Abstract:
:The development of imaging technique to visualize and quantify the structural alteration of the spinal cord injury (SCI) may lead to better understanding and treatments of the injuries. In this work, multiphoton microscopy (MPM) based on two-photon excited fluorescence (TPEF) and second-harmonic generation (SHG) was tentatively applied to quantitatively visualize the cellular microstructures of SCI to demonstrate the feasibility and superiority of MPM in SCI imaging. High-contrast MPM images of normal and injured spinal cord tissue were obtained for comparison. Moreover, the changes of injured spinal cord were characterized by the quantitative analysis of the MPM images. These results showed that MPM combined with quantitative method has the ability to identify the characteristics of spinal cord injury including the changes in the contents of nerve fibers and extracellular matrix. With the advancement of MPM, we believe that this technique has great potential to provide the histological diagnosis for the monitoring and evaluation of SCI.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Liao C,Zhu X,Zhou L,Wang Z,Liu W,Chen Jdoi
10.1007/s10103-018-2630-6subject
Has Abstractpub_date
2019-04-01 00:00:00pages
561-569issue
3eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-018-2630-6journal_volume
34pub_type
杂志文章abstract::Hyperhidrosis and bromhidrosis were lately reported as novel side effects of laser-assisted removal of axillary hair. The goal of our study was to evaluate the reversibility of these two side effects. An observational, single-center cohort study included over a 30-month screening period 30 patients with newly reported...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-013-1404-4
更新日期:2014-03-01 00:00:00
abstract::This review aimed to identify the efficacy of low-level laser therapy (LLLT) in the management of orthodontic pain. This systematic review and meta-analysis was carried out in accordance with Cochrane Handbook and the PRISMA statement. An extensive literature search for RCTs, quasi-RCTs, and CCTs was performed through...
journal_title:Lasers in medical science
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10103-012-1196-y
更新日期:2013-11-01 00:00:00
abstract::Despite the positive effects of low-level laser therapy (LLLT) on muscle fatigue before exercises using a single muscle group, the acute effects of LLLT on performance in cardiopulmonary exercise testing (CPET) are poorly understood. We aimed to assess the acute effects of LLLT on physiologic and electromyographic res...
journal_title:Lasers in medical science
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10103-014-1595-3
更新日期:2014-11-01 00:00:00
abstract::Recent studies have shown that direct laser metal sintering (DLMS) produces structures with complex geometry and consequently that allow better osteoconductive properties. The aim of this patient report was to evaluate the early bone response to DLMS implant surface retrieved from human jaws. Four experimental DLMS im...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-010-0831-8
更新日期:2011-01-01 00:00:00
abstract::Tissue characterisation by fluorescence imaging, using exogenous fluorophores, is a promising method for cancer detection. Histochemical alterations in the composition of mucins, when neoplastic transformations occur, could be exploited to derive more selective fluoroprobes indicative of early malignant transformation...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/pl00011361
更新日期:2001-01-01 00:00:00
abstract::Cancer treatment with chemotherapy or radiotherapy is associated with some side effects including in the oral cavity. One of the more significant oral complications is oral mucositis (OM) which induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking. Although advancements in can...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-019-02757-w
更新日期:2019-09-01 00:00:00
abstract::To evaluate the effect of various media and Iridex MicroPulse P3 (MP3) probe angles on the power output from the Cyclo G6 Glaucoma Laser (G6) System. A laser power meter was used to measure the power output (milliwatts, mW) of the Cyclo G6 System. Each of the ten trials consisted of measurements in six different media...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-020-03089-w
更新日期:2020-07-18 00:00:00
abstract::A rabbit model of endophthalmitis was established to evaluate the antiinflammatory effect of low-level laser therapy (LLLT) as an adjunct to treatment for Staphylococcus epidermidis endophthalmitis. Rabbits were randomly divided into three groups to receive intravitreal injections into their left eye: group A received...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-011-0991-1
更新日期:2012-05-01 00:00:00
abstract::Inflammation of synovial membrane and degeneration of articular cartilage in osteoarthritis (OA) lead to major changes in joint space width (JSW) and biochemical components such as collagen-II telopeptide (CTX-II) and matrix metallo protineases (MMP-3, 8, and 13). Low-level laser therapy (LLLT) is thought to have an a...
