Abstract：
:Both high-intensity ultraviolet and narrowband ultraviolet B (NB-UVB) are important therapeutic options for vitiligo management, but high-intensity ultraviolet is more effective than NB-UVB. However, the underlying mechanisms have not been well investigated. Herein, we compare the effects of high-intensity ultraviolet and NB-UVB on the pigmentation of melanocytes derived from hair follicle-derived neural crest stem cells (HF-NCSCs) in vitro and study the underlying mechanisms. The HF-NCSCs were isolated from mouse whisker follicles. After radiation with high-intensity ultraviolet and NB-UVB, respectively, the cell viability by the CCK-8 assay showed gradual inhibitory effects in a dose-dependent manner, which has no apparent difference between the two modalities. The mRNA for melanogenesis factors such as tyrosinase and tyrp1 of the differentiated melanocytes increased significantly with high-intensity ultraviolet compared to the same dose of NB-UVB exposure. Furthermore, the expression of Mc1r was significantly increased by high-intensity ultraviolet in contrast to NB-UVB at the dosage of 0.5 J. By and large, these data suggest that high-intensity ultraviolet exhibited greater efficiency on the maturation of the melanocyte lineage differentiated from HF-NCSCs compared to NB-UVB with the same dose, which was probably due to the stronger stimulatory action of Mc1r. This may provide new insights into the different efficacies of high-intensity ultraviolet and NB-UVB in the treatment of vitiligo repigmentation.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Dong D,Chen S,Zhang X,Jin C,Zheng Y,Yang Ldoi
10.1007/s10103-014-1568-6subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1649-54issue
5eissn
0268-8921issn
1435-604Xjournal_volume
29pub_type
杂志文章abstract：:The purpose of the study was to evaluate the adaptation and micro-structure of Co-Cr alloy maxillary complete denture base plates fabricated by the selective laser melting (SLM) technique. Twenty pairs of edentulous casts were randomly and evenly divided into two groups, and manufacturing of the Co-Cr alloy maxillary ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-018-2438-4
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abstract：:Facial vitiligo has considerable psychological and emotional impacts. Though topical corticosteroids are the mainstay treatment, adverse reactions are a concern for prolonged use. Additionally, 308-nm excimer lamps have been widely used in vitiligo. This study aimed to assess the effectiveness of a combined 308-nm exc...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
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journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
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abstract：:Core-shell nanoparticles have unusual physical, chemical and biological properties. Until now, for the Ag and TiO2 combination, only Ag core and TiO2 shell nanoparticles have been practically demonstrated. In this investigation, novel TiO2@Ag core-shell (TiO2 core and Ag shell) nanoparticles were produced via ultrason...
journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1213-1
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journal_title：Lasers in medical science
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1221-1
更新日期：2014-01-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1296-3
更新日期：2014-01-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-014-1522-7
更新日期：2015-04-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2008-10-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02864-8
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journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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