The National Exercise and Heart Disease Project. The pre-randomization exercise program. Report number 2.

Abstract:

:The National Exercise and Heart Disease Project (NEHDP) was funded by the Rehabilitation Services Administration (RSA) of the Department of Health, Education and Welfare, to determine the effects of regular physical activity on the rehabilitation, morbidity and mortality of patients with healed myocardial infarctions. Planning and development lasted from June 1972 through September 1974. Since 1974, 932 subjects were referred for evaluation. At randomization, 651 subjects were assigned to exercise treatment (323) or control (328) groups. Those who qualified for randomization had to complete an initial evaluation, attend 14 of 18 consecutively scheduled, low-level physical activity sessions during a period of 6 weeks, and complete a second evaluation. This prerandomization phase was accompanied by significant alterations in work capacity, heart rate levels at rest and during three levels of physical stress, systolic blood pressure reductions during stress but not at rest, and by changes in the level of anxiety and depression. The subjects will be followed for a minimum of 2 years at regular intervals to determine if regularly performed physical activity is beneficial to the rehabilitation of myocardial infarction survivors.

journal_name

Cardiology

journal_title

Cardiology

authors

Naughton J

doi

10.1159/000169916

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

352-67

issue

6

eissn

0008-6312

issn

1421-9751

journal_volume

63

pub_type

临床试验,杂志文章,随机对照试验
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    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173593

    authors: Markiewicz W,Moscovitz M,Edoute Y,Finkelstein R,Raz R

    更新日期:1983-01-01 00:00:00

  • Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation.

    abstract:BACKGROUND:Angiotensin II (Ang II) plays an important role in cardiovascular disease. It also leads to the activation of coagulation. The coagulation protease thrombin induces cellular responses by activating protease-activated receptor 1 (PAR-1). We investigated whether PAR-1 contributes to Ang II-induced cardiovascul...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000452269

    authors: Antoniak S,Cardenas JC,Buczek LJ,Church FC,Mackman N,Pawlinski R

    更新日期:2017-01-01 00:00:00

  • Wandering atrial pacemaker associated with repetitive respiratory strain.

    abstract::Electrocardiographic responses of body-builders and control subjects obtained during the performance of static and dynamic Valsalva maneuvers were studied to determine the causative stimulus for wandering pacemaker activity. The incidence of shifting or wandering pacemaker was nearly double in body-builders, suggestin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173486

    authors: Borgia JF,Nizet PM,Gliner JA,Horvath SM

    更新日期:1982-01-01 00:00:00

  • Management of spontaneous coronary artery dissection: review of the literature and discussion based on a series of 12 young women with acute coronary syndrome.

    abstract::Spontaneous coronary artery dissection (SCAD) is a rare pathology, principally affecting young women free of atheroma risk factors. Its physiopathology remains little understood, and the prognosis for such acute coronary syndromes is poor, as they occur suddenly. Management is often difficult, and no guidelines exist....

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000244608

    authors: Motreff P,Souteyrand G,Dauphin C,Eschalier R,Cassagnes J,Lusson JR

    更新日期:2010-01-01 00:00:00

  • Radioisotopic renal function studies in essential hypertension.

    abstract::Renal and intrarenal distribution of flow together with an index of cardiac output is measurable using a single injection of 123I-o-iodohippurate. The argument is presented that in the treatment of essential hypertension one should avoid using drugs that reduce renal blood flow, a property of chronic therapy with most...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173940

    authors: Britton KE

    更新日期:1985-01-01 00:00:00

  • The Role of Platelet-Derived Growth Factor-B/Platelet-Derived Growth Factor Receptor-β Signaling in Chronic Atrial Fibrillation.

    abstract:OBJECTIVE:To explore the role of platelet-derived growth factor-B (PDGF-B)/platelet-derived growth factor receptor-β (PDGFR-β) signaling in chronic atrial fibrillation (AF). METHODS:Thirty-nine AF patients and 33 patients with sinus rhythm (SR) were enrolled. Twenty canines were randomized into 5 groups: control, sham...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000442940

    authors: Jiang Z,Zhong G,Wen L,Hong Y,Fang S,Sun P,Li S,Li S,Feng G

    更新日期:2016-01-01 00:00:00

  • Evaluation of the exercise test in patients with angiographically documented coronary artery disease.

    abstract::100 male patients with at least 75% obstruction of one or more coronary arteries were subjected to submaximal exercise tests. Among the 73 subjects who had positive tests, 92% of those with one-vessel obstruction had an ST depression of 1 mm, none having more than 2 mm; by contrast, 44% of those with three-vessel dise...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169871

    authors: Friedmann J,Agmon J,Cherbakoff A,Aygen M,Wurzel M

    更新日期:1977-01-01 00:00:00

  • Cardiovascular changes in awake dogs caused by suddenly induced aortic hypertension.

