Increased urinary cortisol and androgen metabolites in a young female with hypertension: partial glucocorticoid resistance syndrome.

Abstract:

:A 21-year-old woman with hypertension confirmed on ambulatory blood pressure monitoring and unresponsive to beta-blockers, diltiazem and amiloride was found to have serum potassium, renin and aldosterone levels at or just below the lower end of normal. Urinary glucocorticoid metabolite analysis revealed high excretion of cortisol and androgen metabolites, with normal serum cortisol levels. This pattern suggests a partial glucocorticoid resistance syndrome; such patients are more responsive to ACE inhibitors and spironolactone.

journal_name

Cardiology

journal_title

Cardiology

authors

Shamim W,Bakhai A,Yousufuddin M,Coats AJ

doi

10.1159/000007015

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

131-2

issue

1-2

eissn

0008-6312

issn

1421-9751

pii

7015

journal_volume

93

pub_type

杂志文章
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