Dysfunction of GABAergic neurons in the parafacial zone mediates sleep disturbances in a streptozotocin-induced rat model of sporadic Alzheimer's disease.

abstract：:Betanin, a natural food colorant with powerful antioxidative properties, has not been studied in terms of neurodegenerative disease intervention. Therefore, the present study aimed to investigate the neuroprotective effects of betanin against trimethyltin chloride (TMT) -induced neurodegeneration in mice. Forty male I...

journal_title：Metabolic brain disease

authors： Thong-Asa W,Prasartsri S,Klomkleaw N,Thongwan N

更新日期：2020-12-01 00:00:00

abstract：:The effect of factors released from N2A neuroblastoma cells on the expression of myelin protein genes in glioma C6 cells, i.e., proteolipid protein (PLP) and myelin-associated glycoprotein (MAG), was studied. Both cells lines were propagated in serum-free DMEM-F10 (1:1) medium. The addition of 50% N2A conditioned medi...

journal_title：Metabolic brain disease

authors： Kanoh M,Wiggins RC,Konat G

更新日期：1992-09-01 00:00:00

abstract：:The selective vulnerability of pyramidal neurons in the CA1 hippocampal region in ischemic rat brain may be preceded by regional alterations of energy metabolism during early reperfusion. We measured ATP, phosphocreatine (PCr), and glucose in paramedian and lateral CA1 and in an area showing little postischemic cell l...

journal_title：Metabolic brain disease

authors： Pettigrew LC,Grotta JC,Rhoades HM,Reid C,McCandless DW

更新日期：1988-09-01 00:00:00

abstract：:3-Nitropropionic acid (3-NPA) is a toxin sometimes produced on moldy crops (sugarcane, peanuts, etc.) in amounts sufficient to cause severe neurological disorders when consumed by humans. In vitro, 3-NPA irreversibly inactivates SDH, a Complex II respiratory enzyme required for mitochondrial energy production. A singl...

journal_title：Metabolic brain disease

authors： Nony PA,Scallet AC,Rountree RL,Ye X,Binienda Z

更新日期：1999-06-01 00:00:00

abstract：:We investigated the biochemical alterations of the striatum of mice subjected to seven experimental schedules with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) treatment. The mice were treated intraperitoneally (i.p.) with MPTP (20 mg/kg in saline) four times a day at 2-hr intervals showed severe ...

journal_title：Metabolic brain disease

authors： Kuroiwa H,Yokoyama H,Kimoto H,Kato H,Araki T

更新日期：2010-06-01 00:00:00

abstract：:Minimal hepatic encephalopathy (MHE) is the earliest form of hepatic encephalopathy (HE) and affects up to 80 % of patients with liver cirrhosis. By definition, MHE is characterized by psychomotor slowing and subtle cognitive deficits,  but obvious clinical manifestations are lacking. Given its covert nature, MHE is o...

journal_title：Metabolic brain disease

authors： Nardone R,De Blasi P,Höller Y,Brigo F,Golaszewski S,Frey VN,Orioli A,Trinka E

更新日期：2016-10-01 00:00:00

abstract：:Severe neurological symptoms, cerebral edema, and atrophy are common features of the inherited metabolic disorder propionic acidemia. However, the pathomechanisms involved in the neuropathology of this disease are not well established. In this study, we investigate the effects of propionic acid (PA), a metabolite accu...

journal_title：Metabolic brain disease

authors： de Almeida LM,Funchal C,Gottfried C,Wajner M,Pessoa-Pureur R

更新日期：2006-03-01 00:00:00

abstract：:We have described the occurrence in freely moving gerbils of slow potential changes (SPC) in two different models of experimental epilepsy: 1) maximal electroshock and 2) bilateral epileptic foci induced by penicillin. SPC is considered a by-product of epileptiform activity in both models and correlates to the SPC whi...

journal_title：Metabolic brain disease

authors： de Azeredo FA,Perret ML

更新日期：1992-06-01 00:00:00

abstract：:Sepsis is a major clinical challenge that is associated with encephalopathy and multi-organ dysfunction. Current therapeutic interventions are relatively ineffective and the development of novel treatments is hampered by the lack of a well-characterised animal model. Therefore, the behavioural, metabolic, physiologica...

journal_title：Metabolic brain disease

authors： Brooks HF,Osabutey CK,Moss RF,Andrews PL,Davies DC

更新日期：2007-12-01 00:00:00

abstract：:The integrity of the blood-brain barrier (BBB) is an important aspect of normal central nervous system (CNS) function. Recently, it was shown that the BBB breakdown is one of the predisposing factors in the pathogenesis of thiamine-deficiency encephalopathy. The result is discussed along with some reviews on previous ...

