Dyrk1A-ASF-CaMKIIδ Signaling Is Involved in Valsartan Inhibition of Cardiac Hypertrophy in Renovascular Hypertensive Rats.

Abstract:

OBJECTIVES:It is known that the expression, activity and alternative splicing of Ca2+/calmodulin-dependent protein kinase IIδ (CaMKIIδ) are dysregulated in the cardiac remodeling process. Recently, we found a further signaling pathway, by which dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) regulates the alternative splicing of CaMKIIδ via the alternative splicing factor (ASF), i.e., Dyrk1A-ASF-CaMKIIδ. In this study, we aimed to investigate whether Dyrk1A-ASF-CaMKIIδ signaling was involved in valsartan inhibition of cardiac hypertrophy in renovascular hypertensive rats. METHODS:Rats were subjected to two kidney-one clip (2K1C) surgery and then treated with valsartan (30 mg/kg/day) for 8 weeks. Hypertrophic parameter analysis was then performed. Western blot analysis was used to determine the protein expression of Dyrk1A and ASF and RT-PCR was used to analyze the alternative splicing of CaMKIIδ in the left ventricular (LV) sample. RESULTS:Valsartan attenuated cardiac hypertrophy in 2K1C rats but without impairment of cardiac systolic function. Increased protein expression of Dyrk1A and decreased protein expression of ASF were observed in the LV sample of 2K1C rats. Treatment of 2K1C rats with valsartan reversed the changes in Dyrk1A and ASF expression in the LV sample. Valsartan adjusted the 2K1C-induced imbalance in alternative splicing of CaMKIIδ by upregulating the mRNA expression of CaMKIIδC and downregulating the mRNA expression of CaMKIIδA and CaMKIIδB. CONCLUSIONS:Valsartan inhibition of cardiac hypertrophy in renovascular hypertensive rats was mediated, at least partly, by Dyrk1A-ASF-CaMKIIδ signaling.

journal_name

Cardiology

journal_title

Cardiology

authors

Yao J,Qin X,Zhu J,Sheng H

doi

10.1159/000441695

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

198-204

issue

3

eissn

0008-6312

issn

1421-9751

pii

000441695

journal_volume

133

pub_type

杂志文章
  • Abnormal left ventricular filling pattern in patients with single vessel coronary artery disease: effect of angioplasty.

    abstract::To study the effect of coronary angioplasty (PTCA) on left ventricular (LV) diastolic filling, mitral Doppler flow tracings of 15 patients with isolated stenosis of the left anterior descending coronary artery (LAD) and normal systolic LV function were recorded before PTCA as well as 24 h and 3 months after successful...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175007

    authors: Ricou F,Lerch R,Meier B,Rutishauser W

    更新日期:1992-01-01 00:00:00

  • The effect of positive inotropes on the failing human myocardium.

    abstract::Heart failure is associated with pathobiochemical changes that can reduce the responsiveness of the myocardium to positive inotropic agents. We studied the contractile effects of a range of inotropic agents on papillary muscle strips from healthy and failing human hearts. Specimens were obtained from patients with dif...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177478

    authors: Erdmann E

    更新日期:1997-01-01 00:00:00

  • Assessment of pseudohypertrophy as a measure of left-ventricular compression in patients with cardiac tamponade.

    abstract:BACKGROUND:Left-ventricular pseudohypertrophy reflecting left-ventricular compression was reported in a selected group of patients with cardiac tamponade. HYPOTHESIS:Criteria for the presence of pseudohypertrophy can be established to guide its use as a sign of left-ventricular compression in patients with cardiac tam...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000047319

    authors: Feinberg MS,Popescu BA,Popescu AC,Di Segni E,Jonas M,Rabinowitz B,Kaplinsky E,Schwammenthal E

    更新日期:2000-01-01 00:00:00

  • The effect of sinus rhythm restoration on high-sensitivity C-reactive protein levels and their association with long-term atrial fibrillation recurrence after electrical cardioversion.

    abstract:OBJECTIVE:Recent studies have shown that high-sensitivity C-reactive protein (hs-CRP) measured before cardioversion (CV) plays a significant role in predicting atrial fibrillation (AF) relapse. The time course of changes in hs-CRP after successful electrical CV remains controversial. The aim of the present study was to...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000327998

    authors: Celebi OO,Celebi S,Canbay A,Ergun G,Aydogdu S,Diker E

    更新日期:2011-01-01 00:00:00

  • When an MI is not an MI: a case of varicella zoster myocarditis.

    abstract::A sixteen-year-old male presented with symptoms and investigations suggestive of acute myocardial infarction. The patient had suffered from a varicella zoster infection 5 days prior to presentation. Varicella myocarditis was suspected and diagnosed following treatment and positive varicella serology. This case highlig...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000106682

    authors: Kelly E,Cullen G,McGurk C

    更新日期:2008-01-01 00:00:00

  • The "Burden" of Malignancy in a Tertiary Hospital Intensive Cardiovascular Care Unit.

    abstract:OBJECTIVES:During the past decade, the most common causes of mortality and morbidity were cardiovascular diseases and malignancies. The aim of the current study was to describe the incidence, course of admission, and short-term (30-day) prognosis of patients with and without malignancy, admitted to a tertiary center in...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000477840

    authors: Mazin I,Matetzky S,Shemer L,Fourey D,Fefer P,Segev A,Abu-Much A,Beigel R,Asher E,Platelets and Thrombosis in Sheba (PLATIS) Study Group.

