Abstract:
:Antipsychotics, such as risperidone, increase food intake and induce alteration in glucose and lipid metabolism concomitantly with overweight and body fat increase, these biological abnormalities belong to the metabolic syndrome definition (high visceral adiposity, hypertriglyceridemia, hyperglycemia, low HDL-cholesterol and high blood pressure). Curcumin is a major component of traditional turmeric (Curcuma longa) which has been reported to improve lipid and glucose metabolism and to decrease weight in obese mice. We questioned the potential capacity of curcumin, contained in Curcuma longa extract (Biocurcuma™), to attenuate the risperidone-induced metabolic dysfunction. Two groups of mice were treated once a week, for 22 weeks, with intraperitoneal injection of risperidone (Risperdal) at a dose 12.5 mpk. Two other groups received intraperitoneal injection of the vehicle of Risperdal following the same schedule. Mice of one risperidone-treated groups and of one of vehicle-treated groups were fed a diet with 0.05% Biocurcuma™ (curcumin), while mice of the two other groups received the standard diet. Curcumin limited the capacity of risperidone to reduce spontaneous motricity, but failed to impede risperidone-induced increase in food intake. Curcumin did not reduce the capacity of risperidone to induce weight gain, but decreased visceral adiposity and decreased the risperidone-induced hepatomegaly, but not steatosis. Furthermore, curcumin repressed the capacity of risperidone to induce the hepatic over expression of enzymes involved in lipid metabolism (LXRα, FAS, ACC1, LPL, PPARγ, ACO, SREBP2) and decreased risperidone-induced glucose intolerance and hypertriglyceridemia. Curcumin decreased risperidone-induced increases in serum markers of hepatotoxicity (ALAT, ASAT), as well as of one major hepatic pro-inflammatory transcription factor (NFκB: p105 mRNA and p65 protein). These findings support that nutritional doses of curcumin contained in Curcuma longa extract are able to partially counteract the risperidone-induced metabolic dysfunction in mice, suggesting that curcumin ought to be tested to reduce the capacity of risperidone to induce the metabolic syndrome in human.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Auger F,Martin F,Pétrault O,Samaillie J,Hennebelle T,Trabelsi MS,Bailleul F,Staels B,Bordet R,Duriez Pdoi
10.1007/s11011-017-0133-ysubject
Has Abstractpub_date
2018-02-01 00:00:00pages
63-77issue
1eissn
0885-7490issn
1573-7365pii
10.1007/s11011-017-0133-yjournal_volume
33pub_type
杂志文章abstract::Statins or HMG-CoA reductase inhibitors have been shown to be effective at lowering cholesterol levels, and the application of these molecules has gradually emerged as an attractive therapeutic strategy for neurodegenerative diseases. Epidemiological studies suggest that statin use is associated with a decreased incid...
journal_title:Metabolic brain disease
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abstract::Adult-onset type II citrullinemia (CTLN2), characterized by a liver-specific deficiency of urea cycle enzyme, argininosuccinate synthetase, is caused by mutations in SLC25A13 that encodes a calcium binding mitochondrial solute carrier protein, citrin. Citrin deficiency causes not only CTLN2 but also neonatal intrahepa...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1023/a:1021961919148
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journal_title:Metabolic brain disease
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doi:10.1007/s11011-018-0215-5
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abstract::It has been suggested that alterations of GABAergic neurotransmission are implicated in the pathophysiology of hepatic encephalopathy (HE). Increased concentrations of endogenous benzodiazepines with positive allosteric modulatory properties at the GABA-A receptor complex were proposed as a pathophysiological mechanis...
