Presence of contractile-type smooth muscle cells in the endocardium.

Abstract:

:A smooth muscle layer exists in the parietal endocardium. Notwithstanding previous pioneer work, little has been known on the phenotypes of these smooth muscles. In humans as in animals, smooth muscles show two distinct phenotypes, the 'synthetic' and 'contractile' states, which can be differentiated on the basis of the expression of two types of myosin heavy chain isoforms, SM1 and SM2. In this study, using SM1- and SM2-specific monoclonal antibodies, we performed immunohistochemical examinations to determine the phenotype of the endocardial smooth muscles. We report here that the endocardial smooth muscles have the contractile phenotype.

journal_name

Cardiology

journal_title

Cardiology

authors

Suzuki T,Aikawa M,Kuro-o M,Watanabe M,Kimura K,Yazaki Y,Nagai R

doi

10.1159/000177055

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

23-7

issue

1

eissn

0008-6312

issn

1421-9751

journal_volume

87

pub_type

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