Abstract：
:Applying different technologies to monitor disease activity and treatment efficacy are essential in a complex disease such as multiple sclerosis. Combining current assays with flow cytometry could create a powerful tool for such analyses. The cell surface expression level of CD74, the MHC class II invariant chain, is a potential disease biomarker that could be monitored by FACS analysis in order to assess disease progression and the clinical efficacy of partial MHC class II constructs in treating MS. These constructs, which can bind to and down-regulate CD74 cell-surface expression on monocytes and inhibit macrophage migration inhibitory factor (MIF) effects, can reverse clinical and histological signs of EAE. These properties of partial class II constructs are highly compatible with a flow cytometry approach for monitoring CD74 expression as a possible biomarker for disease activity/progression and as a treatment response marker.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Benedek G,Meza-Romero R,Bourdette D,Vandenbark AAdoi
10.1007/s11011-014-9634-0subject
Has Abstractpub_date
2015-08-01 00:00:00pages
877-84issue
4eissn
0885-7490issn
1573-7365journal_volume
30pub_type
杂志文章,评审abstract：:Mitochondrial dysfunction is observed in brains of Alzheimer's Disease patients as well as many rodent model systems including those modeling mutations in preseinilin 1 (PSEN1). The aim of our study was to characterize mitochondrial function and number in fibroblasts from AD patients with PSEN1 mutations. We used bioc...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9667-z
更新日期：2015-10-01 00:00:00
abstract：:This study was performed to analyze the mutational spectrum of the phenylalanine hydroxylase (PAH) gene in phenylketonuria (PKU) patients in Northwest China, to identify mutational hot spots, and to determine the correlation between variants and clinical phenotypes of PKU. A large cohort of 475 PKU families in Northwe...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-0387-7
更新日期：2019-06-01 00:00:00
abstract：:Menkes disease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation. With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkes disease becomes of utmost importance for patients' prognosis. In the present study, the clinical characteristics of 12 Kore...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9569-5
更新日期：2015-02-01 00:00:00
abstract：:Soluble amyloid-β protein (Aβ) oligomers have been recognized to be early and key intermediates in Alzheimer's disease-related synaptic dysfunction. In this study, using in vitro electrophysiology, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), a marine-derived acidic oligosaccharide, w...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9521-8
更新日期：2014-09-01 00:00:00
abstract：:Oxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention. Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory ha...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0215-5
更新日期：2018-08-01 00:00:00
abstract：:Hereditary tyrosinemia type I (HT1) is caused by mutations in the fumarylacetoacetate hydrolase (FAH) gene, the template for the final enzyme in the tyrosine catabolism pathway. If left untreated this deficiency of functional FAH leads to a buildup of toxic metabolites that can cause liver disease, kidney dysfunction ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0071-8
更新日期：2017-12-01 00:00:00
abstract：:The mitogen-activated protein kinase (MAP kinase) pathway participates in a number of reactions of the cell when responding to various external stimuli. These stimuli include growth factor binding to its receptor as well as stressful situations such as hypoxia and oxidative stress. It has been postulated that one of t...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1012541011123
更新日期：2001-12-01 00:00:00
abstract：:Mobile phone providers use electromagnetic radiation (EMR) with frequencies ranging from 900 to 1800 MHz. The increasing use of mobile phones has been accompanied by several potentially pathological consequences, such as neurological diseases related to hippocampal (HIPPON) and dorsal root ganglion neuron (DRGN). The ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0180-4
更新日期：2018-06-01 00:00:00
abstract：:Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. Clinically, the disease is characterized by progressive neurological deterioration and renal failure, whose pathophysiology is still undefined. In the present study we investigated the effect of acute MMA administration...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-013-9396-0
更新日期：2013-09-01 00:00:00
abstract：:Near infrared radiation (NIR) is known to penetrate and affect biological systems in multiple ways. Recently, a series of experimental studies suggested that low intensity NIR may protect neuronal cells against a wide range of insults that mimic diseases such as stroke, brain trauma and neurodegeneration. However, the...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9515-6
更新日期：2015-04-01 00:00:00
abstract：:Chronic exposure to stress amplifies locomotor deficits and exacerbates dopamine neuron loss in an animal model for Parkinson's disease. The release of neurotrophic factors such as glial cell-line derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) following neuronal injury attenuates exacerbated degeneration...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-9988-1
更新日期：2017-08-01 00:00:00
abstract：:Sevoflurane, one of the most commonly used volatile anesthetics in clinical treatment, has been shown to induce a widespread increase in brain apoptosis. However, the underlying mechanism is still unknown. Sestrin 2 has been recently shown to regulate intracellular reactive oxygen species (ROS) levels and play a cruci...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9673-1
更新日期：2015-10-01 00:00:00
abstract：:Overwhelming evidence suggests that microglia play an important role in ischemic injury and they polarize into two different phenotypes with distinct functions after ischemic stroke. We performed the present study to investigate whether L-3-n butylphthalide (NBP) has an effect on microglial polarization. Mice were sub...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0307-2
更新日期：2018-12-01 00:00:00
abstract：:Despite the existence of many preclinical studies, scientific evidence is lacking on the clinical use of alpha-lipoic acid (ALA) for central nervous system disorders. Therefore, we aimed at revising the literature concerning the use of ALA for the treatment of psychiatric and neurological conditions and to point out w...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0344-x
更新日期：2019-02-01 00:00:00
abstract：:Central pontine myelinolysis (CPM) is a demyelinating condition affecting not only the pontine base, but also involving other brain areas. It usually occurs on a background of chronic systemic illness, and is commonly observed in individuals with alcoholism, malnutrition and liver disease. Studies carried out 25-30 ye...
