Abstract：
:The optical properties of hemoglobin could indicate the degree of hemolysis. We aimed to utilize this to develop a real-time blood damage monitoring device for cardiopulmonary bypass (CPB) systems. The real-time blood damage monitoring device comprised a near-infrared spectroscopy optical module with a fiber spectrometer and monitoring platform and computer software developed using LabVIEW 2017. The fiber spectrometer operated at wavelengths of 545, 660, and 940 nm and contained a detector fiber bundle (source-detector distance = 1.0-2.5 cm). CPB operation was simulated using an artificial heart-lung machine with a flow rate of 3, 4, or 5 L/min. Four hundred milliliter of anticoagulated porcine blood was continuously rotated for 4 h. The transmittance, reflectivity, and absorbance of the blood were measured using the optical device at a frequency of 25 Hz and then digitally averaged into 1-s interval. Samples of damaged blood were collected at regular intervals for in vitro hemolysis tests to calculate the normalized index of hemolysis (NIH). All experiments were repeated three times. We prepared 28 blood bags containing 400 ml of anticoagulant. Paired t test was used to examine the test-retest reliability of the differences between the three methods and control samples. Statistical tests revealed significant differences in the mean values between the test and control groups over time (P < 0.01). Relationship was established between the real-time monitoring results and the NIH values. An effective blood damage detection method that combined in vitro hemolysis tests and near-infrared spectroscopy was achieved. The results demonstrate the clinical potential of a real-time, low-cost, and reliable blood damage monitoring device to improve the safety of CPB operation.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Gu X,Wang T,Zheng K,Jiang Z,Jiang Hdoi
10.1007/s10103-020-03094-zsubject
Has Abstractpub_date
2020-07-10 00:00:00eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-020-03094-zpub_type
杂志文章abstract：:The aims of this study were to evaluate the effects of Photogem®-mediated photosensitization on rat palatal mucosa and the biodistribution of the photosensitizer in this tissue. A solution of Photogem® (500 or 1000 mg/l) was applied to the palatal mucosa for 30 min and the exposure time to blue LED (460 nm) was 20 min...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0909-y
更新日期：2012-03-01 00:00:00
abstract：:One possible undesirable consequence of orthodontic therapy is the development of incipient caries lesions of enamel around brackets. The aim of this study was to compare the effects of CO2 (λ = 10.6 μm) and Nd:YAG (λ = 1,064 nm) lasers associated or not with topical fluoride application on the prevention of caries le...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1380-8
更新日期：2015-02-01 00:00:00
abstract：:This study aimed to evaluate the effects of low-level laser therapy (LLLT) immediately before tetanic contractions in skeletal muscle fatigue development and possible tissue damage. Male Wistar rats were divided into two control groups and nine active LLLT groups receiving one of three different laser doses (1, 3, and...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-014-1560-1
更新日期：2014-09-01 00:00:00
abstract：:Although ear reconstruction technology has been highly developed in recent years, hair growth on the reconstructed ear has plagued both surgeons and patients. In this paper, the authors introduce a clinical application of intense pulsed light depilation in total auricular reconstruction. From August 2012 to August 201...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-017-2255-1
更新日期：2017-08-01 00:00:00
abstract：:Bothropic venom contains a range of biologically active substances capable of causing severe local and systemic envenoming symptomatology within its victims. The snake anti-venom is effective against systemic effects but has no neutralizing effect against the fast developing local effects. Herein, mice gastrocnemius i...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2252-4
更新日期：2017-08-01 00:00:00
abstract：:Osteoarthritis (OA) is a chronic joint disease that leads to pain and functional incapacity. The aim of the study is to investigate the effects of the incorporation of photobiomodulation (PBM) (via cluster) into a physical exercise program on the level of pain, lower limb muscle strength, and physical capacity, in pat...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-019-02807-3
更新日期：2020-02-01 00:00:00
abstract：:The development of imaging technique to visualize and quantify the structural alteration of the spinal cord injury (SCI) may lead to better understanding and treatments of the injuries. In this work, multiphoton microscopy (MPM) based on two-photon excited fluorescence (TPEF) and second-harmonic generation (SHG) was t...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-018-2630-6
