Hormone replacement therapy does not affect plasma homocysteine in postmenopausal women with coronary artery disease. Free tissue factor pathway inhibitor antigen, a circulating anticoagulant, is related to plasma homocysteine.

Abstract:

OBJECTIVE:The objective was to evaluate the effect of hormone replacement therapy (HRT) on plasma homocysteine levels in postmenopausal women with coronary artery disease (CAD) and to investigate associations of homocysteine to other cardiovascular risk factors. METHODS:The women in this single-center, controlled, and randomized study were examined at baseline, and after 3 and 12 months, after they had been recruited consecutively from patients referred for investigational coronary angiography. All analyses were performed examiner blind. They were randomized to HRT consisting of transdermal application of continuous 17beta-estradiol with cyclic medroxyprogesterone acetate (MPA) tablets for 14 days every 3rd month, or to a control group. RESULTS:After 3 months of unopposed 17beta-estradiol, no significant effect on homocysteine was observed compared to the control group. The absolute decrease of 5% in median plasma homocysteine levels after 12-month HRT did not reach statistical significance. Plasma homocysteine seemed slightly higher in women with three- or four-vessel disease, but the difference was not significant. With increasing homocysteine levels, free tissue factor pathway inhibitor (TFPI) antigen increased, whereas E-selectin decreased. In women with diabetes or elevated blood glucose >6.0 mmol/l, plasma homocysteine was correlated to body mass index, C-peptide and insulin as well as age. CONCLUSION:Transdermal application of 17beta-estradiol and sequential MPA do not affect plasma homocysteine in women with established CAD. Plasma homocysteine is stable in women with CAD over time, and unless special intervention is undertaken, repetitive measurements are not necessary in this particular group of high-risk individuals. The circulating anticoagulant TEPI is related to plasma homocysteine.

journal_name

Cardiology

journal_title

Cardiology

authors

Os I,Os A,Sandset PM,Bølling S,Seljeflot I,Djurovic S,Westheim A

doi

10.1159/000064667

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

6-12

issue

1-2

eissn

0008-6312

issn

1421-9751

pii

64667

journal_volume

98

pub_type

临床试验,杂志文章,随机对照试验
  • Common form of Lyme borreliosis carditis--complete heart block with syncope: report on 3 cases.

    abstract::Third degree atrioventricular (AV) heart block with severe Adams-Stokes attacks in 3 patients with Lyme borreliosis is described. All patients had similar clinical manifestations: previously healthy, they experience syncope as an abrupt onset of the disease. Data on skin changes--erythema migrans--was subsequently obt...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177064

    authors: Vasiljević Z,Dmitrović R,Naumović Z,Ostojić M,Radosavljević M,Karadzić A,Prostran M,Colić M

    更新日期:1996-01-01 00:00:00

  • Exercise-induced human coronary collateral function: quantitative assessment during acute coronary occlusions.

    abstract::In 50 patients undergoing percutaneous transluminal coronary angioplasty because of chronic angina pectoris, a collateral flow index (CFI) was determined at the start and the end of two 1-min coronary occlusions, randomly accompanied by a resting state or a 3-min dynamic handgrip exercise (DHE). CFI expressing collate...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000073039

    authors: Pohl T,Wustmann K,Zbinden S,Windecker S,Mehta H,Meier B,Seiler C

    更新日期:2003-01-01 00:00:00

  • Atrial fibrillation and antithrombotic therapy in a 75-year-old population.

    abstract:AIMS:To find the true prevalence of diagnosed and undiagnosed atrial fibrillation (AF) in a population aged 75 years in 2 municipalities in Norway, and to study the use of antithrombotic therapy in this group. METHODS:All 1,117 citizens in Asker and Baerum municipalities in eastern Norway born in 1930 were invited to ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000107789

    authors: Tveit A,Abdelnoor M,Enger S,Smith P

    更新日期:2008-01-01 00:00:00

  • Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol.

    abstract:OBJECTIVE:Bisoprolol, carvedilol and nebivolol have been shown to be effective in the treatment of heart failure. However, the beta-blocking effects of these drugs have never been compared directly. METHODS:Therefore, we performed a randomized, double-blind, placebo-controlled, cross-over trial in 16 healthy males. Su...

    journal_title:Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000093060

    authors: Stoschitzky K,Stoschitzky G,Brussee H,Bonelli C,Dobnig H

    更新日期:2006-01-01 00:00:00

  • Postinfarction unstable angina. Pathophysiologic basis for current treatment modalities.

