Abstract：
:The effect of factors released from N2A neuroblastoma cells on the expression of myelin protein genes in glioma C6 cells, i.e., proteolipid protein (PLP) and myelin-associated glycoprotein (MAG), was studied. Both cells lines were propagated in serum-free DMEM-F10 (1:1) medium. The addition of 50% N2A conditioned medium (N2ACM) stimulated the proliferation of C6 cells by approximately 4.5 fold as compared to control cells. The N2ACM-treated cells formed aggregates indicating increased cell-cell affinity. The exposure of C6 cells to N2ACM transiently stimulated the expression of both the MAG-specific and the PLP-specific messages up to eight and four fold over the control values, respectively. The maximal upregulation of the PLP gene occurred two days after N2ACM administration and preceded that of the MAG gene by two days. The effect of N2ACM was dose-dependent in the range of 12.5 to 50%. The secretion of N2A paracrine factors that stimulated the myelin gene expression was also time-dependent. The optimal conditioning time for the release of the PLP gene-stimulating activity was one day, while the maximal MAG gene-stimulating activity was found in the medium conditioned for 3 days. This cellular system may provide a convenient model for studies on trophic neuronal-glial interaction. Furthermore, the results indicate a difference in the regulatory mechanisms between the PLP and the MAG genes.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Kanoh M,Wiggins RC,Konat Gdoi
10.1007/BF01000160subject
Has Abstractpub_date
1992-09-01 00:00:00pages
147-56issue
3eissn
0885-7490issn
1573-7365journal_volume
7pub_type
杂志文章abstract：:Overwhelming evidence suggests that microglia play an important role in ischemic injury and they polarize into two different phenotypes with distinct functions after ischemic stroke. We performed the present study to investigate whether L-3-n butylphthalide (NBP) has an effect on microglial polarization. Mice were sub...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0307-2
更新日期：2018-12-01 00:00:00
abstract：:We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyr...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0107-0
更新日期：2018-02-01 00:00:00
abstract：:The mitogen-activated protein kinase (MAP kinase) pathway participates in a number of reactions of the cell when responding to various external stimuli. These stimuli include growth factor binding to its receptor as well as stressful situations such as hypoxia and oxidative stress. It has been postulated that one of t...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1012541011123
更新日期：2001-12-01 00:00:00
abstract：:Today, due to technology development and aversive events of daily life, Human exposure to both radiofrequency and stress is unavoidable. This study investigated the co-exposure to repeated restraint stress and WiFi signal on cognitive function and oxidative stress in brain of male rats. Animals were divided into four ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0016-2
更新日期：2017-10-01 00:00:00
abstract：:Chronic liver disease (CLD) leads to a spectrum of neuropsychiatric disorders named hepatic encephalopathy (HE). Even though brain energy metabolism is believed to be altered in chronic HE, few studies have explored energy metabolism in CLD-induced HE, and their findings were inconsistent. The aim of this study was to...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9715-8
更新日期：2016-12-01 00:00:00
abstract：:In Alzheimer's disease (AD) basal forebrain cholinergic neurons appear to be targeted primarily in early stages of the disease. Scopolamine (muscarinic receptor antagonist) has been used for decades to induce working and reference memory impairment in rodents. In this study, we evaluated the protective effect of kolav...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9902-2
更新日期：2017-02-01 00:00:00
abstract：:The regional energy status and the availability of metabolic substrates during brain development are important, since a variety of fetal metabolic insults have been increasingly implicated in the evolution of neonatal brain disorders. The response of the brain to a metabolic insult is determined, in large part, by the...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1025503115837
更新日期：2003-09-01 00:00:00
abstract：:Sleep disturbances are prevalent among patients with Alzheimer's disease (AD) and often precede the onset and progression of dementia. However, there are no reliable animal models for investigating sleep disturbances in patients with sporadic AD (sAD), which accounts for more than 90% of all AD cases. In the present s...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0125-y
更新日期：2018-02-01 00:00:00
abstract：:We examined how serum cholesterol, an established risk factor for cerebrovascular disease (CVD), relates to cognitive function in healthy middle-older aged individuals with no neurologic or CVD history. A complete lipid panel was obtained from a cohort of one hundred twenty individuals, ages 43-85, who also underwent ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9797-y
更新日期：2016-04-01 00:00:00
abstract：:Today, neurological disorders such as epilepsy, depression, tardive dyskinesia, and stress, and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, dementia, and Huntington's disease affect millions of people all over the world. Existing pharmacological interventions do not meet the desired t...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-019-00400-9
更新日期：2019-08-01 00:00:00
abstract：:A structured analytic approach was developed to evaluate enzyme kinetic parameters using non-linear least-squares fitting. The approach was implemented in a software package called KinSim and designed to run on Windows 95, 98, and NT platforms. The software and the theoretical approach were tested using kinetic data o...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF02679980
更新日期：2000-06-01 00:00:00
abstract：:The present study aimed to investigate the role of vascular endothelial growth factor (VEGF) in the neuroprotective effect of Crocus sativus (saffron) against cerebral ischemia/reperfusion injury (I/R) in rats. Four groups of a total forty I/R rats with 60-min occlusion followed by 48 h reperfusion or sham surgery wer...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00505-1
更新日期：2020-03-01 00:00:00
