Resting-state functional magnetic resonance imaging in hepatic encephalopathy: current status and perspectives.

abstract：:Semi-chronic exposure of ICR male Mice to Aflatoxin B1 (AFB1) in non-toxic doses decreased brain serotonin (5-hydroxytryptamine, 5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA) and catecholamines without altering tryptophan (TRP) or tyrosine (TYR) levels. A TRP load (300 mg/kg, i.p. x 2 hours) slightly increased brain T...

journal_title：Metabolic brain disease

authors： Kimbrough TD,Llewellyn GC,Weekley LB

更新日期：1992-12-01 00:00:00

abstract：:Stress-induced activation of the expression of the endoplasmic reticulum (ER)-resident chaperon and member of the protein disulfide isomerase family erp72 was studied after transient cerebral ischemia in vivo using the four-vessel occlusion method and experimental depletion of ER calcium stores in primary neuronal cel...

journal_title：Metabolic brain disease

authors： Paschen W,Gissel C,Linden T,Doutheil J

更新日期：1998-03-01 00:00:00

abstract：:Increasing evidence indicates that fetal metabolic stress may result in a variety of post-natal perturbations during brain development. The goal of the study was to determine the duration of hypoxia/ischemia that would elicit a demonstrable regional depression of metabolism in the fetal brain and further to examine se...

journal_title：Metabolic brain disease

authors： Pundik S,Robinson S,Lust WD,Zechel J,Buczek M,Selman WR

更新日期：2006-12-01 00:00:00

abstract：:The availability of an animal model is crucial in studying the pathophysiological mechanisms of disease and to test possible therapies. Now, there are several models for the study of liver diseases, but there still remains a lack of a satisfactory animal model of chronic liver disease with hepatic encephalopathy (HE) ...

journal_title：Metabolic brain disease

authors： Jover R,Madaria E,Felipo V,Rodrigo R,Candela A,Compañ A

更新日期：2005-12-01 00:00:00

abstract：:The radiological spectrum of neuromyelitis optica has become broader since the detection of aquaporin4 antibodies. We report a case of neuromyelitis optica patient with pseudotumoral encephalic lesion. A 66 year-old woman presented with sudden left lateral homonymous hemianopsia. A brain MRI showed an isolated and ext...

journal_title：Metabolic brain disease

authors： Fargeot G,Aboab J,Savatovsky J,Marignier R,Lecler A,Gout O

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present work was to investigate the role of ondansetron on the high fat diet (HFD) induced obese mice for behavioral and biochemical alterations using chronic unpredictable mild stress (CUMS) model of depression. Animals were fed with high fat diet for 14 weeks and subjected to different stress procedur...

journal_title：Metabolic brain disease

authors： Kurhe Y,Radhakrishnan M,Gupta D

更新日期：2014-09-01 00:00:00

abstract：:Maternal separation in non-human primates has been proposed as a model of early adversity. The symptoms of separation anxiety were studied in vervet monkeys, during the weaning period, when psychotropic medications were administered. The control group received a normal diet and treatment groups received citalopram, re...

journal_title：Metabolic brain disease

authors： Marais L,Daniels W,Brand L,Viljoen F,Hugo C,Stein DJ

更新日期：2006-09-01 00:00:00

abstract：:Several studies have examined neonatal diabetes, a rare disease characterized by hyperglycemia and low insulin levels that is usually diagnosed in the first 6 month of life. Recently, the effects of diabetes on the brain have received considerable attention. In addition, hyperglycemia may perturb brain function and mi...

journal_title：Metabolic brain disease

authors： Rosa AP,Mescka CP,Catarino FM,de Castro AL,Teixeira RB,Campos C,Baldo G,Graf DD,de Mattos-Dutra A,Dutra-Filho CS,da Rosa Araujo AS

更新日期：2018-02-01 00:00:00

abstract：:Tyrosinemia type II is a genetic disorder characterized by elevated blood levels of the amino acid tyrosine caused by the deficiency of tyrosine aminotransferase enzyme, resulting in neurologic and developmental difficulties in the patients. Although neurological sequelae are common in Tyrosinemia type II patients, th...

journal_title：Metabolic brain disease

authors： Carvalho-Silva M,Gomes LM,de Prá SD,Wessler LB,Schuck PF,Scaini G,de Bem AF,Blum-Silva CH,Reginatto FH,de Oliveira J,Streck EL

更新日期：2020-01-01 00:00:00

abstract：:We have described the occurrence in freely moving gerbils of slow potential changes (SPC) in two different models of experimental epilepsy: 1) maximal electroshock and 2) bilateral epileptic foci induced by penicillin. SPC is considered a by-product of epileptiform activity in both models and correlates to the SPC whi...