journal_title:Lasers in medical science
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10103-016-2114-5
更新日期:2017-02-01 00:00:00
abstract::The optical properties of hemoglobin could indicate the degree of hemolysis. We aimed to utilize this to develop a real-time blood damage monitoring device for cardiopulmonary bypass (CPB) systems. The real-time blood damage monitoring device comprised a near-infrared spectroscopy optical module with a fiber spectrome...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-020-03094-z
更新日期:2020-07-10 00:00:00
abstract::This study aimed to assess the effect of toluidine blue (TB)-mediated photodynamic inactivation of periodontal pathogens (PP) from periodontopathic patients. Photodynamic therapy (PDT) was carried out using TB and 635 nm laser light irradiation. The bactericidal effect was evaluated, and important PDT parameters inclu...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-007-0454-x
更新日期:2008-01-01 00:00:00
abstract::We report the use of spectral domain polarization sensitive optical coherence tomography for ex-vivo imaging of human oral mandibular tissue samples. Our results show that compared to the changes observed in the epithelium thickness and the decay constant of A-scan intensity profile, a much larger degree of change was...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-016-2096-3
更新日期:2017-01-01 00:00:00
abstract::The present study was designed to evaluate the effects of low-level laser (Nd:YAG) therapy and occlusal splints in patients with signs and symptoms of temporomandibular disorders (TMD) characterized with myofascial pain (MP). A total of 30 patients were selected after being diagnosed with MP according to the Research ...
journal_title:Lasers in medical science
pub_type: 临床试验,杂志文章
doi:10.1007/s10103-014-1522-7
更新日期:2015-04-01 00:00:00
abstract::Antimicrobial photodynamic therapy (APDT) combined with endodontic treatment has been recognized as an alternative approach to complement conventional root canal disinfection methods on bacterial biofilms. We developed an in vitro model of bioluminescent Candida albicans biofilm inside curved dental root canals and i...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-014-1629-x
更新日期:2015-08-01 00:00:00
abstract::The traditional needle cricothyroidotomy procedure is performed blindly without any medical equipment. Complications including posterior tracheal wall perforation, accidental vessel puncture, and missed tracheal puncture are reported. Therefore, we proposed a dual-wavelength fiber-optic technique based on the techniqu...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-020-03065-4
更新日期:2020-07-23 00:00:00
abstract::The objective of this study was to assess the effects of 780-nm low-level laser therapy at different periods of 7, 14 and 21 days after cryolesion, including the dose (10 or 50 J/cm(2)), to promote a better muscle repair evidenced by histopathological and immunohistochemical analyses. Fifty-four male rats were divided...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-013-1277-6
更新日期:2014-01-01 00:00:00
abstract::Laser acupuncture is a modality of low-level light therapy used as an alternative to needling for the past three decades. Although it has proved effective for the treatment of various conditions, the mechanisms underlying its effects are not fully understood. To contribute to this understanding, this study was designe...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-012-1260-7
更新日期:2013-09-01 00:00:00
abstract::Bacterial biofilms are often found in chronically infected wounds. Biofilms protect bacteria from antibiotics and impair wound healing. Surgical debridement is often needed to remove the biofilm from an infected wound. Laser-generated shockwave (LGS) treatment is a novel tissue-sparing treatment for biofilm disruption...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-020-03171-3
更新日期:2020-10-27 00:00:00
abstract::The purpose of this study was to compare the effectiveness of 1470- and 980-nm lasers with regard to power output, complications, recanalization rates, and treatment response. We prospectively evaluated the effectiveness of endovenous laser ablation (EVLA) in a total of 152 great and small saphenous veins from 96 pati...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-015-1768-8
更新日期:2015-07-01 00:00:00
abstract::We evaluated the acute electrophysiological effects of low-energy pulsed laser irradiation on isolated frog sciatic nerve measured by extracellular recording technique. A pulsed gallium-arsenide (GaAs) laser (wavelength: 904 nm, pulse duration 220 ns, peak power per pulse: 27W, spot size: 0.28 cm(2), total applied ene...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-002-8268-3
更新日期:2002-01-01 00:00:00
abstract::The neodymium/yttrium-aluminum-garnet (Nd/YAG) laser has been suggested to repair broken prostheses in the mouth. This study investigated the effects of different dentin thicknesses and air cooling on pulpal temperature rise during laser welding. Three intact human maxillary molars were prepared for full-veneer crown....
