Abstract：
:In the United States, therapeutic plasma exchange (TPE) is both performed and requested by a wide range of services, often on an empiric basis (before a diagnosis is established). Whether empiric therapy is beneficial has not been established. Patients were identified from an electronic procedure log that included those patients who received plasmapheresis at Walter Reed Army Medical Center from 1996 to 2003. The clinical indications, referring service, and outcomes (including deaths) that occurred were tabulated. Between March 1997 and August 2003, 568 TPE treatments were performed in 54 patients. The majority of the diagnoses were either neurologic (48%) or hematologic (37%). Thirty-three patients (61%) received TPE for a Category I indication. Twelve cases were performed empirically (without an established diagnosis) at the request of the referring service, most (7) performed for presumed thrombotic thrombocytopenic purpura (TTP). Almost 80% of patients required central venous catheters for treatment. Twelve patients (22%) experienced a major complication including death, and six patients (11%) died. Of the patients who died, 5 (83%) were treated empirically versus one death (17%) among patients not treated empirically, P < 0.001 by Chi Square. Only one of the seven patients treated empirically for TTP died, however. In logistic regression analysis, empiric treatment was the only factor independently associated with death, adjusted odds ratio, 34.2, 95% CI, 3.4, 334.8, P = 0.003. The most common indication for TPE was neurological disease, which also accounted for the highest proportion of complications. With the exception of presumed TTP, performing TPE in the absence of a confirmed diagnosis was not beneficial.
journal_name
J Clin Apherjournal_title
Journal of clinical apheresisauthors
Yeo FE,Bohen EM,Yuan CM,Sawyers ES,Abbott KCdoi
10.1002/jca.20059subject
Has Abstractpub_date
2005-12-01 00:00:00pages
208-16issue
4eissn
0733-2459issn
1098-1101journal_volume
20pub_type
杂志文章abstract：:Since the introduction of hematopoietic growth factors, the collection of mobilized stem cells via leukapheresis has widely replaced the harvest of bone marrow in both autologous and allogeneic transplantation settings. We investigated the frequency and the extent of anticoagulant-induced electrolyte changes and the c...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/1098-1101(2000)15:4<230::aid-jca3>3.0.co;2
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abstract：INTRODUCTION:Nanoscale particle-based drug delivery systems like long circulating liposomal doxorubicin show unique pharmacokinetic properties and improved toxicity profiles. Liposomal doxorubicin accumulates in tumor tissue due to the enhanced permeation and retention effect, but only a small fraction of a total dose ...
journal_title：Journal of clinical apheresis
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doi：10.1002/jca.20229
更新日期：2010-01-01 00:00:00
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journal_title：Journal of clinical apheresis
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doi：10.1002/jca.21496
更新日期：2017-08-01 00:00:00
abstract：:Thrombopoietin (TPO) serum levels in 14 patients (9 male and 5 female, mean age 36 years, range 16 to 55 years) with breast cancer (n = 5), testicular cancer (n = 7), or lymphoma (n = 2), undergoing high dose chemotherapy with peripheral blood stem cell (PBSC) transplantation, were evaluated at the first day of the mo...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/(sici)1098-1101(1999)14:2<57::aid-jca2>3.0
更新日期：1999-01-01 00:00:00
abstract：:We describe the case of a 24 year old male with severe fistulating Crohn's disease who failed mutliple modalities of medical and surgical therapy. We present objective and subjective evidence of disease remission after induction and maintenance treatment with leukocyte apheresis. This is the first described case of su...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21308
更新日期：2014-06-01 00:00:00
abstract：:Many practitioners believe in the phenomenon of being labeled either a "black cloud" or "white cloud" while on-call. A "white-cloud" physician is usually defined as one who sees fewer cases while a "black-cloud" is one who often receives more cases. To evaluate these phenomena, a 35-month prospective study was designe...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21650
更新日期：2018-10-01 00:00:00
abstract：:Thrombopoietin (c-Mpl ligand) is the hematopoietic growth factor that is responsible for regulating the production of platelets from bone marrow megakaryocytes. This approximately 90 kd protein has recently been isolated and is comprised of an erythropoietin domain that is approximately 50% homologous to erythropoieti...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/(SICI)1098-1101(1996)11:3<149::AID-JCA6>3.
