Abstract:
:In view of the limitations of bone reconstruction surgeries using autologous grafts as a gold standard, tissue engineering is emerging as an alternative, which permits the fabrication and improvement of scaffolds to stimulate osteogenesis and angiogenesis, processes that are essential for bone repair. Polymers are used to mimic the extracellular bone matrix and support cell growth. In addition, bone neoformation can be induced by external factors such as laser irradiation, which stimulates bone metabolism. The objective of this study was to evaluate the regeneration of bone defects using collagen and elastin membranes derived from intestinal serosa and bovine auricular cartilage combined with low-level laser application. Thirty-six Wistar rats were operated to create a 3-mm defect in the distal metaphysis of the left femur and divided into six groups: G1 (control, no treatment); G2 (laser); G3 (elastin graft), G4 (elastin+laser); G5 (collagen graft); G6 (collagen+laser). The animals were sacrificed 6 weeks after surgery and the femurs were removed for analysis of bone repair. Macroscopic and radiological results showed the absence of an infectious process in the surgical area. This was confirmed by histological analysis, which revealed no inflammatory infiltrate. Histomorphometry showed that the formation of new bone started from the margins of the bone defect and its volume was greater in elastin+laser and collagen+laser. We conclude that newly formed bone in the graft area was higher in the groups that received the biomaterials and laser. The collagen and elastin matrices showed biocompatibility.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Dos Santos DA,de Guzzi Plepis AM,da Conceição Amaro Martins V,Cardoso GBC,Santos AR Jr,Iatecola A,Andrade TN,Monteiro FM,Calegari ARA,Chacon EL,Cunha MRdoi
10.1007/s10103-019-02864-8subject
Has Abstractpub_date
2020-06-01 00:00:00pages
813-821issue
4eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-019-02864-8journal_volume
35pub_type
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journal_title:Lasers in medical science
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