Valvular heart disease by transthoracic echocardiography is associated with focal brain injury and central neuropsychiatric systemic lupus erythematosus.

Abstract:

BACKGROUND:Previous studies using transesophageal echocardiography (TEE) report an association of valvular heart disease (VHD) with cerebral infarcts and central neuropsychiatric systemic lupus erythematosus (NPSLE). However, TEE cannot be routinely used. AIM:To determine if VHD detected by transthoracic echocardiography (TTE) is associated with focal brain injury on magnetic resonance imaging (MRI) and secondarily with central NPSLE. METHODS:Sixty-nine patients with systemic lupus erythematosus underwent general clinical, neuropsychiatric and laboratory evaluations followed by MRI of the brain and TTE. RESULTS:Forty-one patients (59%) had NPSLE (stroke, transient ischemic attack, cognitive dysfunction, acute confusional state, seizures or psychosis); 46 (67%) had focal brain injury on MRI (cerebral infarcts, white matter lesions or small punctate lesions); 38 (55%) had VHD (vegetations, thickening or regurgitation). VHD was more common in patients with than in those without focal brain injury and NPSLE (all p < 0.05); focal brain lesions were more common in patients with than in those without NPSLE (all p < 0.04); and VHD was an independent predictor of focal brain lesions and NPSLE (both p < 0.04). CONCLUSION:In patients with systemic lupus erythematosus, VHD detected by TTE is associated with focal brain injury and NPSLE.

journal_name

Cardiology

journal_title

Cardiology

authors

Roldan CA,Gelgand EA,Qualls CR,Sibbitt WL Jr

doi

10.1159/000099104

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

331-7

issue

4

eissn

0008-6312

issn

1421-9751

pii

000099104

journal_volume

108

pub_type

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