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Estimation of the total blood volume (TBV) is fundamental to the control of automated red cell exchange (RCE). Error in the TBV estimate can produce outcomes that deviate from the prescribed targets, and may endanger the patient. Both the Spectra Optia and the COBE Spectra use the Nadler formu...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21748
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Transfusion of D+ red blood cells (RBCs) to D- recipients can be accidental or necessary due to D- RBC shortage. Alloimmunization can complicate future transfusions; implications for women of childbearing age are compounded by possible hemolytic disease of the fetus and newborn. Rh immunoprophylaxis is effec...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20225
更新日期：2010-01-01 00:00:00
abstract：:The recent introduction of low-density lipoprotein (LDL)/very low-density lipoprotein (VLDL) selective-removal systems offers an alternative to plasma exchange (PE). For the last 10 years, we have treated a male homozygous hypercholesterolemia type IIA patient with PE using 5% normal serum albumin (NSA) replacement, P...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920070206
更新日期：1992-01-01 00:00:00
abstract：:To compare donor demographics and motivations for donation, we surveyed 159 consecutive whole blood donors (WD) and 146 consecutive plateletpheresis donors. All donors had donation experiences of at least 2 gallons (i.e., 16 previous donations). Evaluation of answers to fixed-response and open-ended questions revealed...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920080206
更新日期：1993-01-01 00:00:00
abstract：:The blood flow property is one of the factors determining blood perfusion and oxygen supply. The viscosity of the blood is primarily related to the hematocrit, but also to the amount of fibrinogen and other macromolecules present in the blood. Patients with ischemic heart disease have shown a rapid and safe improvemen...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/(sici)1098-1101(1997)12:4<183::aid-jca5>3.
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:In organ transplantation, apheresis is frequently used for removal of anti-HLA antibodies. However, it is unclear whether plasmapheresis (PP) or semi-selective immunoadsorption (IA) should be employed, and the optimal number of apheresis sessions required to reach post-treatment objectives is also unknown. ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21858
更新日期：2020-11-30 00:00:00
abstract：:For therapeutic plasma exchange (TPE), continuous flow separators are known to be efficient as exemplified by Fresenius AS104 and COBE Spectra. The AS104 uses an interface monitoring system in the centrifuge during TPE, whereas Spectra uses computer algorithms to establish the plasma-cell interface. To determine the p...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.1014
更新日期：2001-01-01 00:00:00
abstract：:Sickle cell disease (SCD) patients are prone to develop complications that include stroke, acute chest syndrome, and other crises. Some of these complications require chronic transfusion therapy or red cell exchange (RCE), either for therapeutic or prophylactic reasons. Due to a discrepancy of red cell antigens betwee...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.20112
更新日期：2006-12-01 00:00:00
abstract：:Extra-corporeal photopheresis (ECP) is known as safe ultimate treatment option for chronic lung allograft dysfunction (CLAD). Here, we report the first case of ECP as "second-line" immunomodulatory therapy early post-transplant in an adult patient undergoing lung transplantation for severe chronic thromboembolic pulmo...