journal_title：Metabolic brain disease
pub_type： 历史文章,杂志文章
doi：10.1007/s11011-010-9175-0
更新日期：2010-03-01 00:00:00
abstract：:Several studies have examined neonatal diabetes, a rare disease characterized by hyperglycemia and low insulin levels that is usually diagnosed in the first 6 month of life. Recently, the effects of diabetes on the brain have received considerable attention. In addition, hyperglycemia may perturb brain function and mi...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0170-6
更新日期：2018-02-01 00:00:00
abstract：:High plasma levels of methionine (Met) and its metabolites such as methionine sulfoxide (MetO) may occur in several genetic abnormalities. Patients with hypermethioninemia can present neurological dysfunction; however, the neurotoxicity mechanisms induced by these amino acids remain unknown. The aim of the present wor...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0054-9
更新日期：2017-10-01 00:00:00
abstract：:Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain a...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1021982523691
更新日期：2002-12-01 00:00:00
abstract：:Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric disorders that share many genetic risk factors. This study aimed to investigate the association of phosphoinositide-3-kinase regulatory subunit1 (PIK3R1) gene rs3756668 and rs3730089 polymorphisms with SCZ and BD risks and determine the expression le...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-020-00552-z
更新日期：2020-06-01 00:00:00
abstract：:The aim of this study was to explore the neuroprotective effects of active compounds from Schisandra chinensis (Trucz.) Baill. (Magnoliaceae) against the D-galactose (D-gal)-induced neurotoxicity in rat. The Wistar rats were subcutaneously injected with D-gal (150 mg/(kg day)) for six weeks and orally administered wit...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9804-3
更新日期：2016-06-01 00:00:00
abstract：:Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...
journal_title：Metabolic brain disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11011-012-9326-6
更新日期：2012-12-01 00:00:00
abstract：:Because of the importance of cholesterol metabolism in the physiopathogenesis of dementia, and knowing the function of ATP-binding cassette A1 transporter (ABCA1) as a cholesterol flow pump at the cellular and cerebral level, it has been noted that the ABCA1 gene may be a good candidate for disease study. In order to ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-020-00577-4
更新日期：2020-08-01 00:00:00
abstract：:Traumatic brain injury (TBI) results in severe neurological impairments without effective treatments. Inflammation appears to be an important contributor to key pathogenic events such as secondary brain injury following TBI and therefore serves as a promising target for novel therapies. We have recently demonstrated t...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-9991-6
更新日期：2017-10-01 00:00:00
abstract：:Chronic ethanol ingestion results in an "up-regulation" of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in mouse brain. This increase in receptors is associated with ethanol withdrawal seizures, which can be attenuated by NMDA receptor antagonists. Chronic exposure to ethanol (3 days) of rat cerebella...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01991784
更新日期：1995-03-01 00:00:00
abstract：:The integrity of the blood-brain barrier (BBB) is an important aspect of normal central nervous system (CNS) function. Recently, it was shown that the BBB breakdown is one of the predisposing factors in the pathogenesis of thiamine-deficiency encephalopathy. The result is discussed along with some reviews on previous ...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/BF02080931
更新日期：1996-03-01 00:00:00
abstract：:To investigate the pattern of brain volume changes in patients with end-stage renal disease (ESRD) using voxel-based morphometry (VBM) and correlation with clinical and neuropsychological (NP) tests. Fifty seven ESRD patients with no anatomical abnormalities in conventional magnetic resonance imaging [24 patients with...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-013-9438-7
更新日期：2013-12-01 00:00:00
abstract：:The central nervous system is one of the most vulnerable organs affected by mercury toxicity. Both acute and chronic exposure to mercury is also known to cause a variety of neurological or psychiatric disorders. Here, the neuroprotective effect of berberine (BN; 100 mg/kg bwt) on mercuric chloride (HgCl2; 0.4 mg/kg bw...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9652-6
更新日期：2015-08-01 00:00:00
abstract：:Today, neurological disorders such as epilepsy, depression, tardive dyskinesia, and stress, and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, dementia, and Huntington's disease affect millions of people all over the world. Existing pharmacological interventions do not meet the desired t...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-019-00400-9
更新日期：2019-08-01 00:00:00
abstract：:D-Galactose (D-gal) chronic administration via intraperitoneal and subcutaneous routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal and subcutaneous administration of D-gal causes memory impairments, a reduction in the neurogenesis of adult mice, an increase in the levels of the ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-9972-9
更新日期：2017-06-01 00:00:00
abstract：:Tyrosinemia type II is an inborn error of metabolism caused by a deficiency in hepatic cytosolic aminotransferase. Affected patients usually present a variable degree of mental retardation, which may be related to the level of plasma tyrosine. In the present study we evaluated effect of chronic administration of L-tyr...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9615-3
更新日期：2015-02-01 00:00:00
