Abstract：
:The literature on the use of therapeutic apheresis is often criticized for the preponderance of low to very low quality evidence. Shehata et al. examined the apheresis literature published between 1976 and 1999 and found a lack of randomized controlled trials with those identified demonstrating significant limitations. To determine if this has improved, MEDLINE was searched for randomized controlled therapeutic apheresis trials. In addition, the Clinicaltrials.gov database was also searched for actively recruiting randomized controlled therapeutic apheresis trials. The results revealed that the total and average number of publications per year examining therapeutic apheresis has increased substantially in the period 2000-2012 compared to 1976-1999. This was associated with a small increase in the average number of randomized controlled trials reported each year, but these trials represented a smaller percentage of the therapeutic apheresis literature published compared to the 1976-1999 time range. The reported trials continued to have very small numbers of enrolled patients raising questions about their ability to determine whether apheresis represents an effective therapy. Finally, according to the Clinicaltrials.gov database, a small number of randomized controlled trials of therapeutic apheresis are enrolling patients. Despite an increasing emphasis on evidence-based medicine and the need for quality randomized controlled clinical trials, there is still a lack of such trials when it comes to therapeutic apheresis. There continues to be a need for more and better designed randomized trials in therapeutic apheresis.
journal_name
J Clin Apherjournal_title
Journal of clinical apheresisauthors
Winters JLdoi
10.1002/jca.21263subject
Has Abstractpub_date
2013-02-01 00:00:00pages
48-55issue
1eissn
0733-2459issn
1098-1101journal_volume
28pub_type
杂志文章,评审abstract：:This study chronicles leukocyte- and erythrocyte-depleted platelet concentrate collection by a dual stage channel in which three variables: 1) donor peripheral blood platelet concentration, 2) total blood processed, and 3) collection volume were statistically correlated with platelet yield as determined by a multiple ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920020304
更新日期：1985-01-01 00:00:00
abstract：PURPOSE:Wilson's disease is a rare autosomal recessive genetic disorder that results in accumulation of copper in the liver, brain, cornea and kidney. Therapeutic plasma exchange (TPE) has been used to remove copper and provide a bridge to liver transplantation. We report here the collective experiences through the ASF...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,多中心研究
doi：10.1002/jca.21396
更新日期：2016-02-01 00:00:00
abstract：:Prestorage leukocyte reduction of platelet concentrates may reduce adverse effects of transfusion while affording better quality control. Platelets and leukocytes may undergo activation during storage, which could affect the performance of leukocyte reduction filters. The purpose of this study was to evaluate the effi...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/(sici)1098-1101(1997)12:1<14::aid-jca4>3.0
更新日期：1997-01-01 00:00:00
abstract：:Peripheral blood stem cells (PBSC) reinfusion appears to hasten hematologic reconstitution following myeloablative therapy. While procurement of PBSC adds apheresis procedures, rapid engraftment could decrease the demand for platelet transfusions. To determine the impact of PBSC collection on workload in our apheresis...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920070408
更新日期：1992-01-01 00:00:00
abstract：:Over the past 37 year the role of plasma exchange in the treatment of patients with renal disease has undergone several changes. The majority of the changes for the use of plasma exchange relied on randomized control trials and delineations of mechanisms that potentially would benefit from the use of plasma exchange. ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.21221
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Autologous stem cell transplantation (auto-SCT) is a treatment approach in non-Hodgkin lymphoma (NHL) patients. The options for mobilization of CD34+ cells to support high-dose therapy are granulocyte-colony stimulating factors (G-CSFs) alone or after chemotherapy. Limited data exist on the efficacy of lipeg...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21785
更新日期：2020-08-01 00:00:00
abstract：:Extra-corporeal photopheresis (ECP) is known as safe ultimate treatment option for chronic lung allograft dysfunction (CLAD). Here, we report the first case of ECP as "second-line" immunomodulatory therapy early post-transplant in an adult patient undergoing lung transplantation for severe chronic thromboembolic pulmo...
journal_title：Journal of clinical apheresis
pub_type：
doi：10.1002/jca.21831
更新日期：2020-08-24 00:00:00
abstract：:Thrombopoietin (c-Mpl ligand) is the hematopoietic growth factor that is responsible for regulating the production of platelets from bone marrow megakaryocytes. This approximately 90 kd protein has recently been isolated and is comprised of an erythropoietin domain that is approximately 50% homologous to erythropoieti...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/(SICI)1098-1101(1996)11:3<149::AID-JCA6>3.
