Erp72 expression activated by transient cerebral ischemia or disturbance of neuronal endoplasmic reticulum calcium stores.

abstract：:Calotropis procera (CP; Apocynaceae) is reported to have several neuroprotective activities however it's anti-depressant activity yet to be established. Therefore, the present study was proposed to evaluate the anti-depressant activity of the standardized ethanolic extract of CP (ECP) in chronic unpredictable mild str...

journal_title：Metabolic brain disease

authors： Garabadu D,Srivastava N,Murti Y

更新日期：2019-12-01 00:00:00

abstract：:The developing facial neurons of a series of hamsters ranging in age from the 14-day fetus to the 9 day postnatal were axotomized. Postoperative times were graded for each age so that the retrograde response could be observed before any significant amount of cell degeneration or death occurred. The incorporation of tr...

journal_title：Metabolic brain disease

authors： Clark P,Jones KJ,LaVelle A

更新日期：1993-06-01 00:00:00

abstract：:Traumatic brain injury (TBI) is accompanied with enhanced matrix metalloproteinase-9 (MMP-9) activity and elevated levels of plasma fibrinogen (Fg), which is a known inflammatory agent. Activation of MMP-9 and increase in blood content of Fg (i.e. hyperfibrinogenemia, HFg) both contribute to cerebrovascular disorders ...

journal_title：Metabolic brain disease

authors： Muradashvili N,Benton RL,Saatman KE,Tyagi SC,Lominadze D

更新日期：2015-04-01 00:00:00

abstract：:As studies of brain metabolism grow in complexity, investigators turn increasingly to nuclear magnetic resonance spectroscopy combined with 13C isotopic labeling. The unique ability to detect labeling non-destructively in specific carbon positions of individual compounds has opened the way to investigate brain metabol...

journal_title：Metabolic brain disease

authors： Mason GF,Behar KL,Lai JC

更新日期：1996-12-01 00:00:00

abstract：:While alcohol-induced psychotic disorder (AIPD) is well recognised, relatively little is known about the condition. We undertook a review of the literature to identify studies on the epidemiology, clinical manifestations, underlying neurobiology and treatment of AIPD. Few prospective studies have been conducted on AIP...

journal_title：Metabolic brain disease

authors： Jordaan GP,Emsley R

更新日期：2014-06-01 00:00:00

abstract：:As feared and deadly human diseases globally, Rabies virus contrived mechanisms to escape early immune recognition via suppression of the interferon response. This study, preliminarily investigated whether Rabies virus employs epigenetic mechanism for the suppression of the interferon using the Challenge virus standar...

journal_title：Metabolic brain disease

authors： Abdulazeez M,Kia GSN,Abarshi MM,Muhammad A,Ojedapo CE,Atawodi JC,Dantong D,Kwaga JKP

更新日期：2020-06-01 00:00:00

abstract：:There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in skeletal muscle, brain, and likely the lungs, is activated. In addition t...

journal_title：Metabolic brain disease

authors： Holecek M

更新日期：2014-03-01 00:00:00

abstract：:Betanin, a natural food colorant with powerful antioxidative properties, has not been studied in terms of neurodegenerative disease intervention. Therefore, the present study aimed to investigate the neuroprotective effects of betanin against trimethyltin chloride (TMT) -induced neurodegeneration in mice. Forty male I...

journal_title：Metabolic brain disease

authors： Thong-Asa W,Prasartsri S,Klomkleaw N,Thongwan N

更新日期：2020-12-01 00:00:00

abstract：:Alcohol dependence (AD) has a large heritable component. Genetic variation in genes involved in the absorption and elimination of ethanol have been associated with AD. However, some of these polymorphisms are not present in an African population. Previous studies have reported that a type of AD which is characterized ...

journal_title：Metabolic brain disease

authors： Crawford A,Dalvie S,Lewis S,King A,Liberzon I,Fein G,Koenen K,Ramesar R,Stein DJ

更新日期：2014-06-01 00:00:00

abstract：:The commonly used volatile anesthetic sevoflurane has been shown to induce widespread apoptosis in the developing brain, yet the underlying molecular mechanisms are not fully understood. Accumulating research has demonstrated that long noncoding RNAs (lncRNAs) regulate multiple biological processes, including neural d...

journal_title：Metabolic brain disease

authors： Chen X,Zhou X,Lu D,Yang X,Zhou Z,Chen X,Chen Y,He W,Feng X

更新日期：2016-10-01 00:00:00

abstract：:Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental retardation, hyperactivity, cerebral palsy, epilepsy and neuroendocrine disturbances. Herein, we exa...

