Effect of combined laser acupuncture on knee osteoarthritis: a pilot study.


:Our objective was to assess the efficacy and safety of combined 10.6 microm and 650 nm laser irradiation on patients with knee osteoarthritis (OA). Forty patients with OA were randomly allocated to an active laser group or to a placebo laser group (20 per group). They either received active or sham laser treatment at acupoint Dubi (ST 35) in a total of 12 sessions. There was significant difference between the two groups in the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index pain score change from baseline after 2 weeks of treatment (P = 0.047). The pain reduction of the active laser treatment group was 49%, whereas that of the placebo control group was only 13%. However, due to the high patient drop-out rate, the 4-week assessment could not be analyzed. Combined laser treatment seems beneficial to patients with knee OA. However, due to the small sample size and the high drop-out rate of patients in the placebo group, a large sample-size clinical trial is warranted to determine further the therapeutic efficacy of the device.


Lasers Med Sci


Shen X,Zhao L,Ding G,Tan M,Gao J,Wang L,Lao L




Has Abstract


2009-03-01 00:00:00












  • The thermal impact of phototherapy with concurrent super-pulsed lasers and red and infrared LEDs on human skin.

    abstract::From the very first reports describing the method of action of phototherapy, the effects have been considered to be the result of photochemical and photophysical interactions between the absorbed photons and tissue and not related to secondary changes in tissue or skin temperature. However, thermal effects have been r...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Grandinétti Vdos S,Miranda EF,Johnson DS,de Paiva PR,Tomazoni SS,Vanin AA,Albuquerque-Pontes GM,Frigo L,Marcos RL,de Carvalho Pde T,Leal-Junior EC

    更新日期:2015-07-01 00:00:00

  • Development of a real-time blood damage monitoring device for cardiopulmonary bypass system using near-infrared spectroscopy.

    abstract::The optical properties of hemoglobin could indicate the degree of hemolysis. We aimed to utilize this to develop a real-time blood damage monitoring device for cardiopulmonary bypass (CPB) systems. The real-time blood damage monitoring device comprised a near-infrared spectroscopy optical module with a fiber spectrome...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Gu X,Wang T,Zheng K,Jiang Z,Jiang H

    更新日期:2020-07-10 00:00:00

  • Efficacy and safety of fractional carbon dioxide laser for treatment of unwanted facial freckles in phototypes II-IV: a pilot study.

    abstract::Facial freckles are a cosmetic concern to Egyptians, particularly young females. Several therapeutic lines exist with variable response rates and limitations. Fractional carbon dioxide (FCO2) laser provides minimal ablation and therefore less down time and less side effects. The efficacy and safety of this laser techn...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: El Zawahry B,Zaki N,Hafez V,Abdel Hay R,Fahim A

    更新日期:2014-11-01 00:00:00

  • Radiological and biochemical effects (CTX-II, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia.

    abstract::Inflammation of synovial membrane and degeneration of articular cartilage in osteoarthritis (OA) lead to major changes in joint space width (JSW) and biochemical components such as collagen-II telopeptide (CTX-II) and matrix metallo protineases (MMP-3, 8, and 13). Low-level laser therapy (LLLT) is thought to have an a...

    journal_title:Lasers in medical science

    pub_type: 杂志文章,随机对照试验


    authors: S GN,Kamal W,George J,Manssor E

    更新日期:2017-02-01 00:00:00

  • Excimer laser (308 nm) recanalisation of in-stent restenosis: thermal considerations.

    abstract::Excimer laser recanalisation of in-stent restenosis may be a viable modality for improving coronary patency. However, the presence of arterial stents modifies the thermal properties of the irradiated area and may alter temperature patterns generated during ablation. The goal of this study was to evaluate, in vitro, te...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Papaioannou T,Yadegar D,Vari S,Shehada R,Grundfest WS

    更新日期:2001-01-01 00:00:00

  • Light-emitting diode therapy increases collagen deposition during the repair process of skeletal muscle.

    abstract::This study analyzed the effects of light-emitting diode (LED) therapy on the morphology of muscle tissue as well as collagen remodeling and matrix metalloproteinase 2 (MMP-2) activity in the skeletal muscle of rats following acute injury. Wistar rats were divided into four groups: (1) control, (2) sham, (3) untreated ...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: de Melo CA,Alves AN,Terena SM,Fernandes KP,Nunes FD,da Silva Dde F,Bussadori SK,Deana AM,Mesquita-Ferrari RA

    更新日期:2016-04-01 00:00:00

  • Antiinflammatory effect of low-level laser therapy on Staphylococcus epidermidis endophthalmitis in rabbits.