更新日期：2019-04-01 00:00:00
abstract：:This study aimed to investigate the influence of low-power 830 nm gallium-aluminium-arsenide (GaAlAs) laser [continuous wave (CW) 40 mW and fluence 4 J/cm(2), with total energy density of 16 J/cm(2)] on the healing of human infra-bony defects treated with bioactive glass graft material. Twenty patients with chronic pe...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-008-0576-9
更新日期：2009-05-01 00:00:00
abstract：:Biostimulatory effect of cell proliferation and bone formation by laser irradiation has been reported, however, very little is known about the molecular basis of mechanisms. We previously constructed the cDNA library of mouse osteoblastic cells (MC3T3-E1) which enhanced gene expression by laser irradiation using a sub...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/pl00011357
更新日期：2001-01-01 00:00:00
abstract：:The Nd: YAG laser family offers wide possibilities for surgery applications in medicine. The radiation at 213 nm provides similar tissue effects as compared to 193 nm excimer lasers, but offers considerable practical advantages in the operating room. As such, it is of considerable interest to create single-mode Q-swit...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-005-0328-z
更新日期：2005-01-01 00:00:00
abstract：:Acupuncture is a form of traditional Chinese medicine that has developed over thousands of years. We studied the effects of laser puncture, needle acupuncture, and light stimulation on cerebral blood flow in 15 healthy volunteers (mean age 25.0±1.9 years, 5 female, 10 male) with non-invasive transcranial Doppler sonog...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s101030050048
更新日期：2000-01-01 00:00:00
abstract：:The effect of phototherapy with 890-nm light-emitting diodes (LEDs) on the healing of experimentally induced tendinitis in sheep was evaluated in this study. Partial tenotomies measuring 0.2 cm wide × 0.5 cm long were performed on the second third of the superficial digital flexor tendons of 10 healthy sheep. The anim...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-014-1641-1
更新日期：2015-01-01 00:00:00
abstract：:Bisphosphonate-related osteonecrosis of the jaw is a well-known potential side effect of long-term bisphosphonate therapy; the primary objective of the treatment should be to improve patient quality of life through pain and infection management, to prevent the development of new lesions, and to slow disease progressio...
journal_title：Lasers in medical science
pub_type： 杂志文章,评审
doi：10.1007/s10103-016-1929-4
更新日期：2016-08-01 00:00:00
abstract：:We aimed at examining the effects of a percentage of air/water in spray on the cutting efficiency of Er,Cr:YSGG laser for enamel and dentin. The intensity and frequency of irradiation were 3.0 W and 20 Hz for the enamel surface and 2.0 W and 20 Hz for the dentin surface, respectively. Flattened surfaces of enamel and ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-018-2607-5
更新日期：2019-02-01 00:00:00
abstract：:The aim of this study was to histologically and biochemically analyze the effects of light-emitting diode therapy (LEDT) associated with resistance training to prevent sarcopenia in ovariectomized rats. Forty female Wistar rats (12 months old, 295-330 g) were bilaterally ovariectomized and divided into four groups (n ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1251-8
更新日期：2013-11-01 00:00:00
abstract：:Low-back pain is very frequent, especially in active adult population. There are several different orthopaedic condition that can cause low-back pain, and the pain worsen the quality of life significantly. The treatments vary from drugs, physical therapies, kinesiology, local infiltrations, and so on. Laser therapy ha...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-014-1684-3
更新日期：2015-01-01 00:00:00
abstract：:This study aimed to analyze the effects of light-emitting diode (LED) therapy on sternotomy pain and healing in patients who underwent coronary artery bypass grafting (CABG). The patients were followed for 6 months after the surgery to determine their dehiscence. This study was conducted with 90 volunteers who electiv...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-013-1503-2
更新日期：2014-05-01 00:00:00
abstract：:The aim of this study was to evaluate the bactericidal effect of ultraviolet (UV) light at 265-nm (UVC) and 310-nm (UVB) wavelengths from a newly developed UV light-emitting diode (LED) device against cariogenic bacteria in vitro. Suspensions of Streptococcus mutans (S. mutans) and Streptococcus sobrinus were directly...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-018-2685-4
更新日期：2019-07-01 00:00:00
