Abstract：
:The role of oxidative stress in the pathogenesis of phenylketonuria (PKU)-associated disorders has been implicated. Ischemia modified albumin (IMA) is a modified form of serum albumin, which is produced under the conditions of oxidative stress. The aim of this study was to measure the serum level of IMA in the PKU patients and to investigate its ability in predicting the status of oxidative stress in these patients. Fifty treated-PKU patients and fifty age- and sex-matched healthy subjects were included in the study. The blood samples were obtained and the serum level of phenylalanine (Phe) was measured using reverse phase HPLC method. The levels of IMA, malondialdehyde (MDA), gamma-glutamyl transferase (GGT) activity, and uric acid (UA) were determined using colorimetric methods. The levels of serum Phe, IMA, and MDA were significantly higher (p < 0.001) and the level of UA (p < 0.05) was lower in the PKU patients compared to control group. Serum IMA level was positively correlated with MDA (r = 0.585, p < 0.001) and UA (r = 0.6, p < 0.001). An inverse relationship was observed between the serum level of IMA and Phe (r = - 0.410, p < 0. 01). Results of the present study suggest that serum IMA level could be used as a novel marker for the evaluation of oxidative stress in the PKU patients.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Keshavarzi F,Rastegar M,Vessal M,Rafiei Dehbidi G,Khorsand M,Ganjkarimi AH,Takhshid MAdoi
10.1007/s11011-017-0165-3subject
Has Abstractpub_date
2018-06-01 00:00:00pages
675-680issue
3eissn
0885-7490issn
1573-7365pii
10.1007/s11011-017-0165-3journal_volume
33pub_type
杂志文章abstract：:Brain glucose uptake is usually reduced in type 2 diabetes owing to downregulation of brain glucose transporters. The ability of Vernonia amygdalina to stimulate glucose uptake as well as ameliorate glucose-induced oxidative stress and proinflammation were investigated in rat brain. Hot infusion of V. amygdalina leave...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0363-7
更新日期：2019-06-01 00:00:00
abstract：:Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-011-9263-9
更新日期：2011-12-01 00:00:00
abstract：:This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (...
journal_title：Metabolic brain disease
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doi：10.1007/s11011-017-0025-1
更新日期：2017-10-01 00:00:00
abstract：:Adult-onset type II citrullinemia (CTLN2), characterized by a liver-specific deficiency of urea cycle enzyme, argininosuccinate synthetase, is caused by mutations in SLC25A13 that encodes a calcium binding mitochondrial solute carrier protein, citrin. Citrin deficiency causes not only CTLN2 but also neonatal intrahepa...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
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更新日期：2002-12-01 00:00:00
abstract：:The availability of an animal model is crucial in studying the pathophysiological mechanisms of disease and to test possible therapies. Now, there are several models for the study of liver diseases, but there still remains a lack of a satisfactory animal model of chronic liver disease with hepatic encephalopathy (HE) ...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-005-7925-1
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abstract：:Glutaric aciduria type I (GA-I) is an inborn error of lysine and tryptophan metabolism. Clinical manifestations of GA-I include dystonic or dyskinetic cerebral palsy, but when the symptoms occur, treatment is not effective. In Taiwan, newborn screening for GA-I started in 2001; we wish to evaluate the outcomes of pati...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-012-9349-z
更新日期：2013-03-01 00:00:00
abstract：:D-galactose (GAL) causes aging-related changes and oxidative stress in the organism. We investigated the effect of whole fresh blueberry (BB) (Vaccinium corymbosum L.) treatment on oxidative stress in age-related brain damage model. Rats received GAL (300 mg/kg; s.c.; 5 days per week) alone or together with 5 % (BB1) ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9643-z
更新日期：2015-06-01 00:00:00
abstract：:Mobile phone providers use electromagnetic radiation (EMR) with frequencies ranging from 900 to 1800 MHz. The increasing use of mobile phones has been accompanied by several potentially pathological consequences, such as neurological diseases related to hippocampal (HIPPON) and dorsal root ganglion neuron (DRGN). The ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0180-4
更新日期：2018-06-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00471-8
