Abstract:
OBJECTIVES:Endothelin-1 (ET-1) induces cardiac hypertrophy, whereas adiponectin may elicit protective effects in the vasculature and myocardium. We therefore evaluated the relationship between plasma ET-1 and adiponectin levels in heart failure (HF) patients, and the association between adiponectin expression and ET-1-induced hypertrophy of human cardiomyocytes (HCM) in vitro. METHODS:One hundred seventeen patients with chronic HF were enrolled into this study. A group of 7 patients with end-stage HF undergoing heart transplantation was included in the histopathological study. Baseline clinical evaluations and laboratory measurements were performed. HCM cultures were studied to investigate the effect of ET-1 on cell size and adiponectin expression. RESULTS:Plasma ET-1, adiponectin, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) increased with the severity of HF. Higher New York Heart Association functional class, plasma ET-1, adiponectin, and NT-proBNP levels were significant predictors of adverse outcomes in these patients. The myocardial expression of adiponectin was significantly higher in the recipient hearts of patients undergoing emergency or urgent heart transplantation. In cell culture, ET-1 significantly increased cell size and adiponectin expression in HCM. CONCLUSIONS:Adiponectin was significantly elevated in HF and was significantly associated with ET-1. The study provides a basis for further investigation of ET-1 and adiponectin modulation as a therapeutic strategy for ventricular remodeling in HF.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Yin WH,Chen YH,Wei J,Jen HL,Huang WP,Young MS,Chen DC,Liu PLdoi
10.1159/000328780subject
Has Abstractpub_date
2011-01-01 00:00:00pages
207-16issue
4eissn
0008-6312issn
1421-9751pii
000328780journal_volume
118pub_type
杂志文章相关文献
CARDIOLOGY文献大全abstract::The incidence of cardiovascular disease risk factors and other indicators of cardiac impairment were studied in 478 patients prior to their aortocoronary vein bypass operation and 194 patients who had angiographic examination but did not undergo the operation because the clinical and coronary angiographic findings wer...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169758
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Several lines of evidence support the clinical use of trimetazidine as an adjunctive therapy in cardioischemic patients. Therefore, we assessed here the efficacy and safety of adjunctive trimetazidine therapy in acute myocardial infarction (MI) patients by a systematic review and meta-analysis of the current...
journal_title:Cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000446640
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Impaired left ventricular diastolic function is a common finding in essential hypertension. METHODS:In order to investigate possible relationships between flow velocity through the mitral valve (E/A; index of left ventricular diastolic function) and 24-hour blood pressure and heart rate variations, 198 pati...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000078149
更新日期:2004-01-01 00:00:00
abstract::This report describes the effect of age and gender on the results of balloon angioplasty using current technique and indications. A consecutive group of 2,067 patients who underwent angioplasty at a single institution after 1990 is described. Angioplastic success was 92.2% and similar among men and women and the vario...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177127
更新日期:1996-09-01 00:00:00
abstract::Apical segmental dysfunction is an unusual finding in hypertrophic cardiomyopathy (HCM). It is characterized by a poor clinical course and a high incidence of malignant ventricular tachyarrhythmias. Long-term prognosis of patients with HCM and apical segmental dysfunction is still unclear. We report 2 cases of apical ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176917
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of the osteoprotegerin (OPG)/receptor activator of nuclear factor-ĸB (RANK)/RANK ligand (RANKL) axis in the stabilization of spontaneously restored sinus rhythm (SR) in permanent atrial fibrillation (AF) patients after mitral valve (MV) surgery and study its clinical significance...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000342784
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the feasibility and effects of intramuscular injections of autologous bone marrow cells (BMC) combined with off-pump coronary artery bypass grafts (OPCAB) on improving cardiac function in chronic myocardial infarction patients. METHODS:Ninety patients with chronic myocardial ...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000369381
更新日期:2015-01-01 00:00:00
abstract::Abnormal atrial depolarization, characterized by P waves >or=110 ms on the electrocardiogram, can manifest as partial or advanced interatrial conduction delay or interatrial block (IAB). Progression from partial to advanced IAB has been shown to be altered by the use of angiotensin-converting enzyme inhibitors and bet...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000113425
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The shift toward a preventative approach in medical aftercare of congenital heart disease (CHD) patients has led to encouragement of regular physical activity (PA) in this patient population. Objective measures are crucial in accurately displaying PA levels and have increasingly found their way into clinical...
