Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis.


UNLABELLED:Some subjects with multiple sclerosis (MS) present with low blood iron parameters. Anecdotal reports and a single patient study suggest that iron supplementation may be beneficial in these subjects. Myelin is regenerated continually, but prerequisites for this process are iron and a functional folate-vitamin B12-methylation pathway. The aim of this study was to determine iron status, folate and homocysteine in MS subjects, and to evaluate the effect on MS symptoms if deficiencies were addressed. RESULTS:In relapsing-remitting MS subjects, serum iron concentration correlated significantly with age at diagnosis (r=0.49; p=0.008). In Caucasian female MS subjects, serum iron and ferritin concentrations were significantly lower than in matched controls. In a 6-month pilot study, 12 subjects taking a regimen of nutritional supplements designed to promote myelin regeneration, improved significantly neurologically as measured by the Kurzke EDSS (Total Score means 3.50 to 2.45, 29.9%; p=0.021). These were significantly improved (p=0.002) compared to 6 control group patients taking multivitamins (Kurzke Score increased by 13.9% from 4.83 to 5.50). Both groups had significantly reduced homocysteine concentrations at 6 months, suggesting that methylation is necessary but not sufficient for myelin regeneration.


Metab Brain Dis


Metabolic brain disease


van Rensburg SJ,Kotze MJ,Hon D,Haug P,Kuyler J,Hendricks M,Botha J,Potocnik FC,Matsha T,Erasmus RT




Has Abstract


2006-09-01 00:00:00












  • Anxiolytic-like effects of α-asarone in a mouse model of chronic pain.

    abstract::α-asarone (ASR) is a major bioactive compound isolated from the rhizome of Acorus tatarinowii Schott and it has extensive biological effects. Clinically, anxiety disorder is a common comorbidity of chronic pain. However, limited information is available regarding the effects of ASR on chronic pain-related anxiety. Thi...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Tian J,Tian Z,Qin SL,Zhao PY,Jiang X,Tian Z

    更新日期:2017-12-01 00:00:00

  • Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes.

    abstract::Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-α) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjec...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Mustapic M,Popovic Hadzija M,Pavlovic M,Pavkovic P,Presecki P,Mrazovac D,Mimica N,Korolija M,Pivac N,Muck-Seler D

    更新日期:2012-12-01 00:00:00

  • Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia.

    abstract::Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with severe liver disease. Although the molecular basis for the neurological disorder in HE remains elusive, elevated ammonia and its chief metabolite glutamine are believed to be important factors responsible for altered cerebral...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审


    authors: Rao KV,Norenberg MD

    更新日期:2001-06-01 00:00:00

  • Cerebral magnetic resonance imaging in patients with chronic liver disease.

    abstract::Bilateral, symmetrical hyperintensity of the globus pallidus is observed in T1-weighted cerebral magnetic resonance images in from 52 to 100% of patients with chronic liver disease. No significant relationship exists between the presence of these cerebral changes in image signal intensity and the patients' neuropsychi...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审


    authors: Morgan MY

    更新日期:1998-12-01 00:00:00

  • Microglia.

    abstract::Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审


    authors: van Rossum D,Hanisch UK

    更新日期:2004-12-01 00:00:00

  • Wilson disease.

    abstract::Wilson disease (WD) is an autosomal recessive inherited disorder of copper metabolism, resulting in pathological accumulation of copper in many organs and tissues. The hallmarks of the disease are the presence of liver disease, neurologic symptoms, and Kayser-Fleischer corneal rings. The leading neurologic symptoms in...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审


    authors: Kitzberger R,Madl C,Ferenci P

    更新日期:2005-12-01 00:00:00

  • The neuroprotective effect of betanin in trimethyltin-induced neurodegeneration in mice.

    abstract::Betanin, a natural food colorant with powerful antioxidative properties, has not been studied in terms of neurodegenerative disease intervention. Therefore, the present study aimed to investigate the neuroprotective effects of betanin against trimethyltin chloride (TMT) -induced neurodegeneration in mice. Forty male I...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Thong-Asa W,Prasartsri S,Klomkleaw N,Thongwan N