更新日期：2019-12-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9804-3
更新日期：2016-06-01 00:00:00
abstract：:At the present time alcoholism is recognized as a metabolic disease exhibiting the clinical features of craving for alcohol, loss of control over drinking, tolerance and physical dependence on alcohol, while both epidemiological and experimental studies have demonstrated that genetic factors may be important in determ...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/BF01999765
更新日期：1994-06-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-006-9031-4
更新日期：2006-12-01 00:00:00
abstract：:Chronic liver disease (CLD) leads to a spectrum of neuropsychiatric disorders named hepatic encephalopathy (HE). Even though brain energy metabolism is believed to be altered in chronic HE, few studies have explored energy metabolism in CLD-induced HE, and their findings were inconsistent. The aim of this study was to...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9715-8
更新日期：2016-12-01 00:00:00
abstract：:The enzyme nitric oxide synthase has been associated with suicide behavior. NOS1, NOS2 and NOS3 genes are implicated in the production of nitric oxide. However, the association between NOS genes and suicide behavior has not yet been established. To assess the association of Nitric Oxide Synthase (NOS) genes and suicid...
journal_title：Metabolic brain disease
pub_type： 杂志文章,meta分析
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更新日期：2019-08-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-005-2476-z
更新日期：2005-03-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9645-x
更新日期：2015-08-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00999385
更新日期：1986-06-01 00:00:00
abstract：:Mitochondrial glutathione (mGSH) is a critical factor in the cell defense against oxidative and nitrosative stress (ONS), and ONS is a key pathogenic event in hepatic encephalopathy (HE). Acute HE in the thioacetamide (TAA) model caused a 54 % decrease of mGSH content in the rat prefrontal cortex (pfc), but not in the...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-012-9342-6
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journal_title：Metabolic brain disease
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00999694
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01991784
更新日期：1995-03-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00999841
更新日期：1990-09-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9866-2
更新日期：2016-10-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
abstract：:Maple syrup urine disease (MSUD) or branched-chain alpha-keto aciduria (BCKA) is an inherited disorder caused by a deficiency of the branched-chain alpha-keto acid dehydrogenase complex (BCKAD) activity. The blockage of this pathway leads to tissue accumulation of the branched-chain amino acids (BCAA) leucine, isoleuc...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-006-9030-5
更新日期：2006-12-01 00:00:00
abstract：:Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9893-z
更新日期：2017-02-01 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by accumulation and deposition of Aβ peptide in human brain. The present study aimed to determine the protective effect of catechin rich extract of MERM (methanolic extract of Rhizophora mucronata) on Aβ (25-35) induced cognitive impai...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9831-0
更新日期：2016-08-01 00:00:00
abstract：:Semi-chronic exposure of ICR male Mice to Aflatoxin B1 (AFB1) in non-toxic doses decreased brain serotonin (5-hydroxytryptamine, 5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA) and catecholamines without altering tryptophan (TRP) or tyrosine (TYR) levels. A TRP load (300 mg/kg, i.p. x 2 hours) slightly increased brain T...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01000244
更新日期：1992-12-01 00:00:00
abstract：:The present work was carried out to study the influence of ammonia and factors from sera and cerebrospinal fluid (CSF) from patients with different degrees of chronic liver diseases on [3H]D-aspartate (Asp) and [3H]L-glutamate (Glu) high-affinity uptake into the rat hippocampal formation. For comparison, high-affinity...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00996975
更新日期：1990-03-01 00:00:00
abstract：:Studies have shown that oxidative stress is involved in the pathophysiology of bipolar disorder (BD). It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced hyperactivity, a s...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9942-7
更新日期：2017-04-01 00:00:00
