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The serum zinc concentration as a potential biological marker in patients with major depressive disorder.

Abstract：

:Despite many clinical trials assessing the role of zinc in major depressive disorder (MDD), the conclusions still remain ambiguous. The aim of the present clinical study was to determine and comparison the zinc concentration in the blood of MDD patients (active stage or remission) and healthy volunteers (controls), as well as to discuss its potential clinical usefulness as a biomarker of the disease. In this study 69 patients with current depressive episode, 45 patients in remission and 50 controls were enrolled. The zinc concentration was measured by electrothermal atomic absorption spectrometry (ET AAS). The obtained results revealed, that the zinc concentration in depressed phase were statistically lower than in the healthy volunteers [0.89 vs. 1.06 mg/L, respectively], while the zinc level in patients achieve remission was not significantly different from the controls [1.07 vs. 1.06 mg/L, respectively]. Additionally, among the patients achieve remission a significant differences in zinc concentration between group with and without presence of drug-resistance in the previous episode of depression were observed. Also, patients in remission demonstrated correlation between zinc level and the average number of depressive episodes in the last year. Serum zinc concentration was not dependent on atypical features of depression, presence of psychotic symptoms or melancholic syndrome, age, age of onset or duration of disease, number of episodes in the life time, duration of the episode/remission and severity of depression measured by the Hamilton Rating Scale for Depression (HDRS), and the Montgomery-Asberg Depression Rating Scale (MADRS). Concluding, our findings confirm the correlation between zinc deficit present in the depressive episode, and are consistent with the majority of previous studies. These results may also indicate that serum zinc concentration might be considered as a potential biological marker of MDD.

journal_name

Metab Brain Dis

journal_title

Metabolic brain disease

authors

Styczeń K,Sowa-Kućma M,Siwek M,Dudek D,Reczyński W,Szewczyk B,Misztak P,Topór-Mądry R,Opoka W,Nowak G

doi

10.1007/s11011-016-9888-9

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

97-103

issue

eissn

0885-7490

issn

1573-7365

pii

10.1007/s11011-016-9888-9

journal_volume

pub_type

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The serum zinc concentration as a potential biological marker in patients with major depressive disorder.