Abstract：
BACKGROUND AND OBJECTIVES:Estimation of the total blood volume (TBV) is fundamental to the control of automated red cell exchange (RCE). Error in the TBV estimate can produce outcomes that deviate from the prescribed targets, and may endanger the patient. Both the Spectra Optia and the COBE Spectra use the Nadler formulae to estimate TBV. There is a potential for large overestimates of TBV when the Nadler formula for males is applied to prepubertal boys. MATERIALS AND METHODS:This study uses our large clinical experience with RCE to examine procedure outcomes when RCE in prepubertal boys is programed with the female parameter instead of male. We determined the differences between programmed and measured values for three outcomes: (a) Programmed End Hematocrit - Post spun HCT by Hemata Stat II, (b) Programmed End Hematocrit - Post CBC HCT, and (c) Predicted Post Hgb S+C - Measured Post Hgb S+C. We defined the experimental group as Male-Female, where the biological sex was male but programmed sex was female, and two control groups where programmed and biological sex were the same. RESULTS:Small but statistically significant differences were demonstrated between the mean programmed-to-observed deviations of these outcome measures in all but two group and subgroup comparisons; however, the absolute magnitudes of the observed differences were not clinically significant. The suggested weight cutoff to begin programming males as male is 35 kg. CONCLUSION:The study provides experiential validation that performing RCE in prepubertal boys using the female parameter is safe.
journal_name
J Clin Apherjournal_title
Journal of clinical apheresisauthors
Colavita D,Kim HC,Friedman DFdoi
10.1002/jca.21748subject
Has Abstractpub_date
2019-12-01 00:00:00pages
692-699issue
6eissn
0733-2459issn
1098-1101journal_volume
34pub_type
杂志文章abstract：OBJECTIVE:Effects of therapeutic plasma exchange (TPE) on immune cells and their cytokine production in MS, are unknown. Since interleukine-6 and tumor growth factor-β have critical roles in MS immunopathogenesis, the impacts of TPE on the expression of these cytokines and their receptors on the surface of CD4+ T lymph...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21755
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Autoimmune disorders and neurodegenerative disorders take a physical and emotional toll on patients that undergo therapeutic plasma exchange (TPE) treatments. Previous literature has shown that these patients may feel a greater sense of self-burden. Motivational Interviewing (MI) is a technique used in vario...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21645
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Nephrogenic systemic fibrosis (NSF), also known as nephrogenic sclerosing dermopathy (NSD), is a rare progressive fibrosing disease associated with gadolinium based dyes in patients with renal disease. The exact pathophysiology is not well understood. Accepted treatments include corticosteroids, immune modul...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21253
更新日期：2013-08-01 00:00:00
abstract：:Because the administration of hematopoietic growth factors and the use of stem cell support often fails to alleviate the neutropenic phase induced by cytotoxic drugs, several investigators have attempted to expand ex vivo hematopoietic progenitors for clinical use. These attempts have clearly shown that the cultured c...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.10012
更新日期：2002-01-01 00:00:00
abstract：:Recently very potent extracorporeal cholesterol-lowering treatment options have become available for patients with hypercholesterolemia. LDL immunoapheresis treatment selectively removes LDL and lipoprotein(a) from the circulation. Since LDL is the major carrier of lipophilic antioxidants in plasma, the purpose of the...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20026
更新日期：2004-01-01 00:00:00
abstract：:Plasma replacement for thrombotic thrombocytopenic purpura (TTP) is accomplished with various plasma products. This study sought to determine the incidence of allergic reactions with FFP or CPP as replacement in therapeutic plasma exchange (TPE). Forty-one TTP patients were identified retrospectively who received TPE ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.1025
更新日期：2001-01-01 00:00:00
abstract：INTRODUCTION:Nanoscale particle-based drug delivery systems like long circulating liposomal doxorubicin show unique pharmacokinetic properties and improved toxicity profiles. Liposomal doxorubicin accumulates in tumor tissue due to the enhanced permeation and retention effect, but only a small fraction of a total dose ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20229