    更新日期:2017-01-01 00:00:00

  • SGLT-2 Inhibitors in Heart Failure and Type-2 Diabetes: Hitting Two Birds with One Stone?

    abstract::Type 2 diabetes mellitus (T2DM) and heart failure (HF) have a tremendous impact worldwide, markedly reducing life-expectancy and quality of life. It is now known that each disease represents a risk factor for the other. Moreover, when they are combined, the prognosis is significantly worse. Until recently, these patho...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000504694

    authors: Santos-Ferreira D,Gonçalves-Teixeira P,Fontes-Carvalho R

    更新日期:2020-01-01 00:00:00

  • Induction of overdrive excitation in the sinoatrial node in the presence of caffeine.

    abstract::The induction of spontaneous repetitive activity by a drive ('overdrive excitation') was studied in the sinoatrial node of the guinea pig by recording electrical and mechanical activity in sinoatrial preparations made quiescent by exposure to 20 mM caffeine of caffeine plus high [Ca]0. Electrical drive induced action ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174372

    authors: Vassalle M,Carbonin P,Iacono G,Di Gennaro M

    更新日期:1988-01-01 00:00:00

  • Effects of training and of verapamil on exercise capacity in patients recovering from myocardial infarction. A double-blind study.

    abstract::Physical training causes an increase of aerobic capacity in normal and cardiac patients. The influences of training plus placebo and training plus verapamil have been studied in a double-blind randomized trial on 40 patients recovering from actue myocardial infarction. The two groups were comparable as to clinical cha...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000170635

    authors: Rossi P,Giordano A,Tamiz A,Schiavo B,Minuco G

    更新日期:1979-01-01 00:00:00

  • The use of low-dose insulin in cardiogenic shock due to combined overdose of verapamil, enalapril and metoprolol.

    abstract::We describe a case of severe heart failure due to the combined effect of verapamil and enalapril overdose in a patient treated regularly with metoprolol. The patient was dependent for 2 days on glucagon and dopamine infusion but remained oliguric, with deteriorating renal function. Marked improvement in all hemodynami...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000093191

    authors: Hasin T,Leibowitz D,Antopolsky M,Chajek-Shaul T

    更新日期:2006-01-01 00:00:00

  • Glucose and lipid metabolism in essential hypertension: effects of diuretics and ACE-inhibitors.

    abstract::Various aspects of carbohydrate and lipid metabolism were studied in two groups of patients with mild hypertension before and after 6 months' treatment with either lisinopril (n = 10) or hydrochlorothiazide (n = 10). A significant reduction of arterial blood pressure was seen after both treatment regimens. Circulating...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000175965

    authors: De Cesaris R,Ranieri G,Filitti V,Andriani A,Lamontanara G

    更新日期:1993-01-01 00:00:00

  • Gastrointestinal emergencies in cardiac surgery. A retrospective analysis of 3,724 consecutive patients from a single center.

    abstract:OBJECTIVES:The aim of this study is to retrospectively analyze risk factors, diagnosis and management of gastrointestinal (GI) complications following cardiac operations. METHODS:Patients who developed GI complications after a cardiac operation were studied. Anesthesia protocols, techniques of cardiac surgery, potenti...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000119696

    authors: Vassiliou I,Papadakis E,Arkadopoulos N,Theodoraki K,Marinis A,Theodosopoulos T,Palatianos G,Smyrniotis V

    更新日期:2008-01-01 00:00:00

  • Renal function in borderline hypertensive first-degree relatives of essential hypertensives. Effects of sodium load.

    abstract::Renal function in the basal state and after sodium load has been investigated in 21 borderline, hypertensive, first-degree relatives of established hypertensives and in 21 age- and sex-matched, normal subjects with no family history of hypertension. During intravenous infusion of inulin and p-aminohippurate in saline,...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173517

    authors: Trimarco B,De Simone A,Volpe M,Ricciardelli B,Ungaro B,Sacca L,Rengo F,Condorelli M

    更新日期:1982-01-01 00:00:00

  • Blood pressure and sleep apnea: results of long-term nasal continuous positive airway pressure therapy.

