (HE). We tested its influence on the psychometric performance of 18 cirrhotic patients without HE. Twelve nonencephalopatic cirrhotic patients were s...

    journal_title：Metabolic brain disease

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1021926601907

    authors： Masini A,Efrati C,Merli M,Nicolao F,Amodio P,Del Piccolo F,Riggio O

    更新日期：2003-03-01 00:00:00

  • Increased CD74 binding and EAE treatment efficacy of a modified DRα1 molecular construct.

    abstract：:Multiple sclerosis (MS) is a demyelinating and degenerative disease of the central nervous system (CNS) with a strong inflammatory component that affects more than 2 million people worldwide (and at least 400,000 in the United States). In MS, macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-018-0331-2

    authors： Meza-Romero R,Benedek G,Gerstner G,Kent G,Nguyen H,Offner H,Vandenbark AA

    更新日期：2019-02-01 00:00:00

  • Folate supplementation, MTHFR gene polymorphism and neural tube defects: a community based case control study in North India.

    abstract：:The present study analyses the potential role of MTHFR gene polymorphism, folate supplementation and dietary pattern among the mothers of NTD neonates and controls in heterogeneous populations of North India, with the special focus on their ethnic labels. Results indicated significant increased risk for neural tube de...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-011-9256-8

    authors： Deb R,Arora J,Meitei SY,Gupta S,Verma V,Saraswathy KN,Saran S,Kalla AK

    更新日期：2011-09-01 00:00:00

  • Autozygosity mapping of methylmalonic acidemia associated genes by short tandem repeat markers facilitates the identification of five novel mutations in an Iranian patient cohort.

    abstract：:Isolated Methylmalonic acidemia/aciduria (MMA) is a group of inborn errors of metabolism disease which is caused by defect in methylmalonyl-CoA mutase (MCM) enzyme. The enzyme has a key function in the catabolism of branched chain amino acids (BCAA, isoleucine, and valine), methionine, and threonine. MCM is encoded by...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-018-0277-4

    authors： Shafaat M,Alaee MR,Rahmanifar A,Setoodeh A,Razzaghy-Azar M,Bagherian H,Bagheri SD,Zafarghandi Motlagh F,Hashemi M,Abiri M,Zeinali S

    更新日期：2018-10-01 00:00:00

  • Erratum to: Treadmill exercise alters ecstasy- induced long- term potentiation disruption in the hippocampus of male rats.

    abstract：:In the original publication of the article, author name Masoumeh Asadbegi was incorrectly written as Masoumeh Asadbeigi. The authors regret the oversight. ...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s11011-017-0114-1

    authors： Sajadi A,Amiri I,Gharebaghi A,Komaki A,Asadbegi M,Shahidi S,Mehdizadeh M,Asl SS

    更新日期：2017-12-01 00:00:00

  • Effects of fulminant hepatic encephalopathy on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na(+),K (+))- and Mg (2+)-ATPase: comparison of the enzymes' response to in vitro treatment with ammonia.

    abstract：:Hepatic encephalopathy can be a life-threatening complication of fulminant hepatic failure. By understanding the pathophysiology involved in the induction of this neuropsychiatric disorder, future therapeutic and/or preventive attempts could be considered. In this study, an attempt has been made in order to shed more ...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-008-9091-8

    authors： Zarros A,Theocharis S,Skandali N,Tsakiris S

    更新日期：2008-09-01 00:00:00

  • The effect of aflatoxin B1 exposure on serotonin metabolism: response to a tryptophan load.

    abstract：:Semi-chronic exposure of ICR male Mice to Aflatoxin B1 (AFB1) in non-toxic doses decreased brain serotonin (5-hydroxytryptamine, 5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA) and catecholamines without altering tryptophan (TRP) or tyrosine (TYR) levels. A TRP load (300 mg/kg, i.p. x 2 hours) slightly increased brain T...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/BF01000244

    authors： Kimbrough TD,Llewellyn GC,Weekley LB

    更新日期：1992-12-01 00:00:00

  • Mevastatin promotes neuronal survival against Aβ-induced neurotoxicity through AMPK activation.

    abstract：:Statins or HMG-CoA reductase inhibitors have been shown to be effective at lowering cholesterol levels, and the application of these molecules has gradually emerged as an attractive therapeutic strategy for neurodegenerative diseases. Epidemiological studies suggest that statin use is associated with a decreased incid...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0091-4

    authors： Kornelius E,Li HH,Peng CH,Hsiao HW,Yang YS,Huang CN,Lin CL

    更新日期：2017-12-01 00:00:00

  • 1H and 31P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism.

    abstract：:Chronic liver disease (CLD) leads to a spectrum of neuropsychiatric disorders named hepatic encephalopathy (HE). Even though brain energy metabolism is believed to be altered in chronic HE, few studies have explored energy metabolism in CLD-induced HE, and their findings were inconsistent. The aim of this study was to...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-015-9715-8

    authors： Rackayova V,Braissant O,McLin VA,Berset C,Lanz B,Cudalbu C

    更新日期：2016-12-01 00:00:00

  • A comparative study of the effects of cholesterol, beta-sitosterol, beta-sitosterol glucoside, dehydroepiandrosterone sulphate and melatonin on in vitro lipid peroxidation.

