Abstract:
:We evaluated functional and morphological changes after trans-tympanic laser application using several different powers of photobiomodulation (PBM). The left (L) ears of 17 rats were irradiated for 30 min daily over 14 days using a power density of 909.1 (group A, 5040 J), 1136.4 (group B, 6300 J), and 1363.6 (group C, 7560 J) mW/cm(2). The right (N) ears served as controls. The safety of PBM was determined by endoscopic findings, auditory brainstem response (ABR) thresholds, and histological images of hair cells using confocal microscopy, and light microscopic images of the external auditory canal (EAC) and tympanic membrane (TM). Endoscopic findings revealed severe inflammation in the TM of C group; no other group showed damage in the TM. No significant difference in ABR threshold was found in the PBM-treated groups (excluding the group with TM damage). Confocal microscopy showed no histological difference between the AL and AN, or BL and BN groups. However, light microscopy showed more prominent edema, inflammation, and vascular congestion in the TM of BL ears. This study found a dose-response relationship between laser power parameters and TM changes. These results will be useful for defining future allowance criteria for trans-tympanic laser therapies.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Moon TH,Lee MY,Jung JY,Ahn JC,Chang SY,Chung PS,Rhee CK,Kim YH,Suh MWdoi
10.1007/s10103-015-1851-1subject
Has Abstractpub_date
2016-02-01 00:00:00pages
323-33issue
2eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-015-1851-1journal_volume
31pub_type
杂志文章abstract::The aims of this study were to evaluate the effects of Photogem®-mediated photosensitization on rat palatal mucosa and the biodistribution of the photosensitizer in this tissue. A solution of Photogem® (500 or 1000 mg/l) was applied to the palatal mucosa for 30 min and the exposure time to blue LED (460 nm) was 20 min...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-011-0909-y
更新日期:2012-03-01 00:00:00
abstract::Third-degree burn wounds are considered severe injuries because they destroy all the skin layers and may affect subcutaneous tissues, fasciae, muscles, and bones. To favor the healing process of the injured tissues, it is very useful to diminish the occurrence of the inflammatory process. The present study was aimed a...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-012-1213-1
更新日期:2013-07-01 00:00:00
abstract::This study aimed to compare the effects of photobiomodulation (PBM) in different energy densities and irradiances on maintaining cell viability, and proliferation of pulp fibroblasts from human primary teeth (HPF) were cultured in DMEM and used between the fourth and eighth passages. Then, HPF were irradiated with the...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-017-2301-z
更新日期:2017-09-01 00:00:00
abstract::Photobiomodulation (PBM) has been shown to improve wound healing by promoting mesenchymal stem cell migration and proliferation. However, it remains unknown whether an 808-nm diode laser can influence human gingival mesenchymal stem cells (HGMSCs), and which dose this works well. In the present study, it was found tha...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-020-03040-z
更新日期:2020-10-01 00:00:00
abstract::A nevus is described as a benign, often pigmented, skin growth that can be congenital or acquired. Different types of nevi are located at different depths within the skin. Traditional treatments for nevi include topical treatments, dermabrasion, and excision, which are generally ineffective, invasive, and often result...
journal_title:Lasers in medical science
pub_type: 杂志文章,评审
doi:10.1007/s10103-014-1697-y
更新日期:2015-09-01 00:00:00
abstract::A new outpatient non-surgical method using Er:YAG laser for snoring has been demonstrated. The aim of this systematic review and meta-analysis was to investigate the effects of this treatment on snoring. Relevant 1548 articles were searched from various databases from 1 January 2000 to September 2018 including PubMed,...
