Abstract：
:Thrombotic thrombocytopenic purpura (TTP) is a condition caused by deficiency of ADAMTS13 resulting in accumulation of ultra large Von Willebrand factor multimers (ULVWF), leading to micro thrombi in multiple organs. The varying susceptibilities of blood group antigens to ADAMTS13 have been demonstrated. A and B antigens are protective of VWF; and VWF purified from blood group O individuals has been shown to be cleaved faster by ADAMTS13 compared to VWF from blood group AB individuals. We proposed that there may be a difference in the incidence of blood groups in TTP patients compared with the general population. We felt this to be important for a life-threatening disease with poorly understood epidemiology. We report a retrospective analysis of 74 patients presenting from 1993 to 2008 with idiopathic TTP. We studied the incidence across various blood groups and also estimated the recurrence and mortality in each group. The incidence of various blood groups were as follows: O 36%, A 36%, B 25%, and AB 2%, compared with expected frequencies in the Detroit area: O 44%, A 33% B 20%, and AB 3%. There was a trend of lower than expected frequency of blood group O. There were 24 recurrences and 14 deaths, uniform across blood groups. We hypothesized that there may be an association between blood groups and the risk of TTP; however the differences in our study were not statistically significant. Recurrence and disease specific mortality did not appear to be impacted by blood group.
journal_name
J Clin Apherjournal_title
Journal of clinical apheresisauthors
Zuberi L,Yerasuri D,Kuriakose Pdoi
10.1002/jca.20202subject
Has Abstractpub_date
2009-01-01 00:00:00pages
131-3issue
4eissn
0733-2459issn
1098-1101journal_volume
24pub_type
杂志文章abstract：BACKGROUND:There are several regimens used in hematopoietic stem cell (HSC) mobilization in multiple myeloma (MM). Cyclophosphamide (Cy) is one of the most commonly used agents, although it does not always result in collecting adequate number of CD34+ cells. Recently, cytarabine (Ara-C) has been proposed as potentially...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21784
更新日期：2020-08-01 00:00:00
abstract：:The Oklahoma TTP-HUS Registry provides a complete community perspective of thrombotic thrombocytopenic purpura (TTP). This is possible because plasma exchange is the essential treatment for TTP and the Oklahoma Blood Institute provides all plasma exchange procedures for a region encompassing most of the State, includi...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20169
更新日期：2008-01-01 00:00:00
abstract：:Since the introduction of hematopoietic growth factors, the collection of mobilized stem cells via leukapheresis has widely replaced the harvest of bone marrow in both autologous and allogeneic transplantation settings. We investigated the frequency and the extent of anticoagulant-induced electrolyte changes and the c...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/1098-1101(2000)15:4<230::aid-jca3>3.0.co;2
更新日期：2000-01-01 00:00:00
abstract：:Graphite furnace atomic absorption spectroscopy was used to demonstrate a fivefold increase in the median plasma aluminium levels of four patients undergoing therapeutic plasmapheresis. This plasma aluminium loading resulted from contamination of albumin incorporated in the replacement fluids and took place during its...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920030306
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Dysphagia screening is oftentimes a focus of hospitalized patients, but dysphagia can also occur in outpatient settings. Dysphagia can be overlooked by nurses and clinicians, and it is therefore important to educate nurses on the importance of dysphagia screenings. METHODS:This was a randomized prospective ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,随机对照试验
doi：10.1002/jca.21572
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target m...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21655
更新日期：2018-10-01 00:00:00
abstract：:Staphylococcal protein A efficiently binds immunoglobulins and circulating immune complexes (CIC) and provides an effective medium to remove immunoglobulins and CICs from plasma while sparing albumin and most coagulation proteins. Although it activates the complement system its clinical use abrogates the need for plas...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.2920090109
更新日期：1994-01-01 00:00:00
abstract：:Because the administration of hematopoietic growth factors and the use of stem cell support often fails to alleviate the neutropenic phase induced by cytotoxic drugs, several investigators have attempted to expand ex vivo hematopoietic progenitors for clinical use. These attempts have clearly shown that the cultured c...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.10012
更新日期：2002-01-01 00:00:00
abstract：INTRODUCTION:ABO- or HLA-incompatible kidney transplantation is possible thanks to pretransplant antibody-depletion achieved by extracorporeal-treatment modalities. These methods induce depletion of some plasma proteins and may also impact on proteins involved in hemostasis. METHODS:To determine the impact of one sess...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21825
更新日期：2020-08-17 00:00:00
abstract：:The aim of this study was to analyze the impact of various donor and machine parameters on PLT yield in 127 PLT apheresis procedures, to optimize PLT yield achieving clinical and economic advantages. One hundred and twenty-seven apheresis procedures were analyzed. Age, gender, volume processed, Hb, and PLT precounts w...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20116
更新日期：2007-02-01 00:00:00
abstract：:The process of publishing original work in a peer review journal is not complete at the point where the manuscript is first submitted. The journal editors will submit the manuscript to peer review whereby outside experts are asked to vet the manuscript for scientific merit, originality and quality. Reviewers' comments...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.21822
更新日期：2020-08-07 00:00:00
abstract：:In the United States, therapeutic plasma exchange (TPE) is both performed and requested by a wide range of services, often on an empiric basis (before a diagnosis is established). Whether empiric therapy is beneficial has not been established. Patients were identified from an electronic procedure log that included tho...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20059
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND/AIMS:High-volume plasma exchange (HVPE), defined as an exchange of 8 to 12 L per day per procedure or 15% of the ideal body weight with fresh frozen plasma, has shown promising results in improving the survival of patients with acute liver failure (ALF). However, clinical evidence is limited. The aim of this...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21873
更新日期：2021-01-05 00:00:00
abstract：:The removal of immune complexes, autoantibodies and suppressor factors from the circulation of patients with AIDS and AIDS related conditions by plasmapheresis and selective immunoadsorption may play a role as a therapeutic modality in these disorders. Lymphocytapheresis may also be of potential use in AIDS related co...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920020436
更新日期：1985-01-01 00:00:00
abstract：:This study was undertaken to evaluate the relationship between the time to recovery of peripheral blood counts and CD34+ cells in the peripheral blood (PB) and apheresis collections of patients undergoing intensive chemotherapy followed by rhG-CSF. Twenty-three patients with a median age of 42 years (range 17-64) with...
journal_title：Journal of clinical apheresis
pub_type： 临床试验,杂志文章
doi：10.1002/(sici)1098-1101(1998)13:1<1::aid-jca1>3.0.
