Effects of repeated restraint stress and WiFi signal exposure on behavior and oxidative stress in rats.

abstract：:The lifetime prevalence rate for major depressive disorder (MDD) is approximately 17 % for most developed countries around the world. Dietary polyphenols are currently used as an adjuvant therapy to accelerate the therapeutic efficacy on depression. Ferulic acid (FA) or 4-hydroxy-3-methoxy-cinnamic acid (Fig. 1a) is a...

journal_title：Metabolic brain disease

authors： Li G,Ruan L,Chen R,Wang R,Xie X,Zhang M,Chen L,Yan Q,Reed M,Chen J,Xu Y,Pan J,Huang W

更新日期：2015-12-01 00:00:00

abstract：:The free radical scavenging abilities of the structurally related steroids beta-sitosterol, beta-sitosterol glucoside (plant sterols and sterolins), cholesterol, and dehydroepiandrosterone sulphate (DHEAS) were compared with melatonin (an efficient free radical scavenger) in an in vitro system which measures lipid per...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,Daniels WM,van Zyl JM,Taljaard JJ

更新日期：2000-12-01 00:00:00

abstract：:Hepatic encephalopathy is a common complication of hepatic cirrhosis. The clinical diagnosis is based on two concurrent types of symptoms: impaired mental status and impaired neuromotor function. Impaired mental status is characterized by deterioration in mental status with psychomotor dysfunction, impaired memory, an...

journal_title：Metabolic brain disease

authors： Malaguarnera M

更新日期：2013-06-01 00:00:00

abstract：:As feared and deadly human diseases globally, Rabies virus contrived mechanisms to escape early immune recognition via suppression of the interferon response. This study, preliminarily investigated whether Rabies virus employs epigenetic mechanism for the suppression of the interferon using the Challenge virus standar...

journal_title：Metabolic brain disease

authors： Abdulazeez M,Kia GSN,Abarshi MM,Muhammad A,Ojedapo CE,Atawodi JC,Dantong D,Kwaga JKP

更新日期：2020-06-01 00:00:00

abstract：:Effects of sertraline, haloperidol or olanzapine administration on ketamine-induced behaviours in mice were examined. The aim was to ascertain the degree of reversal of such behaviours by sertraline, and compare its effectiveness to haloperidol and olanzapine. Ten-week old mice (N = 120) were equally divided into main...

journal_title：Metabolic brain disease

authors： Onaolapo OJ,Paul TB,Onaolapo AY

更新日期：2017-10-01 00:00:00

abstract：:Semi-chronic exposure of ICR male Mice to Aflatoxin B1 (AFB1) in non-toxic doses decreased brain serotonin (5-hydroxytryptamine, 5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA) and catecholamines without altering tryptophan (TRP) or tyrosine (TYR) levels. A TRP load (300 mg/kg, i.p. x 2 hours) slightly increased brain T...

journal_title：Metabolic brain disease

authors： Kimbrough TD,Llewellyn GC,Weekley LB

更新日期：1992-12-01 00:00:00

abstract：:The availability of an animal model is crucial in studying the pathophysiological mechanisms of disease and to test possible therapies. Now, there are several models for the study of liver diseases, but there still remains a lack of a satisfactory animal model of chronic liver disease with hepatic encephalopathy (HE) ...

journal_title：Metabolic brain disease

authors： Jover R,Madaria E,Felipo V,Rodrigo R,Candela A,Compañ A

更新日期：2005-12-01 00:00:00

abstract：:The regional energy status and the availability of metabolic substrates during brain development are important, since a variety of fetal metabolic insults have been increasingly implicated in the evolution of neonatal brain disorders. The response of the brain to a metabolic insult is determined, in large part, by the...

journal_title：Metabolic brain disease

authors： Lust WD,Pundik S,Zechel J,Zhou Y,Buczek M,Selman WR

更新日期：2003-09-01 00:00:00

abstract：:Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism ...

journal_title：Metabolic brain disease

authors： Yan X,Lukas J,Witt M,Wree A,Hübner R,Frech M,Köhling R,Rolfs A,Luo J

更新日期：2011-12-01 00:00:00

abstract：:Chronic neuroinflammation is strongly associated with AD and altered peripheral and central levels of chemokines and cytokines have been frequently described in those with AD. Given the increasing evidence of ethnicity-related differences in AD, it was of interest to determine if those altered chemokine and cytokine l...