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:Algorithms have been developed to predict the platelet yield after apheresis from the donor's data, as well as the effect on the blood cell count, to extract an acceptable platelet number without affecting the donor. However, the evaluation of these algorithms has not been widely reported. This study aimed...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21846
更新日期：2020-10-05 00:00:00
abstract：:Although rituximab (RTX) is a promising therapeutic agent for treating steroid-resistant nephrotic syndrome (SRNS) resistant to various immunosuppressive agents, some patients have shown resistance to RTX. We report the case of a patient with RTX-resistant nephrotic syndrome and SRNS who was successfully treated with ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21613
更新日期：2018-06-01 00:00:00
abstract：:In-line leukocyte reduction filters (LRF) are available for use with an automated plateletpheresis (PPH) system. Initially, 62% of PPH units produced with such a filter (LRF6, N = 29) had postfiltration (POF) white blood cell (WBC) counts < 5 x 10(6), with a mean POF WBC of 42 x 10(6). In an attempt to decrease POF WB...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920100204
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Perioperative therapeutic plasma exchange in patients with cardiovascular diseases poses several challenges, including alterations in intravascular volume, serum electrolytes, the coagulation cascade, and drug pharmacokinetics. METHODS:This review article summarizes different indications of plasma exchange ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.21676
更新日期：2019-08-01 00:00:00
abstract：:Idiopathic inflammatory demyelinating diseases (IIDDs) of the central nervous system, of which multiple sclerosis is the prototype, represent a family of monophasic, recurrent or progressive diseases with overlapping clinical and pathological manifestations. While most patients recover spontaneously or following a bri...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/(sici)1098-1101(1999)14:3<144::aid-jca7>3.
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:In organ transplantation, apheresis is frequently used for removal of anti-HLA antibodies. However, it is unclear whether plasmapheresis (PP) or semi-selective immunoadsorption (IA) should be employed, and the optimal number of apheresis sessions required to reach post-treatment objectives is also unknown. ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21858
更新日期：2020-11-30 00:00:00
abstract：:Lipid-apheresis (LA) is thought to improve microcirculation. However, limited data are available on the effects on peripheral microcirculation. We investigated upper limb microcirculation of 22 patients undergoing regular LA on a weekly basis before and after LA. Using standardized semiquantitative scales, we analyzed...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20285
更新日期：2011-01-01 00:00:00
abstract：:Recently very potent extracorporeal cholesterol-lowering treatment options have become available for patients with hypercholesterolemia. LDL immunoapheresis treatment selectively removes LDL and lipoprotein(a) from the circulation. Since LDL is the major carrier of lipophilic antioxidants in plasma, the purpose of the...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20026
更新日期：2004-01-01 00:00:00
abstract：:Thrombopoietin (TPO) serum levels in 14 patients (9 male and 5 female, mean age 36 years, range 16 to 55 years) with breast cancer (n = 5), testicular cancer (n = 7), or lymphoma (n = 2), undergoing high dose chemotherapy with peripheral blood stem cell (PBSC) transplantation, were evaluated at the first day of the mo...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/(sici)1098-1101(1999)14:2<57::aid-jca2>3.0
更新日期：1999-01-01 00:00:00
abstract：:Plerixafor in combination with granulocyte-colony stimulating factor (G-CSF) is approved for autologous stem cell mobilization in poor mobilizing patients with multiple myeloma or malignant lymphoma. The purpose of this study was to evaluate efficacy and safety of plerixafor in an immediate rescue approach, administra...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21496
更新日期：2017-08-01 00:00:00
abstract：:One of the most serious problems in applying leukapheresis to human infants is the large extracorporeal blood volume (ECV), resulting in substantial loss of platelets and red blood cells (RBCs). In this study, we developed a safe and effective modified procedure to collect peripheral blood stem cells (PBSCs) from rhes...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.10043
