The effect of aflatoxin B1 exposure on serotonin metabolism: response to a tryptophan load.

abstract：:Several studies have examined neonatal diabetes, a rare disease characterized by hyperglycemia and low insulin levels that is usually diagnosed in the first 6 month of life. Recently, the effects of diabetes on the brain have received considerable attention. In addition, hyperglycemia may perturb brain function and mi...

journal_title：Metabolic brain disease

authors： Rosa AP,Mescka CP,Catarino FM,de Castro AL,Teixeira RB,Campos C,Baldo G,Graf DD,de Mattos-Dutra A,Dutra-Filho CS,da Rosa Araujo AS

更新日期：2018-02-01 00:00:00

abstract：:Patients with chronic liver disease manifest a high incidence (> 75%) of pallidal signal hyperintensity on T1-weighted Magnetic Resonance Imaging (MRI), the intensity of which correlates with blood manganese levels and the presence of extrapyramidal symptoms. A major cause of pallidal hyperintensity on T1-weighted MRI...

journal_title：Metabolic brain disease

authors： Butterworth RF,Spahr L,Fontaine S,Layrargues GP

更新日期：1995-12-01 00:00:00

abstract：:The selective vulnerability of pyramidal neurons in the CA1 hippocampal region in ischemic rat brain may be preceded by regional alterations of energy metabolism during early reperfusion. We measured ATP, phosphocreatine (PCr), and glucose in paramedian and lateral CA1 and in an area showing little postischemic cell l...

journal_title：Metabolic brain disease

authors： Pettigrew LC,Grotta JC,Rhoades HM,Reid C,McCandless DW

更新日期：1988-09-01 00:00:00

abstract：:Hepatic encephalopathy can be a life-threatening complication of fulminant hepatic failure. By understanding the pathophysiology involved in the induction of this neuropsychiatric disorder, future therapeutic and/or preventive attempts could be considered. In this study, an attempt has been made in order to shed more ...

journal_title：Metabolic brain disease

authors： Zarros A,Theocharis S,Skandali N,Tsakiris S

更新日期：2008-09-01 00:00:00

abstract：:3-Nitropropionic acid (3-NPA) is a toxin sometimes produced on moldy crops (sugarcane, peanuts, etc.) in amounts sufficient to cause severe neurological disorders when consumed by humans. In vitro, 3-NPA irreversibly inactivates SDH, a Complex II respiratory enzyme required for mitochondrial energy production. A singl...

journal_title：Metabolic brain disease

authors： Nony PA,Scallet AC,Rountree RL,Ye X,Binienda Z

更新日期：1999-06-01 00:00:00

abstract：:Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...

journal_title：Metabolic brain disease

authors： Maes M

更新日期：2012-12-01 00:00:00

abstract：:There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in skeletal muscle, brain, and likely the lungs, is activated. In addition t...

journal_title：Metabolic brain disease

authors： Holecek M

更新日期：2014-03-01 00:00:00

abstract：:Alcohol dependence (AD) has a large heritable component. Genetic variation in genes involved in the absorption and elimination of ethanol have been associated with AD. However, some of these polymorphisms are not present in an African population. Previous studies have reported that a type of AD which is characterized ...

journal_title：Metabolic brain disease

authors： Crawford A,Dalvie S,Lewis S,King A,Liberzon I,Fein G,Koenen K,Ramesar R,Stein DJ

更新日期：2014-06-01 00:00:00

abstract：:Amyloid-beta (Aβ) interacts with the serine/threonine protein kinase AKT (also known as protein kinase B)/glycogen synthase kinase 3β (GSK3β) pathway and deactivates GSK3β signaling, which result in microtubule protein tau phosphorylation. Atorvastatin, a HMG-CoA reductase inhibitor, has been proven to improve learnin...

journal_title：Metabolic brain disease

authors： Zhou D,Liu H,Li C,Wang F,Shi Y,Liu L,Zhao X,Liu A,Zhang J,Wang C,Chen Z

更新日期：2016-06-01 00:00:00

abstract：:The enzyme nitric oxide synthase has been associated with suicide behavior. NOS1, NOS2 and NOS3 genes are implicated in the production of nitric oxide. However, the association between NOS genes and suicide behavior has not yet been established. To assess the association of Nitric Oxide Synthase (NOS) genes and suicid...

