当前位置： SCI文献检索 > METABOLIC BRAIN DISEASE期刊下所有文献 > Long term exposure to cell phone frequencies (900 and 1800 MHz) induces apoptosis, mitochondrial oxidative stress and TRPV1 channel activation in the hippocampus and dorsal root ganglion of rats.

Long term exposure to cell phone frequencies (900 and 1800 MHz) induces apoptosis, mitochondrial oxidative stress and TRPV1 channel activation in the hippocampus and dorsal root ganglion of rats.

Abstract：

:Mobile phone providers use electromagnetic radiation (EMR) with frequencies ranging from 900 to 1800 MHz. The increasing use of mobile phones has been accompanied by several potentially pathological consequences, such as neurological diseases related to hippocampal (HIPPON) and dorsal root ganglion neuron (DRGN). The TRPV1 channel is activated different stimuli, including CapN, high temperature and oxidative stress. We investigated the contribution TRPV1 to mitochondrial oxidative stress and apoptosis in HIPPON and DRGN following long term exposure to 900 and 1800 MHz in a rat model. Twenty-four adult rats were equally divided into the following groups: (1) control, (2) 900 MHz, and (3) 1800 MHz exposure. Each experimental group was exposed to EMR for 60 min/ 5 days of the week during the one year. The 900 and 1800 MHz EMR exposure induced increases in TRPV1 currents, intracellular free calcium influx (Ca2+), reactive oxygen species (ROS) production, mitochondrial membrane depolarization (JC-1), apoptosis, and caspase 3 and 9 activities in the HIPPON and DRGN. These deleterious processes were further increased in the 1800 MHz experimental group compared to the 900 MHz exposure group. In conclusion, mitochondrial oxidative stress, programmed cell death and Ca2+ entry pathway through TRPV1 activation in the HIPPON and DRGN of rats were increased in the rat model following exposure to 900 and 1800 MHz cell frequencies. Our results suggest that exposure to 900 and 1800 MHz EMR may induce a dose-associated, TRPV1-mediated stress response.

journal_name

Metab Brain Dis

journal_title

Metabolic brain disease

authors

Ertilav K,Uslusoy F,Ataizi S,Nazıroğlu M

doi

10.1007/s11011-017-0180-4

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

753-763

issue

3

eissn

0885-7490

issn

1573-7365

pii

10.1007/s11011-017-0180-4

journal_volume

33

pub_type

杂志文章

相关文献

METABOLIC BRAIN DISEASE文献大全
  • Acute and long-term effects of intracerebroventricular administration of α-ketoisocaproic acid on oxidative stress parameters and cognitive and noncognitive behaviors.

    abstract：:Maple Syrup Urine Disease (MSUD) is biochemically characterized by elevated levels of leucine, isoleucine and valine, as well as their corresponding transaminated branched-chain α-keto acids in tissue and biological fluids. Neurological symptoms and cerebral abnormalities, whose mechanisms are still unknown, are typic...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0035-z

    authors： Taschetto L,Scaini G,Zapelini HG,Ramos ÂC,Strapazzon G,Andrade VM,Réus GZ,Michels M,Dal-Pizzol F,Quevedo J,Schuck PF,Ferreira GC,Streck EL

    更新日期：2017-10-01 00:00:00

  • Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice.

    abstract：:Antipsychotics, such as risperidone, increase food intake and induce alteration in glucose and lipid metabolism concomitantly with overweight and body fat increase, these biological abnormalities belong to the metabolic syndrome definition (high visceral adiposity, hypertriglyceridemia, hyperglycemia, low HDL-choleste...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0133-y

    authors： Auger F,Martin F,Pétrault O,Samaillie J,Hennebelle T,Trabelsi MS,Bailleul F,Staels B,Bordet R,Duriez P

    更新日期：2018-02-01 00:00:00

  • Novel mutations and clinical outcomes of copper-histidine therapy in Menkes disease patients.

    abstract：:Menkes disease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation. With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkes disease becomes of utmost importance for patients' prognosis. In the present study, the clinical characteristics of 12 Kore...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-014-9569-5

    authors： Kim JH,Lee BH,Kim YM,Choi JH,Kim GH,Cheon CK,Yoo HW

    更新日期：2015-02-01 00:00:00

  • Mutation spectrum of PAH gene in phenylketonuria patients in Northwest China: identification of twenty novel variants.

    abstract：:This study was performed to analyze the mutational spectrum of the phenylalanine hydroxylase (PAH) gene in phenylketonuria (PKU) patients in Northwest China, to identify mutational hot spots, and to determine the correlation between variants and clinical phenotypes of PKU. A large cohort of 475 PKU families in Northwe...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-019-0387-7

    authors： Yan Y,Zhang C,Jin X,Zhang Q,Zheng L,Feng X,Hao S,Gao H,Ma X

    更新日期：2019-06-01 00:00:00

  • Measurement of the expiratory ammonia concentration and its clinical significance.