journal_title:Cardiology
pub_type:
doi:10.1159/000512186
更新日期:2021-01-13 00:00:00
abstract::It is well documented that in the treatment of mild or moderate hypertension selective alpha 1-inhibitors such as doxazosin and prazosin lower blood pressure to approximately the same extent as beta-blockers, diuretics, ACE inhibitors and calcium antagonists. However, treatment with selective alpha 1-inhibitors is als...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000175963
更新日期:1993-01-01 00:00:00
abstract::Helicobacter pylori infects over 50% of the worldwide population. For eradication, European, Canadian, and American guidelines recommend a regimen consisting of a proton pump inhibitor, clarithromycin, and metronidazole or amoxicillin dosed twice daily for at least 7 days. When this treatment strategy fails, a complex...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000110489
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Multiple studies have quantified the relationship between aortic size and risk of dissection. However, these studies estimated the risk of dissection without accounting for any increase in aortic size from the dissection process itself. OBJECTIVES:This study aims to compare aortic size before and after diss...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000481930
更新日期:2018-01-01 00:00:00
abstract::Ticagrelor has been shown to be superior to clopidogrel in patients presenting with acute myocardial infarction who undergo early invasive treatment. We discuss a hitherto unreported use of ticagrelor in the management of a patient resistant to multiple thienopyridines at high risk of stent thrombosis. ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000329916
更新日期:2011-01-01 00:00:00
abstract::Three generations of a family with the Romano-Ward syndrome are described. Of all the affected members, only 1 was symptomatic, experiencing episodes of syncope proven to be due to polymorphous ventricular tachycardia (PMVT) induced by chlorimipramine treatment for depression. During treatment of an episode of PMVT wi...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173500
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVES:Atrial fibrillation (AF) is one of the most frequent heart rhythm disorders. It potentially influences cardiac function and its measurement. Cardiac magnetic resonance imaging (CMR) has become the new gold standard for non-invasive assessment of cardiac output (CO). A novel inert gas rebreathing (IGR) device...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000288712
更新日期:2010-01-01 00:00:00
abstract::Since recent studies demonstrated an impaired outcome after percutaneous coronary interventions (PCI) in patients with chronic renal failure but did not address the aetiology of renal failure, we now analysed the outcome of patients with diabetic nephropathy in 721 consecutive patients undergoing PCI. Diabetic nephrop...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000086050
更新日期:2005-01-01 00:00:00
abstract::The combination of oral anticoagulation (OAC) and aspirin was the antithrombotic treatment initially adopted after coronary stenting (PCI-S). Although dual antiplatelet therapy with aspirin and a thienopyridine subsequently proved safer and more effective, OAC and aspirin combination is still used in patients with an ...