journal_title：Metabolic brain disease

authors： de Azeredo FA,Perret ML

更新日期：1992-06-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a variety of symptoms of different severity such as cognitive deficits and impaired motor functions. Currently, HE is seen as a consequence of a low grade cerebral oedema assoc...

journal_title：Metabolic brain disease

authors： Baker L,Lanz B,Andreola F,Ampuero J,Wijeyesekera A,Holmes E,Deutz N

更新日期：2016-12-01 00:00:00

abstract：:Today, due to technology development and aversive events of daily life, Human exposure to both radiofrequency and stress is unavoidable. This study investigated the co-exposure to repeated restraint stress and WiFi signal on cognitive function and oxidative stress in brain of male rats. Animals were divided into four ...

journal_title：Metabolic brain disease

authors： Othman H,Ammari M,Sakly M,Abdelmelek H

更新日期：2017-10-01 00:00:00

abstract：:To characterize an Egyptian patient with glutaric acidemia type I (GA I) and to identify the causative mutation(s) that may be responsible for the disease phenotype. MRI was performed on the patient using the 1.5 T magnet, biochemical analysis was carried out using gas chromatography/mass spectrometry on the patient's...

journal_title：Metabolic brain disease

authors： Moseilhy A,Hassan MM,El Abd HS,Mohammad SA,El Bekay R,Abdel-Motal UM,Ouhtit A,Zaki OK,Zayed H

更新日期：2017-02-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a multifactorial disorder caused by an interaction between environmental risk factors and a genetic background. It is characterized by impairment in communication, social interaction, repetitive behavior, and sensory processing. The etiology of ASD is still not fully understood, and t...

journal_title：Metabolic brain disease

authors： Qasem H,Al-Ayadhi L,Bjørklund G,Chirumbolo S,El-Ansary A

更新日期：2018-08-01 00:00:00

abstract：:Alcohol dependence (AD) has a large heritable component. Genetic variation in genes involved in the absorption and elimination of ethanol have been associated with AD. However, some of these polymorphisms are not present in an African population. Previous studies have reported that a type of AD which is characterized ...

journal_title：Metabolic brain disease

authors： Crawford A,Dalvie S,Lewis S,King A,Liberzon I,Fein G,Koenen K,Ramesar R,Stein DJ

更新日期：2014-06-01 00:00:00

abstract：:Despite many clinical trials assessing the role of zinc in major depressive disorder (MDD), the conclusions still remain ambiguous. The aim of the present clinical study was to determine and comparison the zinc concentration in the blood of MDD patients (active stage or remission) and healthy volunteers (controls), as...

journal_title：Metabolic brain disease

authors： Styczeń K,Sowa-Kućma M,Siwek M,Dudek D,Reczyński W,Szewczyk B,Misztak P,Topór-Mądry R,Opoka W,Nowak G

更新日期：2017-02-01 00:00:00

abstract：:Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-α) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjec...

journal_title：Metabolic brain disease

authors： Mustapic M,Popovic Hadzija M,Pavlovic M,Pavkovic P,Presecki P,Mrazovac D,Mimica N,Korolija M,Pivac N,Muck-Seler D

更新日期：2012-12-01 00:00:00

abstract：:This study was performed to analyze the mutational spectrum of the phenylalanine hydroxylase (PAH) gene in phenylketonuria (PKU) patients in Northwest China, to identify mutational hot spots, and to determine the correlation between variants and clinical phenotypes of PKU. A large cohort of 475 PKU families in Northwe...

journal_title：Metabolic brain disease

authors： Yan Y,Zhang C,Jin X,Zhang Q,Zheng L,Feng X,Hao S,Gao H,Ma X

更新日期：2019-06-01 00:00:00

abstract：:Mutations in NADH dehydrogenase (ND) subunits of complex I lead to mitochondrial encephalomyopathies associated with various phenotypes. This report aims to present the patient's clinical symptomatology in the context of a very rare 13042G>A de novo mutation and with an emphasis on changing phenotypic expression and p...

journal_title：Metabolic brain disease

authors： Schinwelski M,Kierdaszuk B,Dulski J,Tońska K,Kodroń A,Sitek EJ,Bartnik E,Kamińska A,Kwieciński H,Sławek J

更新日期：2015-08-01 00:00:00

abstract：:Sleep disturbances are prevalent among patients with Alzheimer's disease (AD) and often precede the onset and progression of dementia. However, there are no reliable animal models for investigating sleep disturbances in patients with sporadic AD (sAD), which accounts for more than 90% of all AD cases. In the present s...