    abstract：:Although gaseous ammonia (NH3) can freely enter cells through the plasma membrane where NH3 is cyto(neuro)toxic, NH3 and ionic ammonia (NH4+) contents have not been studied in biological materials. We developed a new method for measurement of expiratory NH3 concentration, which may reflect blood NH3 concentrations. Th...

    journal_title：Metabolic brain disease

    pub_type： 临床试验,杂志文章

    doi：

    authors： Wakabayashi H,Kuwabara Y,Murata H,Kobashi K,Watanabe A

    更新日期：1997-06-01 00:00:00

  • Lactate compartmentation in hippocampal slices: evidence for a transporter.

    abstract：:Lactic acid accumulation has been implicated in the evolution of brain damage after ischemia. Since compartmentation of lactate may play a role in acid-base balance, lactate release from gerbil hippocampal slices was examined during a number of metabolic stresses including elevated [K+]e, ischemia, anoxia, and aglycem...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/BF00999841

    authors： Assaf HM,Ricci AJ,Whittingham TS,LaManna JC,Ratcheson RA,Lust WD

    更新日期：1990-09-01 00:00:00

  • Attention dysfunction in cirrhotic patients: an inquiry on the role of executive control, attention orienting and focusing.

    abstract：:Attention alterations are reported in cirrhotics. Aiming at clarifying attention functioning in cirrhotics, an inquiry on the functioning of the anterior (AAS) and the posterior (PAS) attention system was performed. Thirty-six cirrhotics without overt hepatic encephalopathy (24 with EEG or TMT-A alterations) and 16 ma...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-005-4149-3

    authors： Amodio P,Schiff S,Del Piccolo F,Mapelli D,Gatta A,Umiltà C

    更新日期：2005-06-01 00:00:00

  • Elevation of Sestrin-2 expression attenuates Sevoflurane induced neurotoxicity.

    abstract：:Sevoflurane, one of the most commonly used volatile anesthetics in clinical treatment, has been shown to induce a widespread increase in brain apoptosis. However, the underlying mechanism is still unknown. Sestrin 2 has been recently shown to regulate intracellular reactive oxygen species (ROS) levels and play a cruci...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-015-9673-1

    authors： Yi W,Zhang Y,Guo Y,Li D,Li X

    更新日期：2015-10-01 00:00:00

  • Microglia.

    abstract：:Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,评审

    doi：10.1023/b:mebr.0000043984.73063.d8

    authors： van Rossum D,Hanisch UK

    更新日期：2004-12-01 00:00:00

  • Association of genetic variants of ABCA1 with susceptibility to dementia: (SADEM study).

    abstract：:Because of the importance of cholesterol metabolism in the physiopathogenesis of dementia, and knowing the function of ATP-binding cassette A1 transporter (ABCA1) as a cholesterol flow pump at the cellular and cerebral level, it has been noted that the ABCA1 gene may be a good candidate for disease study. In order to ...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-020-00577-4

    authors： Teresa JC,Fernado C,Nancy MR,Gilberto VA,Alberto CR,Roberto RR

    更新日期：2020-08-01 00:00:00

  • Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes.

    abstract：:Cyclic AMP is part of an endogenous mechanism that downregulates inflammatory response, and its intracellular concentration is regulated chiefly by cyclic nucleotide phosphodiesterases type 4. The goal of the present study was to determine whether phosphodiesterases 4 are involved in the inflammatory response of astro...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-009-9150-9

    authors： Borysiewicz E,Fil D,Dlaboga D,O'Donnell JM,Konat GW

    更新日期：2009-09-01 00:00:00

  • Ondansetron attenuates depression co-morbid with obesity in obese mice subjected to chronic unpredictable mild stress; an approach using behavioral battery tests.

    abstract：:The aim of the present work was to investigate the role of ondansetron on the high fat diet (HFD) induced obese mice for behavioral and biochemical alterations using chronic unpredictable mild stress (CUMS) model of depression. Animals were fed with high fat diet for 14 weeks and subjected to different stress procedur...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-014-9574-8

    authors： Kurhe Y,Radhakrishnan M,Gupta D

    更新日期：2014-09-01 00:00:00

  • Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction.

    abstract：:Sepsis is a major clinical challenge that is associated with encephalopathy and multi-organ dysfunction. Current therapeutic interventions are relatively ineffective and the development of novel treatments is hampered by the lack of a well-characterised animal model. Therefore, the behavioural, metabolic, physiologica...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-007-9058-1

    authors： Brooks HF,Osabutey CK,Moss RF,Andrews PL,Davies DC

    更新日期：2007-12-01 00:00:00

  • Effect of propentofylline on the biochemical lesion of the rat brain in aluminium-induced neurotoxicity.