journal_title：Journal of clinical apheresis
pub_type：
doi：10.1002/jca.21831
更新日期：2020-08-24 00:00:00
abstract：:Blood group incompatibility remains a significant barrier to kidney transplantation. Approximately, one-third of donors are blood group incompatible with their intended recipient. Options for these donor-recipient pairs include blood group incompatible transplantation or kidney paired donation. However, the optimal pr...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21390
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Specialized centers claim a need for blood component production independent from the general blood transfusion services. We performed a prospective change control analysis of the transfer of platelet (PLT) production for hematological patients at the University Hospital Basel from the Departme...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21214
更新日期：2012-01-01 00:00:00
abstract：:Extracorporeal photopheresis (ECP) has been shown to be clinically effective in the treatment of many T cell-mediated conditions. ECP's mechanism of action includes the induction of apoptosis and the release of pro-inflammatory cytokines. Recently, we have observed early lymphoid apoptosis, detectable immediately post...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.10039
更新日期：2002-01-01 00:00:00
abstract：:Treatment by low density lipoprotein (LDL) apheresis using dextran sulfate columns (DSC) leads to hemostasis alterations with prolonged activated partial thromboplastin time (APTT) of more than 120 seconds. In order to explain this hypocoagulability, we studied hemostasis parameters both in patients and in the extraco...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920080302
更新日期：1993-01-01 00:00:00
abstract：:The removal of immune complexes, autoantibodies and suppressor factors from the circulation of patients with AIDS and AIDS related conditions by plasmapheresis and selective immunoadsorption may play a role as a therapeutic modality in these disorders. Lymphocytapheresis may also be of potential use in AIDS related co...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920020436
更新日期：1985-01-01 00:00:00
abstract：:This is an attempt at comparing two cell separators for plateletpheresis, namely the Fresenius AS.TEC 204 and Haemonetics MCS 3p, at a tertiary care center in India. Donors who weighed between 55-75 kg, who had a hematocrit of 41-43%, and platelet counts of 250x10(3)-400x10(3)/microl were selected for the study. The c...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20108
更新日期：2007-02-01 00:00:00
abstract：:Antisynthetase syndrome (ASS) is a rare condition characterized by interstitial lung disease (ILD), inflammatory myositis, fever, Raynaud phenomenon, mechanic's hand, and inflammatory polyarthritis in the setting of antibodies to amino acyl-transfer RNA synthetases, with anti-Jo-1 antibody being the most common. Progn...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21387
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Patients undergoing therapeutic plasma exchange (TPE) may present with risks for hemorrhage or thrombosis. Use of replacement fluids devoid of coagulation factors will decrease factor levels and platelet levels. There are no established guidelines for hemostasis management in these situations. MATERIALS AND...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21653
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Hyperleukocytosis is commonly seen in acute and chronic leukemias. Therapeutic leukocytapheresis using an automatic cell separator can help to achieve prompt leukoreduction to reduce the rate of thrombotic events and early mortality as well as to prevent tumor lysis syndrome. AIM:In this study, we report a ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21766
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND/AIMS:High-volume plasma exchange (HVPE), defined as an exchange of 8 to 12 L per day per procedure or 15% of the ideal body weight with fresh frozen plasma, has shown promising results in improving the survival of patients with acute liver failure (ALF). However, clinical evidence is limited. The aim of this...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21873
更新日期：2021-01-05 00:00:00
abstract：:Complement-derived anaphylatoxin may be one of the causes of vascular injury and an indicator of activity in systemic lupus erythematosus (SLE). The present study examines the effectiveness of dextran sulfate (DS) column immunoadsorption treatment to remove anaphylatoxins (C3a, C4a, and C5a) from the blood of patients...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/(sici)1098-1101(1998)13:3<108::aid-jca3>3.
更新日期：1998-01-01 00:00:00
abstract：:For many years dextran sulfate adsorption (DSA) treatment of separated plasma has been an established technology for low-density lipoprotein (LDL)-elimination. Recently a system for the treatment of whole blood based on DSA was introduced into clinical practice. To further characterize DSA treatment of whole blood, th...
journal_title：Journal of clinical apheresis
pub_type： 临床试验,杂志文章
doi：10.1002/jca.20135
更新日期：2007-01-01 00:00:00
abstract：:The literature on the use of therapeutic apheresis is often criticized for the preponderance of low to very low quality evidence. Shehata et al. examined the apheresis literature published between 1976 and 1999 and found a lack of randomized controlled trials with those identified demonstrating significant limitations...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.21263
更新日期：2013-02-01 00:00:00
abstract：:During the course of heparin-induced extracorporeal lipoprotein apheresis, a patient with no prior known renal impairment or proteinuria demonstrated sustained improvement in estimated glomerular filtration rate, commensurate with reduction in serum lipids and creatine phosphokinase levels. Causes and implications of ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20272
更新日期：2011-01-01 00:00:00
