Abstract:
:Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-α) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjects with T2D. The aim was to determine ApoE and G-308A TNF-α gene polymorphisms in unrelated Croatian Caucasians: 207 patients with sporadic AD, 196 T2D patients and 456 healthy controls. Patients with AD had higher frequency of ApoE4 allele compared to T2D patients and controls. The significant association, observed between ApoE2 allele and T2D, disappeared after the data were adjusted for age and sex. The genotype or allele frequencies of G-308A TNF-α gene polymorphism were similar among the patients with AD, T2D and healthy controls. In conclusion, these results do not support the hypothesis that the A allele of G-308A TNF-α gene polymorphism is associated either with AD or T2D. Our data confirm the association between the ApoE4 allele and AD, and point out the E2 allele of ApoE gene as the possible risk factor for T2D.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Mustapic M,Popovic Hadzija M,Pavlovic M,Pavkovic P,Presecki P,Mrazovac D,Mimica N,Korolija M,Pivac N,Muck-Seler Ddoi
10.1007/s11011-012-9310-1subject
Has Abstractpub_date
2012-12-01 00:00:00pages
507-12issue
4eissn
0885-7490issn
1573-7365journal_volume
27pub_type
杂志文章abstract::Increased benzodiazepine (BZ) receptor density has been reported in brains of rabbits with hepatic encephalopathy (HE) due to galactosamine (GalN)-induced fulminant hepatic failure (FHF). These data were generated using detergent-Triton X-100-treated neural membranes. While performing further studies it was noted that...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF01000296
更新日期:1989-09-01 00:00:00
abstract::Ischemic postconditioning (PostC) conventionally refers to a series of brief blood vessel occlusions and reperfusions, which can induce an endogenous neuroprotective effect and reduce cerebral ischemia/reperfusion (I/R) injury. Depending on the site of adaptive ischemic intervention, PostC can be classified as in situ...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-020-00562-x
更新日期:2021-01-01 00:00:00
abstract::Lead exposure has negative effects on developing nervous system and induces apoptosis in newly generated neurons. Natural antioxidants (i.e. Ascorbic acid and Garlic) might protect against lead-induced neuronal cell damage. The aim of the present study was to investigate the protective effects of Ascorbic acid and Gar...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9837-7
更新日期:2016-10-01 00:00:00
abstract::The central nervous system is one of the most vulnerable organs affected by mercury toxicity. Both acute and chronic exposure to mercury is also known to cause a variety of neurological or psychiatric disorders. Here, the neuroprotective effect of berberine (BN; 100 mg/kg bwt) on mercuric chloride (HgCl2; 0.4 mg/kg bw...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-015-9652-6
更新日期:2015-08-01 00:00:00
abstract::Autism (MIM 209850) is a heterogeneous neurodevelopmental disease that manifests within the first 3 years of life. Numerous articles reported that dysfunctional folate-methionine pathway enzymes may play an important role in the pathophysiology of autism. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzym...
journal_title:Metabolic brain disease
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11011-016-9815-0
更新日期:2016-08-01 00:00:00
abstract::Chronic ethanol ingestion results in an "up-regulation" of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in mouse brain. This increase in receptors is associated with ethanol withdrawal seizures, which can be attenuated by NMDA receptor antagonists. Chronic exposure to ethanol (3 days) of rat cerebella...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF01991784
更新日期:1995-03-01 00:00:00
abstract::Stroke is the leading cause of disability among adults as well as the 2nd leading cause of death globally. Ischemic stroke accounts for about 85% of strokes, and currently, tissue plasminogen activator (tPA), whose therapeutic window is limited to up to 4.5 h for the appropriate population, is the only FDA approved dr...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-020-00573-8
更新日期:2020-08-01 00:00:00
abstract::Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. Clinically, the disease is characterized by progressive neurological deterioration and renal failure, whose pathophysiology is still undefined. In the present study we investigated the effect of acute MMA administration...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-013-9396-0
更新日期:2013-09-01 00:00:00
abstract::The impaired insulin signaling has been recognized as a common pathogenetic mechanism between diabetes and Alzheimer's disease (AD). In the progression of AD, brain is characterized by defective insulin receptor substrate-1 (IRS-1) and increased oxidative stress. Thymol, a monoterpene phenol isolated from medicinal he...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9921-z
更新日期:2017-04-01 00:00:00
abstract::Homocystinuria is an inborn error of sulfur amino acid metabolism characterized predominantly by vascular and nervous system dysfunction. In this study we determined the in vitro effects of homocysteine and methionine, metabolites which accumulate in homocystinuria, on Na+, K+-ATPase, and Mg2+-ATPase activities in syn...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1023/a:1015594111778
更新日期:2002-06-01 00:00:00
abstract::Traumatic brain injury (TBI) results in severe neurological impairments without effective treatments. Inflammation appears to be an important contributor to key pathogenic events such as secondary brain injury following TBI and therefore serves as a promising target for novel therapies. We have recently demonstrated t...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-9991-6
更新日期:2017-10-01 00:00:00
abstract::Oxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention. Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory ha...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-018-0215-5
更新日期:2018-08-01 00:00:00
abstract::The role of oxidative stress in the pathogenesis of phenylketonuria (PKU)-associated disorders has been implicated. Ischemia modified albumin (IMA) is a modified form of serum albumin, which is produced under the conditions of oxidative stress. The aim of this study was to measure the serum level of IMA in the PKU pat...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0165-3
更新日期:2018-06-01 00:00:00
