Abstract:
AIMS:The objective of the Coronary Calcification (CC) study was to determine in patients with chronic symptomatic coronary artery disease, if, in addition to standard therapy, nifedipine GITS, relative to placebo, would arrest or slow down the progression of calcium or the development of new atherosclerotic lesions in the coronary arteries. METHODS AND RESULTS:The CC study was part of the ACTION trial. Multi-slice computerized tomography was used to measure and track the progression of CC. Five hundred and eighteen patients were included in this study. The changes in calcium score from baseline every 24 months, over a period of between 4.5 and 6 years, were similar in the nifedipine and placebo treatment groups (p = 0.8). Compared to placebo, more patients in the nifedipine group (71 vs. 60%) were free of new calcified atherosclerotic lesions during follow-up(p = 0.095). CONCLUSION:Nifedipine GITS was not effective in slowing down the progression of calcium in advanced atherosclerotic plaques in patients with stable angina pectoris. Although statistically not significant, Nifedipine demonstrated a trend in slowing down the development of new atherosclerotic lesions.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Motro M,Kirwan BA,de Brouwer S,Poole-Wilson PA,Shemesh J,ACTION CC side-arm study.doi
10.1159/000095308subject
Has Abstractpub_date
2007-01-01 00:00:00pages
165-71issue
3eissn
0008-6312issn
1421-9751pii
95308journal_volume
107pub_type
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