journal_title：Metabolic brain disease

authors： Harata N,Iwasaki Y

更新日期：1996-03-01 00:00:00

abstract：:In this work, we evaluated the effects of Psidium cattleianum (Red Type) (PcRT) fruit extract on metabolic, behavioral, and neurochemical parameters in rats fed with a highly palatable diet (HPD) consisted of sucrose (65% carbohydrates being 34% from condensed milk, 8% from sucrose and 23% from starch, 25% protein and...

journal_title：Metabolic brain disease

authors： Oliveira PS,Chaves VC,Soares MSP,Bona NP,Mendonça LT,Carvalho FB,Gutierres JM,Vasconcellos FA,Vizzotto M,Vieira A,Spanevello RM,Reginatto FH,Lencina CL,Stefanello FM

更新日期：2018-10-01 00:00:00

abstract：:Neuroinflammation has been recognized as a major contributor to brain injury caused by intracerebral hemorrhage (ICH). Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome acts as an important mediator of inflammatory response in various inflammation-related dis...

journal_title：Metabolic brain disease

authors： Cheng Y,Wei Y,Yang W,Song Y,Shang H,Cai Y,Wu Z,Zhao W

更新日期：2017-08-01 00:00:00

abstract：:As feared and deadly human diseases globally, Rabies virus contrived mechanisms to escape early immune recognition via suppression of the interferon response. This study, preliminarily investigated whether Rabies virus employs epigenetic mechanism for the suppression of the interferon using the Challenge virus standar...

journal_title：Metabolic brain disease

authors： Abdulazeez M,Kia GSN,Abarshi MM,Muhammad A,Ojedapo CE,Atawodi JC,Dantong D,Kwaga JKP

更新日期：2020-06-01 00:00:00

abstract：:Traumatic brain injury (TBI) is accompanied with enhanced matrix metalloproteinase-9 (MMP-9) activity and elevated levels of plasma fibrinogen (Fg), which is a known inflammatory agent. Activation of MMP-9 and increase in blood content of Fg (i.e. hyperfibrinogenemia, HFg) both contribute to cerebrovascular disorders ...

journal_title：Metabolic brain disease

authors： Muradashvili N,Benton RL,Saatman KE,Tyagi SC,Lominadze D

更新日期：2015-04-01 00:00:00

abstract：:In the normal adult brain, glucose provides 90% of the energy requirements as well as substrate for nucleic acid and lipid synthesis. In the present study, effects of ethanol on glucose transporters (GLUT) and glucose utilization were examined in rat brain. Male Sprague-Dawley rats weighing 250-300 gms were given eith...

journal_title：Metabolic brain disease

authors： Handa RK,DeJoseph MR,Singh LD,Hawkins RA,Singh SP

更新日期：2000-09-01 00:00:00

abstract：:We report treatment outcome of eleven patients with pyridoxine-dependent epilepsy caused by pathogenic variants in ALDH7A1 (PDE-ALDH7A1). We developed a clinical severity score to compare phenotype with biochemical features, genotype and delays in the initiation of pyridoxine. Clinical severity score included 1) globa...

journal_title：Metabolic brain disease

authors： Al Teneiji A,Bruun TU,Cordeiro D,Patel J,Inbar-Feigenberg M,Weiss S,Struys E,Mercimek-Mahmutoglu S

更新日期：2017-04-01 00:00:00

abstract：UNLABELLED:Some subjects with multiple sclerosis (MS) present with low blood iron parameters. Anecdotal reports and a single patient study suggest that iron supplementation may be beneficial in these subjects. Myelin is regenerated continually, but prerequisites for this process are iron and a functional folate-vitamin...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,Kotze MJ,Hon D,Haug P,Kuyler J,Hendricks M,Botha J,Potocnik FC,Matsha T,Erasmus RT

更新日期：2006-09-01 00:00:00

abstract：:A rat model of glucose-precipitated Wernicke's encephalopathy (WE) has been developed in which glucose loading (10 g/kg, i.p.) of ataxic thiamin-deficient (TD) rats induced episodes of gross neurological dysfunction and sometimes death. The acute effects of a glucose load on the neurological state of thiamin-replete c...

journal_title：Metabolic brain disease

authors： Zimitat C,Nixon PF

更新日期：1999-03-01 00:00:00

abstract：:The free radical scavenging abilities of the structurally related steroids beta-sitosterol, beta-sitosterol glucoside (plant sterols and sterolins), cholesterol, and dehydroepiandrosterone sulphate (DHEAS) were compared with melatonin (an efficient free radical scavenger) in an in vitro system which measures lipid per...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,Daniels WM,van Zyl JM,Taljaard JJ