    abstract::Cardiovascular adaptation to the sudden inflation of a balloon in the descending aorta was investigated in intact awake, standing dogs. The balloon inflation raised pressure in the arterial bed proximal from the balloon. Initially, it lowered heart rate and cardiac output. After 4 sec, heart rate and cardiac output be...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169905

    authors: Ehrlich W,Rodriguez-Lopez E

    更新日期:1978-01-01 00:00:00

  • The association between nonalcoholic fatty liver disease, metabolic syndrome and arterial stiffness in nondiabetic, nonhypertensive individuals.

    abstract:OBJECTIVES:To assess the relationship between nonalcoholic fatty liver disease (NAFLD) and arterial stiffness in nondiabetic, nonhypertensive individuals with and without metabolic syndrome (MetS). METHODS:Hepatic ultrasound and brachial-ankle pulse wave velocity (baPWV) were investigated in 4,467 individuals. The sub...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000341248

    authors: Kim BJ,Kim NH,Kim BS,Kang JH

    更新日期:2012-01-01 00:00:00

  • Postoperative hemodynamic and electrophysiological evaluation of the Senning procedure.

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    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173601

    authors: Epstein ML,Riemenschneider TA,Mathewson JW,Hurley EJ

    更新日期:1983-01-01 00:00:00

  • Single versus Dual Antiplatelet Therapy after Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis.

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    journal_title:Cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1159/000490307

    authors: Hu X,Yang FY,Wang Y,Zhang Y,Chen M

    更新日期:2018-01-01 00:00:00

  • Effects of training and of verapamil on exercise capacity in patients recovering from myocardial infarction. A double-blind study.

    abstract::Physical training causes an increase of aerobic capacity in normal and cardiac patients. The influences of training plus placebo and training plus verapamil have been studied in a double-blind randomized trial on 40 patients recovering from actue myocardial infarction. The two groups were comparable as to clinical cha...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000170635

    authors: Rossi P,Giordano A,Tamiz A,Schiavo B,Minuco G

    更新日期:1979-01-01 00:00:00

  • Rationale and design of the prevention of cardiac dysfunction during an Adjuvant Breast Cancer Therapy (PRADA) Trial.

    abstract:OBJECTIVE:The PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA) study is a randomized, placebo-controlled, double-blind trial to determine whether angiotensin receptor blockers (ARB), or beta-blockers or their combination may prevent the development of left ventricular (LV) dysfunction in ...

    journal_title:Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000343622

    authors: Heck SL,Gulati G,Ree AH,Schulz-Menger J,Gravdehaug B,Røsjø H,Steine K,Bratland A,Hoffmann P,Geisler J,Omland T

    更新日期:2012-01-01 00:00:00

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    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000057673

    authors: Bruckert E

    更新日期:2002-01-01 00:00:00

  • Biventricular Rupture with Extracardiac Left-to-Right Shunt Complicating Acute Myocardial Infarction.

    abstract:BACKGROUND:Simultaneous rupture of the left and right ventricles is an extremely rare mechanical complication of acute myocardial infarction (MI). When associated with the formation of a false aneurysm, an extracardiac left-to-right shunt may occur. METHODS:We summarized all published data describing this unique condi...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000444579

    authors: Yalonetsky S,Aronson D

    更新日期:2016-01-01 00:00:00

  • Pleiotropic effects and cholesterol-lowering therapy.

    abstract::HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors, or 'statins', have revolutionized the management of patients with atherosclerotic vascular disease. Following 2 large acute coronary syndrome trials, additional clinical benefit outside their effect of low-density lipoprotein (LDL) lowering was prop...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000137692

    authors: Shaw SM,Fildes JE,Yonan N,Williams SG

    更新日期:2009-01-01 00:00:00

  • Multivariate approach to the treadmill stress test: prospective study.

    abstract::The multivariate analysis approach in 30 normal subjects and 84 patients significantly improved the sensitivity and correct classification rate when compared to the stress test (ST) response (p less than 0.05). Although the probability of disease could separate normal from diseased subjects, it could not separate sing...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173314

    authors: Ellestad MH,Greenberg PS

    更新日期:1981-01-01 00:00:00

  • Long-Term Outcome of Patients with Perimembranous Ventricular Septal Defect: Results from the Belgian Registry on Adult Congenital Heart Disease.

    abstract:OBJECTIVES:Studies evaluating the long-term outcome of adults with ventricular septal defect (VSD) are important to inform patients about prognosis. This study investigated the long-term outcome of patients with perimembranous VSD (pmVSD) followed in the Belgian Registry on Adult Congenital Heart Disease. METHODS:All ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000448513

    authors: Gabriels C,De Backer J,Pasquet A,Paelinck BP,Morissens M,Helsen F,Van De Bruaene A,Budts W

    更新日期:2017-01-01 00:00:00

  • Prognosis of a normal positron emission tomography 82Rb myocardial perfusion imaging study in women with no history of coronary disease.

