Modification of the leukapheresis procedure for use in rhesus monkeys (Macaca mulata).

Abstract:

:One of the most serious problems in applying leukapheresis to human infants is the large extracorporeal blood volume (ECV), resulting in substantial loss of platelets and red blood cells (RBCs). In this study, we developed a safe and effective modified procedure to collect peripheral blood stem cells (PBSCs) from rhesus monkeys (Macaca mulata) using a Baxter CS3000+ Blood Cell Separator (Baxter, Deerfield, IL) with several devices that reduced chamber size and shortened the standard apheresis kit to decrease ECV from 130 to 70 ml. Pump speed was controlled by monitoring hematocrit values and platelet counts during leukapheresis. This system makes it possible to perform safe and effective leukapheresis in rhesus monkeys whose body weight is similar to that of human infants. A total of 12 leukapheresis procedures were performed in nine monkeys and resulted in the collection of sufficient numbers of white blood cells (mean, 1.38 x 10(9) cells/kg), CD34(+) cells (mean, 17.80 x 10(6) cells/kg), mononuclear cells (mean, 3.67 x 10(8) cells/kg), and colony forming units (mean, 75.02 x 10(6) cells/kg) in all cases. In addition, no complications, such as anemia or thrombocytopenia, occurred after leukapheresis. This modified leukapheresis procedure will be useful to test new approaches in gene therapy, perform organ transplantation using nonhuman primates, and collect PBSCs from human infants in a noninvasive manner. Our nonhuman primate model provides an important framework for such future clinical studies.

journal_name

J Clin Apher

authors

Ageyama N,Kimikawa M,Eguchi K,Ono F,Shibata H,Yoshikawa Y,Terao K

doi

10.1002/jca.10043

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

26-31

issue

1

eissn

0733-2459

issn

1098-1101

journal_volume

18

pub_type

杂志文章
  • Lessons learned from the Oklahoma thrombotic thrombocytopenic purpura-hemolytic uremic syndrome registry.

    abstract::The Oklahoma TTP-HUS Registry provides a complete community perspective of thrombotic thrombocytopenic purpura (TTP). This is possible because plasma exchange is the essential treatment for TTP and the Oklahoma Blood Institute provides all plasma exchange procedures for a region encompassing most of the State, includi...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20169

    authors: George JN,Terrell DR,Swisher KK,Vesely SK

    更新日期:2008-01-01 00:00:00

  • Apheresis donor safety--changes in humoral and cellular immunity.

    abstract::Modern techniques of mechanical hemapheresis have made it possible to selectively remove vast quantities of lymphocytes and plasma immunoglobulins, and the concentration of these substances in donor blood can fall below the normal range. It is feared that this may lead to immunosuppression; a condition associated in s...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920020112

    authors: Strauss RG

    更新日期:1984-01-01 00:00:00

  • Childhood chronic relapsing polyneuropathy: dramatic improvement following plasmapheresis.

    abstract::We present clinical data on two boys with chronic relapsing polyneuropathy. Their recurrent episodes of weakness had produced marked disability which was unresponsive to continuous prednisone therapy. Plasmapheresis produced dramatic improvement in muscle strength and functional ability. The remissions induced have be...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920010110

    authors: Connor RK,Ziter FA,Anstall HB

    更新日期:1982-01-01 00:00:00

  • Analysis of CD34+ cell collection using two mobilization regimens for newly diagnosed multiple myeloma patients reveals the separate impact of mobilization and collection variables.

    abstract::Mobilization regimens for CD34+ cells have generally been judged successful based on the number of cells collected without evaluating mobilization separately from collection. Using retrospective data for patients who collected CD34+ cells on Total Therapy protocols 3a/3b (VTD-PACE) and Total Therapy 4/5 using a novel ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21313

    authors: Abuabdou A,Rosenbaum ER,Usmani SZ,Barlogie B,Cottler-Fox M

    更新日期:2014-10-01 00:00:00

  • Remission of hyper-IgE syndrome treated with plasmapheresis and cytotoxic immunosuppression.

    abstract::A patient with a hyper-IgE syndrome was treated with 60 plasmaphereses over a period of 2 years in conjunction with cytotoxic immunosuppressive drug therapy. During this time her severe dermatitis of 8 years' duration became almost completely inactive, and her circulating IgE level was reduced by 73%. An elevated pret...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920040104

    authors: Dau PC

    更新日期:1988-01-01 00:00:00

  • Heparin-induced thrombocytopenia associated with collection of hematopoietic progenitor cells by apheresis.