    abstract::Unstable angina is an acute coronary syndrome characterized by the rapid progression of clinical symptoms which may culminate in acute myocardial infarction, infarct extension or sudden death. The pathologic substrate involves atherosclerotic plaque rupture with platelet deposition, thrombus formation and coronary art...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000174485

    authors: Becker RC,Gore JM,Alpert JS

    更新日期:1989-01-01 00:00:00

  • [Physiology of orthostatic regulation].

    abstract::The arterial blood pressure is integrated into a feedback control system and practically depends on three parameters, i. e. blood volume, heart dynamics, and peripheral resistance. When circulation is disturbed in the orthostatic, the correcting elements heart and vessels have to adapt themselves according to this dem...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169794

    authors: Rieckert H

    更新日期:1976-01-01 00:00:00

  • Wandering atrial pacemaker associated with repetitive respiratory strain.

    abstract::Electrocardiographic responses of body-builders and control subjects obtained during the performance of static and dynamic Valsalva maneuvers were studied to determine the causative stimulus for wandering pacemaker activity. The incidence of shifting or wandering pacemaker was nearly double in body-builders, suggestin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173486

    authors: Borgia JF,Nizet PM,Gliner JA,Horvath SM

    更新日期:1982-01-01 00:00:00

  • Glycosylated Hemoglobin as a Surrogate for the Prevention of Cardiovascular Events in Cardiovascular Outcome Trials Comparing New Antidiabetic Drugs to Placebo.

    abstract:BACKGROUND AND OBJECTIVES:The value of glycosylated hemoglobin (HbA1c) as a surrogate marker for the prevention of cardiovascular outcomes on antidiabetic drugs is debated. The 2008 FDA guidance led to multiple large clinical trials to evaluate the effect of new antidiabetic drugs versus placebo on major adverse cardia...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000506004

    authors: Ambrosi P,Daumas A,Villani P,Giorgi R

    更新日期:2020-01-01 00:00:00

  • Digital Health in Cardiology: The Estonian Perspective.

    abstract:BACKGROUND:Digital health is rapidly entering clinical practice in cardiology. Estonia is one of the leading nations in implementing digital nationwide solutions. Recently, the European Society of Cardiology organized the 1st Summit on Digital Health in Tallinn, which provided the opportunity to discuss various aspects...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000504564

    authors: Lotman EM,Viigimaa M

    更新日期:2020-01-01 00:00:00

  • Two-Step Distal Radial Artery Cannulation for Challenging Radial Anatomies.

    abstract::The radial artery is the preferred access site for cardiac catheterization because of patient comfort, early ambulation, and improved survival in acute coronary syndromes, when compared to the femoral artery route. However, it is associated with a high radial artery occlusion (RAO) rate, and patent haemostasis which c...

    journal_title:Cardiology

    pub_type:

    doi:10.1159/000510293

    authors: Ferreira-Martins J,Lim PO

    更新日期:2020-12-16 00:00:00

  • Peripheral arterial-vascular disease in women: prevalence, prognosis, and treatment.

    abstract::Lower extremity atherosclerosis results in significant morbidity in women, particularly in women following the menopause. Up to 25% of women aged 55 to 74 years are affected by this disease. When noninvasive testing is used to determine the prevalence of lower extremity atherosclerosis, and men in this age group are e...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000176899

    authors: Gerhard M,Baum P,Raby KE

    更新日期:1995-01-01 00:00:00

  • Coronary artery disease in women: a population-based perspective.

    abstract::Coronary artery disease (CAD) remains a disease of major public health importance among women. In light of this fact, attention has focused recently on the differential expression of the disease in women as compared to men. This review will attempt to describe the characteristics of CAD among women from a population-b...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000176889

    authors: Pagley PR,Goldberg RJ

    更新日期:1995-01-01 00:00:00

  • Oral anticoagulation in nonvalvular atrial fibrillation in clinical practice: impact of CHADS(2) score on outcome.

    abstract:OBJECTIVES:CHADS(2) score predicts embolic risk in patients with nonvalvular atrial fibrillation (NVAF), but also bleeding risk in patients receiving oral anticoagulation (OAC). Our objective is to analyze the effectiveness and safety of OAC in patients with NVAF in daily clinical practice, according to embolic risk ev...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000284450

    authors: Ruiz Ortiz M,Romo E,Mesa D,Delgado M,Anguita M,Castillo JC,Arizón JM,Suárez de Lezo J

    更新日期:2010-01-01 00:00:00

  • Hemodynamics of a stenosis in a complaint artery.

