Efficacy of plasmapheresis and semi-selective immunoadsorption for removal of anti-HLA antibodies.

Abstract:

BACKGROUND:In organ transplantation, apheresis is frequently used for removal of anti-HLA antibodies. However, it is unclear whether plasmapheresis (PP) or semi-selective immunoadsorption (IA) should be employed, and the optimal number of apheresis sessions required to reach post-treatment objectives is also unknown. METHODS:We enrolled 43 patients from Bordeaux University Hospital who were treated with PP (n = 29) or IA (n = 14) for antibody-mediated rejection or pre-transplant desensitization. Using Luminex single-antigen flow beads, we assessed the initial mean fluorescence intensity (MFI) of 1416 positive beads with MFIs obtained after 7 to 8 apheresis sessions (extended protocol) and, if a serum was available, after the first four sessions (short protocol). RESULTS:MFI reduction after extended apheresis protocol was stronger with IA [87% (61%-100%)] than with PP [73% (22%-100%)] (P < .001). Indeed, 59% of the beads had a final MFI < 2000 with IA, whereas only 38% with PP (P < .001). The efficacy of removal depended on initial MFI but not on HLA specificity. A short protocol of apheresis showed excellent results without superiority of IA over PP for antibodies with an initial MFI < 3000. For antibodies showing MFI ≥2000 after four sessions, the residual MFI predicted the effectiveness of four additional sessions. CONCLUSION:Monitoring the MFI of anti-HLA antibodies before and during apheresis protocol can guide physicians in the selection of apheresis technique and the number of sessions to be performed.

journal_name

J Clin Apher

authors

Jambon F,Merville P,Guidicelli G,Taton B,De Précigout V,Couzi L,Moreau K,Visentin J

doi

10.1002/jca.21858

subject

Has Abstract

pub_date

2020-11-30 00:00:00

eissn

0733-2459

issn

1098-1101

pub_type

杂志文章
  • Acquired immunodeficiency syndrome (AIDS)--apheresis and operative risks.

    abstract::The removal of immune complexes, autoantibodies and suppressor factors from the circulation of patients with AIDS and AIDS related conditions by plasmapheresis and selective immunoadsorption may play a role as a therapeutic modality in these disorders. Lymphocytapheresis may also be of potential use in AIDS related co...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920020436

    authors: Kiprov DD,Lippert R,Sandstrom E,Jones FR,Cohen RJ,Abrams D,Busch DF

    更新日期:1985-01-01 00:00:00

  • Assessment of software-derived predictive algorithms for platelet yield and blood cell count after apheresis.

    abstract:INTRODUCTION:Algorithms have been developed to predict the platelet yield after apheresis from the donor's data, as well as the effect on the blood cell count, to extract an acceptable platelet number without affecting the donor. However, the evaluation of these algorithms has not been widely reported. This study aimed...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21846

    authors: Cienfuegos-Pecina E,Ayala-De la Cruz S,Leal-Nava ER,Pérez-Olvera JA,Llaca-Díaz JM,Avilés-Rodríguez LE,Pérez-Chávez F,Díaz-Chuc EA

    更新日期:2020-10-05 00:00:00

  • Literature review of apheresis procedures performed perioperatively in cardiac surgery for ASFA category indications.

    abstract:BACKGROUND:Perioperative therapeutic plasma exchange in patients with cardiovascular diseases poses several challenges, including alterations in intravascular volume, serum electrolytes, the coagulation cascade, and drug pharmacokinetics. METHODS:This review article summarizes different indications of plasma exchange ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章,评审

    doi:10.1002/jca.21676

    authors: Kanellopoulou T,Kostelidou T

    更新日期:2019-08-01 00:00:00

  • Computerization of plateletpheresis quality control records with a commercially available spreadsheet program.