journal_title：Metabolic brain disease

authors： Kartal Ö,Aydınöz S,Kartal AT,Kelestemur T,Caglayan AB,Beker MC,Karademir F,Süleymanoğlu S,Kul M,Yulug B,Kilic E

更新日期：2016-08-01 00:00:00

abstract：:A rat model of glucose-precipitated Wernicke's encephalopathy (WE) has been developed in which glucose loading (10 g/kg, i.p.) of ataxic thiamin-deficient (TD) rats induced episodes of gross neurological dysfunction and sometimes death. The acute effects of a glucose load on the neurological state of thiamin-replete c...

journal_title：Metabolic brain disease

authors： Zimitat C,Nixon PF

更新日期：1999-03-01 00:00:00

abstract：:This study was performed to analyze the mutational spectrum of the phenylalanine hydroxylase (PAH) gene in phenylketonuria (PKU) patients in Northwest China, to identify mutational hot spots, and to determine the correlation between variants and clinical phenotypes of PKU. A large cohort of 475 PKU families in Northwe...

journal_title：Metabolic brain disease

authors： Yan Y,Zhang C,Jin X,Zhang Q,Zheng L,Feng X,Hao S,Gao H,Ma X

更新日期：2019-06-01 00:00:00

abstract：:In Alzheimer's disease (AD) basal forebrain cholinergic neurons appear to be targeted primarily in early stages of the disease. Scopolamine (muscarinic receptor antagonist) has been used for decades to induce working and reference memory impairment in rodents. In this study, we evaluated the protective effect of kolav...

journal_title：Metabolic brain disease

authors： Ishola IO,Adamson FM,Adeyemi OO

更新日期：2017-02-01 00:00:00

abstract：:Several epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia. Besides, some authors suggested that poor glucose control to be associated with worse cognitive function. We aimed to assess cognitive functions and IR-degree over time in diabetic. We also...

journal_title：Metabolic brain disease

authors： Fava A,Colica C,Plastino M,Messina D,Cristiano D,Opipari C,Vaccaro A,Gorgone G,Bosco F,Fratto A,De Bartolo M,Bosco D

更新日期：2017-06-01 00:00:00

abstract：:Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism. Usually diagnosed within the first month of birth, it is essential that the patient strictly follow the dietary restriction of natural protein intake. Otherwise, PKU impacts the development of the brain severely and may result in microceph...

journal_title：Metabolic brain disease

authors： Bortoluzzi VT,Brust L,Preissler T,de Franceschi ID,Wannmacher CMD

更新日期：2019-12-01 00:00:00

abstract：:The radiological spectrum of neuromyelitis optica has become broader since the detection of aquaporin4 antibodies. We report a case of neuromyelitis optica patient with pseudotumoral encephalic lesion. A 66 year-old woman presented with sudden left lateral homonymous hemianopsia. A brain MRI showed an isolated and ext...

journal_title：Metabolic brain disease

authors： Fargeot G,Aboab J,Savatovsky J,Marignier R,Lecler A,Gout O

更新日期：2018-02-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairment, attention deficits and motor dysfunction which eventually c...

journal_title：Metabolic brain disease

authors： Bémeur C,Cudalbu C,Dam G,Thrane AS,Cooper AJ,Rose CF

更新日期：2016-12-01 00:00:00

abstract：:To investigate the hypothesis that neurotoxic metals can exert their toxicity through the direct inhibition of monoamine oxidases (MAOs), the effects of several neurotoxic metal ions on type A (MAO-A) and type B (MAO-B) monoamine oxidase activities in rat forebrain nonsynaptic mitochondria and rat liver mitochondria w...

journal_title：Metabolic brain disease

authors： Leung TK,Lim L,Lai JC

更新日期：1992-09-01 00:00:00

abstract：:This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (...

journal_title：Metabolic brain disease

authors： Asiaei F,Fazel A,Rajabzadeh AA,Hosseini M,Beheshti F,Seghatoleslam M

更新日期：2017-10-01 00:00:00

abstract：:In patients with hepatic encephalopathy (HE) the blood concentration of ammonia is usually highly elevated. Ammonia readily enters brain cells from the blood, and toxic effects of ammonia on brain metabolism and neurotransmission are believed to play a key role in the pathogenesis of HE. It has, however, been a matter...

