当前位置： SCI文献检索 > METABOLIC BRAIN DISEASE期刊下所有文献 > Acute administration of methionine and/or methionine sulfoxide impairs redox status and induces apoptosis in rat cerebral cortex.

Acute administration of methionine and/or methionine sulfoxide impairs redox status and induces apoptosis in rat cerebral cortex.

Abstract：

:High plasma levels of methionine (Met) and its metabolites such as methionine sulfoxide (MetO) may occur in several genetic abnormalities. Patients with hypermethioninemia can present neurological dysfunction; however, the neurotoxicity mechanisms induced by these amino acids remain unknown. The aim of the present work was to study the effects of Met and/or MetO on oxidative stress, genotoxicity, cytotoxicity and to evaluate whether the cell death mechanism is mediated by apoptosis in the cerebral cortex of young rats. Forty-eight Wistar rats were divided into groups: saline, Met 0.4 g/Kg, MetO 0.1 g/Kg and Met 0.4 g/Kg + MetO 0.1 g/Kg, and were euthanized 1 and 3 h after subcutaneous injection. Results showed that TBARS levels were enhanced by MetO and Met+MetO 1 h and 3 h after treatment. ROS was increased at 3 h by Met, MetO and Met+MetO. SOD activity was increased in the Met group, while CAT was reduced in all experimental groups 1 h and 3 h after treatment. GPx activity was enhanced 1 h after treatment by Met, MetO and Met+MetO, however it was reduced in the same experimental groups 3 h after administration of amino acids. Caspase-3, caspase-9 and DNA damage was increased and cell viability was reduced by Met, MetO and Met+MetO at 3 h. Also, Met, MetO and Met+MetO, after 3 h, enhanced early and late apoptosis cells. Mitochondrial electrochemical potential was decreased by MetO and Met+MetO 1 h and 3 h after treatment. These findings help understand the mechanisms involved in neurotoxicity induced by hypermethioninemia.

journal_name

Metab Brain Dis

journal_title

Metabolic brain disease

authors

Soares MSP,Viau CM,Saffi J,Costa MZ,da Silva TM,Oliveira PS,Azambuja JH,Barschak AG,Braganhol E,S Wyse AT,Spanevello RM,Stefanello FM

doi

10.1007/s11011-017-0054-9

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

1693-1703

issue

5

eissn

0885-7490

issn

1573-7365

pii

10.1007/s11011-017-0054-9

journal_volume

32

pub_type

杂志文章

相关文献

METABOLIC BRAIN DISEASE文献大全
  • SB203580 reverses memory deficits and depression-like behavior induced by microinjection of Aβ1-42 into hippocampus of mice.

    abstract：:A high co-morbidity between Alzheimer's disease (AD) and depression suggests there might be similar mechanisms underlying the course of these diseases. Previous studies have shown that p38MAPK plays a critical role in the pathophysiology of AD and depression. However, little is known about whether SB203580, a selectiv...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-016-9880-4

    authors： Guo J,Chang L,Li C,Li M,Yan P,Guo Z,Wang C,Zha Q,Wang Q

    更新日期：2017-02-01 00:00:00

  • Association between polymorphisms of NOS1, NOS2 and NOS3 genes and suicide behavior: a systematic review and meta-analysis.

    abstract：:The enzyme nitric oxide synthase has been associated with suicide behavior. NOS1, NOS2 and NOS3 genes are implicated in the production of nitric oxide. However, the association between NOS genes and suicide behavior has not yet been established. To assess the association of Nitric Oxide Synthase (NOS) genes and suicid...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,meta分析

    doi：10.1007/s11011-019-00406-3

    authors： González-Castro TB,Genis-Mendoza AD,Tovilla-Zárate CA,Juárez-Rojop IE,López-Narvaez ML,Pérez-Hernández N,Rodríguez-Pérez JM,Martínez-Magaña JJ

    更新日期：2019-08-01 00:00:00

  • MicroRNA expression signature of methamphetamine use and addiction in the rat nucleus accumbens.

    abstract：:Methamphetamine (METH) is a highly addictive psycho-stimulant that induces behavioral changes due to high level of METH-induced dopamine in the brain. Nucleus accumbens (NAc) plays an important role in these changes, especially in drug addiction. However, little is known about the underlying molecular mechanisms of ME...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0061-x

    authors： Sim MS,Soga T,Pandy V,Wu YS,Parhar IS,Mohamed Z

    更新日期：2017-12-01 00:00:00

  • Correction to: Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system.

    abstract：:The original article contains mistake. The authors want to add Wenhui Pei as first co-author and Fang Fang as co-corresponding author. ...