    abstract::Heparin-induced thrombocytopenia (HIT) can occur following exposure to heparin and is characterized by thrombocytopenia with increased risk for thrombosis. This condition is mediated by formation of immunoglobulin G antibodies against platelet factor 4/heparin complexes that can subsequently lead to platelet activatio...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21757

    authors: Raval JS,Park YA,Perjar I,Mazepa MA,Vincent BG,Ma AD,Rollins-Raval MA

    更新日期:2020-01-01 00:00:00

  • A prospective comparison of pegfilgrastim and lipegfilgrastim combined with chemotherapy in the mobilization of CD34+ cells in NHL patients.

    abstract:BACKGROUND:Autologous stem cell transplantation (auto-SCT) is a treatment approach in non-Hodgkin lymphoma (NHL) patients. The options for mobilization of CD34+ cells to support high-dose therapy are granulocyte-colony stimulating factors (G-CSFs) alone or after chemotherapy. Limited data exist on the efficacy of lipeg...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21785

    authors: Partanen A,Turunen A,Valtola J,Vasala K,Ågren L,Penttilä K,Pyörälä M,Kuittinen T,Mäntymaa P,Pelkonen J,Jantunen E,Varmavuo V

    更新日期:2020-08-01 00:00:00

  • Computerization of plateletpheresis quality control records with a commercially available spreadsheet program.

    abstract::Many apheresis units lack the resources to acquire customized computer software for record keeping. We have adapted a commercially available "spreadsheet" program (Lotus 1-2-3) to aid in quality control activities for plateletpheresis. Data are entered in a grid pattern wherein each donation occupies one row and succe...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920050407

    authors: McLeod BC,Viernes A,Reed S,Sassetti RJ

    更新日期:1990-01-01 00:00:00

  • Effect of immunoadsorption alone or combined with membrane filtration on hemostasis parameters.

    abstract:INTRODUCTION:ABO- or HLA-incompatible kidney transplantation is possible thanks to pretransplant antibody-depletion achieved by extracorporeal-treatment modalities. These methods induce depletion of some plasma proteins and may also impact on proteins involved in hemostasis. METHODS:To determine the impact of one sess...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21825

    authors: Marlu R,Bennani HN,Seyve L,Malvezzi P,Janbon B,Noble J,Christophe M,Motte L,Imerzoukene F,Chevallier E,Rostaing L,Jouve T

    更新日期:2020-08-17 00:00:00

  • Effect of heparin-induced extracorporeal lipoprotein apheresis on renal function.

    abstract::During the course of heparin-induced extracorporeal lipoprotein apheresis, a patient with no prior known renal impairment or proteinuria demonstrated sustained improvement in estimated glomerular filtration rate, commensurate with reduction in serum lipids and creatine phosphokinase levels. Causes and implications of ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20272

    authors: Chandran PK

    更新日期:2011-01-01 00:00:00

  • Effect of combined treatment with immunoadsorption and membrane filtration on plasma coagulation--Results of a randomized controlled crossover study.

    abstract::The combined use of immunoadsorption (IA) and membrane filtration (MF) may markedly enhance removal of IgM and complement component C1q, supporting its use as an element of recipient desensitization in antibody-incompatible transplantation. However, coagulation factor removal may contribute to altered hemostasis, posi...

    journal_title:Journal of clinical apheresis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/jca.21399

    authors: Biesenbach P,Eskandary F,Ay C,Wiegele M,Derfler K,Schaden E,Haslacher H,Oberbauer R,Böhmig GA

    更新日期:2016-02-01 00:00:00

  • Hemostasis management and therapeutic plasma exchange: Results of a practice survey.

    abstract:BACKGROUND:Patients undergoing therapeutic plasma exchange (TPE) may present with risks for hemorrhage or thrombosis. Use of replacement fluids devoid of coagulation factors will decrease factor levels and platelet levels. There are no established guidelines for hemostasis management in these situations. MATERIALS AND...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21653

    authors: Zantek ND,Boral LI,Li Y,Yamada C,Svensson AM,Crane JE,Smith RE,Pagano MB,Rollins-Raval MA,Schmidt AE,Wong ECC,Wu Y

    更新日期:2018-10-01 00:00:00

  • The sex parameter in estimation of total blood volume for pediatric erythrocytapheresis.

    abstract:BACKGROUND AND OBJECTIVES:Estimation of the total blood volume (TBV) is fundamental to the control of automated red cell exchange (RCE). Error in the TBV estimate can produce outcomes that deviate from the prescribed targets, and may endanger the patient. Both the Spectra Optia and the COBE Spectra use the Nadler formu...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21748

    authors: Colavita D,Kim HC,Friedman DF

    更新日期:2019-12-01 00:00:00

  • Therapeutic plasma exchange in recurrent focal segmental glomerulosclerosis following transplantation.

    abstract::Focal segmental glomerulosclerosis (FSGS) recurs in 30% of renal allograft transplants with graft loss in half of the cases. A humoral factor may be implicated. We report on the use of therapeutic plasma exchange (TPE) in 11 patients with recurrent FSGS post transplantation. Medical records from 1989-2000 were reviewe...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.10025

    authors: Shariatmadar S,Noto TA

    更新日期:2002-01-01 00:00:00

  • Indications for and outcomes of therapeutic plasma exchange after cardiac transplantation: A single center retrospective study.