journal_title:Lasers in medical science
pub_type: 杂志文章,meta分析
doi:10.1007/s10103-020-02987-3
更新日期:2020-08-01 00:00:00
abstract::Photodynamic therapy (PDT) has been used to inhibit intimal hyperplasia in injured arteries. Because of the limited tissue penetration of visible light, an endovascular light source with a guided wire is often required for effective treatment. Indocyanine green (ICG), a near-infrared (NIR) photosensitizer, has been us...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-018-2488-7
更新日期:2018-07-01 00:00:00
abstract::High-intensity focused ultrasound (HIFU) can be applied noninvasively to create focused zones of tissue coagulation on various skin layers. We performed a comparative study of HIFU, evaluating patterns of focused tissue coagulation and ablation upon application thereof. A tissue-mimicking (TM) phantom was prepared wit...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-015-1804-8
更新日期:2015-12-01 00:00:00
abstract::We describe the diversity of indications for laser hair removal (LHR) therapy and compare our experience with the literature. Patients' case notes referred to the Birmingham Regional Skin Laser Centre between 2003 and 2011 for laser hair removal, with indications other than hirsutism, were reviewed retrospectively. Th...
journal_title:Lasers in medical science
pub_type: 杂志文章,评审
doi:10.1007/s10103-013-1464-5
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study is to determine the effectiveness of endoscopic diode laser therapy in patients presenting rectal bleeding due to chronic radiation proctitis (CRP). A retrospective analysis of CRP patients who underwent diode laser therapy in a single institution between 2010 and 2016 was carried out. The pa...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-017-2323-6
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to evaluate the shear bond strength (SBS) of a microhybrid composite resin bonded with three different adhesive systems to Er:YAG laser- (EL) or bur-prepared dentin surfaces and to analyze the quality and ultrastructure of the adhesive-dentin interfaces by scanning electron microscopy (SEM). ...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-013-1424-0
更新日期:2015-02-01 00:00:00
abstract::There is concern that the delicate fibres and cylindrical diffuser tips used for intraluminal PDT of blood vessels might break during the treatment. We have developed and tested a simple system to monitor for fibre breakage during PDT. Light from the laser is passed through a beam expander, then a beam splitter, and t...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-003-0270-x
更新日期:2003-01-01 00:00:00
abstract::In order to design and manufacture a reliable biomedical sensor, sensitive tests have to be performed. This is of superlative importance as it has to be used for the general public. Keeping this into account, the test mechanism of such an extremely sensitive sensor is being done that involves exhaustive protocols rega...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-019-02945-8
更新日期:2020-09-01 00:00:00
abstract::Although the application of Q-switched lasers on nevus of Ota (OTA) is well demonstrated, debates about clinical option between Q-switched alexandrite laser (QSA) and Q-switched Nd:YAG laser (QSNY) still remain. This systematic review and meta-analysis estimated the overall successful rate of OTA pigment clearance and...
journal_title:Lasers in medical science
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10103-016-1885-z
更新日期:2016-04-01 00:00:00
abstract::The molecular changes in gene expression following ablative laser treatment of skin lesions, such as atrophic scars and UV-damaged skin, are not completely understood. A standardized in vitro model of human skin, to study the effects of laser treatment on human skin, has been recently developed. Therefore, the aim of ...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-017-2175-0
更新日期:2017-05-01 00:00:00
abstract::It is well known that laser-assisted hatching (LAH) is the most popular and ideal embryo hatching technology, but the relevance to pregnancy outcomes of cryopreserved-thawed embryo transfer (ET) is controversial. The purpose of this meta-analysis was to evaluate the effects of LAH on pregnancy outcomes of cryopreserve...
journal_title:Lasers in medical science
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10103-017-2372-x
更新日期:2018-04-01 00:00:00
abstract::Primary hepatocellular carcinoma (HCC) and colon carcinoma are two of the most common clinical malignancies along with high morbidity and mortality. As low-power laser irradiation (LPLI) can induce cytotoxicity or cell apoptosis on several types of hyperplasia, LPLI may be a potential alternative treatment for gastroe...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-019-02869-3
更新日期:2020-04-01 00:00:00
abstract::Quantitative characterization of skin collagen on photo-thermal response and its regeneration process is an important but difficult task. In this study, morphology and spectrum characteristics of collagen during photo-thermal response and its light-induced remodeling process were obtained by second-harmonic generation...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-013-1296-3
更新日期:2014-01-01 00:00:00
abstract::We observed the promoting effects of the 2940-nm erbium:YAG (Er:YAG) fractional laser in topical drug delivery for psoriasis. A total of five (four males and one female) recalcitrant psoriasis patients were given laser treatment eight times at 1-week intervals with the following parameters: 5-11% spot density and 100-...