journal_title：Metabolic brain disease

authors： Song JZ,Cui SY,Cui XY,Hu X,Ma YN,Ding H,Ye H,Zhang YH

更新日期：2018-02-01 00:00:00

abstract：:Applying different technologies to monitor disease activity and treatment efficacy are essential in a complex disease such as multiple sclerosis. Combining current assays with flow cytometry could create a powerful tool for such analyses. The cell surface expression level of CD74, the MHC class II invariant chain, is ...

journal_title：Metabolic brain disease

authors： Benedek G,Meza-Romero R,Bourdette D,Vandenbark AA

更新日期：2015-08-01 00:00:00

abstract：:D-Galactose (D-gal) chronic administration via intraperitoneal and subcutaneous routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal and subcutaneous administration of D-gal causes memory impairments, a reduction in the neurogenesis of adult mice, an increase in the levels of the ...

journal_title：Metabolic brain disease

authors： Budni J,Garcez ML,Mina F,Bellettini-Santos T,da Silva S,Luz APD,Schiavo GL,Batista-Silva H,Scaini G,Streck EL,Quevedo J

更新日期：2017-06-01 00:00:00

abstract：:Increasing evidence indicates that excessive drug consumption is sufficient for the transition from recreational and controlled drug use to uncontrolled use and addiction. However, the underlying mechanisms are debated. Some neurobehavioral and neuroimaging evidence indicates that dorsolateral striatum (dlStr)-depende...

journal_title：Metabolic brain disease

authors： Shi JJ,Cao DN,Liu HF,Wang ZY,Lu GY,Wu N,Zhou WH,Li J

更新日期：2019-08-01 00:00:00

abstract：:Depression, common in chronic medical conditions, and hepatic encephalopathy (HE), a reversible neuropsychiatric syndrome due to liver dysfunction, are associated with impaired health-related quality of life (HRQOL) in cirrhosis and hepatitis C (HCV). This study investigated the impact of depression and HE on HRQOL in...

journal_title：Metabolic brain disease

authors： Barboza KC,Salinas LM,Sahebjam F,Jesudian AB,Weisberg IL,Sigal SH

更新日期：2016-08-01 00:00:00

abstract：:The present experiments were conducted to investigate the direct effects of ethanol on the energy metabolism of astrocytes and C6-glioma cells. Primary astrocytes were prepared from cerebral cortices of neonatal rats, and C6-glioma cells were purchased from American Type Culture Collection (ATCC). These cells were exp...

journal_title：Metabolic brain disease

authors： Haghighat N,McCandless DW,Geraminejad P

更新日期：1999-09-01 00:00:00

abstract：:Current data on the neurotrophic effects of steroid hormones suggest that, in brain and spinal cord regions containing receptor systems, steroids act at the level of RNA and protein synthesis to effect metabolic changes associated with nerve-cell survival, elaboration/maintenance of dendritic and axonal processes, syn...

journal_title：Metabolic brain disease

authors： Jones KJ

更新日期：1988-03-01 00:00:00

abstract：:Cadmium (Cd) exposure leads to production of reactive oxygen species (ROS), which are associated with Cd-induced neurotoxicity and nephrotoxicity. Selenium nanoparticles (Se-NPs) have high bioavailability and antioxidant activities so it attracted wide spread attention. The present study examined the possible ameliora...

journal_title：Metabolic brain disease

authors： Sadek KM,Lebda MA,Abouzed TK,Nasr SM,Shoukry M

更新日期：2017-10-01 00:00:00

abstract：:Soluble amyloid-β protein (Aβ) oligomers have been recognized to be early and key intermediates in Alzheimer's disease-related synaptic dysfunction. In this study, using in vitro electrophysiology, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), a marine-derived acidic oligosaccharide, w...

journal_title：Metabolic brain disease

authors： Chang L,Li F,Chen X,Xu S,Wang C,Chen H,Wang Q

更新日期：2014-09-01 00:00:00

abstract：:D-galactose (GAL) causes aging-related changes and oxidative stress in the organism. We investigated the effect of whole fresh blueberry (BB) (Vaccinium corymbosum L.) treatment on oxidative stress in age-related brain damage model. Rats received GAL (300 mg/kg; s.c.; 5 days per week) alone or together with 5 % (BB1) ...

journal_title：Metabolic brain disease

authors： Çoban J,Doğan-Ekici I,Aydın AF,Betül-Kalaz E,Doğru-Abbasoğlu S,Uysal M

更新日期：2015-06-01 00:00:00

abstract：:Sepsis is a major clinical challenge that is associated with encephalopathy and multi-organ dysfunction. Current therapeutic interventions are relatively ineffective and the development of novel treatments is hampered by the lack of a well-characterised animal model. Therefore, the behavioural, metabolic, physiologica...

journal_title：Metabolic brain disease

authors： Brooks HF,Osabutey CK,Moss RF,Andrews PL,Davies DC

更新日期：2007-12-01 00:00:00