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Autoimmune disorders and neurodegenerative disorders take a physical and emotional toll on patients that undergo therapeutic plasma exchange (TPE) treatments. Previous literature has shown that these patients may feel a greater sense of self-burden. Motivational Interviewing (MI) is a technique used in vario...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21645
更新日期：2018-10-01 00:00:00
abstract：:Bone marrow (BM) damage after previous chemotherapy, such as that involving alkylating agents, and radiation therapy alone cannot explain poor hematopoietic progenitor cell mobilization. We examined the T lymphocytes of BM in 67 autologous peripheral blood stem cell transplant (auto-PBSCT) patients with non-Hodgkin ly...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21817
更新日期：2020-07-28 00:00:00
abstract：INTRODUCTION:ABO- or HLA-incompatible kidney transplantation is possible thanks to pretransplant antibody-depletion achieved by extracorporeal-treatment modalities. These methods induce depletion of some plasma proteins and may also impact on proteins involved in hemostasis. METHODS:To determine the impact of one sess...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21825
更新日期：2020-08-17 00:00:00
abstract：BACKGROUND:Therapeutic plasma exchange (TPE) may remove medications from the patient's plasma. Data is limited on the effect of TPE on unfractionated heparin (UFH). STUDY DESIGN AND METHODS:A retrospective review was performed of patients receiving TPE and continuous IV infusion UFH from 1/1/2008 to 6/30/2010. TPE wit...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21441
更新日期：2016-12-01 00:00:00
abstract：:The removal of immune complexes, autoantibodies and suppressor factors from the circulation of patients with AIDS and AIDS related conditions by plasmapheresis and selective immunoadsorption may play a role as a therapeutic modality in these disorders. Lymphocytapheresis may also be of potential use in AIDS related co...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920020436
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Transfusion of D+ red blood cells (RBCs) to D- recipients can be accidental or necessary due to D- RBC shortage. Alloimmunization can complicate future transfusions; implications for women of childbearing age are compounded by possible hemolytic disease of the fetus and newborn. Rh immunoprophylaxis is effec...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20225
更新日期：2010-01-01 00:00:00
abstract：:Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease treated successfully with plasma exchange. Jehovah's Witnesses whose religious beliefs preclude them from accepting plasma exchange may require alternative forms of therapy. We report a case of one such patient who presented with TTP, whom we succ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20150
更新日期：2007-01-01 00:00:00
abstract：:Two patients suffering from allergic bronchial asthma who showed no improvement despite six and four weeks, respectively, of drug therapy were successfully treated with therapeutic plasma exchange. The first patient had no attacks over a period of five months, and the other patient had none for over one year. Although...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920020210
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:Myeloid-derived leucocytes, a major source of inflammatory cytokines, play an important role in the exacerbation of ulcerative colitis (UC). Selective depletion of myeloid leucocytes by adsorptive granulomonocytapheresis (GMA) with an Adacolumn should alleviate inflammation and promote remission. However, th...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21787
更新日期：2020-08-01 00:00:00
abstract：:Leukemic-dendritic cells (leukemic-DCs) have certain limitations, which include difficult generation in 30-40% of patients, and low levels of expression of several key molecules. Therefore, an alternative approach using monocyte-derived DCs pulsed with tumor antigens is required. We investigated the possibility of imm...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20085
更新日期：2006-10-01 00:00:00
abstract：:Many practitioners believe in the phenomenon of being labeled either a "black cloud" or "white cloud" while on-call. A "white-cloud" physician is usually defined as one who sees fewer cases while a "black-cloud" is one who often receives more cases. To evaluate these phenomena, a 35-month prospective study was designe...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21650
更新日期：2018-10-01 00:00:00