abstract::A study evaluating zinc supplementation in patients with Alzheimer's disease yielded variable zinc plasma levels in spite of positive cognitive and physiological results. In an attempt to raise and sustain plasma zinc levels, a single patient was given 15 mg zinc/day with various combinations of vitamins. A sustained ...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-006-9023-4
更新日期:2006-09-01 00:00:00
abstract::The current study evaluated the protective and therapeutic potency of bee pollen in ameliorating the toxic effects of methylmercury (MeHg), by measuring certain biochemical parameters related to neurotransmission, neuroinflammation, apoptosis, and glutamate excitotoxicity in the male neonate brain. Healthy, pregnant f...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-019-00496-z
更新日期:2020-01-01 00:00:00
abstract::Semi-chronic exposure of ICR male Mice to Aflatoxin B1 (AFB1) in non-toxic doses decreased brain serotonin (5-hydroxytryptamine, 5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA) and catecholamines without altering tryptophan (TRP) or tyrosine (TYR) levels. A TRP load (300 mg/kg, i.p. x 2 hours) slightly increased brain T...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF01000244
更新日期:1992-12-01 00:00:00
abstract::This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0025-1
更新日期:2017-10-01 00:00:00
abstract::While risk factors for konzo are known, determinants of cognitive impairment in konzo-affected children remain unknown. We anchored cognitive performance (KABC-II scores) to serum levels of free-thyroxine (free-T4), thyroid-stimulating hormone (TSH), albumin, and motor proficiency (BOT-2 scores) in 40 children includi...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-014-9492-9
更新日期:2014-06-01 00:00:00
abstract::Undernourished suckling rats were administered, by gastric intubation, either soy oil (which is rich in both linoleic and linolenic acids) or safflower oil (which is rich in linoleic acid but deficient in linolenic acid) to determine (1) if dietary supplementation would offset the hypomyelination characteristic of the...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF00999385
更新日期:1986-06-01 00:00:00
abstract::Isolated Methylmalonic acidemia/aciduria (MMA) is a group of inborn errors of metabolism disease which is caused by defect in methylmalonyl-CoA mutase (MCM) enzyme. The enzyme has a key function in the catabolism of branched chain amino acids (BCAA, isoleucine, and valine), methionine, and threonine. MCM is encoded by...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-018-0277-4
更新日期:2018-10-01 00:00:00
abstract::The sprouting of new blood vessels from pre-existing vasculature (angiogenesis) is essential for tumour survival, influenced by tumour cell-endothelial cell interactions and is tightly regulated by biochemical cues including the kallikrein-kinin system (KKS). We examined the structural interaction between neuroblastom...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-006-9008-3
更新日期:2006-09-01 00:00:00
abstract::Patients with chronic liver disease manifest a high incidence (> 75%) of pallidal signal hyperintensity on T1-weighted Magnetic Resonance Imaging (MRI), the intensity of which correlates with blood manganese levels and the presence of extrapyramidal symptoms. A major cause of pallidal hyperintensity on T1-weighted MRI...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/BF02109357
更新日期:1995-12-01 00:00:00
abstract::Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which develops in patients with severe liver diseases and/or portal-systemic shunting. Minimal HE, the earliest manifestation of HE, has drawn increasing attention in the last decade. Minimal HE is associated with a series of brain functional changes, such as ...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-014-9504-9
更新日期:2014-09-01 00:00:00
abstract::Maple Syrup Urine Disease (MSUD) is biochemically characterized by elevated levels of leucine, isoleucine and valine, as well as their corresponding transaminated branched-chain α-keto acids in tissue and biological fluids. Neurological symptoms and cerebral abnormalities, whose mechanisms are still unknown, are typic...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0035-z
更新日期:2017-10-01 00:00:00
abstract::We examined how serum cholesterol, an established risk factor for cerebrovascular disease (CVD), relates to cognitive function in healthy middle-older aged individuals with no neurologic or CVD history. A complete lipid panel was obtained from a cohort of one hundred twenty individuals, ages 43-85, who also underwent ...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9797-y
更新日期:2016-04-01 00:00:00
abstract::Bilateral, symmetrical hyperintensity of the globus pallidus is observed in T1-weighted cerebral magnetic resonance images in from 52 to 100% of patients with chronic liver disease. No significant relationship exists between the presence of these cerebral changes in image signal intensity and the patients' neuropsychi...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1023/a:1020680624084
更新日期:1998-12-01 00:00:00
abstract::Tyrosinemia type II is an inborn error of metabolism caused by a deficiency in hepatic cytosolic aminotransferase. Affected patients usually present a variable degree of mental retardation, which may be related to the level of plasma tyrosine. In the present study we evaluated effect of chronic administration of L-tyr...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-014-9615-3
更新日期:2015-02-01 00:00:00
abstract::Maple syrup urine disease (MSUD) or branched-chain alpha-keto aciduria (BCKA) is an inherited disorder caused by a deficiency of the branched-chain alpha-keto acid dehydrogenase complex (BCKAD) activity. The blockage of this pathway leads to tissue accumulation of the branched-chain amino acids (BCAA) leucine, isoleuc...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-006-9030-5
更新日期:2006-12-01 00:00:00
abstract::First-episode psychosis (FEP) patients are more sensitive to neuroleptic side-effects such as hyperprolactinemia. We examined the prolactin levels of previously minimally treated patients with first episode schizophrenia over their first year of treatment with flupenthixol decanoate and the relationship between prolac...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-019-00474-5
更新日期:2019-12-01 00:00:00
abstract::Aberrant brain functional connectivity has been considered as the important mechanism underlying minimal hepatic encephalopathy (MHE); however, little is known about the change in interhemispheric connection in MHE patients. Twenty patients with HBV-related cirrhosis and MHE and 15 healthy controls were included in th...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-014-9505-8
更新日期:2014-09-01 00:00:00