    abstract::A rabbit model of endophthalmitis was established to evaluate the antiinflammatory effect of low-level laser therapy (LLLT) as an adjunct to treatment for Staphylococcus epidermidis endophthalmitis. Rabbits were randomly divided into three groups to receive intravitreal injections into their left eye: group A received...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Ma WJ,Li XR,Li YX,Xue ZX,Yin HJ,Ma H

    更新日期:2012-05-01 00:00:00

  • Evaluation of irradiation effects of near-infrared free-electron-laser of silver alloy for dental application.

    abstract::In the application of lasers in dentistry, there is a delicate balance between the benefits gained from laser treatment and the heat-related damage arising from laser irradiation. Hence, it is necessary to understand the different processes associated with the irradiation of lasers on dental materials. To obtain insig...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Kuwada-Kusunose T,Kusunose A,Wakami M,Takebayashi C,Goto H,Aida M,Sakai T,Nakao K,Nogami K,Inagaki M,Hayakawa K,Suzuki K,Sakae T

    更新日期:2017-08-01 00:00:00

  • Effects of UVB and UVC irradiation on cariogenic bacteria in vitro.

    abstract::The aim of this study was to evaluate the bactericidal effect of ultraviolet (UV) light at 265-nm (UVC) and 310-nm (UVB) wavelengths from a newly developed UV light-emitting diode (LED) device against cariogenic bacteria in vitro. Suspensions of Streptococcus mutans (S. mutans) and Streptococcus sobrinus were directly...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Uchinuma S,Shimada Y,Matin K,Hosaka K,Yoshiyama M,Sumi Y,Tagami J

    更新日期:2019-07-01 00:00:00

  • Low-level 809 nm GaAlAs laser irradiation increases the proliferation rate of human laryngeal carcinoma cells in vitro.

    abstract::The aim of the study was to investigate the effect of low-level 809 nm laser irradiation on the proliferation rate of human larynx carcinoma cells in vitro. Epithelial tumor cells were obtained from a laryngeal carcinoma and cultured under standard conditions. For laser treatment the cells were spread on 96-well tissu...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Kreisler M,Christoffers AB,Willershausen B,d'Hoedt B

    更新日期:2003-01-01 00:00:00

  • The efficacy of subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy.

    abstract::Central serous chorioretinopathy (CSC) is a disease characterized by a well-defined serous detachment of the neurosensory retina. Therapeutic options in chronic cases are limited, and side effects can result in a limited response. The aim of this article is to assess the efficacy of subthreshold micropulse laser thera...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Uzlu D,Erdöl H,Kola M,Özbay AD

    更新日期:2020-08-19 00:00:00

  • Encrustation of urologic double pigtail catheters-an ex vivo optical coherence tomography (OCT) study.

    abstract::This study aims to evaluate whether optical coherence tomography (OCT) using both the surface and the endoluminal technique is feasible to investigate the locations and degree of encrustation process in clinically used ureteral stents. After removal from patients, 14 polyurethane JJ stents were investigated. A fresh J...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Bader MJ,Zilinberg K,Weidlich P,Waidelich R,Püls M,Gratzke C,Stief CG,Stepp H,Sroka R

    更新日期:2013-05-01 00:00:00

  • Transoral laser microsurgery for laryngeal cancer: a primer and review of laser dosimetry.

    abstract::Transoral laser microsurgery (TLM) is an emerging technique for the management of laryngeal and other head and neck malignancies. It is increasingly being used in place of traditional open surgery because of lower morbidity and improved organ preservation. Since the surgery is performed from the inside working outward...

    journal_title:Lasers in medical science

    pub_type: 杂志文章,评审


    authors: Rubinstein M,Armstrong WB

    更新日期:2011-01-01 00:00:00

  • Non-excision treatment of multiple cutaneous neurofibromas by laser photocoagulation.

    abstract::Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder characterized by skin tumours derived from peripheral nerves. It is a clinically diagnosed disorder of a mainly cosmetic concern. There are different excision modalities for treatment of cutaneous neurofibromas; however, none is considered to be univers...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Elwakil TF,Samy NA,Elbasiouny MS

    更新日期:2008-07-01 00:00:00

  • A randomised controlled trial of ALA vs. Photofrin photodynamic therapy for high-grade dysplasia arising in Barrett's oesophagus.

    abstract::Photofrin photodynamic therapy (PDT) is a licenced treatment for Barrett's oesophagus (BE) with high-grade dysplasia (HGD) but causes strictures and photosensitivity and complete reversal of dysplasia (CR-HGD) by 50 % at 5 years. 5-Aminolaevulinic acid (ALA) is an alternative treatment with non-randomised data suggest...

