Characterization of the CA1 pyramidal neurons in rat model of hepatic cirrhosis: insights into their electrophysiological properties.

abstract：:The commonly used volatile anesthetic sevoflurane has been shown to induce widespread apoptosis in the developing brain, yet the underlying molecular mechanisms are not fully understood. Accumulating research has demonstrated that long noncoding RNAs (lncRNAs) regulate multiple biological processes, including neural d...

journal_title：Metabolic brain disease

authors： Chen X,Zhou X,Lu D,Yang X,Zhou Z,Chen X,Chen Y,He W,Feng X

更新日期：2016-10-01 00:00:00

abstract：:Prenatal stress has been associated with increased vulnerability to psychiatric disturbances including schizophrenia, depression, attention-deficit hyperactivity disorder and autism. Elevated maternal circulating stress hormones alter development of neural circuits in the fetal brain and cause long-term changes in beh...

journal_title：Metabolic brain disease

authors： Mabandla MV,Kellaway LA,Daniels WM,Russell VA

更新日期：2009-12-01 00:00:00

abstract：UNLABELLED:Some subjects with multiple sclerosis (MS) present with low blood iron parameters. Anecdotal reports and a single patient study suggest that iron supplementation may be beneficial in these subjects. Myelin is regenerated continually, but prerequisites for this process are iron and a functional folate-vitamin...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,Kotze MJ,Hon D,Haug P,Kuyler J,Hendricks M,Botha J,Potocnik FC,Matsha T,Erasmus RT

更新日期：2006-09-01 00:00:00

abstract：:Patients with chronic liver disease manifest a high incidence (> 75%) of pallidal signal hyperintensity on T1-weighted Magnetic Resonance Imaging (MRI), the intensity of which correlates with blood manganese levels and the presence of extrapyramidal symptoms. A major cause of pallidal hyperintensity on T1-weighted MRI...

journal_title：Metabolic brain disease

authors： Butterworth RF,Spahr L,Fontaine S,Layrargues GP

更新日期：1995-12-01 00:00:00

abstract：:The experimental model of central pontine myelinolysis--chronic (4-day) hyponatremia induced by daily injections of hypotonic dextrose solutions and vasopressin followed by rapid correction with saline--was used in young fasted and thirsted mice. In normal controls chronic fasting and thirsting lowered plasma and brai...

journal_title：Metabolic brain disease

authors： Thurston JH,Hauhart RE,Nelson JS

更新日期：1987-12-01 00:00:00

abstract：:Despite the existence of many preclinical studies, scientific evidence is lacking on the clinical use of alpha-lipoic acid (ALA) for central nervous system disorders. Therefore, we aimed at revising the literature concerning the use of ALA for the treatment of psychiatric and neurological conditions and to point out w...

journal_title：Metabolic brain disease

authors： de Sousa CNS,da Silva Leite CMG,da Silva Medeiros I,Vasconcelos LC,Cabral LM,Patrocínio CFV,Patrocínio MLV,Mouaffak F,Kebir O,Macedo D,Patrocínio MCA,Vasconcelos SMM

更新日期：2019-02-01 00:00:00

abstract：:To investigate the short-term brain activity changes in cirrhotic patients with Liver transplantation (LT) using resting-state functional MRI (fMRI) with regional homogeneity (ReHo) method. Twenty-six cirrhotic patients as transplant candidates and 26 healthy controls were included in this study. The assessment was re...

journal_title：Metabolic brain disease

authors： Cheng Y,Huang L,Zhang X,Zhong J,Ji Q,Xie S,Chen L,Zuo P,Zhang LJ,Shen W

更新日期：2015-08-01 00:00:00

abstract：:Minimal hepatic encephalopathy (MHE) is the earliest form of hepatic encephalopathy (HE) and affects up to 80 % of patients with liver cirrhosis. By definition, MHE is characterized by psychomotor slowing and subtle cognitive deficits,  but obvious clinical manifestations are lacking. Given its covert nature, MHE is o...

journal_title：Metabolic brain disease

authors： Nardone R,De Blasi P,Höller Y,Brigo F,Golaszewski S,Frey VN,Orioli A,Trinka E

更新日期：2016-10-01 00:00:00

abstract：:Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain a...

journal_title：Metabolic brain disease

authors： Chatauret N,Rose C,Butterworth RF

更新日期：2002-12-01 00:00:00

abstract：:While risk factors for konzo are known, determinants of cognitive impairment in konzo-affected children remain unknown. We anchored cognitive performance (KABC-II scores) to serum levels of free-thyroxine (free-T4), thyroid-stimulating hormone (TSH), albumin, and motor proficiency (BOT-2 scores) in 40 children includi...

