Abstract：
:Soluble amyloid-β protein (Aβ) oligomers have been recognized to be early and key intermediates in Alzheimer's disease-related synaptic dysfunction. In this study, using in vitro electrophysiology, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), a marine-derived acidic oligosaccharide, with oligomeric Aβ. We found that the inhibition of long-term potentiation (LTP) induced by Aβ oligomers can be dose dependently reversed by the application of AOSC, whereas AOSC alone did not alter normal LTP induction. Interestingly, treatment with Aβ monomers with or without AOSC did not affect LTP induction. Additionally, when fresh-made Aβ was co-incubated with AOSC before in vitro testing, there was no impairment of LTP induction. The results from Western blots demonstrated that AOSC prevent the aggregation of Aβ oligomers. These findings indicate that AOSC may reverse Aβ oligomer-mediated cytotoxicity by directly disrupting the amyloid oligomer aggregation, and this action is concentration dependent. Thus, we propose that AOSC might be a potential therapeutic drug for Alzheimer's disease due to its protection against oligomeric Aβ-induced dysfunction of synaptic plasticity.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Chang L,Li F,Chen X,Xu S,Wang C,Chen H,Wang Qdoi
10.1007/s11011-014-9521-8subject
Has Abstractpub_date
2014-09-01 00:00:00pages
683-90issue
3eissn
0885-7490issn
1573-7365journal_volume
29pub_type
杂志文章abstract：:Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neu...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-013-9417-z
更新日期：2013-09-01 00:00:00
abstract：:Current data on the neurotrophic effects of steroid hormones suggest that, in brain and spinal cord regions containing receptor systems, steroids act at the level of RNA and protein synthesis to effect metabolic changes associated with nerve-cell survival, elaboration/maintenance of dendritic and axonal processes, syn...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/BF01001350
更新日期：1988-03-01 00:00:00
abstract：:D-galactose (GAL) causes aging-related changes and oxidative stress in the organism. We investigated the effect of whole fresh blueberry (BB) (Vaccinium corymbosum L.) treatment on oxidative stress in age-related brain damage model. Rats received GAL (300 mg/kg; s.c.; 5 days per week) alone or together with 5 % (BB1) ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9643-z
更新日期：2015-06-01 00:00:00
abstract：:A high co-morbidity between Alzheimer's disease (AD) and depression suggests there might be similar mechanisms underlying the course of these diseases. Previous studies have shown that p38MAPK plays a critical role in the pathophysiology of AD and depression. However, little is known about whether SB203580, a selectiv...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9880-4
更新日期：2017-02-01 00:00:00
abstract：:The experimental model of central pontine myelinolysis--chronic (4-day) hyponatremia induced by daily injections of hypotonic dextrose solutions and vasopressin followed by rapid correction with saline--was used in young fasted and thirsted mice. In normal controls chronic fasting and thirsting lowered plasma and brai...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00999694
更新日期：1987-12-01 00:00:00
abstract：:Acute and chronic administration of Al-gluconate (12.7% Al) at the concentration of 1 mg/kg produces edema in the rat brain, as reflected by the increase in water and Na+ content. The permeability for Evans blue is also increased, which indicates the opening of the blood-brain barrier. Higher concentrations of the Al-...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00996974
更新日期：1990-03-01 00:00:00
abstract：:Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairment, attention deficits and motor dysfunction which eventually c...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-016-9843-9
更新日期：2016-12-01 00:00:00
abstract：:Betanin, a natural food colorant with powerful antioxidative properties, has not been studied in terms of neurodegenerative disease intervention. Therefore, the present study aimed to investigate the neuroprotective effects of betanin against trimethyltin chloride (TMT) -induced neurodegeneration in mice. Forty male I...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-020-00615-1
更新日期：2020-12-01 00:00:00
abstract：:In the brain hyperammonemia interferes with ion homeostasis, membrane potentials, neurotransmission, and neurotransmitter recycling and reduces metabolic rates for oxygen and glucose. Because, cerebral blood flow (CBF) is closely coupled to metabolism, CBF is most often reduced in diseases associated with hyperammonem...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1023/a:1021941414605
更新日期：2002-12-01 00:00:00
abstract：PURPOSE:To analyze brain metabolite changes in HIV-1-seropositive subjects in order to define whether the neuronal impairment is a localized or more diffuse process. MATERIALS AND METHODS:15 patients and 18 volunteers underwent multivoxel proton magnetic resonance (MR) spectroscopy at 1.5T. Nine patients were classifi...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1020609213664
更新日期：1998-06-01 00:00:00
abstract：:Stroke is devastating and a leading cause of morbidity and mortality worldwide. Cerebral ischemia-reperfusion and its subsequent reactive hyperemia lead to neuronal damage in the hippocampus and cognitive decline. Chrysin (5, 7-dihydroxyflavone) is a well-known member of the flavonoid family with antioxidant and neuro...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00527-9
更新日期：2020-02-01 00:00:00
abstract：:Stroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential of Indian Ginseng, also known as Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimenta...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0234-2
更新日期：2018-08-01 00:00:00
abstract：:We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyr...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0107-0
更新日期：2018-02-01 00:00:00
abstract：:Ischemic postconditioning (IPostC) has been reported to have neuroprotection against ischemic diseases, and one cycle of IPostC induces neurogenesis when treated nearby. To expanding these effects, we explored the effects of repetitively remote IPostC (NRIPostC) on neurogenesis in the subgranular zone (SGZ) and subent...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0068-3
