Successful treatment of rituximab- and steroid-resistant nephrotic syndrome with leukocytapheresis.

Abstract:

:Although rituximab (RTX) is a promising therapeutic agent for treating steroid-resistant nephrotic syndrome (SRNS) resistant to various immunosuppressive agents, some patients have shown resistance to RTX. We report the case of a patient with RTX-resistant nephrotic syndrome and SRNS who was successfully treated with leukocytapheresis (LCAP). After LCAP, there was a significant reduction in proteinuria and in the total number of lymphocytes, T cells, and HLA-DR+- activated T cells. Moreover, the patient became sensitive to steroids and RTX. LCAP reduced circulating immune cells including activated T cells and could be effective in treating rituximab-resistant nephrotic syndrome and SRNS and in achieving remission of proteinuria.

journal_name

J Clin Apher

authors

Takakura M,Shimizu M,Mizuta M,Inoue N,Tasaki Y,Ohta K,Furuichi K,Wada T,Yachie A

doi

10.1002/jca.21613

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

409-411

issue

3

eissn

0733-2459

issn

1098-1101

journal_volume

33

pub_type

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