Abstract:
:Mobilized stem cells in the peripheral blood (PB) must be efficiently harvested at the appropriate time before autologous PB stem cell (PBSC) transplantation. Enumeration of CD34+ cells in the PB before apheresis predicts the number of PBSCs that can be collected, but the cytometric techniques used are complex and expensive. Therefore, it is necessary to identify an alternative to the CD34+ cell count in PBSC harvest-time monitoring. Fully automated flow cytometry using blood cell counters now allows reliable quantification of immature myeloid cells in the PB, referred to as hematopoietic progenitor cells (HPC), and reticulated platelets, expressed as the immature platelet fraction (IPF). Immature or reticulated platelets are thought to correlate with thrombopoietic activity of the marrow. Following a chemotherapy nadir, the recovery of white blood cell and platelet counts has been used to determine the right time for apheresis. Therefore, we examined whether the HPC count and IPF value could be used to predict PBSC mobilization in 20 patients with hematological malignancies. The HPC count was found to be correlated with the CD34+ cell count (r = 0.84, P < 0.01), whereas the IPF value was not (r = 0.37, P = 0.44). Therefore, the HPC count, but not the IPF value, is a possible predictor of the timing of autologous stem cell transplantation.
journal_name
J Clin Apherjournal_title
Journal of clinical apheresisauthors
Mitani N,Yujiri T,Tanaka Y,Tanaka M,Fujii Y,Hinoda Y,Tanizawa Ydoi
10.1002/jca.20275subject
Has Abstractpub_date
2011-01-01 00:00:00pages
105-10issue
3eissn
0733-2459issn
1098-1101journal_volume
26pub_type
杂志文章abstract::The removal of immune complexes, autoantibodies and suppressor factors from the circulation of patients with AIDS and AIDS related conditions by plasmapheresis and selective immunoadsorption may play a role as a therapeutic modality in these disorders. Lymphocytapheresis may also be of potential use in AIDS related co...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.2920020436
更新日期:1985-01-01 00:00:00
abstract::To compare donor demographics and motivations for donation, we surveyed 159 consecutive whole blood donors (WD) and 146 consecutive plateletpheresis donors. All donors had donation experiences of at least 2 gallons (i.e., 16 previous donations). Evaluation of answers to fixed-response and open-ended questions revealed...
journal_title:Journal of clinical apheresis
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doi:10.1002/jca.2920080206
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abstract::Two patients suffering from allergic bronchial asthma who showed no improvement despite six and four weeks, respectively, of drug therapy were successfully treated with therapeutic plasma exchange. The first patient had no attacks over a period of five months, and the other patient had none for over one year. Although...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.2920020210
更新日期:1984-01-01 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21214
更新日期:2012-01-01 00:00:00
abstract::The issues of providing quality blood products and maintaining donor safety are primary aims of blood transfusion services. A comprehensive quality system should be in place to fulfill these aims, which can be attained through strict adherence to the established standard operating procedures (SOPs). The Drugs and Cosm...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20056
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Hyperleukocytosis is commonly seen in acute and chronic leukemias. Therapeutic leukocytapheresis using an automatic cell separator can help to achieve prompt leukoreduction to reduce the rate of thrombotic events and early mortality as well as to prevent tumor lysis syndrome. AIM:In this study, we report a ...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21766
更新日期:2020-04-01 00:00:00
abstract::The purpose of this study is to determine whether immunoadsorption treatment using a dextran sulfate (DS) column can remove high-avidity anti-double-stranded DNA (anti-dsDNA) antibody from the blood of patients with systemic lupus erythematosus (SLE). Before and after each immunoadsorption therapy routine, titers of t...