    abstract:INTRODUCTION:Limited data are available describing indications for and outcomes of therapeutic plasma exchange (TPE) in cardiac transplantation. METHODS:In a retrospective study of patients who underwent cardiac transplantation at Duke University Medical Center from 2010 to 2014, we reviewed 3 TPE treatment patterns: ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21622

    authors: Onwuemene OA,Grambow SC,Patel CB,Mentz RJ,Milano CA,Rogers JG,Metjian AD,Arepally GM,Ortel TL

    更新日期:2018-08-01 00:00:00

  • Photopheresis in solid organ transplant rejection.

    abstract::Photopheresis has become a key component in the therapeutic armamentarium of cutaneous T-cell lymphoma, graft-versus-host disease following stem cell transplant, and allograft rejection of solid organs such as heart. Although it is considered a new treatment modality in its present form, the field of phototherapy date...

    journal_title:Journal of clinical apheresis

    pub_type: 历史文章,杂志文章,评审

    doi:10.1002/jca.20089

    authors: Marques MB,Tuncer HH

    更新日期:2006-04-01 00:00:00

  • Plasma exchange versus an affinity column for cholesterol reduction.

    abstract::The recent introduction of low-density lipoprotein (LDL)/very low-density lipoprotein (VLDL) selective-removal systems offers an alternative to plasma exchange (PE). For the last 10 years, we have treated a male homozygous hypercholesterolemia type IIA patient with PE using 5% normal serum albumin (NSA) replacement, P...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920070206

    authors: Burgstaler EA,Pineda AA

    更新日期:1992-01-01 00:00:00

  • Tempo of hematologic recovery correlates with peripheral blood CD34+ cell level in patients undergoing stem cell mobilization.

    abstract::This study was undertaken to evaluate the relationship between the time to recovery of peripheral blood counts and CD34+ cells in the peripheral blood (PB) and apheresis collections of patients undergoing intensive chemotherapy followed by rhG-CSF. Twenty-three patients with a median age of 42 years (range 17-64) with...

    journal_title:Journal of clinical apheresis

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1098-1101(1998)13:1<1::aid-jca1>3.0.

    authors: Williams O,Demirer T,Lilleby K,Buckner CD,Bensinger WI

    更新日期:1998-01-01 00:00:00

  • Antibody response to pneumococcal polysaccharide vaccine in myasthenia gravis: effect of therapeutic plasmapheresis.

    abstract::The removal of specific antibody in experimental animals has been reported to result in a subsequent increase in antibody to levels equal to (rebound) or exceeding those existing prior to removal (overshoot). Anecdotal reports suggest that rebound antibody synthesis after plasmapheresis may occur in humans with autoim...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920050304

    authors: Nasca TJ,Muder RR,Thomas DB,Schrecker JC,Ruben FL

    更新日期:1990-01-01 00:00:00

  • Autoimmunity in transfusion babesiosis: a spectrum of clinical presentations.

    abstract::Transfusion-acquired babesiosis can be an asymptomatic or self-limited febrile hemolytic illness in a healthy host. A persistent, relapsing, and/or fulminant course with the development of life-threatening complications may be seen in immunocompromised or splenectomized patients. As in malaria, erythrocyte parasitemia...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20262

    authors: Herman JH,Ayache S,Olkowska D

    更新日期:2010-01-01 00:00:00

  • Controlled application and removal of liposomal therapeutics: effective elimination of pegylated liposomal doxorubicin by double-filtration plasmapheresis in vitro.

    abstract:INTRODUCTION:Nanoscale particle-based drug delivery systems like long circulating liposomal doxorubicin show unique pharmacokinetic properties and improved toxicity profiles. Liposomal doxorubicin accumulates in tumor tissue due to the enhanced permeation and retention effect, but only a small fraction of a total dose ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20229

    authors: Pütz G,Schmah O,Eckes J,Hug MJ,Winkler K

    更新日期:2010-01-01 00:00:00

  • Induction of leukemic-cell-specific cytotoxic T lymphocytes by autologous monocyte-derived dendritic cells presenting leukemic cell antigens.

    abstract::Leukemic-dendritic cells (leukemic-DCs) have certain limitations, which include difficult generation in 30-40% of patients, and low levels of expression of several key molecules. Therefore, an alternative approach using monocyte-derived DCs pulsed with tumor antigens is required. We investigated the possibility of imm...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20085

    authors: Lee JJ,Park MS,Park JS,Kang HK,Kim SK,Nguyen Pham TN,Zhu XW,Cho D,Nam JH,Kim YJ,Rhee JH,Chung IJ,Kim HJ

