Mineralocorticoid and glucocorticoid receptors in circulating mononuclear leukocytes of patients with primary hyperaldosteronism.

Abstract:

:Mineralocorticoid and glucocorticoid receptors were measured in circulating mononuclear leukocytes in 5 patients affected by Conn's syndrome (3 cases of bilateral adrenal hyperplasia and 2 cases of adenoma plus unilateral hyperplasia). The number of the binding sites per cell resulted significantly lower (189 +/- 114, mean +/- SD), as compared with the normal controls (298 +/- 105). The affinity of aldosterone for the receptor was found to be not different than that of healthy control subjects. The capacity and the affinity of dexamethasone for glucocorticoid receptors ranged in the normal values. These data suggest a possible down-regulation of mineralocorticoid receptors in humans.

journal_name

Cardiology

journal_title

Cardiology

authors

Armanini D,Witzgall H,Strasser T,Weber PC

doi

10.1159/000173953

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

99-101

eissn

0008-6312

issn

1421-9751

journal_volume

72 Suppl 1

pub_type

杂志文章
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    pub_type: 杂志文章,评审

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