更新日期：2000-12-01 00:00:00

abstract：:Calotropis procera (CP; Apocynaceae) is reported to have several neuroprotective activities however it's anti-depressant activity yet to be established. Therefore, the present study was proposed to evaluate the anti-depressant activity of the standardized ethanolic extract of CP (ECP) in chronic unpredictable mild str...

journal_title：Metabolic brain disease

authors： Garabadu D,Srivastava N,Murti Y

更新日期：2019-12-01 00:00:00

abstract：:This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (...

journal_title：Metabolic brain disease

authors： Asiaei F,Fazel A,Rajabzadeh AA,Hosseini M,Beheshti F,Seghatoleslam M

更新日期：2017-10-01 00:00:00

abstract：:We aimed to evaluate the effect of in vitro galactosaemia on acetylcholinesterase (AChE) activity in different suckling rat brain regions. Various concentrations of galactose (Gal), galactose-1-phosphate (Gal-1-P) and/or galactitol (Galtol) were preincubated for 1 h with homogenates from frontal cortex, hippocampus an...

journal_title：Metabolic brain disease

authors： Marinou K,Tsakiris S,Tsopanakis C,Schulpis KH,Behrakis P

更新日期：2005-09-01 00:00:00

abstract：:Over the past 35 years, the outlook for a patient presenting with acute liver failure (ALF) has changed beyond all recognition. A patient presenting in 1984 had an 80 % likelihood of succumbing to intracranial hypertension. Today due to dramatic improvements in intensive care in dedicated liver transplant units, this ...

journal_title：Metabolic brain disease

authors： Ryan JM,Tranah T,Mitry RR,Wendon JA,Shawcross DL

更新日期：2013-03-01 00:00:00

abstract：:We examined how serum cholesterol, an established risk factor for cerebrovascular disease (CVD), relates to cognitive function in healthy middle-older aged individuals with no neurologic or CVD history. A complete lipid panel was obtained from a cohort of one hundred twenty individuals, ages 43-85, who also underwent ...

journal_title：Metabolic brain disease

authors： Leritz EC,McGlinchey RE,Salat DH,Milberg WP

更新日期：2016-04-01 00:00:00

abstract：:Effects of sertraline, haloperidol or olanzapine administration on ketamine-induced behaviours in mice were examined. The aim was to ascertain the degree of reversal of such behaviours by sertraline, and compare its effectiveness to haloperidol and olanzapine. Ten-week old mice (N = 120) were equally divided into main...

journal_title：Metabolic brain disease

authors： Onaolapo OJ,Paul TB,Onaolapo AY

更新日期：2017-10-01 00:00:00

abstract：:Stroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential of Indian Ginseng, also known as Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimenta...

journal_title：Metabolic brain disease

authors： Sood A,Mehrotra A,Dhawan DK,Sandhir R

更新日期：2018-08-01 00:00:00

abstract：:The availability of an animal model is crucial in studying the pathophysiological mechanisms of disease and to test possible therapies. Now, there are several models for the study of liver diseases, but there still remains a lack of a satisfactory animal model of chronic liver disease with hepatic encephalopathy (HE) ...

journal_title：Metabolic brain disease

authors： Jover R,Madaria E,Felipo V,Rodrigo R,Candela A,Compañ A

更新日期：2005-12-01 00:00:00

abstract：:The developing facial neurons of a series of hamsters ranging in age from the 14-day fetus to the 9 day postnatal were axotomized. Postoperative times were graded for each age so that the retrograde response could be observed before any significant amount of cell degeneration or death occurred. The incorporation of tr...

journal_title：Metabolic brain disease

authors： Clark P,Jones KJ,LaVelle A

更新日期：1993-06-01 00:00:00

abstract：:Tyrosinemia type II is an inborn error of metabolism caused by a deficiency in hepatic cytosolic aminotransferase. Affected patients usually present a variable degree of mental retardation, which may be related to the level of plasma tyrosine. In the present study we evaluated effect of chronic administration of L-tyr...

journal_title：Metabolic brain disease

authors： Ferreira GK,Carvalho-Silva M,Gomes LM,Scaini G,Teixeira LJ,Mota IT,Schuck PF,Ferreira GC,Streck EL

更新日期：2015-02-01 00:00:00

abstract：:In Alzheimer's disease (AD) basal forebrain cholinergic neurons appear to be targeted primarily in early stages of the disease. Scopolamine (muscarinic receptor antagonist) has been used for decades to induce working and reference memory impairment in rodents. In this study, we evaluated the protective effect of kolav...

journal_title：Metabolic brain disease

authors： Ishola IO,Adamson FM,Adeyemi OO

更新日期：2017-02-01 00:00:00