journal_title:Cardiology
pub_type: 杂志文章,meta分析
doi:10.1159/000086918
更新日期:2005-01-01 00:00:00
abstract::Heart failure with a preserved ejection fraction (HFpEF) is increasingly prevalent and a leading cause of morbidity and mortality worldwide. HFpEF has a complex pathophysiology, with recent evidence suggesting that an interaction of cardiovascular and noncardiovascular comorbidities (e.g. obesity, hypertension, diabet...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000450573
更新日期:2017-01-01 00:00:00
abstract::Ibopamine is an active dopamine analogue leading to improved renal perfusion and afterload reduction in heart failure. This report describes casuistic experiences in patients with severe heart failure awaiting heart transplantation. All patients could be stabilized, intravenous catecholamines be discontinued, and diur...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175786
更新日期:1992-01-01 00:00:00
abstract::The multivariate analysis approach in 30 normal subjects and 84 patients significantly improved the sensitivity and correct classification rate when compared to the stress test (ST) response (p less than 0.05). Although the probability of disease could separate normal from diseased subjects, it could not separate sing...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173314
更新日期:1981-01-01 00:00:00
abstract::Mass screening for heart disease in children can be accomplished by automatic analysis of phonocardiograms (PCG) obtained from five routine auscultation points. An ECG signal serves as reference. PCG signals exceeding 20% of the amplitude of the first heart sound S1 in the diastolic interval and 40% of S1 in the systo...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169876
更新日期:1978-01-01 00:00:00
abstract::HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors, or 'statins', have revolutionized the management of patients with atherosclerotic vascular disease. Following 2 large acute coronary syndrome trials, additional clinical benefit outside their effect of low-density lipoprotein (LDL) lowering was prop...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000137692
更新日期:2009-01-01 00:00:00
abstract::The venoarterial carbon dioxide tension gradient (P[v-a]CO2) was studied in patients with acute myocardial infarction. Seven patients with congestive heart failure (CHF group) and 10 patients without heart failure (control) were enrolled in this study. In all patients, hemodynamics were continuously monitored. Simulta...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175891
更新日期:1993-01-01 00:00:00
abstract::The early administration of nitrates in acute myocardial infarction (AMI) may lower myocardial oxygen demand and increase blood supply to the ischemic myocardium. Actually, nitrates are the drugs most largely used in AMI patients, but no definite proof of their clinical benefits had been reported before GISSI 3 and IS...
journal_title:Cardiology
pub_type: 杂志文章,meta分析
doi:10.1159/000176441
更新日期:1994-01-01 00:00:00
abstract::The aim of our study was to examine the pathophysiology of ST depression (STD) in leads V1-V3 in the setting of inferior ST elevation myocardial infarction (iSTEMI) through the perspective of cardiac magnetic resonance (CMR). METHODS:Differences in myocardial area at risk (MaR), infarct size, ejection fraction and my...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000491745
更新日期:2018-01-01 00:00:00
abstract:AIMS:The objective of the Coronary Calcification (CC) study was to determine in patients with chronic symptomatic coronary artery disease, if, in addition to standard therapy, nifedipine GITS, relative to placebo, would arrest or slow down the progression of calcium or the development of new atherosclerotic lesions in ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000095308
更新日期:2007-01-01 00:00:00
abstract::In a patient with transient WPW syndrome the electrocardiographic pattern of preexcitation could repeatedly be induced by carotid sinus massage during isoprenaline infusion. Adrenergic and cholinergic discharge may favor the conduction of the impulse over an accessory nonfunctional A-V bundle. ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169756
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVES:MicroRNAs (miRNAs) are noncoding single-stranded RNA molecules that regulate gene expression in physiological functions, development and disease. In recent studies, three miRNAs have been described as muscle or cardiac specific: miR-1, miR-133, and miR-208, being involved in heart development and disease; bu...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000268088
更新日期:2010-01-01 00:00:00
abstract::Patients with acute or chronic heart disease may have limited exercise capacity if they have reduced left ventricular function. Indexes of reduced left ventricular function during exercise are a predictor of subsequent survival although left ventricular ejection fraction is a poor predictor of physical endurance. We e...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000176419
更新日期:1994-01-01 00:00:00
abstract::Cell therapies hold the potential for suppression, modification, or cure of disease. Several unique challenges have been recognized as this field has developed. Many of these involve considerations of trial design. This paper summarizes the discussion and suggestions constructed during the 8th Cardiovascular Clinical ...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000110483
更新日期:2008-01-01 00:00:00