    abstract：:Acute and chronic administration of Al-gluconate (12.7% Al) at the concentration of 1 mg/kg produces edema in the rat brain, as reflected by the increase in water and Na+ content. The permeability for Evans blue is also increased, which indicates the opening of the blood-brain barrier. Higher concentrations of the Al-...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/BF00996974

    authors： Stefanovich V,Joó F

    更新日期：1990-03-01 00:00:00

  • Non-invasive remote ischemic postconditioning stimulates neurogenesis during the recovery phase after cerebral ischemia.

    abstract：:Ischemic postconditioning (IPostC) has been reported to have neuroprotection against ischemic diseases, and one cycle of IPostC induces neurogenesis when treated nearby. To expanding these effects, we explored the effects of repetitively remote IPostC (NRIPostC) on neurogenesis in the subgranular zone (SGZ) and subent...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0068-3

    authors： Huang D,Liu H,Qu Y,Wang P

    更新日期：2017-12-01 00:00:00

  • Mevastatin promotes neuronal survival against Aβ-induced neurotoxicity through AMPK activation.

    abstract：:Statins or HMG-CoA reductase inhibitors have been shown to be effective at lowering cholesterol levels, and the application of these molecules has gradually emerged as an attractive therapeutic strategy for neurodegenerative diseases. Epidemiological studies suggest that statin use is associated with a decreased incid...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0091-4

    authors： Kornelius E,Li HH,Peng CH,Hsiao HW,Yang YS,Huang CN,Lin CL

    更新日期：2017-12-01 00:00:00

  • Regional metabolic status of the E-18 rat fetal brain following transient hypoxia/ischemia.

    abstract：:Increasing evidence indicates that fetal metabolic stress may result in a variety of post-natal perturbations during brain development. The goal of the study was to determine the duration of hypoxia/ischemia that would elicit a demonstrable regional depression of metabolism in the fetal brain and further to examine se...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-006-9031-4

    authors： Pundik S,Robinson S,Lust WD,Zechel J,Buczek M,Selman WR

    更新日期：2006-12-01 00:00:00

  • Hepatic encephalopathy influences high-affinity uptake of transmitter glutamate and aspartate into the hippocampal formation.

    abstract：:The present work was carried out to study the influence of ammonia and factors from sera and cerebrospinal fluid (CSF) from patients with different degrees of chronic liver diseases on [3H]D-aspartate (Asp) and [3H]L-glutamate (Glu) high-affinity uptake into the rat hippocampal formation. For comparison, high-affinity...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/BF00996975

    authors： Schmidt W,Wolf G,Grüngreiff K,Meier M,Reum T

    更新日期：1990-03-01 00:00:00

  • The neuroprotective effect of betanin in trimethyltin-induced neurodegeneration in mice.

    abstract：:Betanin, a natural food colorant with powerful antioxidative properties, has not been studied in terms of neurodegenerative disease intervention. Therefore, the present study aimed to investigate the neuroprotective effects of betanin against trimethyltin chloride (TMT) -induced neurodegeneration in mice. Forty male I...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-020-00615-1

    authors： Thong-Asa W,Prasartsri S,Klomkleaw N,Thongwan N

    更新日期：2020-12-01 00:00:00

  • The association of sleep-disordered breathing and white matter hyperintensities in heart failure patients.

    abstract：:Heart failure patients often manifest white matter hyperintensites on brain magnetic resonance imaging (MRI). White matter hyperintnsities have also been linked with cognitive problems in patients with heart failure. Sleep disordered breathing may contribute to structural brain changes in heart failure. The purpose of...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-018-0309-0

    authors： Moon C,Bendlin BB,Melah KE,Bratzke LC

    更新日期：2018-12-01 00:00:00

  • Protective effects of ascorbic acid and garlic extract against lead-induced apoptosis in developing rat hippocampus.

    abstract：:Lead exposure has negative effects on developing nervous system and induces apoptosis in newly generated neurons. Natural antioxidants (i.e. Ascorbic acid and Garlic) might protect against lead-induced neuronal cell damage. The aim of the present study was to investigate the protective effects of Ascorbic acid and Gar...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-016-9837-7

    authors： Ebrahimzadeh-Bideskan AR,Hami J,Alipour F,Haghir H,Fazel AR,Sadeghi A

    更新日期：2016-10-01 00:00:00

  • Biochemical model for inflammation of the brain: the effect of iron and transferrin on monocytes and lipid peroxidation.

    abstract：:Cerebral inflammation plays a role in diseases such as multiple sclerosis (MS), Alzheimer's disease (AD), and depression. Iron is involved in infection and inflammation through free radical production. Theoretically transferrin should prohibit iron from participating in oxidative reactions, but transferrin has also be...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1023/b:mebr.0000027421.33085.8b

    authors： van Rensburg SJ,van Zyl J,Hon D,Daniels W,Hendricks J,Potocnik F,Erasmus R