journal_title：Metabolic brain disease

authors： González-Castro TB,Genis-Mendoza AD,Tovilla-Zárate CA,Juárez-Rojop IE,López-Narvaez ML,Pérez-Hernández N,Rodríguez-Pérez JM,Martínez-Magaña JJ

更新日期：2019-08-01 00:00:00

abstract：:D-Galactose (D-gal) chronic administration via intraperitoneal and subcutaneous routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal and subcutaneous administration of D-gal causes memory impairments, a reduction in the neurogenesis of adult mice, an increase in the levels of the ...

journal_title：Metabolic brain disease

authors： Budni J,Garcez ML,Mina F,Bellettini-Santos T,da Silva S,Luz APD,Schiavo GL,Batista-Silva H,Scaini G,Streck EL,Quevedo J

更新日期：2017-06-01 00:00:00

abstract：:This study presents further research into the spectrum of variants in genes responsible for the development of phenylketonuria (PKU) and hyperphenylalaninemia (HPA) in patients in Russia. After a study of 25 frequent variants, 293 patients (327 chromosomes without detected variants) from among 1265 probands still had ...

journal_title：Metabolic brain disease

authors： Kuznetcova I,Gundorova P,Ryzhkova O,Polyakov A

更新日期：2019-12-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a variety of symptoms of different severity such as cognitive deficits and impaired motor functions. Currently, HE is seen as a consequence of a low grade cerebral oedema assoc...

journal_title：Metabolic brain disease

authors： Baker L,Lanz B,Andreola F,Ampuero J,Wijeyesekera A,Holmes E,Deutz N

更新日期：2016-12-01 00:00:00

abstract：:The regional energy status and the availability of metabolic substrates during brain development are important, since a variety of fetal metabolic insults have been increasingly implicated in the evolution of neonatal brain disorders. The response of the brain to a metabolic insult is determined, in large part, by the...

journal_title：Metabolic brain disease

authors： Lust WD,Pundik S,Zechel J,Zhou Y,Buczek M,Selman WR

更新日期：2003-09-01 00:00:00

abstract：:Fenproporex (Fen) is an amphetamine-based anorectic; amphetamine use causes a broad range of severe cognitive deficits and anxiogenic-like effects. In this study we evaluated pharmacological effects of the chronic administration of Fen on cognitive and non-cognitive behaviors. Male adult Wistar rats received intraperi...

journal_title：Metabolic brain disease

authors： Gonçalves CL,Furlanetto CB,Valvassori SS,Bavaresco DV,Varela RB,Budni J,Quevedo J,Streck EL

更新日期：2015-04-01 00:00:00

abstract：:The commonly used volatile anesthetic sevoflurane has been shown to induce widespread apoptosis in the developing brain, yet the underlying molecular mechanisms are not fully understood. Accumulating research has demonstrated that long noncoding RNAs (lncRNAs) regulate multiple biological processes, including neural d...

journal_title：Metabolic brain disease

authors： Chen X,Zhou X,Lu D,Yang X,Zhou Z,Chen X,Chen Y,He W,Feng X

更新日期：2016-10-01 00:00:00

abstract：:Current data on the neurotrophic effects of steroid hormones suggest that, in brain and spinal cord regions containing receptor systems, steroids act at the level of RNA and protein synthesis to effect metabolic changes associated with nerve-cell survival, elaboration/maintenance of dendritic and axonal processes, syn...

journal_title：Metabolic brain disease

authors： Jones KJ

更新日期：1988-03-01 00:00:00

abstract：:Neuroinflammation has been recognized as a major contributor to brain injury caused by intracerebral hemorrhage (ICH). Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome acts as an important mediator of inflammatory response in various inflammation-related dis...

journal_title：Metabolic brain disease

authors： Cheng Y,Wei Y,Yang W,Song Y,Shang H,Cai Y,Wu Z,Zhao W

更新日期：2017-08-01 00:00:00

abstract：:Ischemic postconditioning (IPostC) has been reported to have neuroprotection against ischemic diseases, and one cycle of IPostC induces neurogenesis when treated nearby. To expanding these effects, we explored the effects of repetitively remote IPostC (NRIPostC) on neurogenesis in the subgranular zone (SGZ) and subent...

journal_title：Metabolic brain disease

authors： Huang D,Liu H,Qu Y,Wang P

更新日期：2017-12-01 00:00:00

abstract：:The present work was carried out to study the influence of ammonia and factors from sera and cerebrospinal fluid (CSF) from patients with different degrees of chronic liver diseases on [3H]D-aspartate (Asp) and [3H]L-glutamate (Glu) high-affinity uptake into the rat hippocampal formation. For comparison, high-affinity...