journal_title：Metabolic brain disease

authors： Bumoko GM,Sombo MT,Okitundu LD,Mumba DN,Kazadi KT,Tamfum-Muyembe JJ,Lasarev MR,Boivin MJ,Banea JP,Tshala-Katumbay DD

更新日期：2014-06-01 00:00:00

abstract：:Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in...

journal_title：Metabolic brain disease

authors： Fiacco F,Barbato L,Pecoraro MG,Maggio P

更新日期：2017-02-01 00:00:00

abstract：:The lifetime prevalence rate for major depressive disorder (MDD) is approximately 17 % for most developed countries around the world. Dietary polyphenols are currently used as an adjuvant therapy to accelerate the therapeutic efficacy on depression. Ferulic acid (FA) or 4-hydroxy-3-methoxy-cinnamic acid (Fig. 1a) is a...

journal_title：Metabolic brain disease

authors： Li G,Ruan L,Chen R,Wang R,Xie X,Zhang M,Chen L,Yan Q,Reed M,Chen J,Xu Y,Pan J,Huang W

更新日期：2015-12-01 00:00:00

abstract：:The aim of the present work was to investigate the role of ondansetron on the high fat diet (HFD) induced obese mice for behavioral and biochemical alterations using chronic unpredictable mild stress (CUMS) model of depression. Animals were fed with high fat diet for 14 weeks and subjected to different stress procedur...

journal_title：Metabolic brain disease

authors： Kurhe Y,Radhakrishnan M,Gupta D

更新日期：2014-09-01 00:00:00

abstract：:Artificial sweeteners are mainly used as substitutes for sucrose derivates. In this study, we analyzed if the chronic consumption of aspartame or acesulfame potassium at an early age, produces histological alterations, astrogliosis and decreased neuronal viability, in hippocampus, prefrontal cortex, amygdala and hypot...

journal_title：Metabolic brain disease

authors： Solis-Medina A,Martínez-Magaña JJ,Quintanar-Jurado V,Gallegos-Silva I,Juárez-Rojop IE,Tovilla-Zárate CA,Díaz-Zagoya JC,Hernández-Díaz Y,González-Castro TB,López-Narváez ML,Genis-Mendoza AD,Nicolini H

更新日期：2018-12-01 00:00:00

abstract：:Relation between soya bean (SB) consumption and aggressive behavior has not been elucidated yet. Thus, this study was conducted to investigate the effect of large amount of SB consumption on adult male rats' aggressive behavior through investigating changes in the expression of gonadotropin-inhibitory hormone/ RF amid...

journal_title：Metabolic brain disease

authors： Abdel-Aleem GA,Shafik NM,El-Magd MA,Mohamed DA

更新日期：2019-08-01 00:00:00

abstract：:Hereditary tyrosinemia type I (HT1) is caused by mutations in the fumarylacetoacetate hydrolase (FAH) gene, the template for the final enzyme in the tyrosine catabolism pathway. If left untreated this deficiency of functional FAH leads to a buildup of toxic metabolites that can cause liver disease, kidney dysfunction ...

journal_title：Metabolic brain disease

authors： Moore ME,Koenig AE,Hillgartner MA,Otap CC,Barnby E,MacGregor GG

更新日期：2017-12-01 00:00:00

abstract：:Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism ...

journal_title：Metabolic brain disease

authors： Yan X,Lukas J,Witt M,Wree A,Hübner R,Frech M,Köhling R,Rolfs A,Luo J

更新日期：2011-12-01 00:00:00

abstract：:The impaired insulin signaling has been recognized as a common pathogenetic mechanism between diabetes and Alzheimer's disease (AD). In the progression of AD, brain is characterized by defective insulin receptor substrate-1 (IRS-1) and increased oxidative stress. Thymol, a monoterpene phenol isolated from medicinal he...

journal_title：Metabolic brain disease

authors： FangFang,Li H,Qin T,Li M,Ma S

更新日期：2017-04-01 00:00:00

abstract：:There is abundant evidence showing that repeated use of MDMA (3, 4-Methylenedioxymethamphetamine, ecstasy) has been associated with depression, anxiety and deficits in learning and memory, suggesting detrimental effects on hippocampus. Adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the...

journal_title：Metabolic brain disease

authors： Kermanian F,Mehdizadeh M,Soleimani M,Ebrahimzadeh Bideskan AR,Asadi-Shekaari M,Kheradmand H,Haghir H