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    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000323841

    authors: Van Tosh A,Supino PG,Nichols KJ,Garza D,Horowitz SF,Reichek N

    更新日期:2010-01-01 00:00:00

  • Outcome of patients with malignant hypertension and end-stage renal failure treated by long-term hemodialysis.

    abstract::Malignant hypertension is associated with high mortality and morbidity usually caused by cardiovascular events. The course and prognosis of malignant hypertension patients treated with renal replacement therapy has not been thoroughly investigated. In the present work, we compared the clinical evolution and survival o...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006954

    authors: De Lima JJ,da Fonseca JA,Godoy A,Bortolotto LA,Krieger EM

    更新日期:1999-01-01 00:00:00

  • Safety of fenofibrate--US and worldwide experience.

    abstract::Fenofibrate is a fibric acid derivative with enhanced potency and specificity of action on lipids. Preclinical toxicology reveals minimal toxic effects; dose-related changes occurred seldom, with only hepatic effects in rodents (mainly enzyme changes), some renal effects in dogs, and no reactions in monkeys. Teratogen...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,评审

    doi:10.1159/000174488

    authors: Roberts WC

    更新日期:1989-01-01 00:00:00

  • Selective alpha-1 inhibitors: first- or second-line antihypertensive agents?

    abstract::It is well documented that in the treatment of mild or moderate hypertension selective alpha 1-inhibitors such as doxazosin and prazosin lower blood pressure to approximately the same extent as beta-blockers, diuretics, ACE inhibitors and calcium antagonists. However, treatment with selective alpha 1-inhibitors is als...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000175963

    authors: Lund-Johansen P,Hjermann I,Iversen BM,Thaulow E

    更新日期:1993-01-01 00:00:00

  • Sleep quality and quality of life in patients with hypertrophic cardiomyopathy.

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    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000321718

    authors: Pedrosa RP,Lima SG,Drager LF,Genta PR,Amaro AC,Antunes MO,Arteaga E,Mady C,Lorenzi-Filho G

    更新日期:2010-01-01 00:00:00

  • Impact of serum C-reactive protein elevation on the left ventricular spherical change and the development of mitral regurgitation after anterior acute myocardial infarction.

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    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000099057

    authors: Kohno T,Anzai T,Naito K,Ohno Y,Kaneko H,Li HC,Sugano Y,Maekawa Y,Iwanaga S,Asakura Y,Yoshikawa T,Ogawa S

    更新日期:2007-01-01 00:00:00

  • A pilot study exploring the mechanisms involved in the longitudinal propagation of acute aortic dissection through computational fluid dynamic analysis.

    abstract:OBJECTIVE:This study sought to elucidate the underlying hemodynamic mechanisms involved in the longitudinal propagation of acute, type-B aortic dissections. METHODS:Three-dimensional patient-specific aortic geometry was reconstructed from computed tomography images of 3 cases, followed by computational fluid dynamic a...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000358041

    authors: Zhang Y,Lu Q,Feng J,Yu P,Zhang S,Teng Z,Gillard JH,Song R,Jing Z

    更新日期:2014-01-01 00:00:00

  • Valvular heart disease by transthoracic echocardiography is associated with focal brain injury and central neuropsychiatric systemic lupus erythematosus.

    abstract:BACKGROUND:Previous studies using transesophageal echocardiography (TEE) report an association of valvular heart disease (VHD) with cerebral infarcts and central neuropsychiatric systemic lupus erythematosus (NPSLE). However, TEE cannot be routinely used. AIM:To determine if VHD detected by transthoracic echocardiogra...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000099104

    authors: Roldan CA,Gelgand EA,Qualls CR,Sibbitt WL Jr

    更新日期:2007-01-01 00:00:00

  • Does Diabetes Have an Influence on Regional Deformation Parameters in Patients with Normal Systolic Function during Off-Pump Coronary Artery Bypass Grafting?

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    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000380811

    authors: Barisin A,Sonicki Z,Vincelj J,Sutlic Z,Barisin S

    更新日期:2015-01-01 00:00:00

  • Effect of body characteristics on the variables of signal-averaged electrocardiogram in healthy teenage subjects.

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    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175950

    authors: Iwasaka T,Usui H,Masui A,Tamura K,Sugiura T,Karakawa M,Inada M

    更新日期:1993-01-01 00:00:00

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    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000093191

    authors: Hasin T,Leibowitz D,Antopolsky M,Chajek-Shaul T

    更新日期:2006-01-01 00:00:00

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    pub_type: 新闻

    doi:10.1159/000502831

    authors: Xi Q,Liu Z,Song Y,Gan H,Huang Z,Luo Q,Zhao Z

    更新日期:2020-01-01 00:00:00