Abstract：
:The aims of this study were to evaluate the effects of Photogem®-mediated photosensitization on rat palatal mucosa and the biodistribution of the photosensitizer in this tissue. A solution of Photogem® (500 or 1000 mg/l) was applied to the palatal mucosa for 30 min and the exposure time to blue LED (460 nm) was 20 min (144 J/cm(2)). At 0, 1, 3, and 7 days, palatal mucosa was photographed for macroscopic analysis. After killing, the palate was removed for microscopic analysis. Thermal mapping evaluated temperature change in the tissue during irradiation. All experimental groups revealed intact mucosa in the macroscopic analysis. Tissue alterations were observed microscopically for only four out of 80 animals subjected to PDT. Fluorescence emitted by Photogem® was identified and was limited to the epithelial layer. A temperature increase from 35 to 41°C was recorded. Photogem®- mediated PDT was not toxic to the rat palatal mucosa.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Trindade FZ,Pavarina AC,Ribeiro AP,Bagnato VS,Vergani CE,Costa CAdoi
10.1007/s10103-011-0909-ysubject
Has Abstractpub_date
2012-03-01 00:00:00pages
403-11issue
2eissn
0268-8921issn
1435-604Xjournal_volume
27pub_type
杂志文章abstract：:Physical stimulation of body surface points is known to affect various organ functions. In traditional Chinese medicine, so-called acupoints were defined. These points can be physically stimulated to effectively treat various diseases. Here we describe for the first time the effect of CO(2) laser stimulation at the ac...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0973-3
更新日期：2012-03-01 00:00:00
abstract：:The present study was designed to evaluate the effects of low-level laser (Nd:YAG) therapy and occlusal splints in patients with signs and symptoms of temporomandibular disorders (TMD) characterized with myofascial pain (MP). A total of 30 patients were selected after being diagnosed with MP according to the Research ...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-014-1522-7
更新日期：2015-04-01 00:00:00
abstract：:The objective of this study was to evaluate the safety and efficacy of flexible ureteroscopy (FURS) and holmium:YAG laser lithotripsy for the treatment of upper urinary tract stones in patients on active oral anticoagulants. The records of 1081 patients who underwent flexible ureteroscopic holmium:YAG (Ho:YAG) laser l...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2289-4
更新日期：2017-09-01 00:00:00
abstract：:A novel skin phantom is described that is constructed with quantifiable amounts of skin pigments, as well as a light scattering medium in the form of barium sulphate suspension. The two predominant skin pigments (melanin and haemoglobin) are varied in controlled amounts within the phantoms to simulate skin colour in d...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0495-1
更新日期：2008-10-01 00:00:00
abstract：:Crohn's disease is a chronic relapsing and remitting inflammatory condition which affects any part of the gastrointestinal tract. In the oro-facial region, patients can present peri-oral swellings which results in severe facial disfigurement. To date, assessing the degree of facial changes and evaluation of treatment ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1286-5
更新日期：2014-05-01 00:00:00
abstract：:In 30 patients with periodontitis, a total of 278 teeth exhibiting bleeding on probing, subgingival calculus, and a probing depth between 3-6 mm were examined. For each participant, two treatment types were alternatively applied on the contralateral quadrants: scaling and root planing (SRP) as control, and SRP followe...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-010-0799-4
更新日期：2011-07-01 00:00:00
abstract：:Oxygen consumption at the targeted site has a significant effect on dosimetry in photodynamic therapy (PDT). However, oxygen consumption in PDT using a pulsed laser as a light source has not been clarified. We therefore investigated the dependence of cytotoxicity on the oxygen consumption and the photosensitizer photo...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-004-0288-8
更新日期：2004-01-01 00:00:00
abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of infections in humans. Photodynamic therapy using blue light (450 nm) could possibly be used to reduce MRSA on different human tissue surfaces without killing the human cells. It could be less harmful than 300-400 nm light or common disinfectan...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02774-9
更新日期：2019-12-01 00:00:00
abstract：:Recently, investigations suggest the benefits of low-level laser (light) therapy (LLLT) in noninvasive treatment of cellulite, improvement of body countering, and control of lipid profile. However, the underlying key mechanism for such potential effects associated to aerobic plus resistance training to reduce body fat...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-015-1759-9
更新日期：2015-07-01 00:00:00
abstract：:The aim of this study was to investigate the effects of low-level laser (LLL) irradiation on the turnover of fibronectin and collagen type I in periodontal tissue during tooth movement in rats by immunohistochemistry. Thirty male Sprague-Dawley rats aged 15 weeks were assigned to either an experimental group (n = 15) ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-008-0585-8
更新日期：2010-01-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-015-1768-8
更新日期：2015-07-01 00:00:00
abstract：:Bisphosphonate-related osteonecrosis of the jaw is a well-known potential side effect of long-term bisphosphonate therapy; the primary objective of the treatment should be to improve patient quality of life through pain and infection management, to prevent the development of new lesions, and to slow disease progressio...