abstract：:Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric disorders that share many genetic risk factors. This study aimed to investigate the association of phosphoinositide-3-kinase regulatory subunit1 (PIK3R1) gene rs3756668 and rs3730089 polymorphisms with SCZ and BD risks and determine the expression le...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-020-00552-z
更新日期：2020-06-01 00:00:00
abstract：:A study evaluating zinc supplementation in patients with Alzheimer's disease yielded variable zinc plasma levels in spite of positive cognitive and physiological results. In an attempt to raise and sustain plasma zinc levels, a single patient was given 15 mg zinc/day with various combinations of vitamins. A sustained ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-006-9023-4
更新日期：2006-09-01 00:00:00
abstract：:Hepatic encephalopathy (HE) represents a nervous system disorder caused due to liver dysfunction. HE is broadly classified as acute/overt and moderate-minimal HE. Since HE syndrome severely affects quality of life of the patients and it may be life threatening, it is important to develop effective therapeutic strategy...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9556-x
更新日期：2014-12-01 00:00:00
abstract：:Brain glucose uptake is usually reduced in type 2 diabetes owing to downregulation of brain glucose transporters. The ability of Vernonia amygdalina to stimulate glucose uptake as well as ameliorate glucose-induced oxidative stress and proinflammation were investigated in rat brain. Hot infusion of V. amygdalina leave...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0363-7
更新日期：2019-06-01 00:00:00
abstract：:Bilateral, symmetrical hyperintensity of the globus pallidus is observed in T1-weighted cerebral magnetic resonance images in from 52 to 100% of patients with chronic liver disease. No significant relationship exists between the presence of these cerebral changes in image signal intensity and the patients' neuropsychi...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1023/a:1020680624084
更新日期：1998-12-01 00:00:00
abstract：:To characterize an Egyptian patient with glutaric acidemia type I (GA I) and to identify the causative mutation(s) that may be responsible for the disease phenotype. MRI was performed on the patient using the 1.5 T magnet, biochemical analysis was carried out using gas chromatography/mass spectrometry on the patient's...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9879-x
更新日期：2017-02-01 00:00:00
abstract：:The associations between thyroid auto-immunity and neuro-psychiatric disorders are well-documented. However, there exists limited literature specifically linking auto-immune thyroid disease (AITD) to bipolar disorder (BD). Thus, we investigated the likely association between Hashimoto's disease and BD through the extr...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00437-w
更新日期：2019-10-01 00:00:00
abstract：:Hyperammonemia is necessary for development of the cerebral complications to liver disease including hepatic encephalopathy and cerebral edema but the mechanisms are unclear. Ammonia is taken up by the brain in proportion to its arterial concentration. The flux into the brain is most likely by both diffusion of NH3 an...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-014-9494-7
更新日期：2014-12-01 00:00:00
abstract：:This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0025-1
更新日期：2017-10-01 00:00:00
abstract：:We aimed to evaluate the effect of in vitro galactosaemia on acetylcholinesterase (AChE) activity in different suckling rat brain regions. Various concentrations of galactose (Gal), galactose-1-phosphate (Gal-1-P) and/or galactitol (Galtol) were preincubated for 1 h with homogenates from frontal cortex, hippocampus an...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-005-7210-3
更新日期：2005-09-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a multifactorial disorder caused by an interaction between environmental risk factors and a genetic background. It is characterized by impairment in communication, social interaction, repetitive behavior, and sensory processing. The etiology of ASD is still not fully understood, and t...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0206-6
更新日期：2018-08-01 00:00:00
abstract：:Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-α) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjec...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-012-9310-1
更新日期：2012-12-01 00:00:00
abstract：:In the brain hyperammonemia interferes with ion homeostasis, membrane potentials, neurotransmission, and neurotransmitter recycling and reduces metabolic rates for oxygen and glucose. Because, cerebral blood flow (CBF) is closely coupled to metabolism, CBF is most often reduced in diseases associated with hyperammonem...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1023/a:1021941414605
更新日期：2002-12-01 00:00:00
abstract：:Levels of high mobility group box 1 (HMGB1), an important inflammatory mediator, are high in the serum of febrile seizure (FS) patients. However, its roles in FS and secondary epilepsy after prolonged FS are poorly understood. We demonstrate HMGB1's role in the pathogenesis of hyperthermia-induced seizures (HS) and se...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0103-4
更新日期：2017-12-01 00:00:00
abstract：:Near infrared radiation (NIR) is known to penetrate and affect biological systems in multiple ways. Recently, a series of experimental studies suggested that low intensity NIR may protect neuronal cells against a wide range of insults that mimic diseases such as stroke, brain trauma and neurodegeneration. However, the...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9515-6
更新日期：2015-04-01 00:00:00
abstract：:Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9893-z
更新日期：2017-02-01 00:00:00
abstract：:Stress-induced activation of the expression of the endoplasmic reticulum (ER)-resident chaperon and member of the protein disulfide isomerase family erp72 was studied after transient cerebral ischemia in vivo using the four-vessel occlusion method and experimental depletion of ER calcium stores in primary neuronal cel...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1020631029168
更新日期：1998-03-01 00:00:00
abstract：:Betanin, a natural food colorant with powerful antioxidative properties, has not been studied in terms of neurodegenerative disease intervention. Therefore, the present study aimed to investigate the neuroprotective effects of betanin against trimethyltin chloride (TMT) -induced neurodegeneration in mice. Forty male I...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-020-00615-1
更新日期：2020-12-01 00:00:00