    abstract::Arterial blood pressure patterns in 12 men with sleep apnea and arterial hypertension were studied at baseline and after 6 months' therapy with nasal continuous positive airway pressure (nCPAP). Preexisting antihypertensive medication was discontinued 1 week before baseline measurements. Weight did not change during t...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174864

    authors: Mayer J,Becker H,Brandenburg U,Penzel T,Peter JH,von Wichert P

    更新日期:1991-01-01 00:00:00

  • Impact of serum C-reactive protein elevation on the left ventricular spherical change and the development of mitral regurgitation after anterior acute myocardial infarction.

    abstract:BACKGROUND/AIMS:Mitral regurgitation (MR) is frequently observed in patients with acute myocardial infarction (AMI), and is known to convey an adverse prognosis. We sought to clarify the relationship between MR and left ventricular (LV) remodeling, in association with serum C-reactive protein (CRP) elevation. METHODS/...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000099057

    authors: Kohno T,Anzai T,Naito K,Ohno Y,Kaneko H,Li HC,Sugano Y,Maekawa Y,Iwanaga S,Asakura Y,Yoshikawa T,Ogawa S

    更新日期:2007-01-01 00:00:00

  • Systolic anterior motion of the mitral valve with and without asymmetric septal hypertrophy. Role of left ventricular posterior wall motion.

    abstract::Abnormal systolic anterior (SAM) motion of the mitral valve without asymmetric hypertrophy of the interventricular septum was observed in 16 patients (group 1). 5 of the 16 patients had no other evidence of heart disease and the remaining 11 had a variety of cardiac disorders. Left ventricular dimensions, septal and p...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000170860

    authors: Udoshi M,Shah A,Fisher VJ,Dolgin M

    更新日期:1980-01-01 00:00:00

  • Multivariate approach to the treadmill stress test: prospective study.

    abstract::The multivariate analysis approach in 30 normal subjects and 84 patients significantly improved the sensitivity and correct classification rate when compared to the stress test (ST) response (p less than 0.05). Although the probability of disease could separate normal from diseased subjects, it could not separate sing...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173314

    authors: Ellestad MH,Greenberg PS

    更新日期:1981-01-01 00:00:00

  • Age- and gender-related differences in success, major and minor complication rates and the duration of hospitalization after percutaneous transluminal coronary angioplasty.

    abstract::This report describes the effect of age and gender on the results of balloon angioplasty using current technique and indications. A consecutive group of 2,067 patients who underwent angioplasty at a single institution after 1990 is described. Angioplastic success was 92.2% and similar among men and women and the vario...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177127

    authors: Rozenman Y,Gilon D,Zelingher J,Sapoznikov D,Lotan C,Mosseri M,Weiss AT,Hasin Y,Gotsman MS

    更新日期:1996-09-01 00:00:00

  • Water immersion-induced skin wrinkling is related to heart rate variability.

    abstract::Water immersion-induced skin wrinkling (WISW) is dependent on intact peripheral sympathetic function. WISW was hypothesized to reflect autonomic function in subjects without peripheral neuropathy. We prospectively studied 70 healthy subjects (aged 31 ± 8 years, 63% females) without cardiovascular risk factors or neuro...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000316043

    authors: Win S,Salciccioli L,Kamran H,Baweja P,Stewart M,Lazar JM

    更新日期:2010-01-01 00:00:00

  • Sacubitril/Valsartan: Effect on Walking Test and Physical Capability.

    abstract::The 6-min walk test (6MWT) is a simple and inexpensive exercise test to evaluate physical functional capacity that is widely used in heart failure (HF) patients. With the 6MWT, a distance <350 m is associated with increased mortality in patients with HF, and change in walking distance >50 m is considered clinically re...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000484879

    authors: Sgorbini L,Rossetti A,Galati A

    更新日期:2017-01-01 00:00:00

  • Discontinuation of antihypertensive therapy: prevalence of relapses and predictors of successful withdrawal in a hypertensive community.

    abstract::Antihypertensive therapy has been thought to be a life-long treatment. Nevertheless, antihypertensive medication may be discontinued in a substantial proportion of hypertensive patients at least for some time. The current study focused on predictors for the development of elevated blood pressure levels after discontin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177343

    authors: Schmieder RE,Rockstroh JK,Gatzka CD,Rüddel H,Schächinger H

    更新日期:1997-05-01 00:00:00

  • Short- and long-term prognosis after coronary artery bypass grafting in relation to smoking habits.

    abstract::We describe the 2- and 5-year prognoses following coronary artery bypass grafting (CABG) in relation to smoking habits among consecutive patients being operated on in western Sweden during a 3-year period. Among the 2,121 patients, 10.2% admitted smoking at coronary angiography as compared with 7.5% 2 years after CABG...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000177397

    authors: Herlitz J,Haglid M,Albertsson P,Westberg S,Karlson BW,Hartford M,Lurje L,Caidahl K