    abstract::Many apheresis units lack the resources to acquire customized computer software for record keeping. We have adapted a commercially available "spreadsheet" program (Lotus 1-2-3) to aid in quality control activities for plateletpheresis. Data are entered in a grid pattern wherein each donation occupies one row and succe...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920050407

    authors: McLeod BC,Viernes A,Reed S,Sassetti RJ

    更新日期:1990-01-01 00:00:00

  • Adsorption of anaphylatoxins from the plasma of systemic lupus erythematosus patients using dextran sulfate cellulose columns.

    abstract::Complement-derived anaphylatoxin may be one of the causes of vascular injury and an indicator of activity in systemic lupus erythematosus (SLE). The present study examines the effectiveness of dextran sulfate (DS) column immunoadsorption treatment to remove anaphylatoxins (C3a, C4a, and C5a) from the blood of patients...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-1101(1998)13:3<108::aid-jca3>3.

    authors: Matsuki Y,Suzuki K,Kawakami M,Ishizuka T,Hidaka T,Nakamura H

    更新日期:1998-01-01 00:00:00

  • Acute hemolytic transfusion reaction in a pediatric patient following transfusion of apheresis platelets.

    abstract::The practice of transfusing ABO-incompatible platelets, driven primarily by concerns about inventory management, has been considered generally safe because the accompanying plasma is usually diluted in the recipient's total blood volume. However, if the platelet product contains a large volume of plasma or a high conc...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20072

    authors: Sapatnekar S,Sharma G,Downes KA,Wiersma S,McGrath C,Yomtovían R

    更新日期:2005-12-01 00:00:00

  • Impact of the CD4:CD8 ratio in bone marrow on stem cell mobilization and engraftment in autologous stem cell transplant patients.

    abstract::Bone marrow (BM) damage after previous chemotherapy, such as that involving alkylating agents, and radiation therapy alone cannot explain poor hematopoietic progenitor cell mobilization. We examined the T lymphocytes of BM in 67 autologous peripheral blood stem cell transplant (auto-PBSCT) patients with non-Hodgkin ly...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21817

    authors: Oka S,Nohgawa M

    更新日期:2020-07-28 00:00:00

  • High-avidity anti-DNA antibody removal from the serum of systemic lupus erythematosus patients by adsorption using dextran sulfate cellulose columns.

    abstract::The purpose of this study is to determine whether immunoadsorption treatment using a dextran sulfate (DS) column can remove high-avidity anti-double-stranded DNA (anti-dsDNA) antibody from the blood of patients with systemic lupus erythematosus (SLE). Before and after each immunoadsorption therapy routine, titers of t...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-1101(1996)11:1<30::AID-JCA7>3.0

    authors: Matsuki Y,Suzuki K,Kawakami M,Ishizuka T,Kawaguchi Y,Hidaka T,Nakamura H

    更新日期:1996-01-01 00:00:00

  • Dextran-sulfate-adsorption of atherosclerotic lipoproteins from whole blood or separated plasma for lipid-apheresis--comparison of performance characteristics with DALI and Lipidfiltration.

    abstract::For many years dextran sulfate adsorption (DSA) treatment of separated plasma has been an established technology for low-density lipoprotein (LDL)-elimination. Recently a system for the treatment of whole blood based on DSA was introduced into clinical practice. To further characterize DSA treatment of whole blood, th...

    journal_title:Journal of clinical apheresis

    pub_type: 临床试验,杂志文章

    doi:10.1002/jca.20135

    authors: Julius U,Parhofer KG,Heibges A,Kurz S,Klingel R,Geiss HC

    更新日期:2007-01-01 00:00:00

  • Autoimmunity in transfusion babesiosis: a spectrum of clinical presentations.

    abstract::Transfusion-acquired babesiosis can be an asymptomatic or self-limited febrile hemolytic illness in a healthy host. A persistent, relapsing, and/or fulminant course with the development of life-threatening complications may be seen in immunocompromised or splenectomized patients. As in malaria, erythrocyte parasitemia...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20262

    authors: Herman JH,Ayache S,Olkowska D

    更新日期:2010-01-01 00:00:00

  • Thrombopoietin: biology, clinical applications, role in the donor setting.