    abstract：:The free radical scavenging abilities of the structurally related steroids beta-sitosterol, beta-sitosterol glucoside (plant sterols and sterolins), cholesterol, and dehydroepiandrosterone sulphate (DHEAS) were compared with melatonin (an efficient free radical scavenger) in an in vitro system which measures lipid per...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1023/a:1011167023695

    authors： van Rensburg SJ,Daniels WM,van Zyl JM,Taljaard JJ

    更新日期：2000-12-01 00:00:00

  • Abnormal social behavior in mice with tyrosinemia type I is associated with an increase of myelin in the cerebral cortex.

    abstract：:Hereditary tyrosinemia type I (HT1) is caused by mutations in the fumarylacetoacetate hydrolase (FAH) gene, the template for the final enzyme in the tyrosine catabolism pathway. If left untreated this deficiency of functional FAH leads to a buildup of toxic metabolites that can cause liver disease, kidney dysfunction ...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0071-8

    authors： Moore ME,Koenig AE,Hillgartner MA,Otap CC,Barnby E,MacGregor GG

    更新日期：2017-12-01 00:00:00

  • Association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with autism: evidence of genetic susceptibility.

    abstract：:Autism (MIM 209850) is a heterogeneous neurodevelopmental disease that manifests within the first 3 years of life. Numerous articles reported that dysfunctional folate-methionine pathway enzymes may play an important role in the pathophysiology of autism. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzym...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s11011-016-9815-0

    authors： Rai V

    更新日期：2016-08-01 00:00:00

  • Effect of exercise on dopamine neuron survival in prenatally stressed rats.

    abstract：:Prenatal stress has been associated with increased vulnerability to psychiatric disturbances including schizophrenia, depression, attention-deficit hyperactivity disorder and autism. Elevated maternal circulating stress hormones alter development of neural circuits in the fetal brain and cause long-term changes in beh...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-009-9161-6

    authors： Mabandla MV,Kellaway LA,Daniels WM,Russell VA

    更新日期：2009-12-01 00:00:00

  • The characterization of neuroenergetic effects of chronic L-tyrosine administration in young rats: evidence for striatal susceptibility.

    abstract：:Tyrosinemia type II is an inborn error of metabolism caused by a deficiency in hepatic cytosolic aminotransferase. Affected patients usually present a variable degree of mental retardation, which may be related to the level of plasma tyrosine. In the present study we evaluated effect of chronic administration of L-tyr...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-014-9615-3

    authors： Ferreira GK,Carvalho-Silva M,Gomes LM,Scaini G,Teixeira LJ,Mota IT,Schuck PF,Ferreira GC,Streck EL

    更新日期：2015-02-01 00:00:00

  • Possible cause for altered spatial cognition of prepubescent rats exposed to chronic radiofrequency electromagnetic radiation.

    abstract：:The effects of chronic and repeated radiofrequency electromagnetic radiation (RFEMR) exposure on spatial cognition and hippocampal architecture were investigated in prepubescent rats. Four weeks old male Wistar rats were exposed to RF-EMR (900 MHz; SAR-1.15 W/kg with peak power density of 146.60 μW/cm(2)) for 1 h/day,...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-015-9689-6

    authors： Narayanan SN,Kumar RS,Karun KM,Nayak SB,Bhat PG

    更新日期：2015-10-01 00:00:00

  • Association between polymorphisms of NOS1, NOS2 and NOS3 genes and suicide behavior: a systematic review and meta-analysis.

    abstract：:The enzyme nitric oxide synthase has been associated with suicide behavior. NOS1, NOS2 and NOS3 genes are implicated in the production of nitric oxide. However, the association between NOS genes and suicide behavior has not yet been established. To assess the association of Nitric Oxide Synthase (NOS) genes and suicid...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,meta分析

    doi：10.1007/s11011-019-00406-3

    authors： González-Castro TB,Genis-Mendoza AD,Tovilla-Zárate CA,Juárez-Rojop IE,López-Narvaez ML,Pérez-Hernández N,Rodríguez-Pérez JM,Martínez-Magaña JJ

    更新日期：2019-08-01 00:00:00

  • Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat.

    abstract：:In view of the protective effect of brain derived neurotrophic factor (BDNF) against metabolic/excitotoxic insults in vitro, we investigated whether BDNF could limit infarct size after permanent occlusion of the middle cerebral artery in rat (MCAO). BDNF was delivered into the territory of the middle cerebral artery v...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/BF02674671

    authors： Yamashita K,Wiessner C,Lindholm D,Thoenen H,Hossmann KA

    更新日期：1997-12-01 00:00:00