更新日期：2012-12-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a variety of symptoms of different severity such as cognitive deficits and impaired motor functions. Currently, HE is seen as a consequence of a low grade cerebral oedema assoc...

journal_title：Metabolic brain disease

authors： Baker L,Lanz B,Andreola F,Ampuero J,Wijeyesekera A,Holmes E,Deutz N

更新日期：2016-12-01 00:00:00

abstract：:Oxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention. Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory ha...

journal_title：Metabolic brain disease

authors： Singh V,Krishan P,Shri R

更新日期：2018-08-01 00:00:00

abstract：:There is evidence to suggest that, in acute liver failure (ALF), brain ammonia and proinflammatory cytokines may act synergistically to cause brain edema and its complications (intracranial hypertension, brain herniation). However, the molecular mechanisms involved remain to be established. In order to address this is...

journal_title：Metabolic brain disease

authors： Chastre A,Jiang W,Desjardins P,Butterworth RF

更新日期：2010-03-01 00:00:00

abstract：:The present work was carried out to study the influence of ammonia and factors from sera and cerebrospinal fluid (CSF) from patients with different degrees of chronic liver diseases on [3H]D-aspartate (Asp) and [3H]L-glutamate (Glu) high-affinity uptake into the rat hippocampal formation. For comparison, high-affinity...

journal_title：Metabolic brain disease

authors： Schmidt W,Wolf G,Grüngreiff K,Meier M,Reum T

更新日期：1990-03-01 00:00:00

abstract：:Increasing evidence indicates that excessive drug consumption is sufficient for the transition from recreational and controlled drug use to uncontrolled use and addiction. However, the underlying mechanisms are debated. Some neurobehavioral and neuroimaging evidence indicates that dorsolateral striatum (dlStr)-depende...

journal_title：Metabolic brain disease

authors： Shi JJ,Cao DN,Liu HF,Wang ZY,Lu GY,Wu N,Zhou WH,Li J

更新日期：2019-08-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairment, attention deficits and motor dysfunction which eventually c...

journal_title：Metabolic brain disease

authors： Bémeur C,Cudalbu C,Dam G,Thrane AS,Cooper AJ,Rose CF

更新日期：2016-12-01 00:00:00

abstract：:Sleep disturbances are prevalent among patients with Alzheimer's disease (AD) and often precede the onset and progression of dementia. However, there are no reliable animal models for investigating sleep disturbances in patients with sporadic AD (sAD), which accounts for more than 90% of all AD cases. In the present s...

journal_title：Metabolic brain disease

authors： Song JZ,Cui SY,Cui XY,Hu X,Ma YN,Ding H,Ye H,Zhang YH

更新日期：2018-02-01 00:00:00

abstract：:We report treatment outcome of eleven patients with pyridoxine-dependent epilepsy caused by pathogenic variants in ALDH7A1 (PDE-ALDH7A1). We developed a clinical severity score to compare phenotype with biochemical features, genotype and delays in the initiation of pyridoxine. Clinical severity score included 1) globa...

journal_title：Metabolic brain disease

authors： Al Teneiji A,Bruun TU,Cordeiro D,Patel J,Inbar-Feigenberg M,Weiss S,Struys E,Mercimek-Mahmutoglu S

更新日期：2017-04-01 00:00:00

abstract：:At the present time alcoholism is recognized as a metabolic disease exhibiting the clinical features of craving for alcohol, loss of control over drinking, tolerance and physical dependence on alcohol, while both epidemiological and experimental studies have demonstrated that genetic factors may be important in determ...

journal_title：Metabolic brain disease

authors： Gianoulakis C,de Waele JP

更新日期：1994-06-01 00:00:00

abstract：:Menkes disease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation. With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkes disease becomes of utmost importance for patients' prognosis. In the present study, the clinical characteristics of 12 Kore...

journal_title：Metabolic brain disease

authors： Kim JH,Lee BH,Kim YM,Choi JH,Kim GH,Cheon CK,Yoo HW

更新日期：2015-02-01 00:00:00

abstract：:Overwhelming evidence suggests that microglia play an important role in ischemic injury and they polarize into two different phenotypes with distinct functions after ischemic stroke. We performed the present study to investigate whether L-3-n butylphthalide (NBP) has an effect on microglial polarization. Mice were sub...

journal_title：Metabolic brain disease

authors： Li F,Ma Q,Zhao H,Wang R,Tao Z,Fan Z,Zhang S,Li G,Luo Y

更新日期：2018-12-01 00:00:00