Abstract：
:Low-level red laser (LLRL)-tissue interactions have a wide range of medical applications and are garnering increased attention. Although the positive effects of low-level laser therapy (LLLT) have frequently been reported and enhanced collagen accumulation has been identified as one of the most important mechanisms involved, little is known about LLRL-collagen interactions. In this study, we aimed to investigate the influence of LLRL irradiation on collagen, in correlation with fibroblast response. Atomic force microscopy (AFM) and fluorescence spectroscopy were used to characterize surfaces and identify conformational changes in collagen before and after LLRL irradiation. Irradiated and non-irradiated collagen thin films were used as culturing substrates to investigate fibroblast response with fluorescence microscopy. The results demonstrated that LLRL induced small alterations in fluorescence emission and had a negligible effect on the topography of collagen thin films. However, fibroblasts cultured on LLRL-irradiated collagen thin films responded to LRLL. The results of this study show for the first time the effect of LLRL irradiation on pure collagen. Although irradiation did not affect the nanotopography of collagen, it influenced cell behavior. The role of collagen appears to be crucial in the LLLT mechanism, and our results demonstrated that LLRL directly affects collagen and indirectly affects cell behavior.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Stylianou A,Yova Ddoi
10.1007/s10103-015-1823-5subject
Has Abstractpub_date
2015-12-01 00:00:00pages
2369-79issue
9eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-015-1823-5journal_volume
30pub_type
杂志文章abstract：:This study assessed the effect of curcumin as a photosensitizer in antimicrobial photodynamic therapy (aPDT) for the treatment of induced periodontitis in rats. Periodontitis was induced via a ligature around the mandibular first molar on the left side of 96 rats. The ligature was removed 7 days later, and the animals...
journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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更新日期：2020-11-07 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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