    abstract::Thrombopoietin (c-Mpl ligand) is the hematopoietic growth factor that is responsible for regulating the production of platelets from bone marrow megakaryocytes. This approximately 90 kd protein has recently been isolated and is comprised of an erythropoietin domain that is approximately 50% homologous to erythropoieti...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1098-1101(1996)11:3<149::AID-JCA6>3.

    authors: Kuter DJ

    更新日期:1996-01-01 00:00:00

  • Plasma exchange conditioning for ABO-incompatible renal transplantation.

    abstract::The supply of deceased donor kidneys is inadequate to meet demand. To expand the pool of potential donors, ABO-incompatible transplants from living donors have been performed. We present the Mayo Clinic experience with such transplants. Enrollment was open to patients when the only available potential living kidney do...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20002

    authors: Winters JL,Gloor JM,Pineda AA,Stegall MD,Moore SB

    更新日期:2004-01-01 00:00:00

  • Modification of the leukapheresis procedure for use in rhesus monkeys (Macaca mulata).

    abstract::One of the most serious problems in applying leukapheresis to human infants is the large extracorporeal blood volume (ECV), resulting in substantial loss of platelets and red blood cells (RBCs). In this study, we developed a safe and effective modified procedure to collect peripheral blood stem cells (PBSCs) from rhes...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.10043

    authors: Ageyama N,Kimikawa M,Eguchi K,Ono F,Shibata H,Yoshikawa Y,Terao K

    更新日期:2003-01-01 00:00:00

  • First successful use of leukocyte apheresis as maintenance therapy for Crohn's disease in the United Kingdom.

    abstract::We describe the case of a 24 year old male with severe fistulating Crohn's disease who failed mutliple modalities of medical and surgical therapy. We present objective and subjective evidence of disease remission after induction and maintenance treatment with leukocyte apheresis. This is the first described case of su...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21308

    authors: Tate D,Cairnes V,Valori R,Makins R

    更新日期:2014-06-01 00:00:00

  • Predictive factors for inadequate stem cell mobilization in Chinese patients with NHL and HL: 14-year experience of a single-center study.

    abstract:BACKGROUND:Factors affecting progenitor cell mobilization in patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) are incompletely understood. The aim of this retrospective study was to determine which factors are crucial for effective mobilization and collection of autologous peripheral blood stem ce...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21204

    authors: Han X,Ma L,Zhao L,He X,Liu P,Zhou S,Yang J,Qin Y,Yang S,Yao J,Shi Y

    更新日期:2012-01-01 00:00:00

  • Plerixafor as preemptive strategy results in high success rates in autologous stem cell mobilization failure.

    abstract::Plerixafor in combination with granulocyte-colony stimulating factor (G-CSF) is approved for autologous stem cell mobilization in poor mobilizing patients with multiple myeloma or malignant lymphoma. The purpose of this study was to evaluate efficacy and safety of plerixafor in an immediate rescue approach, administra...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21496

    authors: Worel N,Fritsch G,Agis H,Böhm A,Engelich G,Leitner GC,Geissler K,Gleixner K,Kalhs P,Buxhofer-Ausch V,Keil F,Kopetzky G,Mayr V,Rabitsch W,Reisner R,Rosskopf K,Ruckser R,Zoghlami C,Zojer N,Greinix HT

    更新日期:2017-08-01 00:00:00

  • Peripheral blood stem cell transplantation: impact on procedure load and workload in an apheresis unit.

    abstract::Peripheral blood stem cells (PBSC) reinfusion appears to hasten hematologic reconstitution following myeloablative therapy. While procurement of PBSC adds apheresis procedures, rapid engraftment could decrease the demand for platelet transfusions. To determine the impact of PBSC collection on workload in our apheresis...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920070408

    authors: Ghalie R,McLeod B,Richman C,Valentino L,Manson S,Netols C,Kaizer H

    更新日期:1992-01-01 00:00:00

  • Convalescent plasma therapy in patients with COVID-19.