    abstract::The effects of arterial compliance on stenotic hemodynamics were examined in an in vitro arterial preparation. Carotid arteries, obtained from anesthetized mongrel dogs (11.3-15.4 kg), were attached to a perfusion apparatus consisting of a constant pressure reservoir and a fixed distal resistance. To create an intralu...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173478

    authors: Santamore WP,Bove AA,Carey RA

    更新日期:1982-01-01 00:00:00

  • Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation.

    abstract:BACKGROUND:Angiotensin II (Ang II) plays an important role in cardiovascular disease. It also leads to the activation of coagulation. The coagulation protease thrombin induces cellular responses by activating protease-activated receptor 1 (PAR-1). We investigated whether PAR-1 contributes to Ang II-induced cardiovascul...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000452269

    authors: Antoniak S,Cardenas JC,Buczek LJ,Church FC,Mackman N,Pawlinski R

    更新日期:2017-01-01 00:00:00

  • Similarities and differences in design considerations for cell therapy and pharmacologic cardiovascular clinical trials.

    abstract::Cell therapies hold the potential for suppression, modification, or cure of disease. Several unique challenges have been recognized as this field has developed. Many of these involve considerations of trial design. This paper summarizes the discussion and suggestions constructed during the 8th Cardiovascular Clinical ...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000110483

    authors: Lewis RM,Gordon DJ,Poole-Wilson PA,Borer JS,Zannad F

    更新日期:2008-01-01 00:00:00

  • Angiographic follow-up of coronary artery ectasia.

    abstract::Of 1,125 patients catheterized over a period of 8 years, 68 (6%) had coronary ectasia. Twenty-five of them were catheterized at least twice and constituted the study group. The time between the first and last catheterization ranged from 2 to 8 years (mean +/- SD = 4.2 +/- 1.6). Coronary ectasia was more frequent in ma...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176907

    authors: Ilia R,Kafri C,Carmel S,Goldfarb B,Gueron M,Battler A

    更新日期:1995-01-01 00:00:00

  • Soluble VCAM-1 and E-selectin, but not ICAM-1 discriminate endothelial injury in patients with documented coronary artery disease.

    abstract::It has been shown that endothelial cell adhesion molecules play an important role in the development of coronary atherosclerosis and inflammatory disease. We sought to test whether soluble vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin are increased in patients wi...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006995

    authors: Semaan HB,Gurbel PA,Anderson JL,Muhlestein JB,Carlquist JF,Horne BD,Serebruany VL

    更新日期:2000-01-01 00:00:00

  • 21-Deoxytetrahydroaldosterone excretion in primary hyperaldosteronism.

    abstract::In earlier studies by our group it was shown that the urinary tetrahydroaldosterone excretion is a more reliable test for the diagnosis of primary aldosteronism than aldosterone-18-glucuronide ('urinary aldosterone'). However, in several patients with primary aldosteronism even the tetrahydroaldosterone values remaine...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173954

    authors: Abdelhamid S,Lewicka S,Vecsei P,Winter J

    更新日期:1985-01-01 00:00:00

  • Surgical closure of the left atrial appendage - a beneficial procedure?

    abstract:BACKGROUND:Closure of the fibrillating left atrial appendage (LAA) has been recommended during valve surgery to decrease the risk of arterial embolism. However, patients undergoing surgical LAA closure have not systematically been reevaluated for complete LAA obliteration. METHODS AND RESULTS:During a 12-month period,...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000087632

    authors: Schneider B,Stollberger C,Sievers HH

    更新日期:2005-01-01 00:00:00

  • The cost-effective way forward for the management of the patient with heart failure.

    abstract::Heart failure is a huge healthcare issue not only for clinicians but for healthcare managers also, with increasing pressure to demonstrate the cost-effectiveness of therapies especially for common chronic conditions. The cost-effectiveness of heart failure treatments relate to their effects on the progression of the d...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000177166

    authors: Giles T

    更新日期:1996-01-01 00:00:00

  • Manifestation of the Wolff-Parkinson-White syndrome during isoprenaline infusion and carotid sinus massage.

    abstract::In a patient with transient WPW syndrome the electrocardiographic pattern of preexcitation could repeatedly be induced by carotid sinus massage during isoprenaline infusion. Adrenergic and cholinergic discharge may favor the conduction of the impulse over an accessory nonfunctional A-V bundle. ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169756

    authors: Gavrilescu S

    更新日期:1976-01-01 00:00:00

  • Comparison of Quality of Life Perceived by Patients with Bioprosthetic versus Mechanical Valves after Composite Aortic Root Replacement.

