Abstract：
:The lifetime prevalence rate for major depressive disorder (MDD) is approximately 17 % for most developed countries around the world. Dietary polyphenols are currently used as an adjuvant therapy to accelerate the therapeutic efficacy on depression. Ferulic acid (FA) or 4-hydroxy-3-methoxy-cinnamic acid (Fig. 1a) is a main polyphenolic component of Chinese herb Radix Angelicae Sinensis, which is found to have antidepressant-like effects through regulating serotonergic and noradrenergic function. The present study examined the synergistic effect of low doses of FA combined with subthreshold dose of piperine, a bioavailability enhancer, on depression-like behaviors in mice, and investigated the possible mechanism. The administration of FA, even in the highest dose tested, reduced immobility time by 60 % in the tail suspension and forced swimming tests (TST and FST) in mice when compared to control. The maximal antidepressant-like effect of FA was obtained with 200 mg/kg. In addition, piperine only produced a weak antidepressant-like effect in the TST and FST. However, the evidence from the interaction analysis suggested a synergistic effect when low doses of FA were combined with a subthreshold dose of piperine. Further neurochemical evidence such as monoamine levels in the frontal cortex, hippocampus, and hypothalamus and measurements of monoamine oxidase activity also supported a synergistic effect of FA and piperine in the enhancement of monoaminergic function. This finding supports the concept that the combination strategy might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Li G,Ruan L,Chen R,Wang R,Xie X,Zhang M,Chen L,Yan Q,Reed M,Chen J,Xu Y,Pan J,Huang Wdoi
10.1007/s11011-015-9704-ysubject
Has Abstractpub_date
2015-12-01 00:00:00pages
1505-14issue
6eissn
0885-7490issn
1573-7365pii
10.1007/s11011-015-9704-yjournal_volume
30pub_type
杂志文章abstract：:Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...
journal_title：Metabolic brain disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11011-012-9326-6
更新日期：2012-12-01 00:00:00
abstract：:Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism. Usually diagnosed within the first month of birth, it is essential that the patient strictly follow the dietary restriction of natural protein intake. Otherwise, PKU impacts the development of the brain severely and may result in microceph...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00472-7
更新日期：2019-12-01 00:00:00
abstract：:Parkinson's disease is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. Ciclooxygenase-2 activity induction and oxidative stress have been implicated in the aetiology of Parkinson's disease and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-013-9416-0
更新日期：2013-12-01 00:00:00
abstract：:Hereditary tyrosinemia type I (HT1) is caused by mutations in the fumarylacetoacetate hydrolase (FAH) gene, the template for the final enzyme in the tyrosine catabolism pathway. If left untreated this deficiency of functional FAH leads to a buildup of toxic metabolites that can cause liver disease, kidney dysfunction ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0071-8
更新日期：2017-12-01 00:00:00
abstract：:Statins or HMG-CoA reductase inhibitors have been shown to be effective at lowering cholesterol levels, and the application of these molecules has gradually emerged as an attractive therapeutic strategy for neurodegenerative diseases. Epidemiological studies suggest that statin use is associated with a decreased incid...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0091-4
更新日期：2017-12-01 00:00:00
abstract：:The developing facial neurons of a series of hamsters ranging in age from the 14-day fetus to the 9 day postnatal were axotomized. Postoperative times were graded for each age so that the retrograde response could be observed before any significant amount of cell degeneration or death occurred. The incorporation of tr...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00996894
更新日期：1993-06-01 00:00:00
abstract：:Calotropis procera (CP; Apocynaceae) is reported to have several neuroprotective activities however it's anti-depressant activity yet to be established. Therefore, the present study was proposed to evaluate the anti-depressant activity of the standardized ethanolic extract of CP (ECP) in chronic unpredictable mild str...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00471-8
更新日期：2019-12-01 00:00:00
abstract：:Mutations in the HTT gene, consisting of expansion of CAG triplets, cause the Huntington's disease (HD), one of the major neurodegenerative disorders. Formation of aggregates of mutant huntingtin (mHTT, the product of the mutant HTT gene) leads to cellular dysfunctions, and subsequent neurodegeneration which manifest ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00405-4
更新日期：2019-06-01 00:00:00
abstract：:Fenproporex (Fen) is an amphetamine-based anorectic; amphetamine use causes a broad range of severe cognitive deficits and anxiogenic-like effects. In this study we evaluated pharmacological effects of the chronic administration of Fen on cognitive and non-cognitive behaviors. Male adult Wistar rats received intraperi...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9617-1
更新日期：2015-04-01 00:00:00
abstract：:Lactic acid accumulation has been implicated in the evolution of brain damage after ischemia. Since compartmentation of lactate may play a role in acid-base balance, lactate release from gerbil hippocampal slices was examined during a number of metabolic stresses including elevated [K+]e, ischemia, anoxia, and aglycem...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00999841
更新日期：1990-09-01 00:00:00
abstract：:This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0025-1
更新日期：2017-10-01 00:00:00
abstract：:D-galactose (GAL) causes aging-related changes and oxidative stress in the organism. We investigated the effect of whole fresh blueberry (BB) (Vaccinium corymbosum L.) treatment on oxidative stress in age-related brain damage model. Rats received GAL (300 mg/kg; s.c.; 5 days per week) alone or together with 5 % (BB1) ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9643-z
更新日期：2015-06-01 00:00:00
abstract：:This study presents further research into the spectrum of variants in genes responsible for the development of phenylketonuria (PKU) and hyperphenylalaninemia (HPA) in patients in Russia. After a study of 25 frequent variants, 293 patients (327 chromosomes without detected variants) from among 1265 probands still had ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00461-w
更新日期：2019-12-01 00:00:00