    abstract::There are currently no licensed vaccines or therapeutics for COVID-19. Anti-SARS CoV-2 antibody-containing plasmas, obtained from the recovered individuals who had confirmed COVID-19, have been started to be collected using apheresis devices and stored in blood banks in some countries in order to administer to the pat...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章,评审

    doi:10.1002/jca.21806

    authors: Yiğenoğlu TN,Hacıbekiroğlu T,Berber İ,Dal MS,Baştürk A,Namdaroğlu S,Korkmaz S,Ulas T,Dal T,Erkurt MA,Turgut B,Altuntaş F

    更新日期:2020-08-01 00:00:00

  • Higher efficacy of intermediate dose cytarabine + G-CSF compared to cyclophosphamide + G-CSF in hematopoietic stem cell mobilization in patients with multiple myeloma.

    abstract:BACKGROUND:There are several regimens used in hematopoietic stem cell (HSC) mobilization in multiple myeloma (MM). Cyclophosphamide (Cy) is one of the most commonly used agents, although it does not always result in collecting adequate number of CD34+ cells. Recently, cytarabine (Ara-C) has been proposed as potentially...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21784

    authors: Bogucka-Fedorczuk A,Czyz A,Kalicińska E,Sawicki M,Laszkowska-Lewko M,Wicherska-Pawłowska K,Rybka J,Szeremet A,Prajs I,Szymczak D,Wróbel T

    更新日期:2020-08-01 00:00:00

  • Hematopoietic progenitor cell count, but not immature platelet fraction value, predicts successful harvest of autologous peripheral blood stem cells.

    abstract::Mobilized stem cells in the peripheral blood (PB) must be efficiently harvested at the appropriate time before autologous PB stem cell (PBSC) transplantation. Enumeration of CD34+ cells in the PB before apheresis predicts the number of PBSCs that can be collected, but the cytometric techniques used are complex and exp...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20275

    authors: Mitani N,Yujiri T,Tanaka Y,Tanaka M,Fujii Y,Hinoda Y,Tanizawa Y

    更新日期:2011-01-01 00:00:00

  • Lipid-apheresis improves microcirculation of the upper limbs.

    abstract::Lipid-apheresis (LA) is thought to improve microcirculation. However, limited data are available on the effects on peripheral microcirculation. We investigated upper limb microcirculation of 22 patients undergoing regular LA on a weekly basis before and after LA. Using standardized semiquantitative scales, we analyzed...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20285

    authors: Rossenbach J,Mueller GA,Lange K,Armstrong VW,Schmitto JD,Hintze E,Helfmann J,Konstantinides S,Koziolek MJ

    更新日期:2011-01-01 00:00:00

  • Therapeutic plasma exchange: a paired comparison of Fresenius AS104 vs. COBE Spectra.

    abstract::For therapeutic plasma exchange (TPE), continuous flow separators are known to be efficient as exemplified by Fresenius AS104 and COBE Spectra. The AS104 uses an interface monitoring system in the centrifuge during TPE, whereas Spectra uses computer algorithms to establish the plasma-cell interface. To determine the p...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.1014

    authors: Burgstaler EA,Pineda AA

    更新日期:2001-01-01 00:00:00

  • Prospective change control analysis of transfer of platelet concentrate production from a specialized stem cell transplantation unit to a blood transfusion center.

    abstract:BACKGROUND AND OBJECTIVES:Specialized centers claim a need for blood component production independent from the general blood transfusion services. We performed a prospective change control analysis of the transfer of platelet (PLT) production for hematological patients at the University Hospital Basel from the Departme...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21214

    authors: Sigle JP,Medinger M,Stern M,Infanti L,Heim D,Halter J,Gratwohl A,Buser A

    更新日期:2012-01-01 00:00:00

  • Incidence of allergic reactions with fresh frozen plasma or cryo-supernatant plasma in the treatment of thrombotic thrombocytopenic purpura.