    journal_title:Lasers in medical science

    pub_type: 杂志文章,随机对照试验


    authors: Dunn JM,Mackenzie GD,Banks MR,Mosse CA,Haidry R,Green S,Thorpe S,Rodriguez-Justo M,Winstanley A,Novelli MR,Bown SG,Lovat LB

    更新日期:2013-05-01 00:00:00

  • Influence of different types of electromagnetic fields on skin reparatory processes in experimental animals.

    abstract::Wound healing is a very complex process, some phases of which have only recently been explained. Magnetic and electromagnetic fields can modulate this process in a non-thermal way. The aim of this research was to compare the influence of constant and pulsed electromagnetic fields and low-level laser therapy (LLLT) on ...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Matic M,Lazetic B,Poljacki M,Djuran V,Matic A,Gajinov Z

    更新日期:2009-05-01 00:00:00

  • Femtosecond lasers for high-precision orthopedic surgery.

    abstract::Laser micromachining with ultrashort pulses has shown great promise for clean, safe surgical treatment of bone tissue. However, comparisons of performance and development of "best practice" have been hampered by the difficulty of comparing results across a wide variety of experimental approaches and under surgically i...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Ashforth SA,Oosterbeek RN,Bodley OLC,Mohr C,Aguergaray C,Simpson MC

    更新日期:2020-08-01 00:00:00

  • Photobiomodulation via a cluster device associated with a physical exercise program in the level of pain and muscle strength in middle-aged and older women with knee osteoarthritis: a randomized placebo-controlled trial.

    abstract::Osteoarthritis (OA) is a chronic joint disease that leads to pain and functional incapacity. The aim of the study is to investigate the effects of the incorporation of photobiomodulation (PBM) (via cluster) into a physical exercise program on the level of pain, lower limb muscle strength, and physical capacity, in pat...

    journal_title:Lasers in medical science

    pub_type: 杂志文章,随机对照试验


    authors: Vassão PG,de Souza MC,Silva BA,Junqueira RG,de Camargo MR,Dourado VZ,Tucci HT,Renno AC

    更新日期:2020-02-01 00:00:00

  • Optical diagnosis of gallbladder cancers via two-photon excited fluorescence imaging of unstained histological sections.

    abstract::Two-photon excited fluorescence (TPEF) microscopy, based on signal from cells, can provide detailed information on tissue architecture and cellular morphology in unstained histological sections to generate subcellular-resolution images from tissue directly. In this paper, we used TPEF microscopy to image microstructur...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Hong Z,Chen Y,Chen J,Chen H,Xu Y,Zhu X,Zhuo S,Shi Z,Chen J

    更新日期:2015-01-01 00:00:00

  • Photoradiation could influence the cytoskeleton organization and inhibit the survival of human hepatoma cells in vitro.

    abstract::Low-power laser therapy has become popular in clinical applications including promoting wound healing and pain relief. However, effects of this photoradiation on human hepatoma cells are rarely studied. Previously, we found 808 nm gallium aluminum arsenide (GaAlAs) continuous wave laser had an inhibitory effect on the...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Liu YH,Ho CC,Cheng CC,Hsu YH,Lai YS

    更新日期:2006-04-01 00:00:00

  • Effect of low-level laser irradiation on cytotoxicity of benzene in human normal fibroblast cells.

    abstract::Benzene is volatile organic hydrocarbon which is widely used in a wide range of industries. Studies have shown that exposure to benzene consequences serious health risks for human. Understanding the effect and risks of environmental hazard materials in the laser therapy of skin is interesting which can show useful or ...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Salemi M,Khorsandi K,Hosseinzadeh R,Maghami P

    更新日期:2021-01-07 00:00:00

  • Effects of different dentin thicknesses and air cooling on pulpal temperature rise during laser welding.

    abstract::The neodymium/yttrium-aluminum-garnet (Nd/YAG) laser has been suggested to repair broken prostheses in the mouth. This study investigated the effects of different dentin thicknesses and air cooling on pulpal temperature rise during laser welding. Three intact human maxillary molars were prepared for full-veneer crown....