    更新日期：2004-06-01 00:00:00

  • Effect of alcohol on energy storage of primary astrocytes and C6-glioma cells in vitro.

    abstract：:The present experiments were conducted to investigate the direct effects of ethanol on the energy metabolism of astrocytes and C6-glioma cells. Primary astrocytes were prepared from cerebral cortices of neonatal rats, and C6-glioma cells were purchased from American Type Culture Collection (ATCC). These cells were exp...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1023/a:1020606607729

    authors： Haghighat N,McCandless DW,Geraminejad P

    更新日期：1999-09-01 00:00:00

  • Predominant gray matter volume loss in patients with end-stage renal disease: a voxel-based morphometry study.

    abstract：:To investigate the pattern of brain volume changes in patients with end-stage renal disease (ESRD) using voxel-based morphometry (VBM) and correlation with clinical and neuropsychological (NP) tests. Fifty seven ESRD patients with no anatomical abnormalities in conventional magnetic resonance imaging [24 patients with...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-013-9438-7

    authors： Zhang LJ,Wen J,Ni L,Zhong J,Liang X,Zheng G,Lu GM

    更新日期：2013-12-01 00:00:00

  • Neuroprotective efficiency of Mangifera indica leaves extract on cadmium-induced cortical damage in rats.

    abstract：:Due to the high ability of cadmium to cross the blood-brain barrier, cadmium (Cd) causes severe neurological damages. Hence, the purpose of this study was to investigate the possible protective effect of Mangifera indica leaf extract (MLE) against Cd-induced neurotoxicity. Rats were divided into eight groups. Group 1 ...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-018-0222-6

    authors： Al Omairi NE,Radwan OK,Alzahrani YA,Kassab RB

    更新日期：2018-08-01 00:00:00

  • Promising outcomes in glutaric aciduria type I patients detected by newborn screening.

    abstract：:Glutaric aciduria type I (GA-I) is an inborn error of lysine and tryptophan metabolism. Clinical manifestations of GA-I include dystonic or dyskinetic cerebral palsy, but when the symptoms occur, treatment is not effective. In Taiwan, newborn screening for GA-I started in 2001; we wish to evaluate the outcomes of pati...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-012-9349-z

    authors： Lee CS,Chien YH,Peng SF,Cheng PW,Chang LM,Huang AC,Hwu WL,Lee NC

    更新日期：2013-03-01 00:00:00

  • SB203580 reverses memory deficits and depression-like behavior induced by microinjection of Aβ1-42 into hippocampus of mice.

    abstract：:A high co-morbidity between Alzheimer's disease (AD) and depression suggests there might be similar mechanisms underlying the course of these diseases. Previous studies have shown that p38MAPK plays a critical role in the pathophysiology of AD and depression. However, little is known about whether SB203580, a selectiv...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-016-9880-4

    authors： Guo J,Chang L,Li C,Li M,Yan P,Guo Z,Wang C,Zha Q,Wang Q

    更新日期：2017-02-01 00:00:00

  • Fish oil, melatonin and vitamin E attenuates midbrain cyclooxygenase-2 activity and oxidative stress after the administration of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine.

    abstract：:Parkinson's disease is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. Ciclooxygenase-2 activity induction and oxidative stress have been implicated in the aetiology of Parkinson's disease and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-013-9416-0

    authors： Ortiz GG,Pacheco-Moisés FP,Gómez-Rodríguez VM,González-Renovato ED,Torres-Sánchez ED,Ramírez-Anguiano AC

    更新日期：2013-12-01 00:00:00

  • Psychopharmacology of maternal separation anxiety in vervet monkeys.

    abstract：:Maternal separation in non-human primates has been proposed as a model of early adversity. The symptoms of separation anxiety were studied in vervet monkeys, during the weaning period, when psychotropic medications were administered. The control group received a normal diet and treatment groups received citalopram, re...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-006-9011-8

    authors： Marais L,Daniels W,Brand L,Viljoen F,Hugo C,Stein DJ

    更新日期：2006-09-01 00:00:00

  • Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy.

    abstract：:Patients with chronic liver disease manifest a high incidence (> 75%) of pallidal signal hyperintensity on T1-weighted Magnetic Resonance Imaging (MRI), the intensity of which correlates with blood manganese levels and the presence of extrapyramidal symptoms. A major cause of pallidal hyperintensity on T1-weighted MRI...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,评审

    doi：10.1007/BF02109357

    authors： Butterworth RF,Spahr L,Fontaine S,Layrargues GP

    更新日期：1995-12-01 00:00:00