journal_title:Metabolic brain disease
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doi:10.1023/b:mebr.0000043974.89820.22
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1023/a:1020733024934
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journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-018-0239-x
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-007-9058-1
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9893-z
更新日期:2017-02-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9838-6
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abstract::Isolated Methylmalonic acidemia/aciduria (MMA) is a group of inborn errors of metabolism disease which is caused by defect in methylmalonyl-CoA mutase (MCM) enzyme. The enzyme has a key function in the catabolism of branched chain amino acids (BCAA, isoleucine, and valine), methionine, and threonine. MCM is encoded by...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-018-0277-4
更新日期:2018-10-01 00:00:00
abstract::The permeability of the blood-brain barrier to glutamate was measured by quantitative autoradiography in brains of 7-day-old rats (average plasma glutamate 114 microM) and rats injected subcutaneously with glutamate (average plasma glutamate 2,670 microM). Measurements of glutamate permeability were initiated by the i...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:
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abstract::Transient bilateral common carotid artery occlusion (tBCCAO), followed by reperfusion, is a model of transient global hypoperfusion. In the present study we aimed to investigate the probable effects of Vanillic acid (VA) on some physiological parameters including cerebral hyperemia, blood-brain barrier (BBB) disruptio...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-018-0187-5
更新日期:2018-06-01 00:00:00
abstract::D-glycerate 2 kinase (DGK) is an enzyme that mediates the conversion of D-glycerate, an intermediate metabolite of serine and fructose metabolism, to 2-phosphoglycerate. Deficiency of DGK leads to accumulation of D-glycerate in various tissues and its massive excretion in urine. D-glyceric aciduria (DGA) is an autosom...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-019-0384-x
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-014-9550-3
更新日期:2015-04-01 00:00:00
abstract::Mobile phone providers use electromagnetic radiation (EMR) with frequencies ranging from 900 to 1800 MHz. The increasing use of mobile phones has been accompanied by several potentially pathological consequences, such as neurological diseases related to hippocampal (HIPPON) and dorsal root ganglion neuron (DRGN). The ...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0180-4
更新日期:2018-06-01 00:00:00
abstract::Several epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia. Besides, some authors suggested that poor glucose control to be associated with worse cognitive function. We aimed to assess cognitive functions and IR-degree over time in diabetic. We also...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-9977-4
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abstract::Maple Syrup Urine Disease (MSUD) is biochemically characterized by elevated levels of leucine, isoleucine and valine, as well as their corresponding transaminated branched-chain α-keto acids in tissue and biological fluids. Neurological symptoms and cerebral abnormalities, whose mechanisms are still unknown, are typic...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0035-z
更新日期:2017-10-01 00:00:00
abstract::Near infrared radiation (NIR) is known to penetrate and affect biological systems in multiple ways. Recently, a series of experimental studies suggested that low intensity NIR may protect neuronal cells against a wide range of insults that mimic diseases such as stroke, brain trauma and neurodegeneration. However, the...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-014-9515-6
更新日期:2015-04-01 00:00:00
abstract::To investigate the hypothesis that neurotoxic metals can exert their toxicity through the direct inhibition of monoamine oxidases (MAOs), the effects of several neurotoxic metal ions on type A (MAO-A) and type B (MAO-B) monoamine oxidase activities in rat forebrain nonsynaptic mitochondria and rat liver mitochondria w...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF01000159
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abstract::Chronic ethanol ingestion results in an "up-regulation" of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in mouse brain. This increase in receptors is associated with ethanol withdrawal seizures, which can be attenuated by NMDA receptor antagonists. Chronic exposure to ethanol (3 days) of rat cerebella...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF01991784
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journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-013-9457-4
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abstract::Hepatic encephalopathy is a common complication of hepatic cirrhosis. The clinical diagnosis is based on two concurrent types of symptoms: impaired mental status and impaired neuromotor function. Impaired mental status is characterized by deterioration in mental status with psychomotor dysfunction, impaired memory, an...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-013-9376-4
更新日期:2013-06-01 00:00:00
abstract::We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyr...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0107-0
更新日期:2018-02-01 00:00:00
abstract::Thiamine triphosphate (ThTP) was discovered over 60 years ago and it was long thought to be a specifically neuroactive compound. Its presence in most cell types, from bacteria to mammals, would suggest a more general role but this remains undefined. In contrast to thiamine diphosphate (ThDP), ThTP is not a coenzyme. I...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
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abstract::Increasing evidence indicates that excessive drug consumption is sufficient for the transition from recreational and controlled drug use to uncontrolled use and addiction. However, the underlying mechanisms are debated. Some neurobehavioral and neuroimaging evidence indicates that dorsolateral striatum (dlStr)-depende...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-019-00430-3
更新日期:2019-08-01 00:00:00
abstract::The role of oxidative stress in the pathogenesis of phenylketonuria (PKU)-associated disorders has been implicated. Ischemia modified albumin (IMA) is a modified form of serum albumin, which is produced under the conditions of oxidative stress. The aim of this study was to measure the serum level of IMA in the PKU pat...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0165-3
更新日期:2018-06-01 00:00:00
abstract::This study was performed to analyze the mutational spectrum of the phenylalanine hydroxylase (PAH) gene in phenylketonuria (PKU) patients in Northwest China, to identify mutational hot spots, and to determine the correlation between variants and clinical phenotypes of PKU. A large cohort of 475 PKU families in Northwe...
journal_title:Metabolic brain disease
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doi:10.1007/s11011-019-0387-7
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abstract::Overwhelming evidence suggests that microglia play an important role in ischemic injury and they polarize into two different phenotypes with distinct functions after ischemic stroke. We performed the present study to investigate whether L-3-n butylphthalide (NBP) has an effect on microglial polarization. Mice were sub...
journal_title:Metabolic brain disease
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doi:10.1007/s11011-018-0307-2
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abstract::Although the key contributors of altering neurological function in hepatic encephalopathy are relatively well known, the electrophysiological mechanism of CA1 damage, a key vulnerable area during hyperammonemia, have not yet been defined. Therefore, here we focus on the electrophysiological mechanisms of cognitive imp...
journal_title:Metabolic brain disease
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