    abstract::Plasma replacement for thrombotic thrombocytopenic purpura (TTP) is accomplished with various plasma products. This study sought to determine the incidence of allergic reactions with FFP or CPP as replacement in therapeutic plasma exchange (TPE). Forty-one TTP patients were identified retrospectively who received TPE ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.1025

    authors: Reutter JC,Sanders KF,Brecher ME,Jones HG,Bandarenko N

    更新日期:2001-01-01 00:00:00

  • Physiological measurements corroborate symptomatic improvement after therapeutic leukapheresis in a pregnant woman with chronic myelogenous leukemia.

    abstract::Therapeutic leukapheresis can control the white blood cell count (WBC) of pregnant women with chronic myelogenous leukemia (CML) who have hyperleukocytosis without leukostasis. The medical justification for this treatment has not been objectively documented. We report a 27-year-old woman, diagnosed with CML at 10-week...

    journal_title:Journal of clinical apheresis

    pub_type:

    doi:10.1002/jca.21410

    authors: Galera P,Haynes S,Sulmasy P,Bailey JA,Greene M,Vauthrin M,Brettler D,Liebmann J,Mark Madison J,Weinstein R

    更新日期:2016-08-01 00:00:00

  • Clinically relevant hypokalaemia, hypocalcaemia, and loss of hemoglobin and platelets during stem cell apheresis.

    abstract::Since the introduction of hematopoietic growth factors, the collection of mobilized stem cells via leukapheresis has widely replaced the harvest of bone marrow in both autologous and allogeneic transplantation settings. We investigated the frequency and the extent of anticoagulant-induced electrolyte changes and the c...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/1098-1101(2000)15:4<230::aid-jca3>3.0.co;2

    authors: Schlenke P,Frohn C,Steinhardt MM,Kirchner H,Klüter H

    更新日期:2000-01-01 00:00:00

  • Efficacy of low-density lipoprotein apheresis in arteriosclerosis obliterans of the lower extremities: two cases with marked alleviation of clinical symptoms.

    abstract::We have recognized marked effectiveness for intermittent claudication with low-density lipoprotein (LDL) apheresis in two cases of arteriosclerosis obliterans (ASO). The Case 1 was a 73-year-old man with intermittent claudication of both lower extremities (Fontaine class II), digital subtraction angiography (DSA) reve...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20138

    authors: Suzuki T,Sato Y,Niizuma S,Kushiro T,Tani S,Ishikawa K,Kajiwara N,Kanmatsuse K,Ikeda H,Takahashi M,Kojima S

    更新日期:2007-01-01 00:00:00

  • Formatting an experiential learning education module to encourage dysphagia assessment in apheresis patients.

    abstract:BACKGROUND:Dysphagia screening is oftentimes a focus of hospitalized patients, but dysphagia can also occur in outpatient settings. Dysphagia can be overlooked by nurses and clinicians, and it is therefore important to educate nurses on the importance of dysphagia screenings. METHODS:This was a randomized prospective ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/jca.21572

    authors: West J,Stutzman SE,Atem F,Olson DM

    更新日期:2018-02-01 00:00:00

  • Continuous-flow techniques for platelet concentrate collection: a step toward standardization and yield predictability.

    abstract::This study chronicles leukocyte- and erythrocyte-depleted platelet concentrate collection by a dual stage channel in which three variables: 1) donor peripheral blood platelet concentration, 2) total blood processed, and 3) collection volume were statistically correlated with platelet yield as determined by a multiple ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920020304

    authors: Hester JP,Kellogg RM,Mulzet AP,Freireich EJ

    更新日期:1985-01-01 00:00:00

  • Successful management of a Jehovah's Witness with thrombotic thrombocytopenic purpura unwilling to be treated with therapeutic plasma exchange.

    abstract::Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease treated successfully with plasma exchange. Jehovah's Witnesses whose religious beliefs preclude them from accepting plasma exchange may require alternative forms of therapy. We report a case of one such patient who presented with TTP, whom we succ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20150

    authors: Dabak V,Kuriakose P,Raman S

    更新日期:2007-01-01 00:00:00