Abstract:
:Mineralocorticoid and glucocorticoid receptors were measured in circulating mononuclear leukocytes in 5 patients affected by Conn's syndrome (3 cases of bilateral adrenal hyperplasia and 2 cases of adenoma plus unilateral hyperplasia). The number of the binding sites per cell resulted significantly lower (189 +/- 114, mean +/- SD), as compared with the normal controls (298 +/- 105). The affinity of aldosterone for the receptor was found to be not different than that of healthy control subjects. The capacity and the affinity of dexamethasone for glucocorticoid receptors ranged in the normal values. These data suggest a possible down-regulation of mineralocorticoid receptors in humans.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Armanini D,Witzgall H,Strasser T,Weber PCdoi
10.1159/000173953subject
Has Abstractpub_date
1985-01-01 00:00:00pages
99-101eissn
0008-6312issn
1421-9751journal_volume
72 Suppl 1pub_type
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