journal_title：Metabolic brain disease

authors： Schmidt W,Wolf G,Grüngreiff K,Meier M,Reum T

更新日期：1990-03-01 00:00:00

abstract：:Susceptibility to Wilson's disease (WD) and its clinical manifestations are thought to be affected by genetic factors, including polymorphisms. The role of brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases is now widely discussed. The aim of the present study was to evaluate th...

journal_title：Metabolic brain disease

authors： Mirowska-Guzel D,Litwin T,Gromadzka G,Czlonkowski A,Czlonkowska A

更新日期：2013-09-01 00:00:00

abstract：:In view of the protective effect of brain derived neurotrophic factor (BDNF) against metabolic/excitotoxic insults in vitro, we investigated whether BDNF could limit infarct size after permanent occlusion of the middle cerebral artery in rat (MCAO). BDNF was delivered into the territory of the middle cerebral artery v...

journal_title：Metabolic brain disease

authors： Yamashita K,Wiessner C,Lindholm D,Thoenen H,Hossmann KA

更新日期：1997-12-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with severe liver disease. Although the mechanisms responsible for HE remain elusive, ammonia is generally considered to be involved in its pathogenesis, and astrocytes are thought to be the principal target of ammonia neurotoxici...

journal_title：Metabolic brain disease

authors： Rama Rao KV,Jayakumar AR,Norenberg DM

更新日期：2003-06-01 00:00:00

abstract：:We examined how serum cholesterol, an established risk factor for cerebrovascular disease (CVD), relates to cognitive function in healthy middle-older aged individuals with no neurologic or CVD history. A complete lipid panel was obtained from a cohort of one hundred twenty individuals, ages 43-85, who also underwent ...

journal_title：Metabolic brain disease

authors： Leritz EC,McGlinchey RE,Salat DH,Milberg WP

更新日期：2016-04-01 00:00:00

abstract：:Ischemic postconditioning (PostC) conventionally refers to a series of brief blood vessel occlusions and reperfusions, which can induce an endogenous neuroprotective effect and reduce cerebral ischemia/reperfusion (I/R) injury. Depending on the site of adaptive ischemic intervention, PostC can be classified as in situ...

journal_title：Metabolic brain disease

authors： Li CY,Ma W,Liu KP,Yang JW,Wang XB,Wu Z,Zhang T,Wang JW,Liu W,Liu J,Liang Y,Zhang XK,Li JJ,Guo JH,Li LY

更新日期：2021-01-01 00:00:00

abstract：:While alcohol-induced psychotic disorder (AIPD) is well recognised, relatively little is known about the condition. We undertook a review of the literature to identify studies on the epidemiology, clinical manifestations, underlying neurobiology and treatment of AIPD. Few prospective studies have been conducted on AIP...

journal_title：Metabolic brain disease

authors： Jordaan GP,Emsley R

更新日期：2014-06-01 00:00:00

abstract：:Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain a...

journal_title：Metabolic brain disease

authors： Chatauret N,Rose C,Butterworth RF

更新日期：2002-12-01 00:00:00

abstract：:Hepatic encephalopathy is a common complication of hepatic cirrhosis. The clinical diagnosis is based on two concurrent types of symptoms: impaired mental status and impaired neuromotor function. Impaired mental status is characterized by deterioration in mental status with psychomotor dysfunction, impaired memory, an...

journal_title：Metabolic brain disease

authors： Malaguarnera M

更新日期：2013-06-01 00:00:00

abstract：:Wilson disease (WD) is an autosomal recessive inherited disorder of copper metabolism, resulting in pathological accumulation of copper in many organs and tissues. The hallmarks of the disease are the presence of liver disease, neurologic symptoms, and Kayser-Fleischer corneal rings. The leading neurologic symptoms in...

journal_title：Metabolic brain disease

authors： Kitzberger R,Madl C,Ferenci P

更新日期：2005-12-01 00:00:00

abstract：:Today, neurological disorders such as epilepsy, depression, tardive dyskinesia, and stress, and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, dementia, and Huntington's disease affect millions of people all over the world. Existing pharmacological interventions do not meet the desired t...

journal_title：Metabolic brain disease

authors： Husain I,Zameer S,Madaan T,Minhaj A,Ahmad W,Iqubaal A,Ali A,Najmi AK

更新日期：2019-08-01 00:00:00