Abstract:
:We report reversible abnormalities in magnetic resonance spectra acquired from a patient with AIDS undergoing antibiotic and corticosteroid therapy for disseminated nocardiosis, a rare opportunistic infection of immunosuppressed patients which can cause cerebral abscess formation. There was no clinical, CT or MRI evidence of HIV-1 encephalitis. MR spectra were acquired before and after treatment using a two-dimensional chemical shift imaging technique (TR 1500ms, TE 130ms). Prior to treatment, a rise in the choline to creatine ratio and a reduction in the N-acetylaspartate to creatine ratio were observed in MR spectra localized to areas of the left anteromedial centrum semiovale that appeared normal on MR imaging. After 16 weeks, the patient had recovered with complete resolution of the cerebral abscesses on MRI. The MR spectral abnormalities also returned to normal. Two months later, the patient had a relapse with focal neurological signs and further abscesses were demonstrated on MRI of the brain. The patient subsequently died and histopathological and microbiological findings at autopsy confirmed the clinical picture of a recurrence of cerebral nocardiosis with no evidence of HIV-1 encephalitis. This case illustrates reversible MR-measurable metabolite changes in the brain of an HIV-seropositive patient without HIV-1 encephalitis who underwent treatment for cerebral nocardiosis.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Marcus CD,Taylor-Robinson SD,Cox IJ,Sargentoni J,Shaunak Sdoi
10.1023/a:1020733024934subject
Has Abstractpub_date
1999-12-01 00:00:00pages
231-7issue
4eissn
0885-7490issn
1573-7365journal_volume
14pub_type
杂志文章abstract::As feared and deadly human diseases globally, Rabies virus contrived mechanisms to escape early immune recognition via suppression of the interferon response. This study, preliminarily investigated whether Rabies virus employs epigenetic mechanism for the suppression of the interferon using the Challenge virus standar...
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journal_title:Metabolic brain disease
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更新日期:2011-09-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
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