abstract：:In an in vitro study, the effect of light polarization on the efficiency of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) of basal cell carcinoma (BCC) was investigated. Three states of light polarization (non-polarized, linearly polarized, and circularly polarized) were considered. Cells were exposed to gre...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2369-5
更新日期：2018-02-01 00:00:00
abstract：:The purpose of this study was to evaluate the acid resistance of erbium:yttrium-aluminum-garnet (Er:YAG) lased sub-surface dentin using a scanning electron microscope (SEM). Dentin disks were exposed to a single pulse of Er:YAG laser irradiation at 80 mJ/pulse under water spray, with the contact sapphire tip vertical ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-008-0553-3
更新日期：2009-07-01 00:00:00
abstract：:Minimal hepatic encephalopathy (MHE) has been shown to affect daily functioning, quality of life, driving and overall mortality. However, little is known about treating or diagnosing early impairments involved in MHE. We studied one of its precipitating factors, portal hypertension. The purpose was to evaluate an enha...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-2042-4
更新日期：2016-11-01 00:00:00
abstract：:The efficacy of intense pulsed light (IPL) in remodeling the extracellular matrix of aged skin had been proven by an increasing number of clinical trials. However, because of the lack of research about the underlying molecular and signaling mechanisms, its efficiency had not been accepted universally. A potential mech...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-010-0870-1
更新日期：2011-05-01 00:00:00
abstract：:We review the different spectroscopic techniques including the most recent laser-induced breakdown spectroscopy (LIBS) for the characterization of materials in any phase (solid, liquid or gas) including biological materials. A brief history of the laser and its application in bioscience is presented. The development o...
journal_title：Lasers in medical science
pub_type： 杂志文章,评审
doi：10.1007/s10103-011-0921-2
更新日期：2011-09-01 00:00:00
abstract：:Alopecia areata (AA) is a common autoimmune disease that presents with non-scarring alopecia. It is characterized by intra- or peri-follicular lymphocytic infiltrates composed of CD4+ and CD8+ T-cells on histology. To this day, few treatments are effective for AA. Here we present findings of using a low-level laser co...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0953-7
更新日期：2012-03-01 00:00:00
abstract：:The present study was designed to evaluate the effects of low-level laser (Nd:YAG) therapy and occlusal splints in patients with signs and symptoms of temporomandibular disorders (TMD) characterized with myofascial pain (MP). A total of 30 patients were selected after being diagnosed with MP according to the Research ...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-014-1522-7
更新日期：2015-04-01 00:00:00
abstract：:Zirconia has been regarded as a promising material for dental implants, and Nd:YAG laser treatment has been proposed as a potential strategy to improve its bioactivity. The main aim of the present study was to evaluate the in vitro behavior of human fetal osteoblasts in contact with laser-textured zirconia implant sur...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-020-03066-3
更新日期：2020-12-01 00:00:00
abstract：:This review aimed to identify the efficacy of low-level laser therapy (LLLT) in the management of orthodontic pain. This systematic review and meta-analysis was carried out in accordance with Cochrane Handbook and the PRISMA statement. An extensive literature search for RCTs, quasi-RCTs, and CCTs was performed through...
journal_title：Lasers in medical science
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10103-012-1196-y
更新日期：2013-11-01 00:00:00
abstract：:Endometriosis is a chronic disease affecting mainly women of the reproductive age. Its most common manifestations include impaired fecundity, pelvic pain, and dyschezia. Laparoscopic removal of endometriotic foci remains to be the gold standard for the treatment of endometriosis. More effective techniques of endoscopi...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-014-1630-4
更新日期：2015-01-01 00:00:00
abstract：:The potential of laser-induced fluorescence (LIF) spectroscopy for the characterization of different stages of dental caries using 404-nm diode laser excitation was investigated. In vitro spectra from 16 sound, 10 noncavitated carious and 10 cavitated carious molar teeth were recorded on a miniature fibre-optic spectr...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-010-0771-3
更新日期：2011-05-01 00:00:00
abstract：:Low-level laser irradiation (LLLI) and recombinant human bone morphogenetic protein type 2 (rhBMP-2) have been used to stimulate bone formation. LLLI stimulates proliferation of osteoblast precursor cells and cell differentiation and rhBMP-2 recruits osteoprogenitor cells to the bone healing area. This in vivo study e...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-1022-y
更新日期：2012-09-01 00:00:00