    更新日期:2020-12-01 00:00:00

  • Cognitive impairment is correlated with insulin resistance degree: the "PA-NICO-study".

    abstract::Several epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia. Besides, some authors suggested that poor glucose control to be associated with worse cognitive function. We aimed to assess cognitive functions and IR-degree over time in diabetic. We also...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Fava A,Colica C,Plastino M,Messina D,Cristiano D,Opipari C,Vaccaro A,Gorgone G,Bosco F,Fratto A,De Bartolo M,Bosco D

    更新日期:2017-06-01 00:00:00

  • Vernonia Amygdalina Del. stimulated glucose uptake in brain tissues enhances antioxidative activities; and modulates functional chemistry and dysregulated metabolic pathways.

    abstract::Brain glucose uptake is usually reduced in type 2 diabetes owing to downregulation of brain glucose transporters. The ability of Vernonia amygdalina to stimulate glucose uptake as well as ameliorate glucose-induced oxidative stress and proinflammation were investigated in rat brain. Hot infusion of V. amygdalina leave...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Erukainure OL,Oyebode OA,Ibeji CU,Koorbanally NA,Islam MS

    更新日期:2019-06-01 00:00:00

  • Dysfunction of GABAergic neurons in the parafacial zone mediates sleep disturbances in a streptozotocin-induced rat model of sporadic Alzheimer's disease.

    abstract::Sleep disturbances are prevalent among patients with Alzheimer's disease (AD) and often precede the onset and progression of dementia. However, there are no reliable animal models for investigating sleep disturbances in patients with sporadic AD (sAD), which accounts for more than 90% of all AD cases. In the present s...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Song JZ,Cui SY,Cui XY,Hu X,Ma YN,Ding H,Ye H,Zhang YH

    更新日期:2018-02-01 00:00:00

  • Erp72 expression activated by transient cerebral ischemia or disturbance of neuronal endoplasmic reticulum calcium stores.

    abstract::Stress-induced activation of the expression of the endoplasmic reticulum (ER)-resident chaperon and member of the protein disulfide isomerase family erp72 was studied after transient cerebral ischemia in vivo using the four-vessel occlusion method and experimental depletion of ER calcium stores in primary neuronal cel...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Paschen W,Gissel C,Linden T,Doutheil J

    更新日期:1998-03-01 00:00:00

  • Hepatic encephalopathy influences high-affinity uptake of transmitter glutamate and aspartate into the hippocampal formation.

    abstract::The present work was carried out to study the influence of ammonia and factors from sera and cerebrospinal fluid (CSF) from patients with different degrees of chronic liver diseases on [3H]D-aspartate (Asp) and [3H]L-glutamate (Glu) high-affinity uptake into the rat hippocampal formation. For comparison, high-affinity...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Schmidt W,Wolf G,Grüngreiff K,Meier M,Reum T

    更新日期:1990-03-01 00:00:00

  • Association of genetic variants of ABCA1 with susceptibility to dementia: (SADEM study).

    abstract::Because of the importance of cholesterol metabolism in the physiopathogenesis of dementia, and knowing the function of ATP-binding cassette A1 transporter (ABCA1) as a cholesterol flow pump at the cellular and cerebral level, it has been noted that the ABCA1 gene may be a good candidate for disease study. In order to ...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Teresa JC,Fernado C,Nancy MR,Gilberto VA,Alberto CR,Roberto RR

    更新日期:2020-08-01 00:00:00

  • The therapeutic and protective effects of bee pollen against prenatal methylmercury induced neurotoxicity in rat pups.

    abstract::The current study evaluated the protective and therapeutic potency of bee pollen in ameliorating the toxic effects of methylmercury (MeHg), by measuring certain biochemical parameters related to neurotransmission, neuroinflammation, apoptosis, and glutamate excitotoxicity in the male neonate brain. Healthy, pregnant f...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Ben Bacha A,Norah AO,Al-Osaimi M,Harrath AH,Mansour L,El-Ansary A

    更新日期:2020-01-01 00:00:00

  • Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington's disease patients.

