Abstract:
:The present study aimed to investigate the role of vascular endothelial growth factor (VEGF) in the neuroprotective effect of Crocus sativus (saffron) against cerebral ischemia/reperfusion injury (I/R) in rats. Four groups of a total forty I/R rats with 60-min occlusion followed by 48 h reperfusion or sham surgery were used. The sham and left-brain I/R control groups where treated with normal saline. The rats of the other two groups received saffron extract (100 or 200 mg/kg, ip, respectively) for 3 successive weeks prior to left-brain I/R. Other four doses of saffron extract were received by the rats of the last 2 groups 60 min prior to operation, during the surgery, and on days 1 and 2 following reperfusion. I/R group showed marked neurobehavioral, neurochemical and histopathological alterations. The results revealed a significant reduction in neurological deficit scores in the saffron-treated rats at both doses. Saffron significantly attenuated lipid peroxidation, decreased NO and brain natriuretic peptide (BNP) contents in I/R-brain tissue. On the other hand, saffron reversed the depletion of GSH in the injured brain. Moreover, saffron treatment evidently reduced apoptosis as revealed by a decrease in caspase-3 and Bax protein expression with a marked decrease in the apoptotic neuronal cells compared to I/R group. In addition, saffron administration effectively upregulated the expression of VEGF in I/R-brain tissue. In conclusion, saffron treatment offers significant neuroprotection against I/R damage possibly through diminishing oxidative stress and apoptosis and enhancement of VEGF.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Abdel-Rahman RF,El Awdan SA,Hegazy RR,Mansour DF,Ogaly HA,Abdelbaset Mdoi
10.1007/s11011-019-00505-1subject
Has Abstractpub_date
2020-03-01 00:00:00pages
427-439issue
3eissn
0885-7490issn
1573-7365pii
10.1007/s11011-019-00505-1journal_volume
35pub_type
杂志文章abstract::Betanin, a natural food colorant with powerful antioxidative properties, has not been studied in terms of neurodegenerative disease intervention. Therefore, the present study aimed to investigate the neuroprotective effects of betanin against trimethyltin chloride (TMT) -induced neurodegeneration in mice. Forty male I...
journal_title:Metabolic brain disease
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
abstract::Oxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention. Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory ha...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-018-0215-5
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abstract::Homocystinuria is an inborn error of sulfur amino acid metabolism characterized predominantly by vascular and nervous system dysfunction. In this study we determined the in vitro effects of homocysteine and methionine, metabolites which accumulate in homocystinuria, on Na+, K+-ATPase, and Mg2+-ATPase activities in syn...
journal_title:Metabolic brain disease
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abstract::Susceptibility to Wilson's disease (WD) and its clinical manifestations are thought to be affected by genetic factors, including polymorphisms. The role of brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases is now widely discussed. The aim of the present study was to evaluate th...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-013-9399-x
更新日期:2013-09-01 00:00:00
abstract::Autism (MIM 209850) is a heterogeneous neurodevelopmental disease that manifests within the first 3 years of life. Numerous articles reported that dysfunctional folate-methionine pathway enzymes may play an important role in the pathophysiology of autism. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzym...
journal_title:Metabolic brain disease
pub_type: 杂志文章,meta分析,评审
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abstract::A high co-morbidity between Alzheimer's disease (AD) and depression suggests there might be similar mechanisms underlying the course of these diseases. Previous studies have shown that p38MAPK plays a critical role in the pathophysiology of AD and depression. However, little is known about whether SB203580, a selectiv...
journal_title:Metabolic brain disease
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doi:10.1007/s11011-016-9880-4
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abstract::We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyr...
journal_title:Metabolic brain disease
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doi:10.1007/s11011-017-0107-0
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abstract::Following axonal interruption, structural, metabolic and physiological parameters change in motorneurons. Also, glial cells are involved in this process. Microglia proliferate and express new proteins such as vimentin or MHC antigens. Astrocytes show hypertrophy, increased GFAP synthesis, and formation of lamellae. Bo...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/BF00999498
更新日期:1989-03-01 00:00:00
abstract::Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain a...