    journal_title：Metabolic brain disease

    pub_type： 已发布勘误

    doi：10.1007/s11011-020-00612-4

    authors： Sun Y,Pei W,Zhang N,Qu Y,Cao Y,Li J,Yang Y,Yang T,Fang F,Sun Y

    更新日期：2020-12-01 00:00:00

  • Atorvastatin ameliorates cognitive impairment, Aβ1-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice.

    abstract：:Amyloid-beta (Aβ) interacts with the serine/threonine protein kinase AKT (also known as protein kinase B)/glycogen synthase kinase 3β (GSK3β) pathway and deactivates GSK3β signaling, which result in microtubule protein tau phosphorylation. Atorvastatin, a HMG-CoA reductase inhibitor, has been proven to improve learnin...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-016-9803-4

    authors： Zhou D,Liu H,Li C,Wang F,Shi Y,Liu L,Zhao X,Liu A,Zhang J,Wang C,Chen Z

    更新日期：2016-06-01 00:00:00

  • Cerebral blood flow in hyperammonemia: heterogeneity and starling forces in capillaries.

    abstract：:In the brain hyperammonemia interferes with ion homeostasis, membrane potentials, neurotransmission, and neurotransmitter recycling and reduces metabolic rates for oxygen and glucose. Because, cerebral blood flow (CBF) is closely coupled to metabolism, CBF is most often reduced in diseases associated with hyperammonem...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,评审

    doi：10.1023/a:1021941414605

    authors： Larsen FS

    更新日期：2002-12-01 00:00:00

  • EGb761 improves the cognitive function of elderly db/db-/- diabetic mice by regulating the beclin-1 and NF-κB signaling pathways.

    abstract：:To assess whether EGb761 could protect elderly diabetic mice with cognitive disorders and explore the role of beclin-1-mediated autophagy in these protective effects. Two-month-old male db/db-/- mice and wild-type C57/BL6 mice were randomly divided into six groups: db/db-/- control, db/db-/- 50 mg, db/db-/- 100 mg, wi...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-018-0295-2

    authors： Guan ZF,Zhang XM,Tao YH,Zhang Y,Huang YY,Chen G,Tang WJ,Ji G,Guo QL,Liu M,Zhang Q,Wang NN,Yu ZY,Hao-Yang,Wu GF,Tang ZP,Du ZG,Shang XL,Liu YC,Mei GH,Guo JC,Zhou HG

    更新日期：2018-12-01 00:00:00

  • Resting-state functional magnetic resonance imaging in hepatic encephalopathy: current status and perspectives.

    abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which develops in patients with severe liver diseases and/or portal-systemic shunting. Minimal HE, the earliest manifestation of HE, has drawn increasing attention in the last decade. Minimal HE is associated with a series of brain functional changes, such as ...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,评审

    doi：10.1007/s11011-014-9504-9

    authors： Zhang LJ,Wu S,Ren J,Lu GM

    更新日期：2014-09-01 00:00:00

  • Modulation of crucial adenosinetriphosphatase activities due to U-74389G administration in a porcine model of intracerebral hemorrhage.

    abstract：:Spontaneous intracerebral hemorrhage (ICH) represents a partially-understood cerebrovascular disease of high incidence, morbidity and mortality. We, herein, report the findings of our study concerning the role of two important adenosinetriphosphatases (ATPases) in a porcine model of spontaneous ICH that we have recent...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-013-9380-8

    authors： Bimpis A,Papalois A,Tsakiris S,Kalafatakis K,Zarros A,Gkanti V,Skandali N,Al-Humadi H,Kouzelis C,Liapi C

    更新日期：2013-09-01 00:00:00

  • Acquired hepatocerebral degeneration (AHD): a peculiar neurological impairment in advanced chronic liver disease.

    abstract：:We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyr...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0107-0

    authors： Pigoni A,Iuculano F,Saetti C,Airaghi L,Burdick L,Spreafico S,Curioni M,Lombardi R,Valenti L,Fracanzani AL,Fargion S

    更新日期：2018-02-01 00:00:00

  • Vanillic acid attenuates cerebral hyperemia, blood-brain barrier disruption and anxiety-like behaviors in rats following transient bilateral common carotid occlusion and reperfusion.

    abstract：:Transient bilateral common carotid artery occlusion (tBCCAO), followed by reperfusion, is a model of transient global hypoperfusion. In the present study we aimed to investigate the probable effects of Vanillic acid (VA) on some physiological parameters including cerebral hyperemia, blood-brain barrier (BBB) disruptio...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-018-0187-5

    authors： Khoshnam SE,Farbood Y,Fathi Moghaddam H,Sarkaki A,Badavi M,Khorsandi L

    更新日期：2018-06-01 00:00:00

  • Long term exposure to cell phone frequencies (900 and 1800 MHz) induces apoptosis, mitochondrial oxidative stress and TRPV1 channel activation in the hippocampus and dorsal root ganglion of rats.