    abstract::Mutations in the HTT gene, consisting of expansion of CAG triplets, cause the Huntington's disease (HD), one of the major neurodegenerative disorders. Formation of aggregates of mutant huntingtin (mHTT, the product of the mutant HTT gene) leads to cellular dysfunctions, and subsequent neurodegeneration which manifest ...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Pierzynowska K,Gaffke L,Cyske Z,Węgrzyn G

    更新日期:2019-06-01 00:00:00

  • Mutation spectrum of PAH gene in phenylketonuria patients in Northwest China: identification of twenty novel variants.

    abstract::This study was performed to analyze the mutational spectrum of the phenylalanine hydroxylase (PAH) gene in phenylketonuria (PKU) patients in Northwest China, to identify mutational hot spots, and to determine the correlation between variants and clinical phenotypes of PKU. A large cohort of 475 PKU families in Northwe...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Yan Y,Zhang C,Jin X,Zhang Q,Zheng L,Feng X,Hao S,Gao H,Ma X

    更新日期:2019-06-01 00:00:00

  • Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3.

    abstract::Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental retardation, hyperactivity, cerebral palsy, epilepsy and neuroendocrine disturbances. Herein, we exa...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Kartal Ö,Aydınöz S,Kartal AT,Kelestemur T,Caglayan AB,Beker MC,Karademir F,Süleymanoğlu S,Kul M,Yulug B,Kilic E

    更新日期:2016-08-01 00:00:00

  • Rivastigmine reverses cognitive deficit and acetylcholinesterase activity induced by ketamine in an animal model of schizophrenia.

    abstract::Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neu...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Zugno AI,Julião RF,Budni J,Volpato AM,Fraga DB,Pacheco FD,Deroza PF,Luca RD,de Oliveira MB,Heylmann AS,Quevedo J

    更新日期:2013-09-01 00:00:00

  • The role of the MAP-kinase superfamily in beta-amyloid toxicity.

    abstract::The mitogen-activated protein kinase (MAP kinase) pathway participates in a number of reactions of the cell when responding to various external stimuli. These stimuli include growth factor binding to its receptor as well as stressful situations such as hypoxia and oxidative stress. It has been postulated that one of t...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Daniels WM,Hendricks J,Salie R,Taljaard JJ

    更新日期:2001-12-01 00:00:00

  • Creatine plus pyruvate supplementation prevents oxidative stress and phosphotransfer network disturbances in the brain of rats subjected to chemically-induced phenylketonuria.

    abstract::Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism. Usually diagnosed within the first month of birth, it is essential that the patient strictly follow the dietary restriction of natural protein intake. Otherwise, PKU impacts the development of the brain severely and may result in microceph...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Bortoluzzi VT,Brust L,Preissler T,de Franceschi ID,Wannmacher CMD

    更新日期:2019-12-01 00:00:00

  • Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review.

    abstract::Despite the existence of many preclinical studies, scientific evidence is lacking on the clinical use of alpha-lipoic acid (ALA) for central nervous system disorders. Therefore, we aimed at revising the literature concerning the use of ALA for the treatment of psychiatric and neurological conditions and to point out w...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: de Sousa CNS,da Silva Leite CMG,da Silva Medeiros I,Vasconcelos LC,Cabral LM,Patrocínio CFV,Patrocínio MLV,Mouaffak F,Kebir O,Macedo D,Patrocínio MCA,Vasconcelos SMM

    更新日期:2019-02-01 00:00:00

  • Pretreatment with vitamins E and C prevent the impairment of memory caused by homocysteine administration in rats.

    abstract::Homocystinuria is a metabolic disorder caused by deficiency of cystathione beta-synthase activity leading to tissue accumulation of homocysteine (Hcy); affected patients present neurological dysfunction. Considering that Hcy induces free radical formation and that memory is impaired by oxidative stress, in the present...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Reis EA,Zugno AI,Franzon R,Tagliari B,Matté C,Lammers ML,Netto CA,Wyse AT

    更新日期:2002-09-01 00:00:00

  • Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats.

