Abstract:
:A rat model of glucose-precipitated Wernicke's encephalopathy (WE) has been developed in which glucose loading (10 g/kg, i.p.) of ataxic thiamin-deficient (TD) rats induced episodes of gross neurological dysfunction and sometimes death. The acute effects of a glucose load on the neurological state of thiamin-replete control and TD rats were assessed by scoring of clinical observations and performance measured on a moving belt (MB) apparatus at 30 min intervals for 2 hr after the challenge. Glucose loading or saline treatment (2.5 mL, i.p.) had no significant behavioural or clinical consequences when administered to controls or rats fed TD diet for <21 days. Glucose loading of ataxic rats fed TD diet for 28-35 days precipitated episodes of gross ataxia and signs of advanced neurological dysfunction (e.g. loss of righting reflex and hyperexcitability) leading to significant increases in the Ataxia (p<0.05) and Advanced Sign (p<0.05) scores within 2 hr after the challenge. Simultaneously, the performance of these animals on the MB decreased 10-fold. Regular glucose challenges significantly increased the rate of progression of disease in TD rats when compared with untreated TD rats. This model may be useful for the further investigation of the pathogenesis of WE at the molecular level.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Zimitat C,Nixon PFdoi
10.1023/a:1020653312697subject
Has Abstractpub_date
1999-03-01 00:00:00pages
1-20issue
1eissn
0885-7490issn
1573-7365journal_volume
14pub_type
杂志文章abstract::D-glycerate 2 kinase (DGK) is an enzyme that mediates the conversion of D-glycerate, an intermediate metabolite of serine and fructose metabolism, to 2-phosphoglycerate. Deficiency of DGK leads to accumulation of D-glycerate in various tissues and its massive excretion in urine. D-glyceric aciduria (DGA) is an autosom...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-019-0384-x
更新日期:2019-04-01 00:00:00
abstract::Oral glutamine challenge is a method to increase blood ammonia and may be used to study the ammonia lowering effect of drugs potentially useful in hepatic encephalopathy (HE). We tested its influence on the psychometric performance of 18 cirrhotic patients without HE. Twelve nonencephalopatic cirrhotic patients were s...
journal_title:Metabolic brain disease
pub_type: 临床试验,杂志文章
doi:10.1023/a:1021926601907
更新日期:2003-03-01 00:00:00
abstract::In the original publication of the article, author name Masoumeh Asadbegi was incorrectly written as Masoumeh Asadbeigi. The authors regret the oversight. ...
journal_title:Metabolic brain disease
pub_type: 杂志文章,已发布勘误
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abstract::Mitochondrial dysfunction is observed in brains of Alzheimer's Disease patients as well as many rodent model systems including those modeling mutations in preseinilin 1 (PSEN1). The aim of our study was to characterize mitochondrial function and number in fibroblasts from AD patients with PSEN1 mutations. We used bioc...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-015-9667-z
更新日期:2015-10-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by accumulation and deposition of Aβ peptide in human brain. The present study aimed to determine the protective effect of catechin rich extract of MERM (methanolic extract of Rhizophora mucronata) on Aβ (25-35) induced cognitive impai...
journal_title:Metabolic brain disease
pub_type: 杂志文章
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abstract::Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain a...
journal_title:Metabolic brain disease
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-013-9438-7
更新日期:2013-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-005-7925-1
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journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1023/a:1021961919148
更新日期:2002-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF01000159
更新日期:1992-09-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9888-9
更新日期:2017-02-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-009-9161-6
更新日期:2009-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/BF01999765
更新日期:1994-06-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/BF02109357
更新日期:1995-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-016-9906-y
更新日期:2016-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-015-9737-2
更新日期:2016-02-01 00:00:00
abstract:UNLABELLED:Some subjects with multiple sclerosis (MS) present with low blood iron parameters. Anecdotal reports and a single patient study suggest that iron supplementation may be beneficial in these subjects. Myelin is regenerated continually, but prerequisites for this process are iron and a functional folate-vitamin...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-006-9019-0
更新日期:2006-09-01 00:00:00
abstract::A structured analytic approach was developed to evaluate enzyme kinetic parameters using non-linear least-squares fitting. The approach was implemented in a software package called KinSim and designed to run on Windows 95, 98, and NT platforms. The software and the theoretical approach were tested using kinetic data o...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF02679980
更新日期:2000-06-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-019-00461-w
更新日期:2019-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-018-0307-2
更新日期:2018-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-007-9078-x
更新日期:2008-03-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-019-00430-3
更新日期:2019-08-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9933-8
更新日期:2017-04-01 00:00:00
abstract::Studies have shown that oxidative stress is involved in the pathophysiology of bipolar disorder (BD). It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced hyperactivity, a s...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9942-7
更新日期:2017-04-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-011-9263-9
更新日期:2011-12-01 00:00:00
abstract::Maple Syrup Urine Disease (MSUD) is biochemically characterized by elevated levels of leucine, isoleucine and valine, as well as their corresponding transaminated branched-chain α-keto acids in tissue and biological fluids. Neurological symptoms and cerebral abnormalities, whose mechanisms are still unknown, are typic...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0035-z
更新日期:2017-10-01 00:00:00
abstract::Thiamine triphosphate (ThTP) was discovered over 60 years ago and it was long thought to be a specifically neuroactive compound. Its presence in most cell types, from bacteria to mammals, would suggest a more general role but this remains undefined. In contrast to thiamine diphosphate (ThDP), ThTP is not a coenzyme. I...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-014-9509-4
更新日期:2014-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0016-2
更新日期:2017-10-01 00:00:00
abstract::The heterogeneity of monoamine oxidase (MAO; EC 1.4.3.4) activities was studied in two fractions of synaptic mitochondria (SM & SM2) and one fraction of non-synaptic ("free") mitochondria (M) isolated from three rat brain regions (cerebral cortex, striatum, and pons & medulla) by the Lai and Clark (1979, 1989) method ...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF01996074
更新日期:1994-03-01 00:00:00