    abstract：:Mobile phone providers use electromagnetic radiation (EMR) with frequencies ranging from 900 to 1800 MHz. The increasing use of mobile phones has been accompanied by several potentially pathological consequences, such as neurological diseases related to hippocampal (HIPPON) and dorsal root ganglion neuron (DRGN). The ...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0180-4

    authors： Ertilav K,Uslusoy F,Ataizi S,Nazıroğlu M

    更新日期：2018-06-01 00:00:00

  • Metabolic changes in axotomized fetal and early postnatal hamster facial motoneurons: an autoradiographic study.

    abstract：:The developing facial neurons of a series of hamsters ranging in age from the 14-day fetus to the 9 day postnatal were axotomized. Postoperative times were graded for each age so that the retrograde response could be observed before any significant amount of cell degeneration or death occurred. The incorporation of tr...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/BF00996894

    authors： Clark P,Jones KJ,LaVelle A

    更新日期：1993-06-01 00:00:00

  • Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway.

    abstract：:The impaired insulin signaling has been recognized as a common pathogenetic mechanism between diabetes and Alzheimer's disease (AD). In the progression of AD, brain is characterized by defective insulin receptor substrate-1 (IRS-1) and increased oxidative stress. Thymol, a monoterpene phenol isolated from medicinal he...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-016-9921-z

    authors： FangFang,Li H,Qin T,Li M,Ma S

    更新日期：2017-04-01 00:00:00

  • Effects of 1,4-butanediol administration on oxidative stress in rat brain: study of the neurotoxicity of gamma-hydroxybutyric acid in vivo.

    abstract：:gamma-Hydroxybutyric acid (GHB) is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased in the neurometabolic-inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity or due to intoxication. SSADH deficiency is biochemically characterize...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-009-9136-7

    authors： Sgaravatti AM,Magnusson AS,Oliveira AS,Mescka CP,Zanin F,Sgarbi MB,Pederzolli CD,Wyse AT,Wannmacher CM,Wajner M,Dutra-Filho CS

    更新日期：2009-06-01 00:00:00

  • Microglia.

    abstract：:Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,评审

    doi：10.1023/b:mebr.0000043984.73063.d8

    authors： van Rossum D,Hanisch UK

    更新日期：2004-12-01 00:00:00

  • Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice.

    abstract：:Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolesc...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0140-z

    authors： Wu H,Liu Q,Kalavagunta PK,Huang Q,Lv W,An X,Chen H,Wang T,Heriniaina RM,Qiao T,Shang J

    更新日期：2018-02-01 00:00:00

  • Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles.

    abstract：:Cadmium (Cd) exposure leads to production of reactive oxygen species (ROS), which are associated with Cd-induced neurotoxicity and nephrotoxicity. Selenium nanoparticles (Se-NPs) have high bioavailability and antioxidant activities so it attracted wide spread attention. The present study examined the possible ameliora...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0053-x

    authors： Sadek KM,Lebda MA,Abouzed TK,Nasr SM,Shoukry M

    更新日期：2017-10-01 00:00:00

  • Evidence of hippocampal astrogliosis and antioxidant imbalance after L-tyrosine chronic administration in rats.

    abstract：:Tyrosinemia type II is a genetic disorder characterized by elevated blood levels of the amino acid tyrosine caused by the deficiency of tyrosine aminotransferase enzyme, resulting in neurologic and developmental difficulties in the patients. Although neurological sequelae are common in Tyrosinemia type II patients, th...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-019-00511-3

    authors： Carvalho-Silva M,Gomes LM,de Prá SD,Wessler LB,Schuck PF,Scaini G,de Bem AF,Blum-Silva CH,Reginatto FH,de Oliveira J,Streck EL

    更新日期：2020-01-01 00:00:00

  • A comparative study of the effects of cholesterol, beta-sitosterol, beta-sitosterol glucoside, dehydroepiandrosterone sulphate and melatonin on in vitro lipid peroxidation.

    abstract：:The free radical scavenging abilities of the structurally related steroids beta-sitosterol, beta-sitosterol glucoside (plant sterols and sterolins), cholesterol, and dehydroepiandrosterone sulphate (DHEAS) were compared with melatonin (an efficient free radical scavenger) in an in vitro system which measures lipid per...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1023/a:1011167023695

    authors： van Rensburg SJ,Daniels WM,van Zyl JM,Taljaard JJ

    更新日期：2000-12-01 00:00:00

  • Improvement of memory and neurological deficit with Ocimum basilicum L. extract after ischemia reperfusion induced cerebral injury in mice.

    abstract：:Oxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention. Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory ha...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-018-0215-5

    authors： Singh V,Krishan P,Shri R

    更新日期：2018-08-01 00:00:00

  • Indian Ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in experimental model of stroke.