更新日期：1998-01-01 00:00:00
abstract：:Blood group incompatibility remains a significant barrier to kidney transplantation. Approximately, one-third of donors are blood group incompatible with their intended recipient. Options for these donor-recipient pairs include blood group incompatible transplantation or kidney paired donation. However, the optimal pr...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21390
更新日期：2015-12-01 00:00:00
abstract：:Extracorporeal photopheresis (ECP) in young pediatric patients has a risk for procedural hypotension and anemia due to extracorporeal fluid shifts. A standard mitigation policy in these patients is to prime the device with packed red blood cells (RBC) or whole blood. We now report multiple episodes of hemolysis while ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21740
更新日期：2019-12-01 00:00:00
abstract：INTRODUCTION:Limited data are available describing indications for and outcomes of therapeutic plasma exchange (TPE) in cardiac transplantation. METHODS:In a retrospective study of patients who underwent cardiac transplantation at Duke University Medical Center from 2010 to 2014, we reviewed 3 TPE treatment patterns: ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21622
更新日期：2018-08-01 00:00:00
abstract：:In December 2007, the FDA issued a guidance document recommending that apheresis cell separators be configured with a postdonation platelet count target of > or =100,000 platelets/microL. Currently, our Trima Accel apheresis cell separators are configured with a postdonation platelet count target of > or =50,000 plate...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20214
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Factors affecting progenitor cell mobilization in patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) are incompletely understood. The aim of this retrospective study was to determine which factors are crucial for effective mobilization and collection of autologous peripheral blood stem ce...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21204
更新日期：2012-01-01 00:00:00
abstract：:One of the most serious problems in applying leukapheresis to human infants is the large extracorporeal blood volume (ECV), resulting in substantial loss of platelets and red blood cells (RBCs). In this study, we developed a safe and effective modified procedure to collect peripheral blood stem cells (PBSCs) from rhes...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.10043
更新日期：2003-01-01 00:00:00
abstract：:Bone marrow (BM) damage after previous chemotherapy, such as that involving alkylating agents, and radiation therapy alone cannot explain poor hematopoietic progenitor cell mobilization. We examined the T lymphocytes of BM in 67 autologous peripheral blood stem cell transplant (auto-PBSCT) patients with non-Hodgkin ly...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21817
更新日期：2020-07-28 00:00:00
abstract：:Folinic acid (FA) has been reported to expand the pool of peripheral blood stem cells (PBSC) after chemotherapy. We evaluated the efficacy of FA for harvesting PBSC following cytotoxic chemotherapy in 4 patients with acute leukemia. After achieving a complete remission (CR), 3 courses of chemotherapy for a consolidati...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920070410
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The ability to cryopreserve a portion of the cells treated during extracorporeal photopheresis (ECP) would improve therapy logistics, particularly for pediatric patients, by allowing multiple therapeutic doses to be collected from a single apheresis session. However, the effect of cryopreservation on ECP-tre...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21354
更新日期：2015-06-01 00:00:00
abstract：:Leukemic-dendritic cells (leukemic-DCs) have certain limitations, which include difficult generation in 30-40% of patients, and low levels of expression of several key molecules. Therefore, an alternative approach using monocyte-derived DCs pulsed with tumor antigens is required. We investigated the possibility of imm...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20085
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:Perioperative therapeutic plasma exchange in patients with cardiovascular diseases poses several challenges, including alterations in intravascular volume, serum electrolytes, the coagulation cascade, and drug pharmacokinetics. METHODS:This review article summarizes different indications of plasma exchange ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.21676
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Transfusion of D+ red blood cells (RBCs) to D- recipients can be accidental or necessary due to D- RBC shortage. Alloimmunization can complicate future transfusions; implications for women of childbearing age are compounded by possible hemolytic disease of the fetus and newborn. Rh immunoprophylaxis is effec...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20225
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Patients undergoing therapeutic plasma exchange (TPE) may present with risks for hemorrhage or thrombosis. Use of replacement fluids devoid of coagulation factors will decrease factor levels and platelet levels. There are no established guidelines for hemostasis management in these situations. MATERIALS AND...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21653
更新日期：2018-10-01 00:00:00
abstract：:The purpose of this study is to determine whether immunoadsorption treatment using a dextran sulfate (DS) column can remove high-avidity anti-double-stranded DNA (anti-dsDNA) antibody from the blood of patients with systemic lupus erythematosus (SLE). Before and after each immunoadsorption therapy routine, titers of t...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/(SICI)1098-1101(1996)11:1<30::AID-JCA7>3.0
更新日期：1996-01-01 00:00:00
abstract：:Inadvertent hypothermia due to massive infusion of stored blood can be prevented by pretransfusion warming. One approach is the heating of individual packs by means of electromagnetic conduction, which is a method safely used over the last 25 years. The prototype instrument, which has now been re-engineered, can effec...
journal_title：Journal of clinical apheresis
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/jca.2920070105
更新日期：1992-01-01 00:00:00