journal_title：Lasers in medical science
pub_type： 杂志文章,评审
doi：10.1007/s10103-016-1929-4
更新日期：2016-08-01 00:00:00
abstract：:In an in vitro study, the effect of light polarization on the efficiency of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) of basal cell carcinoma (BCC) was investigated. Three states of light polarization (non-polarized, linearly polarized, and circularly polarized) were considered. Cells were exposed to gre...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2369-5
更新日期：2018-02-01 00:00:00
abstract：:The relative amounts of 5-aminolaevulinic acid (ALA)-induced hydrophobic and hydrophilic porphyrins produced in normal mouse tissue and solid Ehrlich ascites carcinoma in mice were investigated as a function of added glucose, light irradiation and restricted blood flow to the tumour. Protoporphyrin IX (PpIX) is the pr...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/BF02765103
更新日期：1997-10-01 00:00:00
abstract：:The aim of the present study was to evaluate the success rate of failed implants re-implanted after surface treatment with CO2 laser. Despite the widespread use of dental implants, there are many incidents of failures. It is believed that lasers can be applied to decontaminate the implant surface without damaging the ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-1921-z
更新日期：2016-07-01 00:00:00
abstract：:Laser micromachining with ultrashort pulses has shown great promise for clean, safe surgical treatment of bone tissue. However, comparisons of performance and development of "best practice" have been hampered by the difficulty of comparing results across a wide variety of experimental approaches and under surgically i...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02899-x
更新日期：2020-08-01 00:00:00
abstract：:The purpose of the study was to evaluate the adaptation and micro-structure of Co-Cr alloy maxillary complete denture base plates fabricated by the selective laser melting (SLM) technique. Twenty pairs of edentulous casts were randomly and evenly divided into two groups, and manufacturing of the Co-Cr alloy maxillary ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-018-2438-4
更新日期：2018-07-01 00:00:00
abstract：:Low-intensity laser therapy is based on the excitation of endogenous chromophores in biotissues and free-radical generation could be involved in its biological effects. In this work, the effects of the low-intensity infrared laser on plasma protein content and oxidative stress in blood from Wistar rats were studied. B...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0945-7
更新日期：2012-01-01 00:00:00
abstract：:The aim of the present study was to investigate the effects of photobiomodulation (PBM) therapy on the expression of heat shock protein 70 (HSP70) and tissue repair in an experimental model of collagenase-induced Achilles tendinitis. Thirty Wistar rats (aged 12 weeks) were randomly distributed among control group (n =...
journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2020-10-10 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s101030200025
更新日期：2002-01-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02941-y
更新日期：2020-09-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0989-8
更新日期：2012-05-01 00:00:00
abstract：:Osteoarthritis (OA) triggers increased levels of inflammatory markers, including prostaglandin (PG) E2 and proinflammatory cytokines. The elevation of cytokine levels is closely associated with increased articular tissue degeneration. Thus, the use of combination therapies may presumably be able to enhance the effects...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-2091-8
更新日期：2017-01-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-008-0576-9
更新日期：2009-05-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
abstract：:Fungal infection of nails, onychomycosis, is predominantly caused by Trichophyton rubrum. This infection is an important public health concern due to its persistent nature and high recurrence rates. Alternative treatments are urgently required. One such alternative is phototherapy involving the action of photothermal ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1287-4
更新日期：2014-01-01 00:00:00
abstract：:The aim of the present study was to investigate the influence of low-level red (660 nm) and infrared (780 nm) laser with four different radiance exposures on human umbilical vein endothelial cells (HUVECs) in vitro. HUVECs (1.5 × 104) were incubated in 96-well culture plates. The cells were maintained in M199 medium s...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-020-03016-z
更新日期：2021-02-01 00:00:00
abstract：:The aim of this study was to investigate the effect of different working modes (pulsed and micropulsed) and power settings of a standardized 980-nm diode laser on collateral thermal soft-tissue damage. A total of 108 bovine liver samples were cut with a diode laser at various settings in pulsed and micropulsed mode an...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-1007-x
更新日期：2012-09-01 00:00:00
abstract：:Various therapies for the treatment of sprains have emerged as advances occur in biomedical engineering and photobiology. Therapy with coherent and non-coherent light is a treatment modality for various musculoskeletal injuries. The main certified phototherapy benefits are the reduction of nociceptive processes and th...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-018-2460-6
更新日期：2018-07-01 00:00:00
abstract：:Low-level red laser (LLRL)-tissue interactions have a wide range of medical applications and are garnering increased attention. Although the positive effects of low-level laser therapy (LLLT) have frequently been reported and enhanced collagen accumulation has been identified as one of the most important mechanisms in...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-015-1823-5
更新日期：2015-12-01 00:00:00