    abstract：:Stroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential of Indian Ginseng, also known as Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimenta...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-018-0234-2

    authors： Sood A,Mehrotra A,Dhawan DK,Sandhir R

    更新日期：2018-08-01 00:00:00

  • Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia.

    abstract：:Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with severe liver disease. Although the molecular basis for the neurological disorder in HE remains elusive, elevated ammonia and its chief metabolite glutamine are believed to be important factors responsible for altered cerebral...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,评审

    doi：10.1023/a:1011666612822

    authors： Rao KV,Norenberg MD

    更新日期：2001-06-01 00:00:00

  • Dietary supplementation of undernourished rats with soy or safflower oil: effects on myelin polyunsaturated fatty acids.

    abstract：:Undernourished suckling rats were administered, by gastric intubation, either soy oil (which is rich in both linoleic and linolenic acids) or safflower oil (which is rich in linoleic acid but deficient in linolenic acid) to determine (1) if dietary supplementation would offset the hypomyelination characteristic of the...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/BF00999385

    authors： Divakaran P,Pavlina T,Johnson RC,Cotter R,Madsen D,Wiggins R

    更新日期：1986-06-01 00:00:00

  • Short term cadmium administration dose dependently elicits immediate biochemical, neurochemical and neurobehavioral dysfunction in male rats.

    abstract：:Cadmium is a toxic environmental and industrial pollutant. Cadmium toxicity has been reported to produce biochemical and behavioral dysfunction that may cause adverse effects on several organs including the central nervous system. The present study was designed to investigate the neurotoxic effects of Cadmium Chloride...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-014-9578-4

    authors： Haider S,Anis L,Batool Z,Sajid I,Naqvi F,Khaliq S,Ahmed S

    更新日期：2015-02-01 00:00:00

  • Erratum to: Treadmill exercise alters ecstasy- induced long- term potentiation disruption in the hippocampus of male rats.

    abstract：:In the original publication of the article, author name Masoumeh Asadbegi was incorrectly written as Masoumeh Asadbeigi. The authors regret the oversight. ...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s11011-017-0114-1

    authors： Sajadi A,Amiri I,Gharebaghi A,Komaki A,Asadbegi M,Shahidi S,Mehdizadeh M,Asl SS

    更新日期：2017-12-01 00:00:00

  • Acute and long-term effects of intracerebroventricular administration of α-ketoisocaproic acid on oxidative stress parameters and cognitive and noncognitive behaviors.

    abstract：:Maple Syrup Urine Disease (MSUD) is biochemically characterized by elevated levels of leucine, isoleucine and valine, as well as their corresponding transaminated branched-chain α-keto acids in tissue and biological fluids. Neurological symptoms and cerebral abnormalities, whose mechanisms are still unknown, are typic...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-017-0035-z

    authors： Taschetto L,Scaini G,Zapelini HG,Ramos ÂC,Strapazzon G,Andrade VM,Réus GZ,Michels M,Dal-Pizzol F,Quevedo J,Schuck PF,Ferreira GC,Streck EL

    更新日期：2017-10-01 00:00:00

  • Glucose loading precipitates acute encephalopathy in thiamin-deficient rats.

    abstract：:A rat model of glucose-precipitated Wernicke's encephalopathy (WE) has been developed in which glucose loading (10 g/kg, i.p.) of ataxic thiamin-deficient (TD) rats induced episodes of gross neurological dysfunction and sometimes death. The acute effects of a glucose load on the neurological state of thiamin-replete c...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1023/a:1020653312697

    authors： Zimitat C,Nixon PF

    更新日期：1999-03-01 00:00:00

  • The study of the full spectrum of variants leading to hyperphenylalaninemia have revealed 10 new variants in the PAH gene.

    abstract：:This study presents further research into the spectrum of variants in genes responsible for the development of phenylketonuria (PKU) and hyperphenylalaninemia (HPA) in patients in Russia. After a study of 25 frequent variants, 293 patients (327 chromosomes without detected variants) from among 1265 probands still had ...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/s11011-019-00461-w

    authors： Kuznetcova I,Gundorova P,Ryzhkova O,Polyakov A

    更新日期：2019-12-01 00:00:00

  • Cortical slow potential changes during convulsions induced by maximal electroshock or penicillin focus.

    abstract：:We have described the occurrence in freely moving gerbils of slow potential changes (SPC) in two different models of experimental epilepsy: 1) maximal electroshock and 2) bilateral epileptic foci induced by penicillin. SPC is considered a by-product of epileptiform activity in both models and correlates to the SPC whi...

    journal_title：Metabolic brain disease

    pub_type： 杂志文章

    doi：10.1007/BF01000149

    authors： de Azeredo FA,Perret ML

    更新日期：1992-06-01 00:00:00