abstract：:Tyrosinemia type II is an inborn error of metabolism caused by a deficiency in hepatic cytosolic aminotransferase. Affected patients usually present a variable degree of mental retardation, which may be related to the level of plasma tyrosine. In the present study we evaluated effect of chronic administration of L-tyr...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9615-3
更新日期：2015-02-01 00:00:00
abstract：:Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-α) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjec...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-012-9310-1
更新日期：2012-12-01 00:00:00
abstract：:Bilateral, symmetrical hyperintensity of the globus pallidus is observed in T1-weighted cerebral magnetic resonance images in from 52 to 100% of patients with chronic liver disease. No significant relationship exists between the presence of these cerebral changes in image signal intensity and the patients' neuropsychi...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1023/a:1020680624084
更新日期：1998-12-01 00:00:00
abstract：:The blood-brain barrier and the intestinal barrier show signs of disruption in patients with idiopathic Parkinson's disease (PD) and animal models of nigrostriatal degeneration, and likewise in amyotrophic lateral sclerosis (ALS) models. A substantial body of evidence shows that defects in epithelial membrane barriers...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-018-0239-x
更新日期：2018-08-01 00:00:00
abstract：:Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental retardation, hyperactivity, cerebral palsy, epilepsy and neuroendocrine disturbances. Herein, we exa...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9816-z
更新日期：2016-08-01 00:00:00
abstract：:Sepsis is a major clinical challenge that is associated with encephalopathy and multi-organ dysfunction. Current therapeutic interventions are relatively ineffective and the development of novel treatments is hampered by the lack of a well-characterised animal model. Therefore, the behavioural, metabolic, physiologica...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-007-9058-1
更新日期：2007-12-01 00:00:00
abstract：:We have described the occurrence in freely moving gerbils of slow potential changes (SPC) in two different models of experimental epilepsy: 1) maximal electroshock and 2) bilateral epileptic foci induced by penicillin. SPC is considered a by-product of epileptiform activity in both models and correlates to the SPC whi...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01000149
更新日期：1992-06-01 00:00:00
abstract：:Homocystinuria is a metabolic disorder caused by deficiency of cystathione beta-synthase activity leading to tissue accumulation of homocysteine (Hcy); affected patients present neurological dysfunction. Considering that Hcy induces free radical formation and that memory is impaired by oxidative stress, in the present...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1019982223034
更新日期：2002-09-01 00:00:00
abstract：:Heart failure patients often manifest white matter hyperintensites on brain magnetic resonance imaging (MRI). White matter hyperintnsities have also been linked with cognitive problems in patients with heart failure. Sleep disordered breathing may contribute to structural brain changes in heart failure. The purpose of...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0309-0
更新日期：2018-12-01 00:00:00
abstract：:As studies of brain metabolism grow in complexity, investigators turn increasingly to nuclear magnetic resonance spectroscopy combined with 13C isotopic labeling. The unique ability to detect labeling non-destructively in specific carbon positions of individual compounds has opened the way to investigate brain metabol...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/BF02029492
更新日期：1996-12-01 00:00:00
abstract：:The effect of factors released from N2A neuroblastoma cells on the expression of myelin protein genes in glioma C6 cells, i.e., proteolipid protein (PLP) and myelin-associated glycoprotein (MAG), was studied. Both cells lines were propagated in serum-free DMEM-F10 (1:1) medium. The addition of 50% N2A conditioned medi...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01000160
更新日期：1992-09-01 00:00:00
abstract：:Iron is an important micronutrient for neuronal function and survival. It plays an essential role in DNA and protein synthesis, neurotransmission and electron transport chain due to its dual redox states. On the contrary, iron also catalyses the production of free radicals and hence, causes oxidative stress. Therefore...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-014-9522-7
更新日期：2014-09-01 00:00:00
abstract：:Chronic neuroinflammation is strongly associated with AD and altered peripheral and central levels of chemokines and cytokines have been frequently described in those with AD. Given the increasing evidence of ethnicity-related differences in AD, it was of interest to determine if those altered chemokine and cytokine l...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00512-2
更新日期：2020-01-01 00:00:00
abstract：:Increasing evidence indicates that fetal metabolic stress may result in a variety of post-natal perturbations during brain development. The goal of the study was to determine the duration of hypoxia/ischemia that would elicit a demonstrable regional depression of metabolism in the fetal brain and further to examine se...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-006-9031-4
更新日期：2006-12-01 00:00:00
abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a variety of symptoms of different severity such as cognitive deficits and impaired motor functions. Currently, HE is seen as a consequence of a low grade cerebral oedema assoc...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-016-9906-y
更新日期：2016-12-01 00:00:00
abstract：:Schizophrenia is known to be associated with metabolic disturbances including diabetes mellitus, obesity and cardiovascular diseases. A growing body of evidence has suggested abnormal cytokine levels in schizophrenia. In the present study, we explored the effects of low-grade chronic inflammation on behavioral stereot...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9630-4
更新日期：2015-06-01 00:00:00
abstract：:The enzyme nitric oxide synthase has been associated with suicide behavior. NOS1, NOS2 and NOS3 genes are implicated in the production of nitric oxide. However, the association between NOS genes and suicide behavior has not yet been established. To assess the association of Nitric Oxide Synthase (NOS) genes and suicid...
journal_title：Metabolic brain disease
pub_type： 杂志文章,meta分析
doi：10.1007/s11011-019-00406-3
更新日期：2019-08-01 00:00:00
