Anti-inflammatory effect of low-intensity laser on the healing of third-degree burn wounds in rats.

Abstract:

:Third-degree burn wounds are considered severe injuries because they destroy all the skin layers and may affect subcutaneous tissues, fasciae, muscles, and bones. To favor the healing process of the injured tissues, it is very useful to diminish the occurrence of the inflammatory process. The present study was aimed at comparing the effect of different energetic densities of AlGaInP laser on the inflammatory process and in the healing of third-degree burn wounds in Wistar rats. This study was approved by the Ethics Committee, in which 36 adult male rats were selected and suffered the induction of third-degree burn injury. These rats were divided as follows: group 1-control (treated with silver sulfadiazine), group 2-received energy density of 3 J/cm(2), and group 3-received energy density of 6 J/cm(2). All animals daily received an occlusive bandage with silver sulfadiazine and 8 % papain. The laser therapy was performed alternatively three times a week. The animals were evaluated on the 3rd, 7th, 14th, and 21st days after the initial lesion and euthanized for the macroscopic, histologic, and morphometric analysis. A higher production of collagen was observed at 7 days and a greater re-epithelialization at 21 days in group 3 (6 J/cm(2)). Furthermore, the latter when compared to the other groups presented macroscopically a better aspect of the scar at 21 days with more granulation tissue and fibrosis. We conclude that the AlGaInP laser used in dosages of 3 and 6 J/cm(2) favors the healing of third-degree burn wounds induced in rats.

journal_name

Lasers Med Sci

authors

de Moraes JM,Eterno de Oliveira Mendonça D,Moura VB,Oliveira MA,Afonso CL,Vinaud MC,Bachion MM,de Souza Lino R Jr

doi

10.1007/s10103-012-1213-1

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

1169-76

issue

4

eissn

0268-8921

issn

1435-604X

journal_volume

28

pub_type

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