    更新日期:2006-10-01 00:00:00

  • Thrombopoietin serum levels at the start of mobilization, collection, and transfusion of autologous peripheral blood stem cells.

    abstract::Thrombopoietin (TPO) serum levels in 14 patients (9 male and 5 female, mean age 36 years, range 16 to 55 years) with breast cancer (n = 5), testicular cancer (n = 7), or lymphoma (n = 2), undergoing high dose chemotherapy with peripheral blood stem cell (PBSC) transplantation, were evaluated at the first day of the mo...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-1101(1999)14:2<57::aid-jca2>3.0

    authors: Bojko P,Nowak N,Moritz T,Flasshove M,Harstrick A,Seeber S

    更新日期:1999-01-01 00:00:00

  • Higher efficacy of intermediate dose cytarabine + G-CSF compared to cyclophosphamide + G-CSF in hematopoietic stem cell mobilization in patients with multiple myeloma.

    abstract:BACKGROUND:There are several regimens used in hematopoietic stem cell (HSC) mobilization in multiple myeloma (MM). Cyclophosphamide (Cy) is one of the most commonly used agents, although it does not always result in collecting adequate number of CD34+ cells. Recently, cytarabine (Ara-C) has been proposed as potentially...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21784

    authors: Bogucka-Fedorczuk A,Czyz A,Kalicińska E,Sawicki M,Laszkowska-Lewko M,Wicherska-Pawłowska K,Rybka J,Szeremet A,Prajs I,Szymczak D,Wróbel T

    更新日期:2020-08-01 00:00:00

  • Prediction of immunoglobulin M reduction via therapeutic dose of simple plasma exchange and double filtration plasmapheresis using membrane separation in patients with hyperviscosity syndrome caused by Waldenstrom macroglobulinemia.

    abstract:BACKGROUND:Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target m...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21655

    authors: Miyamoto Y,Hamasaki Y,Matsumoto A,Doi K,Noiri E,Nangaku M

    更新日期:2018-10-01 00:00:00

  • The treatment of nephrogenic systemic fibrosis with therapeutic plasma exchange.

    abstract:BACKGROUND:Nephrogenic systemic fibrosis (NSF), also known as nephrogenic sclerosing dermopathy (NSD), is a rare progressive fibrosing disease associated with gadolinium based dyes in patients with renal disease. The exact pathophysiology is not well understood. Accepted treatments include corticosteroids, immune modul...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21253

    authors: Poisson JL,Low A,Park YA

    更新日期:2013-08-01 00:00:00

  • Apheresis red blood cells associated with repeated hemolysis during blood priming of the Cellex Photopheresis System.

    abstract::Extracorporeal photopheresis (ECP) in young pediatric patients has a risk for procedural hypotension and anemia due to extracorporeal fluid shifts. A standard mitigation policy in these patients is to prime the device with packed red blood cells (RBC) or whole blood. We now report multiple episodes of hemolysis while ...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21740

    authors: Cooling L,Thompson T,Downs T,Abusin G,Yanik G

    更新日期:2019-12-01 00:00:00

  • Impact of the CD4:CD8 ratio in bone marrow on stem cell mobilization and engraftment in autologous stem cell transplant patients.

    abstract::Bone marrow (BM) damage after previous chemotherapy, such as that involving alkylating agents, and radiation therapy alone cannot explain poor hematopoietic progenitor cell mobilization. We examined the T lymphocytes of BM in 67 autologous peripheral blood stem cell transplant (auto-PBSCT) patients with non-Hodgkin ly...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.21817

    authors: Oka S,Nohgawa M

    更新日期:2020-07-28 00:00:00

  • Sequential transplants using mobilized peripheral blood progenitor cells.

    abstract::Modest success has been achieved with the use of high-dose cytotoxic therapy and bone marrow transplantation in solid tumors. Patient outcome can potentially be improved with further intensification of the therapy. The rapid hematologic recovery achieved with mobilized peripheral blood progenitor cells (PBPC) may redu...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.2920090307

    authors: Ghalie R,Richman CM,Bender JG,McLeod BC,Lee W,Czyzewski A,Manson S,Cobleigh MA,Reed S,Pierre R

    更新日期:1994-01-01 00:00:00

  • Postdonation platelet counts are safe when collecting platelets with the Trima Accel using a postdonation platelet count target of > or =50,000 platelets/microL.

    abstract::In December 2007, the FDA issued a guidance document recommending that apheresis cell separators be configured with a postdonation platelet count target of > or =100,000 platelets/microL. Currently, our Trima Accel apheresis cell separators are configured with a postdonation platelet count target of > or =50,000 plate...

    journal_title:Journal of clinical apheresis

    pub_type: 杂志文章

    doi:10.1002/jca.20214

    authors: Alex J,Roberts B,Raife T

    更新日期:2009-01-01 00:00:00