journal_title:Lasers in medical science
pub_type: 临床试验,杂志文章
doi:10.1007/s10103-017-2259-x
更新日期:2017-08-01 00:00:00
abstract::To identify the best low level laser photobiomodulation application site at the same irradiation time to increase the viability of the skin flap in rats. Eighteen male rats (Rattus norvegicus: var. Albinus, Rodentia Mammalia) were randomly distributed into three groups (n = 6). Group I (GI) was submitted to simulated ...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-018-2694-3
更新日期:2019-07-01 00:00:00
abstract::This study aimed to analyze the effects of light-emitting diode (LED) therapy on sternotomy pain and healing in patients who underwent coronary artery bypass grafting (CABG). The patients were followed for 6 months after the surgery to determine their dehiscence. This study was conducted with 90 volunteers who electiv...
journal_title:Lasers in medical science
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10103-013-1503-2
更新日期:2014-05-01 00:00:00
abstract::Antimicrobial photodynamic therapy (APDT) combined with endodontic treatment has been recognized as an alternative approach to complement conventional root canal disinfection methods on bacterial biofilms. We developed an in vitro model of bioluminescent Candida albicans biofilm inside curved dental root canals and i...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-014-1629-x
更新日期:2015-08-01 00:00:00
abstract::Photosensitizers belonging to the boron-dipyrromethenes (BODIPYs) class were recently found endowed with good efficacy in the antibacterial photodynamic therapy (aPDT) against both Gram-positive and Gram-negative bacteria. In this paper, we report on the remarkable adjuvant effect exerted in this respect by linear pol...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-017-2345-0
更新日期:2018-08-01 00:00:00
abstract::Scars from self-inflicted wounds, referred to as "hesitation marks," are usually linear, flat, poorly oriented, white in color, and often located on the forearm. Many patients do not undergo treatment for these due to limited available modalities. The aim of this study was to evaluate the efficacy and safety of the pi...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-016-1981-0
更新日期:2016-09-01 00:00:00
abstract::The aim of this in vitro study was to evaluate some parameters of dental etching when irradiated with an erbium, chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser. One-hundred sound human third molars were selected and randomly distributed into ten groups (n = 10). The class V cavities of group 1 (control) w...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-008-0623-6
更新日期:2010-05-01 00:00:00
abstract::Fungal infection of nails, onychomycosis, is predominantly caused by Trichophyton rubrum. This infection is an important public health concern due to its persistent nature and high recurrence rates. Alternative treatments are urgently required. One such alternative is phototherapy involving the action of photothermal ...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-013-1287-4
更新日期:2014-01-01 00:00:00
abstract:UNLABELLED:The aim of this study was to compare the effects of the pulsed-dye laser (PDL) at a wavelength of 585 nm with those at 595 nm in the treatment of post-surgical scars, starting on the day of suture removal. The study was a prospective, non-randomized, double-blind, controlled, clinical trial, set in an outpat...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-009-0698-8
更新日期:2009-09-01 00:00:00
abstract::The aim of this in vitro study was to assess the effect of Er:YAG laser surface treatment on the tensile bond strength of a sealant in permanent teeth. A total of 30 sound third molars were selected and embedded in cold-cure acrylic resin. The enamel surfaces were flattened by a grinding. The teeth were randomly divid...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-010-0869-7
更新日期:2012-03-01 00:00:00
abstract::Down syndrome (DS) has characteristics that include mental retardation, a characteristic phenotype, congenital heart defects, immune disorders, and increased risk of periodontal disease (PD). Antimicrobial photodynamic therapy (aPDT) is the combined use of photosensitizers associated with low-level laser (LLL) and oxy...
journal_title:Lasers in medical science
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10103-016-2020-x
更新日期:2016-12-01 00:00:00
abstract::Antibiotics and photodynamic therapy (PDT) are widely employed in curing acne. However, antibiotics as an effective treatment would lead to bacterial resistance and severe side effects. In this study, we aimed to develop a novel TBO hydrogel, which could prolong the retention time of photosensitizer (TBO) at the lesio...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-019-02727-2
更新日期:2019-10-01 00:00:00