journal_title:Metabolic brain disease
pub_type: 杂志文章
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-012-9310-1
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-015-9652-6
更新日期:2015-08-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-018-0262-y
更新日期:2018-10-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-013-9466-3
更新日期:2014-03-01 00:00:00
abstract::Near infrared radiation (NIR) is known to penetrate and affect biological systems in multiple ways. Recently, a series of experimental studies suggested that low intensity NIR may protect neuronal cells against a wide range of insults that mimic diseases such as stroke, brain trauma and neurodegeneration. However, the...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-014-9515-6
更新日期:2015-04-01 00:00:00
abstract::The enzyme nitric oxide synthase has been associated with suicide behavior. NOS1, NOS2 and NOS3 genes are implicated in the production of nitric oxide. However, the association between NOS genes and suicide behavior has not yet been established. To assess the association of Nitric Oxide Synthase (NOS) genes and suicid...
journal_title:Metabolic brain disease
pub_type: 杂志文章,meta分析
doi:10.1007/s11011-019-00406-3
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF02674671
更新日期:1997-12-01 00:00:00
abstract::This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0025-1
更新日期:2017-10-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9893-z
更新日期:2017-02-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-005-4149-3
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF02679980
更新日期:2000-06-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9902-2
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF00999694
更新日期:1987-12-01 00:00:00
abstract::Prenatal stress has been associated with increased vulnerability to psychiatric disturbances including schizophrenia, depression, attention-deficit hyperactivity disorder and autism. Elevated maternal circulating stress hormones alter development of neural circuits in the fetal brain and cause long-term changes in beh...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-009-9161-6
更新日期:2009-12-01 00:00:00
abstract::Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which develops in patients with severe liver diseases and/or portal-systemic shunting. Minimal HE, the earliest manifestation of HE, has drawn increasing attention in the last decade. Minimal HE is associated with a series of brain functional changes, such as ...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-014-9504-9
更新日期:2014-09-01 00:00:00
abstract::We investigated the biochemical alterations of the striatum of mice subjected to seven experimental schedules with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) treatment. The mice were treated intraperitoneally (i.p.) with MPTP (20 mg/kg in saline) four times a day at 2-hr intervals showed severe ...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-010-9195-9
更新日期:2010-06-01 00:00:00
abstract::Maple syrup urine disease (MSUD) or branched-chain alpha-keto aciduria (BCKA) is an inherited disorder caused by a deficiency of the branched-chain alpha-keto acid dehydrogenase complex (BCKAD) activity. The blockage of this pathway leads to tissue accumulation of the branched-chain amino acids (BCAA) leucine, isoleuc...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-006-9030-5
更新日期:2006-12-01 00:00:00
abstract::Statins or HMG-CoA reductase inhibitors have been shown to be effective at lowering cholesterol levels, and the application of these molecules has gradually emerged as an attractive therapeutic strategy for neurodegenerative diseases. Epidemiological studies suggest that statin use is associated with a decreased incid...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0091-4
更新日期:2017-12-01 00:00:00
abstract::Over the past 35 years, the outlook for a patient presenting with acute liver failure (ALF) has changed beyond all recognition. A patient presenting in 1984 had an 80 % likelihood of succumbing to intracranial hypertension. Today due to dramatic improvements in intensive care in dedicated liver transplant units, this ...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-012-9363-1
更新日期:2013-03-01 00:00:00
abstract::We examined how serum cholesterol, an established risk factor for cerebrovascular disease (CVD), relates to cognitive function in healthy middle-older aged individuals with no neurologic or CVD history. A complete lipid panel was obtained from a cohort of one hundred twenty individuals, ages 43-85, who also underwent ...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9797-y
更新日期:2016-04-01 00:00:00
abstract::Cystinosis is a systemic genetic disease caused by a lysosomal transport deficiency accumulating cystine in most tissues. Tissue damage depends on cystine accumulation, but the mechanisms of this damage are still obscure. Cysteamine administration depletes cystine accumulated, increasing survive of affected patients. ...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-007-9078-x
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