Abstract:
:Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by accumulation and deposition of Aβ peptide in human brain. The present study aimed to determine the protective effect of catechin rich extract of MERM (methanolic extract of Rhizophora mucronata) on Aβ (25-35) induced cognitive impairment and neuronal toxicity in mice. In the present study AD characteristics were induced by intracerberoventricular administration of aggregated Aβ (25-35) in the Swiss albino mice. Learning and memory deficits were assessed using behavioral assays such as Morris water maze, Y-maze and step down avoidance tasks. Oxidative stress mediated impairment were assessed by measuring the activities of enzymatic and non-enzymatic antioxidants, level of apoptotic protein and oxidative markers in the hippocampus and frontal cortex region. Histolopathological analysis of brain was also carried out. Results illustrated that oral treatment of MERM (200 and 400 mg/kg bw) significantly attenuated Aβ (25-35) induced memory impairment as evaluated by behavioral tests. In addition treatment with MERM attenuated the elevation of β-secretase activity accompanying the reduced level of Aβ (25-35) in the cortex and hippocampus of brain. MERM also enhanced the cognitive function by significantly inhibiting AChE, BuChE and MAO-B. Furthermore, MERM attenuated lipid peroxidation, protein oxidation, restored the antioxidant status and inhibited neuronal apoptosis by down-regulating the level of caspase 3 and Bax protein. These data suggest that MERM rich in catechin can act as promising drug for AD treatment because of its antioxidant, anti-apoptotic and reducing Aβ oligomer activities.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Suganthy N,Malar DS,Devi KPdoi
10.1007/s11011-016-9831-0subject
Has Abstractpub_date
2016-08-01 00:00:00pages
937-49issue
4eissn
0885-7490issn
1573-7365pii
10.1007/s11011-016-9831-0journal_volume
31pub_type
杂志文章abstract::The cholesterol-raising properties of the apolipoprotein E (APOE) epsilon-4 (ε-4) allele has been validated in the South African population. Mounting evidence supports the added value of APOE genotyping for the evaluation of cardiovascular risk in dyslipidemic patients beyond its established role in the diagnosis of l...
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journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
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pub_type: 杂志文章
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journal_title:Metabolic brain disease
pub_type: 杂志文章
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journal_title:Metabolic brain disease
pub_type: 杂志文章
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journal_title:Metabolic brain disease
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更新日期:2015-02-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/BF01999765
更新日期:1994-06-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
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journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
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pub_type: 杂志文章,评审
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journal_title:Metabolic brain disease
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pub_type: 杂志文章,meta分析,评审
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journal_title:Metabolic brain disease
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
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abstract::Tyrosinemia type II is a genetic disorder characterized by elevated blood levels of the amino acid tyrosine caused by the deficiency of tyrosine aminotransferase enzyme, resulting in neurologic and developmental difficulties in the patients. Although neurological sequelae are common in Tyrosinemia type II patients, th...
journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-005-7910-8
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abstract::We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyr...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0107-0
更新日期:2018-02-01 00:00:00