    abstract:OBJECTIVE:To assess whether postoperative quality of life (QOL) for composite aortic root replacement patients differs according to whether it is based on the use of mechanical valves or bioprosthetic valves. METHODS:The study included 146 consecutive patients who underwent composite aortic root replacement at our ins...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000438783

    authors: Repack A,Ziganshin BA,Elefteriades JA,Mukherjee SK

    更新日期:2016-01-01 00:00:00

  • Cardiovascular Comorbidities Are the Main Predictors of Cardiac Reverse Remodeling following Kidney Transplantation.

    abstract:BACKGROUND:End-stage renal disease is associated with cardiac remodeling, which is partly reversible after kidney transplantation (KT). We aimed to determine the association of cardiovascular comorbidities or kidney-related factors with cardiac reverse remodeling after KT. METHODS:We performed echocardiography in 56 p...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000504381

    authors: Kobayashi M,Huttin O,Schikowski J,Bozec E,Zohra L,Frimat L,Girerd N,Girerd S

    更新日期:2020-01-01 00:00:00

  • Mineralocorticoid and glucocorticoid receptors in circulating mononuclear leukocytes of patients with primary hyperaldosteronism.

    abstract::Mineralocorticoid and glucocorticoid receptors were measured in circulating mononuclear leukocytes in 5 patients affected by Conn's syndrome (3 cases of bilateral adrenal hyperplasia and 2 cases of adenoma plus unilateral hyperplasia). The number of the binding sites per cell resulted significantly lower (189 +/- 114,...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173953

    authors: Armanini D,Witzgall H,Strasser T,Weber PC

    更新日期:1985-01-01 00:00:00

  • Most Important Prognostic Values to Predict Major Adverse Cardiovascular, Cerebrovascular, and Renal Events in Patients with Chronic Kidney Disease Including Hemodialysis for 2 Years.

    abstract::Patients with chronic kidney disease (CKD) have an increased risk of adverse cardiovascular/cerebrovascular events. The aim of this study is to clarify whether stress myocardial perfusion single-photon emission computed tomography (SPECT) could predict cardiovascular/cerebrovascular events. In the Gunma-CKD SPECT Stud...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000496330

    authors: Toyama T,Kasama S,Sato M,Sano H,Ueda T,Sasaki T,Nakahara T,Higuchi T,Tsushima Y,Kurabayashi M

    更新日期:2019-01-01 00:00:00

  • Prognosis of a normal positron emission tomography 82Rb myocardial perfusion imaging study in women with no history of coronary disease.

    abstract:OBJECTIVES:Myocardial perfusion imaging (MPI) with positron emission tomography (PET) has advantages over single-photon emission computerized tomography, particularly for women. This investigation was undertaken to define the prognosis of a normal stress PET MPI study in women. METHODS:The cohort comprised 457 women e...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000323841

    authors: Van Tosh A,Supino PG,Nichols KJ,Garza D,Horowitz SF,Reichek N

    更新日期:2010-01-01 00:00:00

  • Prediction of left ventricular functional recovery by dobutamine echocardiography, F-18 deoxyglucose or 99mTc sestamibi nuclear imaging in patients with chronic myocardial infarction.

    abstract:BACKGROUND:Currently, several modalities are available to predict viability, however, studies comparing various modalities validated by functional recovery after revascularization are scarce. This study analyzed the relative merits of low-dose dobutamine echocardiography, F-18 deoxyglucose (FDG) positron emission tomog...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000067311

    authors: Lund GK,Freyhoff J,Schwaiger M,Lübeck M,Lund CH,Buchert R,Sheehan FH,Meinertz T,Nienaber CA

    更新日期:2002-01-01 00:00:00

  • Transvenous pacemaker leads do not worsen tricuspid regurgitation: a prospective echocardiographic study.

    abstract::Limited prospective data are available regarding the influence of pacemaker leads on tricuspid valve function. To examine the true incidence of these complications, 35 patients were prospectively examined by two-dimensional and Doppler echocardiography before and after implantation of either a permanent pacemaker or a...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000007005

    authors: Leibowitz DW,Rosenheck S,Pollak A,Geist M,Gilon D

    更新日期:2000-01-01 00:00:00

  • Arrhythmogenic right ventricular cardiomyopathy: the challenge of genetic interpretation in clinically suspected cases.

    abstract::This is the case of a 43-year-old Caucasian man with frequent episodes of paroxysmal atrial fibrillation (AF) and normal resting electrocardiogram (ECG), who fulfilled two minor diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC): late potentials by signal-averaged ECG and regional right ven...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000342274

    authors: Anastasakis A,Vouliotis AI,Protonotarios N,Stefanadis C

    更新日期:2012-01-01 00:00:00