journal_title:Journal of clinical apheresis
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更新日期:1996-01-01 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/(sici)1098-1101(1997)12:1<14::aid-jca4>3.0
更新日期:1997-01-01 00:00:00
abstract::Blood group incompatibility remains a significant barrier to kidney transplantation. Approximately, one-third of donors are blood group incompatible with their intended recipient. Options for these donor-recipient pairs include blood group incompatible transplantation or kidney paired donation. However, the optimal pr...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20119
更新日期:2007-01-01 00:00:00
abstract::We sought to optimize direct intravenous infusion of calcium gluconate (CaGlu) for maintaining plasma ionized calcium concentration ([Ca2+ ]) and preventing hypocalcemic reactions during 34 consecutive 1-volume therapeutic plasma exchanges (TPEs) in eight patients. CaGlu, 2 g in 50 mL of 0.9% NaCl, was prepared by our...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21742
更新日期:2019-12-01 00:00:00
abstract::Graphite furnace atomic absorption spectroscopy was used to demonstrate a fivefold increase in the median plasma aluminium levels of four patients undergoing therapeutic plasmapheresis. This plasma aluminium loading resulted from contamination of albumin incorporated in the replacement fluids and took place during its...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.2920030306
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Securing adequate vascular access is essential for a successful apheresis procedure. In most, peripheral access is preferred but it is not always technically possible. Ultrasound-Guided Peripheral Vascular Access (USG-PIVA) is a well-documented technique in the setting of Emergency departments. However, limi...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21440
更新日期:2016-12-01 00:00:00
abstract::The blood flow property is one of the factors determining blood perfusion and oxygen supply. The viscosity of the blood is primarily related to the hematocrit, but also to the amount of fibrinogen and other macromolecules present in the blood. Patients with ischemic heart disease have shown a rapid and safe improvemen...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/(sici)1098-1101(1997)12:4<183::aid-jca5>3.
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:Algorithms have been developed to predict the platelet yield after apheresis from the donor's data, as well as the effect on the blood cell count, to extract an acceptable platelet number without affecting the donor. However, the evaluation of these algorithms has not been widely reported. This study aimed...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21846
更新日期:2020-10-05 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.10043
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Patients undergoing therapeutic plasma exchange (TPE) may present with risks for hemorrhage or thrombosis. Use of replacement fluids devoid of coagulation factors will decrease factor levels and platelet levels. There are no established guidelines for hemostasis management in these situations. MATERIALS AND...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21653
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Hereditary thrombotic thrombocytopenic purpura, also called Upshaw-Schulman syndrome (USS), is a rare disease caused by genetic mutations in the ADAMTS13 gene, which severely decrease the activity of ADAMTS13, a metalloprotease that cleaves von Willebrand factor multimers (VWF). Genotypically identical patie...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21664
更新日期:2019-02-01 00:00:00
abstract::Excess free iodide in the blood (ingested or injected) may cause thyrotoxicosis in patients at risk. Iodinated contrast solutions contain small amounts of free iodide and may be of significance for patients affected by Graves' disease, multinodular goiter or living in areas of iodine deficiency. Herein, we report a 57...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20161
更新日期:2008-01-01 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.2920050304
更新日期:1990-01-01 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章,多中心研究
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更新日期:2016-02-01 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20202
更新日期:2009-01-01 00:00:00
abstract::Leukemic-dendritic cells (leukemic-DCs) have certain limitations, which include difficult generation in 30-40% of patients, and low levels of expression of several key molecules. Therefore, an alternative approach using monocyte-derived DCs pulsed with tumor antigens is required. We investigated the possibility of imm...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20085
更新日期:2006-10-01 00:00:00
abstract::Either bone marrow or peripheral blood may be harvested to provide hematopoietic stem cells (HSC) for autologous transplantation. Both, however, comprise heterogeneous cell populations. The HSC necessary for successful engraftment constitute a very small fraction of the cells harvested. After collection, the harvested...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章,评审
doi:10.1002/jca.2920070307
更新日期:1992-01-01 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.2920090307
更新日期:1994-01-01 00:00:00
abstract::Bone marrow (BM) damage after previous chemotherapy, such as that involving alkylating agents, and radiation therapy alone cannot explain poor hematopoietic progenitor cell mobilization. We examined the T lymphocytes of BM in 67 autologous peripheral blood stem cell transplant (auto-PBSCT) patients with non-Hodgkin ly...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
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更新日期:2020-07-28 00:00:00
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journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20138
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target m...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21655
更新日期:2018-10-01 00:00:00
abstract::The infusion of high-dose (275 mg/kg body weight) immune globulin intravenous (IGIV) after 466 plasma exchanges in 64 patients with autoimmune disease was studied. Side effects occurred during 15% of IGIV infusions. For the most part they were transient and mild, and could be controlled by slowing the infusion rate. T...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.2920010207
更新日期:1983-01-01 00:00:00