journal_title：Metabolic brain disease

authors： Ferguson SA,Varma V,Sloper D,Panos JJ,Sarkar S

更新日期：2020-01-01 00:00:00

abstract：:Homocystinuria is an inborn error of sulfur amino acid metabolism characterized predominantly by vascular and nervous system dysfunction. In this study we determined the in vitro effects of homocysteine and methionine, metabolites which accumulate in homocystinuria, on Na+, K+-ATPase, and Mg2+-ATPase activities in syn...

journal_title：Metabolic brain disease

authors： Streck EL,Zugno AI,Tagliari B,Wannmacher C,Wajner M,Wyse AT

更新日期：2002-06-01 00:00:00

abstract：:Increased benzodiazepine (BZ) receptor density has been reported in brains of rabbits with hepatic encephalopathy (HE) due to galactosamine (GalN)-induced fulminant hepatic failure (FHF). These data were generated using detergent-Triton X-100-treated neural membranes. While performing further studies it was noted that...

journal_title：Metabolic brain disease

authors： Rössle M,Mullen KD,Jones EA

更新日期：1989-09-01 00:00:00

abstract：:Mitochondrial glutathione (mGSH) is a critical factor in the cell defense against oxidative and nitrosative stress (ONS), and ONS is a key pathogenic event in hepatic encephalopathy (HE). Acute HE in the thioacetamide (TAA) model caused a 54 % decrease of mGSH content in the rat prefrontal cortex (pfc), but not in the...

journal_title：Metabolic brain disease

authors： Ruszkiewicz J,Fręśko I,Hilgier W,Albrecht J

更新日期：2013-03-01 00:00:00

abstract：:A high co-morbidity between Alzheimer's disease (AD) and depression suggests there might be similar mechanisms underlying the course of these diseases. Previous studies have shown that p38MAPK plays a critical role in the pathophysiology of AD and depression. However, little is known about whether SB203580, a selectiv...

journal_title：Metabolic brain disease

authors： Guo J,Chang L,Li C,Li M,Yan P,Guo Z,Wang C,Zha Q,Wang Q

更新日期：2017-02-01 00:00:00

abstract：:Statins or HMG-CoA reductase inhibitors have been shown to be effective at lowering cholesterol levels, and the application of these molecules has gradually emerged as an attractive therapeutic strategy for neurodegenerative diseases. Epidemiological studies suggest that statin use is associated with a decreased incid...

journal_title：Metabolic brain disease

authors： Kornelius E,Li HH,Peng CH,Hsiao HW,Yang YS,Huang CN,Lin CL

更新日期：2017-12-01 00:00:00

abstract：:First-episode psychosis (FEP) patients are more sensitive to neuroleptic side-effects such as hyperprolactinemia. We examined the prolactin levels of previously minimally treated patients with first episode schizophrenia over their first year of treatment with flupenthixol decanoate and the relationship between prolac...

journal_title：Metabolic brain disease

authors： Retief M,Chiliza B,Phahladira L,Emsley R,Asmal L

更新日期：2019-12-01 00:00:00

abstract：:Tyrosinemia type II is an inborn error of metabolism caused by a deficiency in hepatic cytosolic aminotransferase. Affected patients usually present a variable degree of mental retardation, which may be related to the level of plasma tyrosine. In the present study we evaluated effect of chronic administration of L-tyr...

journal_title：Metabolic brain disease

authors： Ferreira GK,Carvalho-Silva M,Gomes LM,Scaini G,Teixeira LJ,Mota IT,Schuck PF,Ferreira GC,Streck EL

更新日期：2015-02-01 00:00:00

abstract：:Glutamate neurotoxicity was studied in primary neuronal cultures prepared from rat cerebral cortex and hippocampal CA1 sector. Neurons were cultivated with 5% native horse serum and then exposed to 0.1 or 1.0 mM glutamate for 5 min. Subsequently, neurons were allowed to recover for 24 hours either in the presence or i...

journal_title：Metabolic brain disease

authors： Uto A,Dux E,Hossmann KA

更新日期：1994-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by accumulation and deposition of Aβ peptide in human brain. The present study aimed to determine the protective effect of catechin rich extract of MERM (methanolic extract of Rhizophora mucronata) on Aβ (25-35) induced cognitive impai...

journal_title：Metabolic brain disease

authors： Suganthy N,Malar DS,Devi KP

更新日期：2016-08-01 00:00:00

abstract：:Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...