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Secilmis A,Bulbul M,Sari T,Usumez A

    更新日期:2013-01-01 00:00:00

  • Comparison of two power densities on the healing of palatal wounds after connective tissue graft removal: randomized clinical trial.

    abstract:UNLABELLED:Connective tissue graft (CTG), which is considered to be among the best techniques for treating gingival recession, has presented stable long-term results. However, this technique causes morbidity and discomfort in the palatine region due to graft removal at that site. A previous study reports that photobiom...

    journal_title:Lasers in medical science

    pub_type: 杂志文章,随机对照试验


    authors: da Silva Neves FL,Silveira CA,Dias SB,Santamaria Júnior M,de Marco AC,Kerbauy WD,de Melo Filho AB,Jardini MA,Santamaria MP

    更新日期:2016-09-01 00:00:00

  • Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin.

    abstract::Dermatosis papulosa nigra (DPN) is a common condition of pigmented skin. Whilst lesions are benign, they may be symptomatic or cosmetically disfiguring. Ablative lasers have previously been reported as a useful therapeutic modality in DPN. We report the largest case series to date of patients with DPN ablated with the...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Ali FR,Bakkour W,Ferguson JE,Madan V

    更新日期:2016-04-01 00:00:00

  • The effect of pre-operative topical anaesthetic cream on the ablative width and coagulative depth of ablative fractional resurfacing laser.

    abstract::Topical anaesthetic cream (TAC) is commonly used as a pre-treatment of ablative fractional resurfacing (AFR) laser. Most of anaesthetic cream contains distilled water as major component. Therefore, pre-operative TAC may interfere the photothermal reaction in the skin treated with fractional carbon-dioxide (FCO2) laser...

    journal_title:Lasers in medical science

    pub_type: 临床试验,杂志文章


    authors: Punyaratabandhu P,Wanitphakdeedecha R,Pattanaprichakul P,Sitthinamsuwan P,Phothong W,Eimpunth S,Lohsiriwat V,Manuskiatti W

    更新日期:2017-02-01 00:00:00

  • Tensile bond strength of sealants following Er:YAG laser etching compared to acid etching in permanent teeth.

    abstract::The aim of this in vitro study was to assess the effect of Er:YAG laser surface treatment on the tensile bond strength of a sealant in permanent teeth. A total of 30 sound third molars were selected and embedded in cold-cure acrylic resin. The enamel surfaces were flattened by a grinding. The teeth were randomly divid...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Shahabi S,Bagheri HG,Ramazani K

    更新日期:2012-03-01 00:00:00

  • Efficacy of low-level laser therapy in the management of orthodontic pain: a systematic review and meta-analysis.

    abstract::This review aimed to identify the efficacy of low-level laser therapy (LLLT) in the management of orthodontic pain. This systematic review and meta-analysis was carried out in accordance with Cochrane Handbook and the PRISMA statement. An extensive literature search for RCTs, quasi-RCTs, and CCTs was performed through...

    journal_title:Lasers in medical science

    pub_type: 杂志文章,meta分析,评审


    authors: He WL,Li CJ,Liu ZP,Sun JF,Hu ZA,Yin X,Zou SJ

    更新日期:2013-11-01 00:00:00

  • Association of photobiomodulation therapy (PBMT) and exercises programs in pain and functional capacity of patients with knee osteoarthritis (KOA): a systematic review of randomized trials.

    abstract::Knee osteoarthritis (KOA) is a common degenerative disease in which several treatments and treatment associations have been investigated. This review analyzed the efficacy of the association of photobiomodulation therapy (PBMT) and exercises for people with KOA in randomized controlled clinical trials. PubMed, Scopus,...

    journal_title:Lasers in medical science

    pub_type: 杂志文章,评审


    authors: Vassão PG,Parisi J,Penha TFC,Balão AB,Renno ACM,Avila MA

    更新日期:2021-01-03 00:00:00

  • Tissue ablation-rate measurements with a long-pulsed, fibre-deliverable 308 nm excimer laser.

    abstract::This ablation rate study has been carried out with a fibre-deliverable, 308 nm, XeCl laser, producing long pulses of 200 ns as opposed to the usual 10-20 ns. This in-depth study aimed to evaluate the ablation rates for this longer pulse length. The effects on the ablation depth of dentine, enamel, soft tissue and bone...

    journal_title:Lasers in medical science

    pub_type: 杂志文章


    authors: Murray AK,Dickinson MR

    更新日期:2004-01-01 00:00:00

  • Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis.

    abstract::Although the application of Q-switched lasers on nevus of Ota (OTA) is well demonstrated, debates about clinical option between Q-switched alexandrite laser (QSA) and Q-switched Nd:YAG laser (QSNY) still remain. This systematic review and meta-analysis estimated the overall successful rate of OTA pigment clearance and...

    journal_title:Lasers in medical science

    pub_type: 杂志文章,meta分析,评审


    authors: Yu P,Yu N,Diao W,Yang X,Feng Y,Qi Z

    更新日期:2016-04-01 00:00:00