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-012-1108-1
更新日期:2013-01-01 00:00:00
abstract::To evaluate the efficacy of laser fibrotomy in patients with oral submucous fibrosis (OSMF) and also to correlate the habit variables causing OSMF. Thirty patients diagnosed clinically and histopathologically with OSMF were included in the study. Laser fibrotomy was done under local anesthesia using Zolar diode laser ...
journal_title:Lasers in medical science
pub_type: 临床试验,杂志文章
doi:10.1007/s10103-018-2531-8
更新日期:2018-11-01 00:00:00
abstract::Although numerous papers have recently been published on ablative fractional resurfacing, there is a lack of information in literature on very long-term results. The aim of this retrospective study is to evaluate the efficacy, adverse side effects, and long-term results of a random fractional ultrapulsed CO2 laser on ...
journal_title:Lasers in medical science
pub_type: 临床试验,杂志文章
doi:10.1007/s10103-012-1116-1
更新日期:2013-02-01 00:00:00
abstract::Wound healing is a very complex process, some phases of which have only recently been explained. Magnetic and electromagnetic fields can modulate this process in a non-thermal way. The aim of this research was to compare the influence of constant and pulsed electromagnetic fields and low-level laser therapy (LLLT) on ...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-008-0564-0
更新日期:2009-05-01 00:00:00
abstract::The objective of this study was to determine the efficacy and safety of a novel method of facial rejuvenation using a 2940-nm erbium:YAG laser with Spatially Modulated Ablation™. A pilot study was performed in 16 women with moderate to severe signs of facial aging relative to chronological age, who underwent two treat...
journal_title:Lasers in medical science
pub_type: 临床试验,杂志文章
doi:10.1007/s10103-016-2010-z
更新日期:2016-09-01 00:00:00
abstract::The use of the CO(2) laser in the management of oral dysplastic lesions has become a more common practice. Very few studies have evaluated recurrence, residual disease malignant transformation, and overall outcome in patients undergoing such a procedure. In this prospective study, a total of 123 oral dysplastic lesion...
journal_title:Lasers in medical science
pub_type: 临床试验,杂志文章
doi:10.1007/s10103-011-0916-z
更新日期:2012-01-01 00:00:00
abstract::The efficacy of intense pulsed light (IPL) in remodeling the extracellular matrix of aged skin had been proven by an increasing number of clinical trials. However, because of the lack of research about the underlying molecular and signaling mechanisms, its efficiency had not been accepted universally. A potential mech...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-010-0870-1
更新日期:2011-05-01 00:00:00
abstract::Our objective was to assess the efficacy and safety of combined 10.6 microm and 650 nm laser irradiation on patients with knee osteoarthritis (OA). Forty patients with OA were randomly allocated to an active laser group or to a placebo laser group (20 per group). They either received active or sham laser treatment at ...
journal_title:Lasers in medical science
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10103-007-0536-9
更新日期:2009-03-01 00:00:00
abstract::Reepithelialization and wound closure are the desired outcome for several ulcerative conditions. Such resolution reduces the possibility of wound contamination and maintenance of the injury and improves the reestablishment of tissue morphology and functions. Investigators are seeking adjuvant therapies that can accele...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-017-2176-z
更新日期:2018-02-01 00:00:00
abstract::The aim of the present study was to investigate and compare the effects of high intensity laser therapy (HILT) and low level laser therapy (LLLT) on the treatment of patients with Bell's palsy. Forty-eight patients participated in and completed this study. The mean age was 43 ± 9.8 years. They were randomly assigned i...
journal_title:Lasers in medical science
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10103-013-1352-z
更新日期:2014-01-01 00:00:00