更新日期：2010-01-01 00:00:00
abstract：:Thrombotic thrombocytopenic purpura (TTP) is a rare but severe disorder characterized by hemolytic anemia, thrombocytopenia, fever, renal failure, and neurologic manifestations. Plasma exchange is the most effective treatment for this condition reducing mortality from 90% in untreated patients to 10%. However, infecti...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20119
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Specialized centers claim a need for blood component production independent from the general blood transfusion services. We performed a prospective change control analysis of the transfer of platelet (PLT) production for hematological patients at the University Hospital Basel from the Departme...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21214
更新日期：2012-01-01 00:00:00
abstract：:We have recognized marked effectiveness for intermittent claudication with low-density lipoprotein (LDL) apheresis in two cases of arteriosclerosis obliterans (ASO). The Case 1 was a 73-year-old man with intermittent claudication of both lower extremities (Fontaine class II), digital subtraction angiography (DSA) reve...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20138
更新日期：2007-01-01 00:00:00
abstract：:Acute thrombotic thrombocytopenic purpura (TTP) occurred in three patients following abdominal surgeries. One patient underwent extensive lysis for intestinal adhesions with bowel resection, another cholecystectomy for acute cholecystitis, and the third right colectomy and partial intestinal resection for colon cancer...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/1098-1101(2000)15:3<176::aid-jca4>3.0.co;2
更新日期：2000-01-01 00:00:00
abstract：:Extra-corporeal photopheresis (ECP) is known as safe ultimate treatment option for chronic lung allograft dysfunction (CLAD). Here, we report the first case of ECP as "second-line" immunomodulatory therapy early post-transplant in an adult patient undergoing lung transplantation for severe chronic thromboembolic pulmo...
journal_title：Journal of clinical apheresis
pub_type：
doi：10.1002/jca.21831
更新日期：2020-08-24 00:00:00
abstract：INTRODUCTION:ABO- or HLA-incompatible kidney transplantation is possible thanks to pretransplant antibody-depletion achieved by extracorporeal-treatment modalities. These methods induce depletion of some plasma proteins and may also impact on proteins involved in hemostasis. METHODS:To determine the impact of one sess...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21825
更新日期：2020-08-17 00:00:00
abstract：:For therapeutic plasma exchange (TPE), continuous flow separators are known to be efficient as exemplified by Fresenius AS104 and COBE Spectra. The AS104 uses an interface monitoring system in the centrifuge during TPE, whereas Spectra uses computer algorithms to establish the plasma-cell interface. To determine the p...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.1014
更新日期：2001-01-01 00:00:00
abstract：:Therapeutic plasma exchange (TPE) is an increasingly utilized immunosuppressive adjunct for treatment of antibody-mediated rejection (AMR) following organ transplantation. TPE works through removal of donor-specific HLA antibodies (DSAs) in the recipient's plasma. However, there is no clear laboratory measure evaluati...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21270
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Dysphagia screening is oftentimes a focus of hospitalized patients, but dysphagia can also occur in outpatient settings. Dysphagia can be overlooked by nurses and clinicians, and it is therefore important to educate nurses on the importance of dysphagia screenings. METHODS:This was a randomized prospective ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,随机对照试验
doi：10.1002/jca.21572
更新日期：2018-02-01 00:00:00
abstract：:The removal of specific antibody in experimental animals has been reported to result in a subsequent increase in antibody to levels equal to (rebound) or exceeding those existing prior to removal (overshoot). Anecdotal reports suggest that rebound antibody synthesis after plasmapheresis may occur in humans with autoim...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920050304
更新日期：1990-01-01 00:00:00
abstract：:The process of publishing original work in a peer review journal is not complete at the point where the manuscript is first submitted. The journal editors will submit the manuscript to peer review whereby outside experts are asked to vet the manuscript for scientific merit, originality and quality. Reviewers' comments...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.21822
更新日期：2020-08-07 00:00:00