journal_title：Metabolic brain disease

authors： Sørensen M,Munk OL,Keiding S

更新日期：2009-03-01 00:00:00

abstract：:Stroke is the leading cause of disability among adults as well as the 2nd leading cause of death globally. Ischemic stroke accounts for about 85% of strokes, and currently, tissue plasminogen activator (tPA), whose therapeutic window is limited to up to 4.5 h for the appropriate population, is the only FDA approved dr...

journal_title：Metabolic brain disease

authors： Sarvari S,Moakedi F,Hone E,Simpkins JW,Ren X

更新日期：2020-08-01 00:00:00

abstract：:Tyrosinemia type II is an inborn error of metabolism caused by a deficiency in hepatic cytosolic aminotransferase. Affected patients usually present a variable degree of mental retardation, which may be related to the level of plasma tyrosine. In the present study we evaluated effect of chronic administration of L-tyr...

journal_title：Metabolic brain disease

authors： Ferreira GK,Carvalho-Silva M,Gomes LM,Scaini G,Teixeira LJ,Mota IT,Schuck PF,Ferreira GC,Streck EL

更新日期：2015-02-01 00:00:00

abstract：:Lead exposure has negative effects on developing nervous system and induces apoptosis in newly generated neurons. Natural antioxidants (i.e. Ascorbic acid and Garlic) might protect against lead-induced neuronal cell damage. The aim of the present study was to investigate the protective effects of Ascorbic acid and Gar...

journal_title：Metabolic brain disease

authors： Ebrahimzadeh-Bideskan AR,Hami J,Alipour F,Haghir H,Fazel AR,Sadeghi A

更新日期：2016-10-01 00:00:00

abstract：:Maple Syrup Urine Disease (MSUD) is biochemically characterized by elevated levels of leucine, isoleucine and valine, as well as their corresponding transaminated branched-chain α-keto acids in tissue and biological fluids. Neurological symptoms and cerebral abnormalities, whose mechanisms are still unknown, are typic...

journal_title：Metabolic brain disease

authors： Taschetto L,Scaini G,Zapelini HG,Ramos ÂC,Strapazzon G,Andrade VM,Réus GZ,Michels M,Dal-Pizzol F,Quevedo J,Schuck PF,Ferreira GC,Streck EL

更新日期：2017-10-01 00:00:00

abstract：:At the present time alcoholism is recognized as a metabolic disease exhibiting the clinical features of craving for alcohol, loss of control over drinking, tolerance and physical dependence on alcohol, while both epidemiological and experimental studies have demonstrated that genetic factors may be important in determ...

journal_title：Metabolic brain disease

authors： Gianoulakis C,de Waele JP

更新日期：1994-06-01 00:00:00

abstract：:Acute and chronic administration of Al-gluconate (12.7% Al) at the concentration of 1 mg/kg produces edema in the rat brain, as reflected by the increase in water and Na+ content. The permeability for Evans blue is also increased, which indicates the opening of the blood-brain barrier. Higher concentrations of the Al-...

journal_title：Metabolic brain disease

authors： Stefanovich V,Joó F

更新日期：1990-03-01 00:00:00

abstract：:Hyperammonemia is necessary for development of the cerebral complications to liver disease including hepatic encephalopathy and cerebral edema but the mechanisms are unclear. Ammonia is taken up by the brain in proportion to its arterial concentration. The flux into the brain is most likely by both diffusion of NH3 an...

journal_title：Metabolic brain disease

authors： Ott P,Vilstrup H

更新日期：2014-12-01 00:00:00

abstract：:Several studies have examined neonatal diabetes, a rare disease characterized by hyperglycemia and low insulin levels that is usually diagnosed in the first 6 month of life. Recently, the effects of diabetes on the brain have received considerable attention. In addition, hyperglycemia may perturb brain function and mi...

journal_title：Metabolic brain disease

authors： Rosa AP,Mescka CP,Catarino FM,de Castro AL,Teixeira RB,Campos C,Baldo G,Graf DD,de Mattos-Dutra A,Dutra-Filho CS,da Rosa Araujo AS

更新日期：2018-02-01 00:00:00

abstract：:Chronic neuroinflammation is strongly associated with AD and altered peripheral and central levels of chemokines and cytokines have been frequently described in those with AD. Given the increasing evidence of ethnicity-related differences in AD, it was of interest to determine if those altered chemokine and cytokine l...

journal_title：Metabolic brain disease

authors： Ferguson SA,Varma V,Sloper D,Panos JJ,Sarkar S

更新日期：2020-01-01 00:00:00