更新日期：2017-12-01 00:00:00
abstract：:Substantial evidence demonstrated that maternal dietary nutrients can significantly determine the susceptibility to developing metabolic disorders in the offspring. Therefore, we aimed to investigate the later-life effects of maternal and postweaning diets interaction on epigenetic modification of the central nervous ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9678-9
更新日期：2015-10-01 00:00:00
abstract：:Increasing evidence indicates that excessive drug consumption is sufficient for the transition from recreational and controlled drug use to uncontrolled use and addiction. However, the underlying mechanisms are debated. Some neurobehavioral and neuroimaging evidence indicates that dorsolateral striatum (dlStr)-depende...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00430-3
更新日期：2019-08-01 00:00:00
abstract：:Glutaric aciduria type I (GA-I) is an inborn error of lysine and tryptophan metabolism. Clinical manifestations of GA-I include dystonic or dyskinetic cerebral palsy, but when the symptoms occur, treatment is not effective. In Taiwan, newborn screening for GA-I started in 2001; we wish to evaluate the outcomes of pati...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-012-9349-z
更新日期：2013-03-01 00:00:00
abstract：:The integrity of the blood-brain barrier (BBB) is an important aspect of normal central nervous system (CNS) function. Recently, it was shown that the BBB breakdown is one of the predisposing factors in the pathogenesis of thiamine-deficiency encephalopathy. The result is discussed along with some reviews on previous ...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/BF02080931
更新日期：1996-03-01 00:00:00
abstract：:Maple syrup urine disease (MSUD) or branched-chain alpha-keto aciduria (BCKA) is an inherited disorder caused by a deficiency of the branched-chain alpha-keto acid dehydrogenase complex (BCKAD) activity. The blockage of this pathway leads to tissue accumulation of the branched-chain amino acids (BCAA) leucine, isoleuc...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-006-9030-5
更新日期：2006-12-01 00:00:00
abstract：:Glutaric aciduria type 1 is a neurometabolic disorder, caused by riboflavin-dependent glutaryl-CoA dehydrogenase deficiency. As its consequence, accumulation of the putatively neurotoxic metabolites (glutaric and 3-hydroxyglutaric acids) in body tissues, but especially within the brain, is observed. Estimated incidenc...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0357-5
更新日期：2019-04-01 00:00:00
abstract：:We investigated the biochemical alterations of the striatum of mice subjected to seven experimental schedules with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) treatment. The mice were treated intraperitoneally (i.p.) with MPTP (20 mg/kg in saline) four times a day at 2-hr intervals showed severe ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-010-9195-9
更新日期：2010-06-01 00:00:00
abstract：:Isolated Methylmalonic acidemia/aciduria (MMA) is a group of inborn errors of metabolism disease which is caused by defect in methylmalonyl-CoA mutase (MCM) enzyme. The enzyme has a key function in the catabolism of branched chain amino acids (BCAA, isoleucine, and valine), methionine, and threonine. MCM is encoded by...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0277-4
更新日期：2018-10-01 00:00:00
abstract：:Tyrosinemia type II is a genetic disorder characterized by elevated blood levels of the amino acid tyrosine caused by the deficiency of tyrosine aminotransferase enzyme, resulting in neurologic and developmental difficulties in the patients. Although neurological sequelae are common in Tyrosinemia type II patients, th...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00511-3
更新日期：2020-01-01 00:00:00
abstract：:There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in skeletal muscle, brain, and likely the lungs, is activated. In addition t...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-013-9428-9
更新日期：2014-03-01 00:00:00
abstract：:Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolesc...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0140-z
更新日期：2018-02-01 00:00:00
abstract：:The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). The VAChT gene is located within the first intron of the ChAT gene. This unique genomic organization permits coordinat...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/BF02680013
更新日期：2000-03-01 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by accumulation and deposition of Aβ peptide in human brain. The present study aimed to determine the protective effect of catechin rich extract of MERM (methanolic extract of Rhizophora mucronata) on Aβ (25-35) induced cognitive impai...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9831-0
更新日期：2016-08-01 00:00:00
abstract：:The radiological spectrum of neuromyelitis optica has become broader since the detection of aquaporin4 antibodies. We report a case of neuromyelitis optica patient with pseudotumoral encephalic lesion. A 66 year-old woman presented with sudden left lateral homonymous hemianopsia. A brain MRI showed an isolated and ext...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0141-y
更新日期：2018-02-01 00:00:00
abstract：:Stroke is the leading cause of disability among adults as well as the 2nd leading cause of death globally. Ischemic stroke accounts for about 85% of strokes, and currently, tissue plasminogen activator (tPA), whose therapeutic window is limited to up to 4.5 h for the appropriate population, is the only FDA approved dr...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-020-00573-8
更新日期：2020-08-01 00:00:00
abstract：:Hepatic encephalopathy (HE) represents a nervous system disorder caused due to liver dysfunction. HE is broadly classified as acute/overt and moderate-minimal HE. Since HE syndrome severely affects quality of life of the patients and it may be life threatening, it is important to develop effective therapeutic strategy...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9556-x
更新日期：2014-12-01 00:00:00
