Heparin-induced thrombocytopenia associated with collection of hematopoietic progenitor cells by apheresis.

Abstract:

:Heparin-induced thrombocytopenia (HIT) can occur following exposure to heparin and is characterized by thrombocytopenia with increased risk for thrombosis. This condition is mediated by formation of immunoglobulin G antibodies against platelet factor 4/heparin complexes that can subsequently lead to platelet activation. Herein, we detail the clinical and laboratory findings, treatments, and outcomes of two patients who developed HIT and thrombosis after undergoing collection of hematopoietic progenitor cells by apheresis (HPC-A) for autologous HPC transplant. Given that heparin may be used during HPC-A collections, these cases emphasize the importance of prompt consideration of HIT in patients that develop thrombocytopenia and thrombosis following HPC-A collection with heparin anticoagulation.

journal_name

J Clin Apher

authors

Raval JS,Park YA,Perjar I,Mazepa MA,Vincent BG,Ma AD,Rollins-Raval MA

doi

10.1002/jca.21757

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

59-61

issue

1

eissn

0733-2459

issn

1098-1101

journal_volume

35

pub_type

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