    更新日期:1997-11-01 00:00:00

  • Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol.

    abstract:OBJECTIVE:Bisoprolol, carvedilol and nebivolol have been shown to be effective in the treatment of heart failure. However, the beta-blocking effects of these drugs have never been compared directly. METHODS:Therefore, we performed a randomized, double-blind, placebo-controlled, cross-over trial in 16 healthy males. Su...

    journal_title:Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000093060

    authors: Stoschitzky K,Stoschitzky G,Brussee H,Bonelli C,Dobnig H

    更新日期:2006-01-01 00:00:00

  • Pioglitazone improves endothelial function in non-diabetic patients with coronary artery disease.

    abstract:OBJECTIVE:To test the hypothesis that pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, will improve endothelial function in non-diabetic subjects with coronary artery disease, we conducted a prospective study to evaluate the effect of this medication on the brachial artery vasomotor function an...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000096601

    authors: Staniloae C,Mandadi V,Kurian D,Coppola J,Bernaski E,El-Khally Z,Morlote M,Pinassi E,Ambrose J

    更新日期:2007-01-01 00:00:00

  • Hypomethylation of the Angiotensin II Type I Receptor (AGTR1) Gene Along with Environmental Factors Increases the Risk for Essential Hypertension.

    abstract:OBJECTIVES:The present study aimed to evaluate the hypertension status of community residents, analyze environmental and epigenetic factors, and propose prevention measures for hypertension. METHODS:In our study, different methylation levels were distinguished utilizing melting temperature (Tm) values in both the case...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000458520

    authors: Lin J,Lin S,Wu Y,Wang X,Wu S,Li H

    更新日期:2017-01-01 00:00:00

  • Hormone replacement therapy does not affect plasma homocysteine in postmenopausal women with coronary artery disease. Free tissue factor pathway inhibitor antigen, a circulating anticoagulant, is related to plasma homocysteine.

    abstract:OBJECTIVE:The objective was to evaluate the effect of hormone replacement therapy (HRT) on plasma homocysteine levels in postmenopausal women with coronary artery disease (CAD) and to investigate associations of homocysteine to other cardiovascular risk factors. METHODS:The women in this single-center, controlled, and...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000064667

    authors: Os I,Os A,Sandset PM,Bølling S,Seljeflot I,Djurovic S,Westheim A

    更新日期:2002-01-01 00:00:00

  • Dyspnea and reversibility of antiplatelet agents: ticagrelor, elinogrel, cangrelor, and beyond.

    abstract:CONTEXT:Oral reversible platelet P2Y12 receptor inhibitors (ticagrelor and elinogrel) cause double-digit rates of dyspnea, while irreversible oral antiplatelet drugs (aspirin, ticlopidoine, clopidogrel, and prasugrel) or intravenous glycoprotein IIb/IIIa inhibitors (abciximab, eptifibatide, or tirofiban) do not increas...

    journal_title:Cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000354876

    authors: Serebruany VL,Sibbing D,DiNicolantonio JJ

    更新日期:2014-01-01 00:00:00

  • Association of apolipoprotein J polymorphism 1598delT with coronary artery disease and lipoprotein levels.

    abstract:OBJECTIVES:To investigate a polymorphism of the apolipoprotein J (APOJ) gene in relation to coronary artery disease (CAD) and lipid variables in a Chinese male population of genetically unrelated individuals. METHODS:In this study, we recruited 126 control male subjects and 237 CAD male patients. CAD was defined as a ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000326852

    authors: Pan JP,Wei SL,Chiang SC,Lee-Chen GJ

    更新日期:2011-01-01 00:00:00

  • Digital Health in Cardiology: The Estonian Perspective.

    abstract:BACKGROUND:Digital health is rapidly entering clinical practice in cardiology. Estonia is one of the leading nations in implementing digital nationwide solutions. Recently, the European Society of Cardiology organized the 1st Summit on Digital Health in Tallinn, which provided the opportunity to discuss various aspects...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000504564

    authors: Lotman EM,Viigimaa M

    更新日期:2020-01-01 00:00:00

  • A pilot study exploring the mechanisms involved in the longitudinal propagation of acute aortic dissection through computational fluid dynamic analysis.

    abstract:OBJECTIVE:This study sought to elucidate the underlying hemodynamic mechanisms involved in the longitudinal propagation of acute, type-B aortic dissections. METHODS:Three-dimensional patient-specific aortic geometry was reconstructed from computed tomography images of 3 cases, followed by computational fluid dynamic a...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000358041

    authors: Zhang Y,Lu Q,Feng J,Yu P,Zhang S,Teng Z,Gillard JH,Song R,Jing Z

    更新日期:2014-01-01 00:00:00