journal_title：Metabolic brain disease

authors： Maes M

更新日期：2012-12-01 00:00:00

abstract：:Several epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia. Besides, some authors suggested that poor glucose control to be associated with worse cognitive function. We aimed to assess cognitive functions and IR-degree over time in diabetic. We also...

journal_title：Metabolic brain disease

authors： Fava A,Colica C,Plastino M,Messina D,Cristiano D,Opipari C,Vaccaro A,Gorgone G,Bosco F,Fratto A,De Bartolo M,Bosco D

更新日期：2017-06-01 00:00:00

abstract：:Tyrosinemia type II is a genetic disorder characterized by elevated blood levels of the amino acid tyrosine caused by the deficiency of tyrosine aminotransferase enzyme, resulting in neurologic and developmental difficulties in the patients. Although neurological sequelae are common in Tyrosinemia type II patients, th...

journal_title：Metabolic brain disease

authors： Carvalho-Silva M,Gomes LM,de Prá SD,Wessler LB,Schuck PF,Scaini G,de Bem AF,Blum-Silva CH,Reginatto FH,de Oliveira J,Streck EL

更新日期：2020-01-01 00:00:00

abstract：:The present experiments were conducted to investigate the direct effects of ethanol on the energy metabolism of astrocytes and C6-glioma cells. Primary astrocytes were prepared from cerebral cortices of neonatal rats, and C6-glioma cells were purchased from American Type Culture Collection (ATCC). These cells were exp...

journal_title：Metabolic brain disease

authors： Haghighat N,McCandless DW,Geraminejad P

更新日期：1999-09-01 00:00:00

abstract：:Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neu...

journal_title：Metabolic brain disease

authors： Zugno AI,Julião RF,Budni J,Volpato AM,Fraga DB,Pacheco FD,Deroza PF,Luca RD,de Oliveira MB,Heylmann AS,Quevedo J

更新日期：2013-09-01 00:00:00

abstract：:Thiamine triphosphate (ThTP) was discovered over 60 years ago and it was long thought to be a specifically neuroactive compound. Its presence in most cell types, from bacteria to mammals, would suggest a more general role but this remains undefined. In contrast to thiamine diphosphate (ThDP), ThTP is not a coenzyme. I...

journal_title：Metabolic brain disease

authors： Bettendorff L,Lakaye B,Kohn G,Wins P

更新日期：2014-12-01 00:00:00

abstract：:Homocystinuria is a metabolic disorder caused by deficiency of cystathione beta-synthase activity leading to tissue accumulation of homocysteine (Hcy); affected patients present neurological dysfunction. Considering that Hcy induces free radical formation and that memory is impaired by oxidative stress, in the present...

journal_title：Metabolic brain disease

authors： Reis EA,Zugno AI,Franzon R,Tagliari B,Matté C,Lammers ML,Netto CA,Wyse AT

更新日期：2002-09-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a variety of symptoms of different severity such as cognitive deficits and impaired motor functions. Currently, HE is seen as a consequence of a low grade cerebral oedema assoc...

journal_title：Metabolic brain disease

authors： Baker L,Lanz B,Andreola F,Ampuero J,Wijeyesekera A,Holmes E,Deutz N

更新日期：2016-12-01 00:00:00

abstract：:The combination of Parkinson syndrome (PS) and prolonged visually evoked potentials (VEPs) in a single patient with hepatic encephalopathy (HE) has not been reported. A 52-year-old male with chronic HE developed PS in early 2001. Treatment with L-DOPA was only of minimal effect. In August 2001 he was admitted because ...

journal_title：Metabolic brain disease

authors： Finsterer J,Bernauer E

更新日期：2005-03-01 00:00:00

abstract：:A study evaluating zinc supplementation in patients with Alzheimer's disease yielded variable zinc plasma levels in spite of positive cognitive and physiological results. In an attempt to raise and sustain plasma zinc levels, a single patient was given 15 mg zinc/day with various combinations of vitamins. A sustained ...

journal_title：Metabolic brain disease

authors： Potocnik FC,van Rensburg SJ,Hon D,Emsley RA,Moodie IM,Erasmus RT

更新日期：2006-09-01 00:00:00

abstract：:Maternal separation in non-human primates has been proposed as a model of early adversity. The symptoms of separation anxiety were studied in vervet monkeys, during the weaning period, when psychotropic medications were administered. The control group received a normal diet and treatment groups received citalopram, re...

journal_title：Metabolic brain disease

authors： Marais L,Daniels W,Brand L,Viljoen F,Hugo C,Stein DJ

更新日期：2006-09-01 00:00:00