    abstract::Intracerebroventricular (ICV) injection of streptozotocin (STZ) is a well established procedure to induce neuroinflammation leading to dementia in experimental animals. However, the optimal dose of STZ has not been determined. In the present study, rats were ICV injected with 1.5, 3 and 6 mg of STZ per kg of body weig...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Ghosh R,Sil S,Gupta P,Ghosh T

    更新日期:2020-12-01 00:00:00

  • Psychopharmacology of maternal separation anxiety in vervet monkeys.

    abstract::Maternal separation in non-human primates has been proposed as a model of early adversity. The symptoms of separation anxiety were studied in vervet monkeys, during the weaning period, when psychotropic medications were administered. The control group received a normal diet and treatment groups received citalopram, re...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Marais L,Daniels W,Brand L,Viljoen F,Hugo C,Stein DJ

    更新日期:2006-09-01 00:00:00

  • Targeting cyclooxygenase-2 in depression is not a viable therapeutic approach and may even aggravate the pathophysiology underpinning depression.

    abstract::Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,meta分析,评审


    authors: Maes M

    更新日期:2012-12-01 00:00:00

  • Erratum to: Treadmill exercise alters ecstasy- induced long- term potentiation disruption in the hippocampus of male rats.

    abstract::In the original publication of the article, author name Masoumeh Asadbegi was incorrectly written as Masoumeh Asadbeigi. The authors regret the oversight. ...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,已发布勘误


    authors: Sajadi A,Amiri I,Gharebaghi A,Komaki A,Asadbegi M,Shahidi S,Mehdizadeh M,Asl SS

    更新日期:2017-12-01 00:00:00

  • Lignans from Schisandra chinensis ameliorate cognition deficits and attenuate brain oxidative damage induced by D-galactose in rats.

    abstract::The aim of this study was to explore the neuroprotective effects of active compounds from Schisandra chinensis (Trucz.) Baill. (Magnoliaceae) against the D-galactose (D-gal)-induced neurotoxicity in rat. The Wistar rats were subcutaneously injected with D-gal (150 mg/(kg day)) for six weeks and orally administered wit...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Yan T,Shang L,Wang M,Zhang C,Zhao X,Bi K,Jia Y

    更新日期:2016-06-01 00:00:00

  • Induction of Rabies Virus Infection in Mice Brain may Up and Down Regulate Type II Interferon gamma via epigenetic modifications.

    abstract::As feared and deadly human diseases globally, Rabies virus contrived mechanisms to escape early immune recognition via suppression of the interferon response. This study, preliminarily investigated whether Rabies virus employs epigenetic mechanism for the suppression of the interferon using the Challenge virus standar...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Abdulazeez M,Kia GSN,Abarshi MM,Muhammad A,Ojedapo CE,Atawodi JC,Dantong D,Kwaga JKP

    更新日期:2020-06-01 00:00:00

  • The association of sleep-disordered breathing and white matter hyperintensities in heart failure patients.

    abstract::Heart failure patients often manifest white matter hyperintensites on brain magnetic resonance imaging (MRI). White matter hyperintnsities have also been linked with cognitive problems in patients with heart failure. Sleep disordered breathing may contribute to structural brain changes in heart failure. The purpose of...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Moon C,Bendlin BB,Melah KE,Bratzke LC

    更新日期:2018-12-01 00:00:00

  • Autozygosity mapping of methylmalonic acidemia associated genes by short tandem repeat markers facilitates the identification of five novel mutations in an Iranian patient cohort.

    abstract::Isolated Methylmalonic acidemia/aciduria (MMA) is a group of inborn errors of metabolism disease which is caused by defect in methylmalonyl-CoA mutase (MCM) enzyme. The enzyme has a key function in the catabolism of branched chain amino acids (BCAA, isoleucine, and valine), methionine, and threonine. MCM is encoded by...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章


    authors: Shafaat M,Alaee MR,Rahmanifar A,Setoodeh A,Razzaghy-Azar M,Bagherian H,Bagheri SD,Zafarghandi Motlagh F,Hashemi M,Abiri M,Zeinali S

    更新日期:2018-10-01 00:00:00