abstract：:Thrombotic microangiopathy (TMA) is a recognized complication of malignant hypertension (HTN). Such patients have blood pressures > or = 200/140 mmHg but the condition is defined by the presence of papilledema and is frequently complicated by acute renal failure. Here we report two patients with severe HTN (systolic >...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20016
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:Wilson's disease is a rare autosomal recessive genetic disorder that results in accumulation of copper in the liver, brain, cornea and kidney. Therapeutic plasma exchange (TPE) has been used to remove copper and provide a bridge to liver transplantation. We report here the collective experiences through the ASF...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,多中心研究
doi：10.1002/jca.21396
更新日期：2016-02-01 00:00:00
abstract：:Blood products are frequently required immediately prior to, during, or just after an apheresis procedure. Transfusion-related acute lung injury (TRALI) is now the leading cause of transfusion-related mortality, surpassing ABO-incompatible hemolytic reactions. The reported incidence of TRALI varies but is estimated at...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20158
更新日期：2008-01-01 00:00:00
abstract：:The Oklahoma TTP-HUS Registry provides a complete community perspective of thrombotic thrombocytopenic purpura (TTP). This is possible because plasma exchange is the essential treatment for TTP and the Oklahoma Blood Institute provides all plasma exchange procedures for a region encompassing most of the State, includi...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20169
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target m...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21655
更新日期：2018-10-01 00:00:00
abstract：:The cell separator MCS-3P is an apheresis system offering the flexibility to collect standardized red blood cells, plasma, and/or platelets from one donor. Two different programs were used for the red cell apheresis--RBCP (collection of one unit of red cells and two units of plasma) and RBCPS (one unit of red cells an...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920090308
更新日期：1994-01-01 00:00:00
abstract：:An improved method for intermittent-flow erythrocytapheresis in patients with sickle cell disease is reported. The method, a modification of the standard red cell exchange procedure for the Haemonetics 30S unit, dilutes with physiologic saline the patient's blood as it flows from the draw line and before it reaches th...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920030203
更新日期：1986-01-01 00:00:00
abstract：:Targeted extracorporeal granulocyte and monocyte apheresis (GMA) has produced clinical efficacy together with down modulation of specific inflammatory cytokines in patients with ulcerative colitis (UC). This study was to investigate if preoperative GMA produces immunological effect on dysregulated immune activity afte...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,随机对照试验
doi：10.1002/jca.21299
更新日期：2014-04-01 00:00:00
abstract：:Leukemic-dendritic cells (leukemic-DCs) have certain limitations, which include difficult generation in 30-40% of patients, and low levels of expression of several key molecules. Therefore, an alternative approach using monocyte-derived DCs pulsed with tumor antigens is required. We investigated the possibility of imm...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20085
更新日期：2006-10-01 00:00:00
abstract：:Management of aTTP in patients who refuse or are intolerant to plasma remains challenging, but new drugs can be implemented with success. A 39-year-old woman presented to the Emergency department for bruises at the upper and lower limbs together with worsening anemia and thrombocytopenia; PLASMIC score was seven, indi...
journal_title：Journal of clinical apheresis
pub_type：
doi：10.1002/jca.21877
更新日期：2021-01-18 00:00:00
abstract：BACKGROUND:Autologous stem cell transplantation (auto-SCT) is a treatment approach in non-Hodgkin lymphoma (NHL) patients. The options for mobilization of CD34+ cells to support high-dose therapy are granulocyte-colony stimulating factors (G-CSFs) alone or after chemotherapy. Limited data exist on the efficacy of lipeg...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21785
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Factors affecting progenitor cell mobilization in patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) are incompletely understood. The aim of this retrospective study was to determine which factors are crucial for effective mobilization and collection of autologous peripheral blood stem ce...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21204
更新日期：2012-01-01 00:00:00
